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The zinc finger transcription factor,KLF2,protects against COVID-19 associated endothelial dysfunction

Signal Transduction and Targeted Therapy 2021年第8期6卷 2502-2510页

作者： Suowen Xu Yujie Liu Yu Ding Sihui Luo Xueying Zheng Xiumei wu zhenghong Liu Iqra Ilyas Suyu Chen Shuxin Han Peter J.Little Mukesh K.Jain Jianping Weng Institute of Endocrine and Metabolic Diseases The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Department of Obstetrics and Gynecology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhuiP.R.China Department of Endocrinology and Metabolism The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Sunshine Coast Health Institute University of the Sunshine CoastBirtinyaQLDAustralia School of Pharmacy Pharmacy Australia Centre of Excellencethe University of QueenslandWoolloongabbaQLDAustralia Department of Medicine Case Cardiovascular Research InstituteCase Western Reserve UniversityClevelandOHUSA Department of Medicine Harrington Heart and Vascular InstituteUniversity Hospitals Cleveland Medical CenterClevelandOHUSA The First Affiliated Hospital Bengbu Medical CollegeBengbuChina

Coronavirus disease 2019(COVID-19)is regarded as an endothelial disease(endothelialitis)with its patho-mechanism being incompletely *** evidence has demonstrated that endothelial dysfunction precipitates COVID-19 and its accompanying multi-organ ***,pharmacotherapies targeting endothelial dysfunction have potential to ameliorate COVID-19 and its cardiovascular *** objective of the present study is to evaluate whether kruppel-like factor 2(KLF2),a master regulator of vascular homeostasis,represents a therapeutic target for C0VID-19-induced endothelial ***,we demonstrate that the expression of KLF2 was reduced and monocyte adhesion was increased in endothelial cells treated with COVID-19 patient serum due to elevated levels of pro-adhesive molecules,ICAM1 and ***-1β and TNF-α;two cytokines elevated in cytokine release syndrome in COVID-19 patients,decreased KLF2 gene ***(atorvastatin and tannic acid)and genetic(adenoviral overexpression)approaches to augment KLF2 levels attenuated COVID-19-serum-induced increase in endothelial inflammation and monocyte ***-generation RNA-sequencing data showed that atorvastatin treatment leads to a cardiovascular protective transcriptome associated with improved endothelial function(vasodilation,antiinflammation,antioxidant status,anti-thrombosis/-coagulation,anti-fibrosis,and reduced angiogenesis).Finally,knockdown of KLF2 partially reversed the ameliorative effect of atorvastatin on COVID-19-serum-induced endothelial inflammation and monocyte ***,the present study implicates loss of KLF2 as an important molecular event in the development of COVID-19-induced vascular disease and suggests that efforts to augment KLF2 levels may be therapeutically beneficial.

关键词： KLF2 inflammation elevated

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选择性激光烧结用尼龙1212粉末的制备

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工程塑料应用 2023年第2期51卷 23-28页

作者：金叶高唯孙茂银金正宏吴健贵州省冶金化工研究所贵阳550014 贵州森远增材制造科技有限公司贵阳550014

为得到适用于选择性激光烧结的原材料,降低选择性激光烧结用尼龙1212生产成本,用溶剂沉淀法制备了尼龙1212粉末,讨论了溶剂种类、溶解温度、成核温度等因素对尼龙1212粉末粒度和形貌的影响。通过显微镜、扫描电子显微镜、粒度分析、差... 详细信息

