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Pathogen-induced methylglyoxal negatively regulates rice bacterial blight resistance by inhibiting OsCDR1 protease activity

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Molecular Plant 2024年第2期17卷 325-341页

作者： zheng-wei fu Jian-Hui Li Xiang Gao Shi-Jia Wang Ting-Ting Yuan Ying-Tang Lu State Key Laboratory of Hybrid Rice College of Life SciencesRenmin Hospital of Wuhan UniversityWuhan UniversityWuhan 430072China Key Laboratory of Biology and Genetic Improvement of OilCrops Ministry of Agriculture and Rural AffairsOilCrops Research Institute of the Chinese Academy of Agricultural SciencesWuhan 430062China

Xanthomonas oryzae ***(Xoo)causes bacterial blight(BB),a globally devastating disease of rice(Oryza sativa)that is responsible for significant crop *** and sugar metabolites are important for pathogen infection,providing energy and regulating events associated with defense responses;howev-er,the mechanisms by which they regulate such events in BB are *** an inevitable sugar metabolite,methylglyoxal(MG)is involved in plant growth and responses to various abiotic stresses,but the underlying mechanisms remain *** and how MG functions in plant biotic stress responses is almost completely ***,we report that the Xoo strain PXO99 induces OsWRKY62.1 to repress transcrip-tion of OsGLY Il genes by directly binding to their promoters,resulting in overaccumulation of *** negatively regulates rice resistance against Pxo99:osglyll2 mutants with higher MG levels are more sus-ceptible to the pathogen,whereas OsGLYIl2-overexpressing plants with lower MG content show greater resistance than the wild *** of OsGLYll2 to prevent excessive MG accumulation confers broad-spectrum resistance against the biotrophic bacterial pathogens Xoo and Xanthomonas oryzae *** and the necrotrophic fungal pathogen Rhizoctonia solani,which causes rice sheath *** evidence shows that MG reduces rice resistance against PXO99 through CONSTITUTIVE DISEASE RESISTANCE 1(OsCDR1).MGmodifies the Arg97 residue of OsCDR1to inhibit its aspartic protease activ-ity,which is essential for OsCDR1-enhanced *** together,these findings illustrate how Xoo promotes infection by hijacking a sugar metabolite in the host plant.

关键词： Oryza sativa bacterial blight OsWRKY62.1 methylglyoxal OsCDR1

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A novel fluorogenic probe for monoamine oxidase assays

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Chinese Chemical Letters 2008年第8期19卷 947-950页

作者： You You Lu Yu Guang Wang Bin Dai Yi Qi Dai Zhao Wang zheng wei fu Qing Zhu College of Biological and Environmental Engineering Zhejiang University of Technology Hangzhou 310014 China

Monoamine oxidase is flavoenzymes, widely distributed in mammals. It is well recognized that MAOs serve an important role in metabolism that they have close relationship with health .Along with the discoveries between MAOs and neurotic disease, more and more studies have been jumped in .In this paper, we design a new probe for assaying the activities of MAOs. The results showed that the probe [7-（3-aminopropoxy）coumarin] is simple, effective and sensitive for MAOB.

关键词： Monoamine oxidase Fluorogenic probe Assay

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Hydrogen peroxide sulfenylates and inhibits the photorespiratory enzyme PGLP1 to modulate plant thermotolerance

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Plant Communications 2024年第6期5卷 139-153页

作者： zheng-wei fu Feng Ding Bing-Lei Zhang Wen-Cheng Liu Zi-Hong Huang Shi-Hang Fan Yu-Rui Feng Ying-Tang Lu wei Hua Key Laboratory of Biology and Genetic Improvement of Oil Crops Ministry of Agriculture and Rural AffairsOil Crops Research Institute of the Chinese Academy of Agricultural SciencesWuhan 430062China State Key Laboratory of Hybrid Rice College of Life SciencesWuhan UniversityWuhan 430072China School of Landscape and Ecological Engineering Hebei University of EngineeringHandan 056038China State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifeng 475004China Hubei Hongshan Laboratory Wuhan 430070China

