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以校企联合实验室为载体提升药学生创新创业能力

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药学教育 2024年第4期40卷 38-41页

作者：陈铭任兴发祁小乐吴正红中国药科大学国际医药商学院南京211198 月旭科技(上海)股份有限公司上海201613 中国药科大学药学院南京211198

工业药剂学是一门综合性很强的应用技术学科,也是培养药物制剂卓越工程师的核心学科,对学生创新实践能力提出了较高的要求。课程团队发挥联合实验室的载体作用,拓展课题来源渠道,采用双师培养模式,建立系统评价体系,有力地提升了学生的... 详细信息

工业药剂学是一门综合性很强的应用技术学科,也是培养药物制剂卓越工程师的核心学科,对学生创新实践能力提出了较高的要求。课程团队发挥联合实验室的载体作用,拓展课题来源渠道,采用双师培养模式,建立系统评价体系,有力地提升了学生的创新创业能力。

关键词：校企联合实验室创新创业工业药剂学药学教育

三种不同饮用水处理方式对小鼠生长发育的影响

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实验动物科学 2024年第1期41卷 63-69页

作者：王学文武卫国吴征宏邱丽媛李晓庆刘佐民中国食品药品检定研究院实验动物资源研究所北京102629 安维迪生命科学(浙江)有限公司嘉兴314001

目的比较三种不同处理方式的饮用水对SPF级小鼠生长发育的影响。方法实验选用54只SPF小鼠,随机分成3组,分别饮用高压灭菌水、高压酸化水和无菌水袋水90 d,其他饲养管理条件相同。在饲养过程中对饮用水中常规水质指标、微生物以及动物体... 详细信息

目的比较三种不同处理方式的饮用水对SPF级小鼠生长发育的影响。方法实验选用54只SPF小鼠,随机分成3组,分别饮用高压灭菌水、高压酸化水和无菌水袋水90 d,其他饲养管理条件相同。在饲养过程中对饮用水中常规水质指标、微生物以及动物体质量、饮水量、脏器重量和脏器病理形态学等进行测定,测定结果应用SPSS 13.0进行组间差异分析。结果饮水水质常规指标检测合格;14 d内无菌水袋水和酸化水无菌检测均为阴性,高压灭菌水第1天起检测出现阳性;14 d内,酸化水组日均饮水量显著低于高压灭菌水组(P<0.01);与高压灭菌水组相比,水袋水组心脏系数显著升高,肺指数显著降低(P<0.05),酸化水组肝系数显著增高(P<0.05);脏器组织病理形态学结果显示小鼠脏器没有发生病变,为正常脏器组织。结论酸化水和无菌水袋在抑菌方面优于高压灭菌水,无菌水袋水和高压灭菌水在饮水量方面优于酸化水,三种不同处理方式饮用水对于脏器质量和体质量影响无统计学意义。

关键词：高压灭菌水酸化水无菌水袋 SPF小鼠生长发育

Synchronous conjugation of i-motif DNA and therapeutic siRNA on the vertexes of tetrahedral DNA nanocages for efficient gene silence

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Acta Pharmaceutica Sinica B 2021年第10期11卷 3286-3296页

作者： Xiu Han Xiang Xu Ziheng wu zhenghong wu Xiaole Qi Key Laboratory of Modern Chinese Medicines China Pharmaceutical UniversityNanjing 210009China Medical School of Nanjing University Nanjing UniversityNanjing 210093China Parkville Campus Monash UniversityVIC 3052Australia

The functionality of DNA biomacromolecules has been widely excavated,as therapeutic drugs,carriers,and functionalized modification *** this study,we developed a series of DNA tetrahedron nanocages(Td),via synchronous conjugating different numbers of i-(X)and therapeutic siRNA on four vertexes of tetrahedral DNA nanocage(aX-Td@bsiRNA,a+b=4).This i-motif-conjugated Td exhibited good endosomal escape behaviours in A549 tumor cells,and the escape efficiency was affected by the number of ***,the downregulating mRNA and protein expression level of epidermal growth factor receptor(EGFR)caused by this siRNA embedded Td were verified in A549 *** tumor growth inhibition efficiency of the 2X-Td@2siRNA treated group in tumorbearing mice was significantly higher than that of non-i-motif-conjugated Td@2siRNA(3.14-fold)and free siRNA(3.63-fold).These results demonstrate a general strategy for endowing DNA nanostructures with endosomal escape behaviours to achieve effective in vivo gene delivery and therapy.