为得到适用于选择性激光烧结的原材料,降低选择性激光烧结用尼龙1212生产成本,用溶剂沉淀法制备了尼龙1212粉末,讨论了溶剂种类、溶解温度、成核温度等因素对尼龙1212粉末粒度和形貌的影响。通过显微镜、扫描电子显微镜、粒度分析、差示扫描量热法等对制备的尼龙1212进行了表征,结果表明采用溶剂沉淀法可有效地制备出分散良好且粒径在20~80μm范围内的尼龙1212球形粉末,其最佳制备工艺条件为:乙醇作溶剂、溶解温度为160℃,将成核温度控制在130℃。对自制尼龙1212和市售选择性激光烧结用尼龙1212进行了松装密度、熔体流动速率、拉伸及弯曲等性能表征,发现两者的粉末性能和制件性能接近,其中自制尼龙1212的弯曲强度和弯曲弹性模量略高于市售尼龙1212,已达到了选择性激光烧结对原材料的要求,能烧结出光滑制件,其尺寸精度可达到±0.1 mm。

关键词：选择性激光烧结溶剂沉淀法尼龙1212 制备工艺

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窄粒径分布近球形PA12粉末制备及其SLS制件性能研究

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塑料工业 2023年第4期51卷 158-164页

作者：高唯金叶孙茂银金正宏吴健贵州省冶金化工研究所贵州贵阳550014 贵州森远增材制造科技有限公司贵州贵阳550014

采用溶剂沉淀法,以聚酰胺12(PA12)母粒和乙醇为原料,通过添加二氧化硅(SiO_(2))控制其球形度及分散度,改善降温速率、溶质/溶剂比及搅拌速度等工艺条件制备粒径分布较窄的PA12粉末。结果表明,SiO_(2)质量浓度为0.15 g/mL,降温速率为0.15... 详细信息

采用溶剂沉淀法,以聚酰胺12(PA12)母粒和乙醇为原料,通过添加二氧化硅(SiO_(2))控制其球形度及分散度,改善降温速率、溶质/溶剂比及搅拌速度等工艺条件制备粒径分布较窄的PA12粉末。结果表明,SiO_(2)质量浓度为0.15 g/mL,降温速率为0.15℃/min,溶质/溶剂比为1∶6,搅拌速度为300 r/min时,PA12粉末形貌规则,球体粒径分布为25~85μm,平均粒径为49.7μm,表面质量较好。SLS成形件表现出较好的力学性能,拉伸强度为43.8 MPa,弯曲强度为47.2 MPa,断裂伸长率为28.1%。

关键词：聚酰胺12 二氧化硅形貌粒径力学性能

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Stereocontrolled construction of dihydrothiopyrano[2,3-b]indole skeleton via organocatalyzed asymmetric cascade aza-Michael-aldol reaction

Stereocontrolled construction of dihydrothiopyrano[2,3-b]ind...

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手性中国2014学术研讨会

作者： Lulu wu Youming Wang zhenghong Zhou State Key Laboratory of Elemento-Organic Chemistry Institute of Elemento-Organic ChemsitryNankai UniversitySynergetic Innovation Center of Chemical Science and Engineering（Tianjin）

＜正＞Indole frameworks,especially chiral ones,are widely distributed in a large number of bioactive natural products and pharmaceuticals.1 Owing to the importance of these bioactive indole derivatives,it is not surprising that enormous efforts have been devoted to the development of efficient syntheses of enantioenriched indole *** the other hand,the interest in the thiopyran heterocycles has been

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含考虑IDR的冷热电联供微网的主动配电网经济优化调度

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电力系统保护与控制 2022年第3期50卷 19-28页

作者：杨晓辉张柳芳吴龙杰冷正旸刘康徐正宏南昌大学信息工程学院江西南昌330031

多个冷热电联供微网接入主动配电网后,微网和配网作为不同利益主体,系统经济调度更具复杂性。为保护各自隐私,提出了一种含冷热电联供微网的主动配电网经济优化调度模型。运用机会约束规划来处理冷热电联供微网群中新能源及冷热电负荷... 详细信息

