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Neuroendocrine carcinoma of the common hepatic duct coexisting with distal cholangiocarcinoma:A case report and review of literature

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1449-1460页

作者： Fei Chen wei-wei Li Juan-Fen Mo Min-Jie Chen Su-Hang Wang Shu-Ying Yang zheng-wei song Department of Hepatobiliary Surgery The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Graduate School Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina The Key Laboratory The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Pathology The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Intensive Medicine The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Neuroendocrine carcinoma(NEC)of the extrahepatic bile duct is very rare,and the treatment and prognosis are ***,we report the case of a middleaged female with primary large cell NEC(LCNEC)of the common hepatic duct combined with distal cholangiocarcinoma(dCCA).Additionally,after a review of the relevant literature,we summarize and compare mixed neuroendocrine-nonneuroendocrine neoplasm(MiNEN)and pure NEC to provide a reference for selecting the appropriate treatment and predicting the prognosis of this rare *** SUMMARY A 62-year-old female presented to the hospital due to recurrent abdominal pain for 2 *** examination showed mild tenderness in the upper abdomen and a positive Courvoisier *** tests showed elevated liver transaminase and carbohydrate antigen 199 *** examination revealed node dissection was performed,and hepatic duct tumours were unexpectedly found during *** suggested poorly differentiated LCNEC(approximately 0.5 cm×0.5 cm×0.4 cm),Ki-67(50%),synaptophysin+,and chromogranin A+.dCCA pathology suggested moderately differentiated *** patient eventually developed lymph node metastasis in the liver,bone,peritoneum,and abdominal cavity and died 24 months after *** sequencing methods were used to compare gene mutations in the two primary bile duct *** The prognosis of MiNEN and pure NEC alone is different,and the selection of treatment options needs to be differentiated.

关键词： Neuroendocrine carcinoma Mixed neuroendocrine-non-neuroendocrine neoplasm Cholangiocarcinoma Extrahepatic bile duct Case report

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Preparation and characterization of Rb-doped TiO_(2) powders for photocatalytic applications

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Rare Metals 2024年第2期43卷 555-561页

作者： Lu Jia Li-Mei Yang wei Wang song-Tao Huang zheng Xu National Engineering Laboratory of Biohydrometallurgy General Research Institute for Nonferrous MetalsBeijing100088China

TiO_(2)nanoparticles doped with different concentrations of Rb were prepared by sol–gel *** crystal structures of samples were characterized by X-ray diffraction(XRD)and transmission electron microscopy(TEM).It was confirmed by the Rietveld refinement method that the as-prepared samples crystallize in anatase phase and Rb doping induces expansion and distortion of the crystal *** with the pure TiO_(2),the Rb-doped nanoparticles have smaller crystal size and better *** rate of methylene blue was used to evaluate the photocatalytic activity of Rb–TiO_(2).It indicated that doping Rb into TiO_(2)can effectively improve the photocatalytic activity of TiO_(2)and the mechanisms were discussed in *** using the sample doped with 0.20%Rb,methylene blue degraded with the fastest rate(97%within 60 min).

关键词： Rb doping TiO_(2) Photocatalysis Sol-gel

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Investigation of improving the thermophysical properties and corrosion resistance of RE_(2)SiO_(5)/RE_(2)Si_(2)O_(7)multiphase silicates by component design with RE doping

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Journal of Advanced Ceramics 2024年第6期13卷 842-860页

作者： Zeyu Chen Yiling Huang Zhaoxuan Zhang wei zheng Xuemei song Yaran Niu Yi Zeng The State Key Lab of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Inorganic Coating Materials CAS Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China