关键词： i-motif siRNA Gene delivery DNA tetrahedron Endosomal escape Cancer Gene silence Biocompatibility

Combination of High Yield Strength and Improved Ductility of 21Cr Lean Duplex Stainless Steel by Tailoring Cold Deformation and Low-Temperature Short-Term Aging

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Acta Metallurgica Sinica(English Letters) 2024年第4期37卷 695-702页

作者： zhenghong Liu Zhigang wu Ying Han Xiaolei Song Guoqing Zu Weiwei Zhu Xu Ran Key Laboratory of Advanced Structural Materials Ministry of EducationChangchun University of TechnologyChangchun130012China School of Materials Science and Engineering Changchun University of TechnologyChangchun130012China Jilin Province Key Laboratory of Advanced Materials Processing and Application for Rail Transit Changchun University of TechnologyChangchun130012China

Proper matching of cold-rolled deformation and low-temperature short-term aging can simultaneously enhance the strength and ductility of the lean duplex stainless steel. To investigate this, the microstructure evolution of cold-rolled and aging steels was observed by using scanning electron microscopy, transmission electron microscopy and electron backscattered diffraction. Additionally, the phase volume fraction was measured using X-ray diffraction. In this study, it was observed that the elongation of 21Cr lean duplex stainless steel significantly increased to 16.7% after undergoing moderate cold deformation (~ 40% reduction) and subsequent aging treatment at 550 ℃ for 30 min. Remarkably, the material still maintained a high yield strength of 1045 MPa. Such an excellent mechanical property was attributed to a unique microstructure combination of fine α'-martensite, twins, coarsened austenite resulting from partial martensite reverse transformation, and two-phase fine layered structure. The result of this study may open up new horizons for the alloy development in order to overcome the low ductility of cold-rolled high-strength lean duplex stainless steel.

关键词： Lean duplex stainless steel Cold rolling Aging Microstructure Mechanical properties Use our pre-submission checklist

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三种饮用水对NIH小鼠血液指标的影响

实验动物科学 2024年第3期41卷 46-50页

作者：王学文吴征宏彭卫娟邱丽媛董浩左琴刘佐民中国食品药品检定研究院实验动物资源研究所北京102629 安维迪生命科学(浙江)有限公司嘉兴314001

目的探讨三种饮用水对NIH小鼠血液指标的影响。方法将54只NIH小鼠随机分为3组,分别饮用高压灭菌水、高压酸化水和无菌水袋水(膜过滤水),在实验30、60和90 d分别取血进行血常规和血生化检测,并取肝组织进行组织病理学检查,探讨三种饮... 详细信息

目的探讨三种饮用水对NIH小鼠血液指标的影响。方法将54只NIH小鼠随机分为3组,分别饮用高压灭菌水、高压酸化水和无菌水袋水(膜过滤水),在实验30、60和90 d分别取血进行血常规和血生化检测,并取肝组织进行组织病理学检查,探讨三种饮用水对小鼠健康状态的影响。结果 60 d水袋水组白蛋白(ALB)显著高于高压灭菌水组(P0.05),肝组织病理学结果显示各组小鼠肝组织未发现病变,为正常肝组织。结论三种饮用水对NIH小鼠健康状态无明显影响。

关键词：三种饮用水 NIH小鼠血液指标

Micromotor-derived composites for biomedicine delivery and other related purposes

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Bio-Design and Manufacturing 2020年第2期3卷 133-147页

作者： Xiang Xu Zhiyi Huo Jiaming Guo Hao Liu Xiaole Qi zhenghong wu Key Laboratory of Modern Chinese Medicines China Pharmaceutical UniversityNanjing 210009People's Republic of China

Biocompatible designed micromotor has attracted more and more concerns in the field of biomedicine due to their self-propulsion and delivery *** micromotors,mostly consisting of alkali earth metals,hydrogels,or other motile biomaterials,can effectively transform chemical energy into mechanical or kinetic energy to achieve the expected delivery of cargos to the sites of *** for conveying power,the modifiable surface and inner cavity of micromotors guarantee that their potential as versatile delivery systems for therapeutic ***,this review generalizes the propelling mechanisms,composites,and shapes of ***,the application of micromotor-derived composites for biomedicine delivery and other versatile purposes are also discussed.