多个冷热电联供微网接入主动配电网后,微网和配网作为不同利益主体,系统经济调度更具复杂性。为保护各自隐私,提出了一种含冷热电联供微网的主动配电网经济优化调度模型。运用机会约束规划来处理冷热电联供微网群中新能源及冷热电负荷的随机性,采用分布式建模方法,以各自区域的运行成本最小化为目标,运用目标级联法来并行求取各自区域的最优经济调度结果。同时在冷热电联供微网用户侧引入综合需求响应(Integrated Demand Respond,IDR),有利于降低供用能成本。通过改进的IEEE33节点系统算例验证表明,引入IDR后,能有效降低系统运行成本,运用目标级联法能在保护各自区域隐私的基础上求取主动配电网和冷热电联供微网各自最优的经济调度结果。

关键词：冷热电联供微网主动配电网综合需求响应机会约束规划目标级联法

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Numerical studies on the radiation uniformity of Z-pinch dynamic hohlraum

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Matter and Radiation at Extremes 2018年第5期3卷 248-255页

作者： Fuyuan wu Yanyun Chu Rafael Ramis zhenghong Li Yanyun Ma Jianlun Yang Zhen Wang Fan Ye Zhanchang Huang Jianmin Qi Lin Zhou Chuan Liang Shijia Chen Zheyi Ge Xiaohu Yang Shangwu Wang College of Liberal Arts and Sciences National University of Defense TechnologyChangsha410073China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang621900China E.T.S.I.Aeronauticos y del Espacio Universidad Politecnica de MadridMadrid28040Spain IFSA Collaborative Innovation Center Shanghai Jiao Tong UniveristyShanghai200240China

Radiation uniformity is important for Z-pinch dynamic hohlraum driven fusion. In order to understand the radiation uniformity of Z-pinchdynamic hohlraum, the code MULTI-2D with a new developed magnetic field package is employed to investigate the related physical processeson Julong-I facility with drive current about 7e8 MA. Numerical simulations suggest that Z-pinch dynamic hohlraum with radiation temperaturemore than 100 eV can be created on Julong-I facility. Although some X-rays can escape out of the hohlraum from Z-pinch plasma and electrodes, the radiation field near the foam center is quite uniform after a transition time. For the load parameters used in this paper, the transitiontime for the thermal wave transports from r = 1 mm to r = 0 mm is about 2.0 ns. Implosion of a testing pellet driven by cylindrical dynamichohlraum shows that symmetrical implosion is hard to achieve due to the relatively slow propagation speed of thermal wave and the compressionof cylindrical shock in the foam. With the help of quasi-spherical implosion, the hohlraum radiation uniformity and corresponding pelletimplosion symmetry can be significantly improved thanks to the shape modulation of thermal wave front and shock wave front.

关键词： Z-pinch Dynamic hohlraum Radiation uniformity Shock wave Thermal wave

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镉胁迫对绢毛委陵菜-丛枝菌根真菌共生体根系结构和生理的影响

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植物研究 2022年第4期42卷 647-656页

作者：高冰高鹏飞范卫芳冯郑红吴建慧东北林业大学园林学院哈尔滨150040

为从生理水平上揭示绢毛委陵菜(Potentilla sericea L.)-丛枝菌根真菌共生体对镉胁迫的应答机制,以绢毛委陵菜多年生植株为试验材料,分别接种根内根生囊霉(Rhizophagus intraradices)和摩西球囊霉(Funneliformis mosseae),80 d后以不同... 详细信息

为从生理水平上揭示绢毛委陵菜(Potentilla sericea L.)-丛枝菌根真菌共生体对镉胁迫的应答机制,以绢毛委陵菜多年生植株为试验材料,分别接种根内根生囊霉(Rhizophagus intraradices)和摩西球囊霉(Funneliformis mosseae),80 d后以不同浓度的镉胁迫处理并测定菌根侵染率,研究侵染率较高菌种的共生体植株的生理指标变化和结构变化。结果表明:摩西球囊霉较根内根生囊霉对绢毛委陵菜菌根侵染率高,达100%,而根内根生囊霉侵染率为89.33%;接种摩西球囊霉真菌的植物,当镉质量浓度达10 mg·L^(-1)时,细胞壁小范围破裂、液泡出现变小的趋势,高浓度镉(20 mg·L^(-1))处理时,根系细胞壁破裂,细胞无法维持原有形态;镉胁迫下,Cd(5 mg·L^(-1))~Cd(10 mg·L^(-1))MDA含量显著上升(P0.05),植物可以抵抗一定浓度范围的镉胁迫。综合来看,接种摩西球囊菌可以增强绢毛委陵菜耐镉胁迫能力,为利用绢毛委陵菜修复镉污染土壤提供了理论依据。