In this research,a novel method for regulating components in RE_(2)SiO_(5)/RE_(2)Si_(2)O_(7)multiphase silicates was developed,combining the benefits of a suitable thermal expansion coefficient(CTE)and outstanding corrosion resistance against calcium–magnesium–alumino–silicate(CMAS).This approach enhanced the overall thermophysical ***,the results from the CMAS corrosion resistance test indicated that(Lu_(1/3)Yb_(1/3)Tm_(1/3))_(2)SiO_(5)/(Lu_(1/3)Yb_(1/3)Tm_(1/3))_(2)Si_(2)O_(7)and(Lu_(1/4)Yb_(1/4)Tm_(1/4)Er_(1/4))_(2)SiO_(5)/(Lu_(1/4)Yb_(1/4)Tm_(1/4)Er_(1/4))_(2)Si_(2)O_(7)exhibited exceptional resistance to CMAS penetration,even at temperatures up to 1500℃.To comprehend the corrosion mechanism of CMAS on these silicates,we introduced a reaction–diffusion model,which involved observing the changes in the interface between the corrosion product layer and the silicate *** was achieved using electron backscatter diffraction(EBSD).These findings lay a theoretical basis for selecting rare earth elements in RE_(2)SiO_(5)/RE_(2)Si_(2)O_(7)multiphase silicates based on the radii of different rare earth cations.

关键词： thermal conductivity environmental barrier coatings(EBCs) thermal expansion coefficient(CTE) multiphase silicates calcium-magnesium-alumino-silicate(CMAS)corrosion resistance reaction-diffusion

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Liquid lens based holographic camera for real 3D scene hologram acquisition using end-to-end physical model-driven network

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Light(Science & Applications) 2024年第3期13卷 488-497页

作者： Di Wang Zhao-song Li Yi zheng You-Ran Zhao Chao Liu Jin-Bo Xu Yi-wei zheng Qian Huang Chen-Liang Chang Da-wei Zhang song-Lin Zhuang Qiong-Hua Wang School of Instrumentation and Optoelectronic Engineering Beihang UniversityBeijing 100191China School of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China

With the development of artificial intelligence,neural network provides unique opportunities for holography,such as high fidelity and dynamic *** to obtain real 3D scene and generate high fidelity hologram in real time is an urgent ***,we propose a liquid lens based holographic camera for real 3D scene hologram acquisition using an end-to-end physical model-driven network(EEPMD-Net).As the core component of the liquid camera,the first 10 mm large aperture electrowetting-based liquid lens is proposed by using specially fabricated *** design of the liquid camera ensures that the multi-layers of the real 3D scene can be obtained quickly and with great imaging *** EEPMD-Net takes the information of real 3D scene as the input,and uses two new structures of encoder and decoder networks to realize low-noise phase *** comparing the intensity information between the reconstructed image after depth fusion and the target scene,the composite loss function is constructed for phase optimization,and the high-fidelity training of hologram with true depth of the 3D scene is realized for the first *** holographic camera achieves the high-fidelity and fast generation of the hologram of the real 3D scene,and the reconstructed experiment proves that the holographic image has the advantage of low *** proposed holographic camera is unique and can be used in 3D display,measurement,encryption and other fields.

关键词： calculation solution holographic

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On-surface synthesis and characterization of polyynic carbon chains

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National Science Review 2024年第3期11卷 192-199页

作者： Wenze Gao wei zheng Luye Sun Faming Kang zheng Zhou wei Xu Interdisciplinary Materials Research Center School of Materials Science and Engineering Tongji University

Carbyne, an elusive sp-hybridized linear carbon allotrope, has fascinated chemists and physicists for decades. Due to its high chemical reactivity and extreme instability, carbyne was much less explored in contrast to the sp2-hybridized carbon allotropes such as graphene. Herein, we report the on-surface synthesis of polyynic carbon chains by demetallization of organometallic polyynes on the Au（111） surface;the longest one observed consists of ～60 alkyne units（120 carbon atoms）. The polyynic structure of carbon chains with alternating triple and single bonds was unambiguously revealed by bond-resolved atomic force microscopy. Moreover, an atomically precise polyyne, C14, was successfully produced via tip-induced dehalogenation and ring-opening of the decachloroanthracene molecule(C14Cl10) on a bilayer NaCl/Au（111） surface at 4.7 K, and a band gap of 5.8 eV was measured by scanning tunnelling spectroscopy,in a good agreement with the theoretical HOMO–LUMO gap（5.48 eV）.

