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eScience 2023年第5期3卷 49-68页

作者： Zhengqing Ye Ying Jiang Li Li Feng Wu Renjie Chen Beijing Key Laboratory of Environmental Science and Engineering School of Material Science&EngineeringBeijing Institute of TechnologyBeijing100081China State Key Laboratory of Reliability and Intelligence of Electrical Equipment School of Material Science and EngineeringHebei University of TechnologyTianjin300401China Advanced Technology Research Institute Beijing Institute of TechnologyJinan250300China Collaborative Innovation Center of Electric Vehicles in Beijing Beijing100081China

The electrocatalytic sulfur reduction reaction(SRR)and sulfur evolution reaction(SER),two fundamental multistep conversion processes in lithium–sulfur batteries(LSBs),are root-cause solutions to overcome sluggish redox kinetics and the polysulfide shuttling effect.Metal–organic framework(MOF)electrocatalysts have emerged as good platforms for catalyzing SRR and SER,but their catalytic performance is challenged by poor electrical conductivity and limited chemical stability.Functionalized MOFs and their hybrids may be beneficial for stabilizing and improving the desired catalytic properties to achieve high-performance LSBs.This review provides a detailed overview of engineering principles for improving the activity,selectivity,and stability of MOFrelated electrocatalysts via composition modulation and nanostructure design as well as hybrid assembly.It presents and discusses the various advances achieved by using in situ characterization techniques,simulations,and theoretical calculations to reveal the dynamic evolution of MOF-related electrocatalysts,enabling an in-depth understanding of the catalysis mechanism at the molecular/atomic level.Lastly,prospects and possible research directions for MOF-related sulfur electrocatalysts are proposed.

关键词： MOF-related electrocatalysts Sulfur reduction/evolution Composition modulation Structure design Mechanism research Lithium-sulfur batteries

Proteomics analysis provides novel biomarkers and therapeutic target candidates in the treatment of the Huang-Pu-Tong-Qiao formula in an AD rat mode

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BIOCELL 2023年第6期47卷 1265-1277页

作者： QIAN CHEN XIN LEI GUANHUA HU YAN WANG zhengqing FANG GUOQUAN WANG HANG SONG SHU ye BIAO CAI School of Integrated Chinese and Western Medicine Anhui University of Chinese MedicineHefei230012China Anhui Province Key Laboratory of Chinese Medicinal Formula Anhui University of Chinese MedicineHefei230012China

Background:Huang-Pu-Tong-Qiao formula(HPTQ),a traditional Chinese herbal formula,has a variety of pharmacological effects.It has been used to treat Alzheimer’s disease(AD)for decades.This study aimed to screen differentially expressed proteins in the hippocampus of AD model rats treated with HPTQ.Proteomic studies of the effects of HPTQ on AD are key to understanding the therapeutic mechanisms of HPTQ and identifying potential therapeutic targets.Methods:We hence used the isobaric tags for relative and absolute quantification(ITRAQ)approach to investigate the differentially expressed proteins in the hippocampus of AD model rats before and after HPTQ administration and to identify the potential therapeutic target proteins of HPTQ.In this study,the learning and memory abilities of AD rats were examined by the Morris water maze test.After HPTQ administration,the differentially expressed proteins in the hippocampus of AD rats were quantified and analyzed in silico.Furthermore,western blotting was used to verify the expression of related proteins.Results:The Morris water maze results showed that HPTQ could improve the learning and memory ability of AD model rats.The proteomics analysis results showed that 57 proteins were differentially expressed,of which 35 were up-regulated and 22 were down-regulated.Bioinformatics analysis indicated that proteins with altered expression after HPTQ treatment were involved in several biological processes that have the potential to exert neuroprotective effects.These included promoting the translation of ribosomes,improving the deposition of amyloid-beta(Aβ),regulating autophagy,regulating neuronal synaptic function and plasticity,and alleviating oxidative stress.Conclusion:In conclusion,we identified several potential therapeutic target proteins and related mechanistic pathways of HPTQ in the treatment of AD,laying the foundation for further investigation of the therapeutic effects of HPTQ.