关键词：绢毛委陵菜镉胁迫 AM真菌生理指标根系结构

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Expression and contribution of microphthalmia-associated transcription factor to the melanin deposition in Liancheng white ducks

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Journal of Integrative Agriculture 2020年第3期19卷 800-809页

作者： XIN Qing-wu MIAO Zhong-wei LIU Zhao-yuan LI Li ZHANG Lin-li ZHU Zhi-ming ZHANG zhenghong ZHENG Nen-zhu WANG Zheng-chao Institute of Animal Husbandry and Veterinary Medicine Fujian Academy of Agricultural SciencesFuzhou 350013P.R.China Provincial Key Laboratory for Developmental Biology and Neurosciences/Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education College of Life SciencesFujian Normal UniversityFuzhou 350007P.R.China

The present study investigates the expression of microphthalmia-associated transcription factor(MITF) and its contribution to the melanin deposition in Liancheng white *** PCR was used to clone the MITF gene sequence from the skin tissue of female Liancheng white *** spectrophotometry was used to detect the melanin *** mRNA expression and melanin deposition in different tissues and organs were detected and their correlation was *** MITF gene(GenBank number: MG516570) was 1 323 bp in length,contains a complete CDS region(34-1 323 bp) and codes 429 amino acids with 100% homology to the MITF of Anas platyrhynchos and over 95% homology to those of Gallus gallus and Coturnix *** evolution analysis reveals a close relationship of Liancheng white ducks with ***,and also to lesser extents with Anser cygnoides,silky fowl and ***,as well as Sus scrofa,Ovis aries and other ***-time quantitative PCR(qPCR) analysis demonstrated that MITF was expressed in skin,gizzard,liver,kidney and muscle,and of these tissues,its expression was the highest in the skin tissue(skin>gizzard>liver>kidney>muscle).Ultraviolet spectrophotometry showed that melanin deposition was positively correlated with the MITF expression level in these five tissues and organs(P<0.05).Together,these results demonstrated a tissue-specific pattern of MITF expression and a positive correlation between MITF expression and melanin deposition,indicating that MITF expression may contribute to the melanin deposition in Liancheng white ducks.

关键词： microphthalmia-associated transcription factor genetic evolution analysis melanin deposition Liancheng white ducks

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基于深度学习的航空铆钉分类及异常情况检测

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中国安全生产科学技术 2023年第6期19卷 199-205页

作者：夏正洪何琥吴建军魏汝祥中国民用航空飞行学院空中交通管理学院四川广汉618307 中国民用航空华北地区管理局北京100621 安阳学院航空工程学院河南安阳455000

针对航空铆钉小目标检测准确率较低、速率较慢等问题,提出1种基于深度学习的航空铆钉分类及异常情况检测方法。首先,根据钉头外观对航空铆钉进行分类,制作航空铆钉数据集;然后,构建航空铆钉分类及异常情况检测模型;最后,从置信度、召回... 详细信息