Climate change is resulting in more frequent and rapidly changing temperatures at both extremes that severely affect the growth and production of plants,particularly *** stress caused by high temperatures is one of the most damaging factors for ***,the role of hydrogen peroxide(H_(2)O_(2))in modulating plant thermotolerance is largely unknown,and the regulation of photorespiration essential for C3 species remains to be fully ***,we report that heat stress promotes H2O2 accumulation in chloroplasts and that H2O2 stimulates sulfenylation of the chloroplast-localized photorespiratory enzyme 2-phosphoglycolate phosphatase 1(PGLP1)at cysteine 86,inhibiting its activity and promoting the accumulation of the toxic metabolite *** also demonstrate that PGLP1 has a positive function in plant thermotolerance,as PGLP1 antisense lines have greater heat sensitivity and PGLP1-overexpressing plants have higher heat-stress tolerance than the wild ***,our results demonstrate that heat-induced H2O2 in chloroplasts sulfenylates and inhibits PGLP1 to modulate plant ***,targeting CATALASE2 to chloroplasts can largely prevent the heatinduced overaccumulation of H2O2 and the sulfenylation of PGLP1,thus conferring thermotolerance without a plant growth *** findings reveal that heat-induced H2O2 in chloroplasts is important for heat-caused plant damage.

关键词： heat stress photorespiration hydrogen peroxide PGLP1 2-phosphoglycolate

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Research progress of tumor-associated macrophages in immune checkpoint inhibitor tolerance in colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4064-4079页

作者： Qi Fan zheng-wei fu Ming Xu Feng Lv Jia-Song Shi Qi-Qi Zeng De-Hai Xiong Intestinal Center Chongqing University Three Gorges HospitalChongqing 404000China Department of Gastroenterology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008Jiangsu ProvinceChina

The relevant mechanism of tumor-associated macrophages(TAMs)in the treatment of colorectal cancer patients with immune checkpoint inhibitors(ICIs)is discussed,and the application prospects of TAMs in reversing the treatment tolerance of ICIs are discussed to provide a reference for related *** a class of drugs widely used in clinical tumor immunotherapy,ICIs can act on regulatory molecules on cells that play an inhibitory role-immune checkpoints-and kill tumors in the form of an immune response by activating a variety of immune cells in the immune *** sensitivity of patients with different types of colorectal cancer to ICI treatment varies *** phenotype and function of TAMs in the colorectal cancer microenvironment are closely related to the efficacy of *** can regulate the phenotypic function of TAMs,and TAMs can also affect the tolerance of colorectal cancer to ICI *** play an important role in ICI resistance,and making full use of this target as a therapeutic strategy is expected to improve the immunotherapy efficacy and prognosis of patients with colorectal cancer.

关键词： Colorectal cancer Immune checkpoint inhibitor resistance Tumor microenvironment Tumor-associated macrophages Review

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Intestinal natural killer/T-cell lymphoma presenting as a pancreatic head space-occupying lesion:A case report

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World Journal of Gastrointestinal Oncology 2023年第1期15卷 195-204页