关键词： polyyne scanning probe microscopy carbon allotrope on-surface synthesis organometallic polyyne

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Robotic vs laparoscopic abdominoperineal resection for rectal cancer:A propensity score matching cohort study and metaanalysis

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1280-1290页

作者： Li song Wen-Qiong Xu zheng-Qiang wei Gang Tang Department of Gastrointestinal Surgery Chengdu Fifth People's HospitalChengdu 610000Sichuan ProvinceChina Department of Nephrology Chengdu Fifth People's HospitalChengdu 610000Sichuan ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400000China Division of Biliary Tract Surgery Department of General SurgeryWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Robotic surgery(RS)is gaining popularity;however,evidence for abdominoperineal resection(APR)of rectal cancer(RC)is *** To compare the efficacy of RS and laparoscopic surgery(LS)in APR for *** We retrospectively identified patients with RC who underwent APR by RS or LS from April 2016 to June *** regarding short-term surgical outcomes were compared between the two *** reduce the effect of potential confounding factors,propensity score matching was used,with a 1:1 ratio between the RS and LS groups.A meta-analysis of seven trials was performed to compare the efficacy of robotic and laparoscopic APR for RC *** Of 133 patients,after propensity score matching,there were 42 patients in each *** postoperative complication rate was significantly lower in the RS group(17/42,40.5%)than in the LS group(27/42,64.3%)(P=0.029).There wasno significant difference in operative time(P=0.564),intraoperative transfusion(P=0.314),reoperation rate(P=0.314),lymph nodes harvested(P=0.309),or circumferential resection margin(CRM)positive rate(P=0.314)between the two *** meta-analysis showed patients in the RS group had fewer positive CRMs(P=0.04),lesser estimated blood loss(P<0.00001),shorter postoperative hospital stays(P=0.02),and fewer postoperative complications(P=0.002)than patients in the LS *** Our study shows that RS is a safe and effective approach for APR in RC and offers better short-term outcomes than LS.

关键词： Robotic surgery Laparoscopic surgery Abdominoperineal resection Postoperative complications Propensity score

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Accurately tracking hypersonic gliding vehicles via an LEO mega-constellation in relay tracking mode

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Journal of Systems Engineering and Electronics 2024年第1期35卷 211-221页

作者： LI Zhao WANG Yidi zheng wei College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China

In order to effectively defend against the threats of the hypersonic gliding vehicles(HGVs),HGVs should be tracked as early as possible,which is beyond the capability of the ground-based *** benefited by the developing megaconstellations in low-Earth orbit,this paper proposes a relay tracking mode to track HGVs to overcome the above *** whole tracking mission is composed of several tracking intervals with the same *** each tracking interval,several appropriate satellites are dispatched to track the *** that are planned to take part in the tracking mission are selected by a new derived observability *** tracking performances of the proposed tracking mode and the other two traditional tracking modes,including the stare and track-rate modes,are compared by *** results show that the relay tracking mode can track the whole trajectory of a HGV,while the stare mode can only provide a very short tracking ***,the relay tracking mode achieve higher tracking accuracy with fewer attitude controls than the track-rate mode.

关键词： target tracking mega-constellation hypersonic gliding vehicle(HGV) sensor selection observability analysis

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Improving the spaceborne GNSS-R altimetric precision based on the novel multilayer feedforward neural network weighted joint prediction model

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Defence Technology（防务技术） 2024年第2期32卷 271-284页

作者： Yiwen Zhang wei zheng Zongqiang Liu Qian Xuesen Laboratory of Space Technology China Academy of Space TechnologyBeijing 100094China China Academy of Aerospace Science and Innovation Beijing 100176China State Key Laboratory of Space-Ground Integrated Information Technology Beijing Institute of Satellite Information EngineeringBeijing 100194China