针对航空铆钉小目标检测准确率较低、速率较慢等问题,提出1种基于深度学习的航空铆钉分类及异常情况检测方法。首先,根据钉头外观对航空铆钉进行分类,制作航空铆钉数据集;然后,构建航空铆钉分类及异常情况检测模型;最后,从置信度、召回率r、精确率p、平均精度值AP、全类平均精度mAP等指标对检测结果进行评价,并将该算法与YOLOx-s、YOLOx-m、YOLOv5、YOLOv4检测结果进行对比。研究结果表明:该算法可以实现对航空铆钉的分类及异常情况检测,检测结果的置信度约为90%,精确率、召回率、AP值分别在95%,85%,88%以上;本文所涉及铆钉分类及异常情况检测效果由好到坏顺序依次为:开槽盘头自攻铆钉、十字槽头铆钉、半圆头铆钉、平头铆钉、沉头铆钉、抽芯铆钉、异常情况;与其他算法相比,基于深度学习的航空铆钉分类及异常情况的检测,其效果和速度均有一定优势。研究结果可为减小航空铆钉松动和脱落风险、减轻飞机重量、防止金属疲劳和提升飞行可靠性及稳定性提供参考。

关键词：深度学习航空铆钉目标检测精确率召回率

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Tea domain transcription factor TEAD4 mitigatesTGF-β signaling and hepatocellular carcinomaprogression independently of YAP

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Journal of Molecular Cell Biology 2023年第2期15卷 3-16页

作者： Weicheng Luo Yi Li Yi Zeng Yining Li Minzhang Cheng Cheng Zhang Fei Li Yiqing wu Chunhong Huang Xiaolong Yang Joachim Kremerskothen Jianmin Zhang Chunbo Zhang Shuo Tu Zhihua Li Zhĳun Luo zhenghong Lin Xiaohua Yan Department of Biochemistry and Molecular Biology School of Basic Medical SciencesNanchang University Jiangxi Medical CollegeNanchang 330031China Department of Rheumatology and Clinical Immunology Jiangxi Provincial People’s HospitalThe First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006China Center for Experimental Medicine The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Pathology and Molecular Medicine Queen’s UniversityKingstonON K7L 3N6Canada Department of Nephrology Hypertension and RheumatologyUniversity Hospital MünsterMünster 48149Germany Department of Cancer Genetics&Genomics Roswell Park Comprehensive Cancer CenterElm and Carlton StreetsBuffaloNY 14203USA School of Pharmacy Nanchang University Jiangxi Medical CollegeNanchang 330008China Key Laboratory of Breast Diseases of Jiangxi Province Nanchang People’s HospitalNanchang 330025China Department of Pathology School of Basic Medical SciencesNanchang University Jiangxi Medical CollegeNanchang 330006China School of Life Sciences Chongqing UniversityChongqing 405200China

Tea domain transcription factor 4 (TEAD4) plays a pivotal role in tissue development and homeostasis by interacting with Yesassociated protein (YAP) in response to Hippo signaling inactivation. TEAD4 and YAP can also cooperate with transforminggrowth factor-β (TGF-β)-activated Smad proteins to regulate gene transcription. Yet, it remains unclear whether TEAD4 playsa YAP-independent role in TGF-β signaling. Here, we unveil a novel tumor suppressive function of TEAD4 in liver cancer viamitigating TGF-β signaling. Ectopic TEAD4 inhibited TGF-β-induced signal transduction, Smad transcriptional activity, and targetgene transcription, consequently suppressing hepatocellular carcinoma cell proliferation and migration in vitro and xenografttumorgrowth in mice. Consistently, depletion of endogenous TEAD4 by siRNAs enhanced TGF-β signaling in cancer cells. Mechanistically,TEAD4 associates with receptor-regulated Smads (Smad2/3) and Smad4 in the nucleus, thereby impairing the binding of Smad2/3to the histone acetyltransferase p300. Intriguingly, these negative effects of TEAD4 on TGF-β/Smad signaling are independent ofYAP, as impairing the TEAD4–YAP interaction through point mutagenesis or depletion of YAP and/or its paralog TAZ has little ***, these results unravel a novel function of TEAD4 in fine tuning TGF-β signaling and liver cancer progression in a YAPindependent manner.

关键词： TGF-β TEAD4 p300 signaling regulation transcriptional activity hepatocellular carcinoma

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