关键词： Alzheimer’s disease ITRAQ Huang-Pu-Tong-Qiao

Simultaneous Al2O3 Doping and Sulfation in Hierarchically Porous ZrO2 Solid Acids by an One-pot Synthesis for Enhanced Recycling Catalytic Performances

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中国化学：英文版 2011年第3期29卷 483-488页

作者： Wang, Nan Chen, Yu ye, zhengqing Chen, Hangrong Shi, Jianlin State Key Lab of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China

氧化铝在层次地多孔的氧化锆固体酸做和硫酸化经由一个壶和 bi-surfactant-assisted 同时被完成了自己组装过程，把铝硫酸盐用作艾尔和 SO42 吗？来源。没有氧化铝没有层次地多孔的结构，做和做 Al 的 sulfated 氧化锆，准备的合成的稳... 详细信息

氧化铝在层次地多孔的氧化锆固体酸做和硫酸化经由一个壶和 bi-surfactant-assisted 同时被完成了自己组装过程，把铝硫酸盐用作艾尔和 SO42 吗？来源。没有氧化铝没有层次地多孔的结构，做和做 Al 的 sulfated 氧化锆，准备的合成的稳固的酸与 sulfated 氧化锆相比为酯化作用反应显示出许多提高的酸味和再循环的催化活动。

关键词：氧化铝掺杂多孔氧化锆一锅合成硫酸铝固体酸循环利用性能增强催化

NIb of Potyviruses Interacts with NPR1 and Suppresses Its Sumoylation to Decrease Salicylic Acid-mediated Plant Immunity

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NIb of Potyviruses Interacts with NPR1 and Suppresses Its Su...

Straight-Path Following and Formation Control of USVs Using Distributed Deep Reinforcement Learning and Adaptive Neural Network

中国植物病理学会2023年学术年会

作者： LIU Jiahui WU Xiaoyun FANG Yue LIU ye FU zhengqing WANG Aiming CHENG Xiaofei Department of Biological Sciences University of South Carolina London Research and Development Centre Agriculture and Agri-Food Canada

Salicylic acid( SA) signaling pathway plays essential roles in maintaining basal resistance and establishing systemic acquired resistance in plants.NONEXPRESSER OF PATHOGENESIS-RELATED GENES 1(NPR1), the receptor of SA, is the master regulator of SA-mediated resistance.Here, we report that the SA signaling pathway also plays a pivotal role in restricting compatible infection by turnip mosaic virus, a member of the largest plant RNA virus genus Potyvirus of the family Potyviridae.Interestingly, we found that such resistance is counteracted by the viral RNA-dependent RNA polymerase, NUCLEAR INCLUSION B(NIb).We discovered that Nib directly binds to the SUMO-interacting motif 3(SIM3) of NPR1 to prevent SUMO3 interaction and sumoylation, which also impedes the subsequent phosphorylation of NPR1 at Serl1/Ser15.Moreover, we found that the NibNPR1 interaction can be intensified by the sumoylation of NIb by SUMO3.Finally, we show that targeting NPR1 SIM3 is a conserved ability of NIb from diverse potyviruses.These data reveal a novel molecular "arms race" by which potyviruses deploy NIb to suppress NPR1-mediated resistance through disrupting NPR1 sumoylation to promote virus infection.

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IEEE/CAA Journal of Automatica Sinica 2023年第2期10卷 572-574页

作者： zhengqing Han Yintao Wang Qi Sun the School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an 710072China

Dear Editor,This letter presents a distributed deep reinforcement learning(DRL) based approach to deal with the path following and formation control problems for underactuated unmanned surface vehicles(USVs). By constructing two independent actor-critic architectures,the deep deterministic policy gradient(DDPG) method is proposed to determine the desired heading and speed command for each USV.

关键词： Deep policy heading

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面向航发叶片同步抛光的型面聚类分组方法

机械工程学报 2022年第15期58卷 292-301页

作者：张云王小东陈志同朱正清叶欢北方工业大学机械与材料工程学院北京100144 北京航空航天大学机械工程及自动化学院北京100083

叶片是航空发动机核心零件,其制造能力的提升是航空制造业关注的重点。在多主轴阵列机床高效加工的技术背景下,针对批次叶片实际型面一致性不佳造成的同步定轨迹抛光质量不足问题,提出了基于形状的叶片型面聚类分组方法。首先,依据抛光... 详细信息

叶片是航空发动机核心零件,其制造能力的提升是航空制造业关注的重点。在多主轴阵列机床高效加工的技术背景下,针对批次叶片实际型面一致性不佳造成的同步定轨迹抛光质量不足问题,提出了基于形状的叶片型面聚类分组方法。首先,依据抛光去量与预压量关系确定组内叶片容许差异。其次,依据抽样叶片实际型面差异确定分组标志点分布。然后,将两两叶片型面的一致性表示为分组标志点实测数据的向量差,在组内叶片容许差异约束下以Ray-Turi指数为目标确立最优分组。最后,以批次叶片为对象验证了所提聚类分组方法的有效性。验证结果表明该方法可提高批次叶片分组后实际型面的组内一致性(实例为0.0985 mm内),组间超容许差异区域所占比例达到16.67%以上。对分组后叶片进行同步抛光,截面线轮廓度≤0.054 mm,且相同位置处抛光后精度差异≤0.021 mm,从而说明了该方法有助于实现批次叶片的高质量多主轴同步抛光。