作者： Ya-Nan Wang Yi-Miao Zhu Xiao-Ju Lei Yuan Chen Wan-Mao Ni zheng-wei fu Wen-Sheng Pan College of Biotechnology and Bioengineering Zhejiang University of TechnologyHangzhou 310032Zhejiang ProvinceChina Department of Gastroenterology Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Department of Endoscopy Center Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Department of Pathology Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Cancer Center Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang ProvinceZhejiang Provincial People’s HospitalHangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Molecular Diagnosis Laboratory Zhejiang Provincial People's HospitalPeople's Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Intestinal natural killer/T-cell lymphoma(NKTCL)is a rare and aggressive non-Hodgkin’s lymphoma,and its occurrence is closely related to Epstein-Barr virus *** addition,the clinical symptoms of NKTCL are not obvious,and the specific pathogenesis is still *** NKTCL may occur in any segment of the intestinal tract,its distinct location in the periampullary region,which leads clinicians to consider mimics of a pancreatic head mass,should also be ***,there remain huge challenges in the diagnosis and treatment of intestinal *** SUMMARY In this case,we introduce a male who presented to the clinic with edema of both lower limbs,accompanied by diarrhea,and abdominal *** ultrasound(EUS)showed well-defined homogeneous hypoechoic lesions with abundant blood flow signals and compression signs in the head of the *** the guidance of EUS-fine needle biopsy(FNB)with 19 gauge or 22 gauge needles,combined with multicolor flow cytometry immunophenotyping(MFCI)helped us diagnose *** treatments,the patient was prescribed the steroid(dexamethasone),methotrexate,ifosfamide,L-asparaginase,and etoposide chemotherapy ***,he died of leukopenia and severe septic shock in a local *** Clinicians should enhance their understanding of *** key factors,including EUS characteristics,the right choice of FNB needle,and combination with MFCI,are crucial for improving the diagnostic rate and reducing the misdiagnosis rate.

关键词： Intestinal natural killer/T-cell lymphoma Endoscopic ultrasound-guided fine-needle biopsy Multicolor flow cytometry immunophenotyping Diagnosis Case report

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High-performance ultraviolet-visible photodetector with high sensitivity and fast response speed based on MoS_(2)-on-ZnO photogating heterojunction

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Tungsten 2023年第1期5卷 91-99页

作者： Xing-Lai Zhang Jing Li Bing Leng Liu Yang Yan-Dong Song Si-Yu Feng Li-Zhi Feng Zi-Tong Liu zheng-wei fu Xin Jiang Bao-Dan Liu Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesNo.72 Wenhua RoadShenyang 110016China School of Material Science and Engineering Northeastern UniversityNo.11 Wenhua RoadShenyang 110819China Foshan Graduate School of Northeastern University No.2 Zhihui RoadFoshan 528300China Department of Plastic Surgery The First Affiliated Hospital of China Medical UniversityNo.155 North Nanjing StreetShenyang 110001China School of Materials Science and Engineering University of Science and Technology of ChinaNo.72 Wenhua RoadShenyang 110016China

Photogating is an effective strategy to modulate the channel conductance of the device with light-induced gate field or voltage,thereby improving the performance of optoelectronic *** this work,to overcome the long response time and low photoresponse of one-dimensional ZnO,a MoS_(2)-on-ZnO photogating vertical heterojunction photodetector is design and ***,the ZnO nanowire with high carrier mobility can response ultraviolet light and supply a highspeed carrier transport channel,while the MoS_(2) flake as a photogating layer can response with visible light and transfer photogenerated electrons into the ZnO nanowire to adjust its ***,the irradiation of visible light is equivalent to applying a photo-induced gate voltage on the ZnO *** addition,the photogenerated electrons will not transmit through the MoS_(2) with low carrier mobility,so that not only the visible light response of the photodetector can be realized,but also its ultraviolet light response is able to be *** ultraviolet light irradiation,the photoresponsivity of the photodetector can be reached to 273 A W-1and the response speed is less than 24 *** important,based on this unique heterojunction structure,MoS_(2)-on-ZnO photodetector also illustrates an excellent visible light response with a high photoresponsivity(74 A W-1) and fast response speed(<24 ms) due to the photogating *** work not only paves the way to design high-performance photodetectors with high photoresponsivity and fast response speed,but also provide a promising approach to improve the performance of optoelectronic devices using photogating effect.