Global navigation satellite system-reflection(GNSS-R)sea surface altimetry based on satellite constellation platforms has become a new research direction and inevitable trend,which can meet the altimetric precision at the global scale required for underwater *** present,there are still research gaps for GNSS-R altimetry under this mode,and its altimetric capability cannot be specifically ***,GNSS-R satellite constellations that meet the global altimetry needs to be ***,the matching precision prediction model needs to be established to quantitatively predict the GNSS-R constellation altimetric ***,the GNSS-R constellations altimetric precision under different configuration parameters is calculated,and the mechanism of the influence of orbital altitude,orbital inclination,number of satellites and simulation period on the precision is analyzed,and a new multilayer feedforward neural network weighted joint prediction model is ***,the fit of the prediction model is verified and the performance capability of the model is tested by calculating the R2 value of the model as 0.9972 and the root mean square error(RMSE)as 0.0022,which indicates that the prediction capability of the model is ***,using the novel multilayer feedforward neural network weighted joint prediction model,and considering the research results and realistic costs,it is proposed that when the constellation is set to an orbital altitude of 500 km,orbital inclination of 75and the number of satellites is 6,the altimetry precision can reach 0.0732 m within one year simulation period,which can meet the requirements of underwater navigation precision,and thus can provide a reference basis for subsequent research on spaceborne GNSS-R sea surface altimetry.

关键词： GNSS-R satellite constellations Sea surface altimetric precision Underwater navigation Multilayer feedforward neural network

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Immunobiology of COVID-19: Mechanistic and therapeutic insights from animal models

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Zoological Research 2024年第4期45卷 747-766页

作者： Hong-Yi zheng Tian-Zhang song Yong-Tang zheng State Key Laboratory of Genetic Evolution&Animal Models KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesCenter for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China National Resource Center for Non-Human Primates National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China

The distribution of the immune system throughout the body complicates in vitro assessments of coronavirus disease 2019(COVID-19)immunobiology,often resulting in a lack of reproducibility when extrapolated to the whole ***,developing animal models is imperative for a comprehensive understanding of the pathology and immunology of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** review summarizes current progress related to COVID-19 animal models,including non-human primates(NHPs),mice,and hamsters,with a focus on their roles in exploring the mechanisms of immunopathology,immune protection,and long-term effects of SARS-CoV-2 infection,as well as their application in immunoprevention and immunotherapy of SARS-CoV-2 *** among these animal models and their specific applications are also highlighted,as no single model can fully encapsulate all aspects of *** effectively address the challenges posed by COVID-19,it is essential to select appropriate animal models that can accurately replicate both fatal and non-fatal infections with varying courses and *** animal model libraries and associated research tools is key to resolving the global COVID-19 pandemic,serving as a robust resource for future emerging infectious diseases.

关键词： SARS-CoV-2 COVID-19 Animal models Infection immunology Immunotherapy

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High-Order Decoupled and Bound Preserving Local Discontinuous Galerkin Methods for a Class of Chemotaxis Models

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Communications on Applied Mathematics and Computation 2024年第1期6卷 372-398页

作者： wei zheng Yan Xu School of Mathematical Sciences University of Science and Technology of ChinaHefei230026AnhuiChina

In this paper,we explore bound preserving and high-order accurate local discontinuous Galerkin(LDG)schemes to solve a class of chemotaxis models,including the classical Keller-Segel(KS)model and two other density-dependent *** use the convex splitting method,the variant energy quadratization method,and the scalar auxiliary variable method coupled with the LDG method to construct first-order temporal accurate schemes based on the gradient flow structure of the *** semi-implicit schemes are decoupled,energy stable,and can be extended to high accuracy schemes using the semi-implicit spectral deferred correction *** bound preserving DG discretizations are only worked on explicit time integration methods and are difficult to get high-order *** overcome these difficulties,we use the Lagrange multipliers to enforce the implicit or semi-implicit LDG schemes to satisfy the bound constraints at each time *** bound preserving limiter results in the Karush-Kuhn-Tucker condition,which can be solved by an efficient active set semi-smooth Newton *** numerical experiments illustrate the high-order accuracy and the effect of bound preserving.

关键词： Chemotaxis models Local discontinuous Galerkin(LDG)scheme Convex splitting method Variant energy quadratization method Scalar auxiliary variable method Spectral deferred correction method

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