关键词： Micromotor Propulsion Targeted delivery Retention Penetration

Current progress of computational modeling for guiding clinical atrial fibrillation ablation

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2021年第10期22卷 805-817页

作者： zhenghong wu Yunlong LIU Lv TONG Diandian DONG Dongdong DENG Ling XIA College of Biomedical Engineering&Instrument Science Zhejiang UniversityHangzhou 310027China School of Biomedical Engineering Dalian University of TechnologyDalian 116024China

Atrial fibrillation(AF)is one of the most common arrhythmias,associated with high morbidity,mortality,and healthcare costs,and it places a significant burden on both individuals and ***-arrhythmic drugs are the most commonly used strategy for treating ***,drug therapy faces challenges because of its limited efficacy and potential side *** ablation is widely used as an alternative treatment for ***,because the mechanism of AF is not fully understood,the recurrence rate after ablation remains *** addition,the outcomes of ablation can vary significantly between medical institutions and patients,especially for persistent ***,the issue of which ablation strategy is optimal is still far from *** modeling has the advantages of repeatable operation,low cost,freedom from risk,and complete control,and is a useful tool for not only predicting the results of different ablation strategies on the same model but also finding optimal personalized ablation targets for clinical reference and even *** review summarizes three-dimensional computational modeling simulations of catheter ablation for AF,from the early-stage attempts such as Maze III or circumferential pulmonary vein isolation to the latest advances based on personalized substrate-guided ***,we summarize current developments and challenges and provide our perspectives and suggestions for future directions.

关键词： Atrial fibrillation Catheter ablation Computational modeling Atrial fibrosis

Bone mesenchymal stem cell-derived exosomes involved co-delivery and synergism effect with icariin via mussel-inspired multifunctional hydrogel for cartilage protection

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Asian Journal of Pharmaceutical Sciences 2023年第3期18卷 49-63页

作者： Jia Zeng Peng Sun Yuanqian Zhao Xinning Fang zhenghong wu Xiaole Qi Key Laboratory of Modern Chinese Medicines China Pharmaceutical UniversityNanjing 210009China Industrial Technology Innovation Platform Zhejiang Center for Safety Study of Drug SubstancesHangzhou 310018China

Mesenchymal stem cells(MSC)are particularly effective in promoting cartilage regeneration due to their immunomodulatory,anti-inflammatory and regenerative repair functions of tissues and ***,the intra-articular delivery and synergy with other therapeutic drugs have been the key issues driving their further *** report a mussel-inspired multifunctional hydrogel system,which could achieve co-delivery and synergism effect of MSC-derived exosomes(Exos)with icariin(ICA).The ICA and Exos co-delivered articular cavity injection system are expected to retain in the joint cavity and promote cartilage regeneration,due to the thermosensitive,self-healing and adhesion properties of the mussel-inspired multifunctional *** experimental results proved that Exos enhanced the cellular uptake of ICA by more than 2-fold evenly,and the synergism of Exos and ICA efficiently improve the cell proliferation and *** synergic treatment,the content of matrix metalloproteinase 13 in the supernatant and intracellular decreased by 47%and 59%,*** vivo study,ICA-loaded Exos exhibited prolonged retention behavior bymultifunctional hydrogel delivery,thus displayed an increased cartilage *** the model of osteoarthritis,co-delivery hydrogel system relieved the cartilage recession,ensuring appropriate cartilage thickness.

关键词： Osteoarthritis Icariin Exosomes Multifunctional hydrogel

Applications and developments of gene therapy drug delivery systems for genetic diseases

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Asian Journal of Pharmaceutical Sciences 2021年第6期16卷 687-703页

作者： Xiuhua Pan Hanitrarimalala Veroniaina Nan Su Kang Sha Fenglin Jiang zhenghong wu Xiaole Qi China Pharmaceutical University Nanjing 211198China

Genetic diseases seriously threaten human health and have always been one of the refractory conditions facing ***,gene therapy drugs such as siRNA,shRNA,antisense oligonucleotide,CRISPR/Cas9 system,plasmid DNA and miRNA have shown great potential in biomedical *** avoid the degradation of gene therapy drugs in the body and effectively deliver them to target tissues,cells and organelles,the development of excellent drug delivery vehicles is of utmost *** vectors are the most widely used delivery vehicles for gene therapy in vivo and in vitro due to their high transfection efficiency and stable transgene *** the development of nanotechnology,novel nanocarriers are gradually replacing viral vectors,emerging superior *** review mainly illuminates the current widely used gene therapy drugs,summarizes the viral vectors and non-viral vectors that deliver gene therapy drugs,and sums up the application of gene therapy to treat genetic ***,the challenges and opportunities of the field are discussed from the perspective of developing an effective nano-delivery system.

关键词： Gene therapy drugs Viral vectors Non-viral vectors Genetic diseases Nano-delivery system