Bone mesenchymal stem cell-derived exosomes involved co-delivery and synergism effect with icariin via mussel-inspired multifunctional hydrogel for cartilage protection

作     者：Jia Zeng Peng Sun Yuanqian Zhao Xinning Fang Zhenghong Wu Xiaole Qi Jia Zeng;Peng Sun;Yuanqian Zhao;Xinning Fang;Zhenghong Wu;Xiaole Qi

作者机构：Key Laboratory of Modern Chinese MedicinesChina Pharmaceutical UniversityNanjing 210009China Industrial Technology Innovation PlatformZhejiang Center for Safety Study of Drug SubstancesHangzhou 310018China 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2023年第18卷第3期

页      面：49-63页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Osteoarthritis Icariin Exosomes Multifunctional hydrogel 

摘      要：Mesenchymal stem cells(MSC)are particularly effective in promoting cartilage regeneration due to their immunomodulatory,anti-inflammatory and regenerative repair functions of tissues and ***,the intra-articular delivery and synergy with other therapeutic drugs have been the key issues driving their further *** report a mussel-inspired multifunctional hydrogel system,which could achieve co-delivery and synergism effect of MSC-derived exosomes(Exos)with icariin(ICA).The ICA and Exos co-delivered articular cavity injection system are expected to retain in the joint cavity and promote cartilage regeneration,due to the thermosensitive,self-healing and adhesion properties of the mussel-inspired multifunctional *** experimental results proved that Exos enhanced the cellular uptake of ICA by more than 2-fold evenly,and the synergism of Exos and ICA efficiently improve the cell proliferation and *** synergic treatment,the content of matrix metalloproteinase 13 in the supernatant and intracellular decreased by 47%and 59%,*** vivo study,ICA-loaded Exos exhibited prolonged retention behavior bymultifunctional hydrogel delivery,thus displayed an increased cartilage *** the model of osteoarthritis,co-delivery hydrogel system relieved the cartilage recession,ensuring appropriate cartilage thickness.