关键词：航发叶片复杂型面同步抛光型面一致性聚类分组

Large-scale analysis of the position-dependent binding and regulation of human RNA binding proteins

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Quantitative Biology 2020年第2期8卷 119-129页

作者： Jianan Lin zhengqing Ouyang Department of Biostatistics and Epidemiology School of Public Health and Health SciencesUniversity of MassachusettsAmherstMA 01003USA Department of Biomedical Engineering University of ConnecticutStorrsCT 06269USA

Background:RNA binding proteins(RBPs)play essential roles in the regulation of RNA metabolism.Recent studies have disclosed that RBPs achieve their functions via binding to their targets in a position-dependent pattern on RNAs.However,few studies have systematially addressed the associations between the RBP's functions and their positional binding preferences.Methods:Here,we present large-scale analyses on the functional targets of human RBPs by integrating the enhanced cross-linking and immunoprecipitation followed by sequencing(eCLIP-seq)datasets and the shRNA knockdown followed by RNA-seq datasets that are deposited in the integrated ENCyclopedia of DNA Elements in the human genome(ENCODE)data portal.Results:We found that(1)binding to the translation termination site and the 3'untranslated region is important to most human RBP's in the RNA decay regulation;(2)RBPs’binding and regulation follow a cell-ty pe specific pattern.Conclusions:These analysis results show the strong relationship between the binding position and the functions of RBPs,which provides novel insights into the RBPs'regulation mechanisms.

关键词： RNA binding protein CLIP-seq RNA-seq knockdown RNA regulation

Networked Protection Scheme with Feeding Section as a Unit for High-speed Railway Traction Power Supply System

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CSEE Journal of Power and Energy Systems 2023年第5期9卷 1935-1941页

作者： zhengqing Han Rui Shen Shuping Liu Shibin Gao the School of Electrical Engineering Southwest Jiaotong UniversityChengduChengdu 611756China

In order to rapidly clear a fault in all-parallel autotransformer(AT)railway system,the existing protection scheme trips both faulted line and healthy line.To solve this problem,a novel unit protection scheme is proposed in this paper.From fault characteristics measured at substation(SS),AT station(ATS)and section post(SP),we can observe that SS protective relays can detect all the faults but could not be selective,and ATS or SP relays can discriminate the faulted line but not sensitively enough;therefore,we make full use of the fault characteristics and propose a novel unit protection scheme.We employ directional distance protections at SS,ATS and SP,and unify them with networked inter-tripping signals and interlocking signals.When a forward distance protection detects a fault and does not receive inter-locking signals from reverse distance protections of other relays in a short setting time,it will trip the relevant circuit breaker and send an inter-tripping signal to other relays in the same protection unit.Field test results show the proposed scheme trips only the faulted line rapidly and never interrupts the power supply of healthy lines;therefore,the proposed protection scheme obtains both selectivity and speed.

关键词： All-parallel AT railway system distance protection unit protection

Coordination-driven structure reconstruction in polymer of intrinsic microporosity membranes for efficient propylene/propane separation

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The Innovation 2022年第6期3卷 137-144页

作者： Yanxiong Ren Boyang Chong Wei Xu zhengqing Zhang Lin Liu Yingzhen Wu Yutao Liu Haifei Jiang Xu Liang Hong Wu Hongjun Zhang Bangjiao ye Chongli Zhong Guangwei He Zhongyi Jiang Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhou 350207China Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Chemistry and Chemical Engineering Guangdong Laboratory Shantou 515031China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Separation Membranes and Membrane Processes Tiangong UniversityTianjin 300387China

Polymers of intrinsic microporosity(PIMs),integrating unique microporous structure and solution-processability,are one class of the most promising membrane materials for energy-efficient gas separations.However,the micropores generated from inefficient chain packing often exhibit wide pore size distribution,making it very challenging to achieve efficient olefin/paraffin separations.Here,we propose a coordination-driven reconstruction(CDR)strategy,where metal ions are incorporated into amidoxime-functionalized PIM-1(AO-PIM)to in situ generate coordination crosslinking networks.By varying the type and content of metal ions,the resulting crosslinking structures can be optimized,and the molecular sieving capability of PIM membranes can be dramatically enhanced.Particularly,the introduction of alkali or alkaline earth metals renders more precise micropores contributing to superior C3H6/C3H8 separation performance.K+incorporated AO-PIM membranes exhibit a high ideal C3H6/C3H8 selectivity of 50,surpassing almost all the reported polymer membranes.Moreover,the coordination crosslinking structure significantly improves the membrane stability under higher pressure as well as the plasticization resistant performance.We envision that this straightforward and generic CDR strategy could potentially unlock the potentials of PIMs for olefin/paraffin separations and many other challenging gas separations.

关键词： separation porosity crosslinking