关键词： MoS_(2) ZnO Two-dimension Photogating Photodetectors

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铸牢中华民族共同体意识体验教育内容体系论析——基于共建、共治及共享的视角

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贵州民族研究 2022年第5期43卷 8-14页

作者：韦正富贵州师范大学历史与政治学院贵州贵阳550025

教育是铸牢中华民族共同体意识实现的重要途径,而教育内容体系的适应性、科学性是实现铸牢中华民族共同体意识有效产出的重要基础。随着民族地区受教育水平的整体提升以及在市场机制、互联网+等现代工具的共同作用下,民族地区农村信息... 详细信息

教育是铸牢中华民族共同体意识实现的重要途径,而教育内容体系的适应性、科学性是实现铸牢中华民族共同体意识有效产出的重要基础。随着民族地区受教育水平的整体提升以及在市场机制、互联网+等现代工具的共同作用下,民族地区农村信息壁垒逐步被突破,自由主义凸显及个性化需求的满足等等,使传统基于中华民族同根、同源的历史事实和新中国静态层面的符号要素作为教育内容体系的认知教育的功能式微,而基于现象、个案等为基础的动态体验教育需求凸显。因此,共建、共治及共享的动态信息基础上的体验教育内容体系建构是新时代铸牢中华民族共同体意识高效、持续产出的新路。

关键词：共建、共治及共享中华民族共同体意识体验教育内容体系

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地面输料孔在神东煤炭集团公司的应用

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煤炭工程 2014年第11期46卷 23-26页

作者：郑复伟神东煤炭集团公司设计公司内蒙古鄂尔多斯017209

通过建设地面输料孔,将矿务工程所用的混凝土、碎石等材料直接输送到井下作业场所附近,有效地缓解了井下辅助运输压力,降低了矿井辅助运输成本。论文详细介绍了神东煤炭集团公司17个井工煤矿地面输料孔设计原理、位置选择、输料管选择,... 详细信息

通过建设地面输料孔,将矿务工程所用的混凝土、碎石等材料直接输送到井下作业场所附近,有效地缓解了井下辅助运输压力,降低了矿井辅助运输成本。论文详细介绍了神东煤炭集团公司17个井工煤矿地面输料孔设计原理、位置选择、输料管选择,通过实例分析了输料孔建设带来的技术经济效益,指出地面输料孔在井工煤矿中推广应用的前景广阔。

关键词：井下辅助运输地面输料孔输料管神东

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Wnt4,Bmp2,PRL在胚胎停育和正常早孕蜕膜中的差异性表达

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中国妇产科临床杂志 2018年第3期19卷 238-240页

作者：黄芳郑伟傅君浙江大学医学院附属第二医院妇产科杭州310009 宁波市妇女儿童医院

目的比较Wnt4＇Bmp2,PRL在一胎早孕，二胎早孕，一胎胚胎停育，二胎胚胎停育蜕膜中的表达差异，探讨它们与早孕的关系及一胎分娩史与胚胎停育的关系。方法选取一胎，二胎胚胎停育患者及正常一胎，二胎早孕自愿流产女性各30例，用免疫组... 详细信息

目的比较Wnt4＇Bmp2,PRL在一胎早孕，二胎早孕，一胎胚胎停育，二胎胚胎停育蜕膜中的表达差异，探讨它们与早孕的关系及一胎分娩史与胚胎停育的关系。方法选取一胎，二胎胚胎停育患者及正常一胎，二胎早孕自愿流产女性各30例，用免疫组化法检测蜕膜中Wnt4，Bmp2，PRL的表达。结果Wht4，Bmp2，PRL在正常早孕蜕膜中的表达显著强于胚胎停育蜕膜（P〈0．01），Wnt4，Bmp2，PRL在一胎和二胎胚胎停育蜕膜中的表达差异无统计学意义（P〉0．05）。结论早孕期蜕膜中Wnt4，Bmp2的正常表达对子宫内膜蜕膜化及维持妊娠有重要意义，单纯一胎分娩史与胚胎停育无相关性。

关键词：胚胎停止发育蜕膜化早孕一胎二胎

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论西南民族地区基层公共服务系统建设

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云南民族大学学报（哲学社会科学版） 2010年第6期27卷 68-72页

作者：韦正富李敬南京大学行政管理学院江苏南京210093 云南民族大学法学院云南昆明650031

公共服务系统是公共部门提供公共产品和公共服务所依赖的各个环节及其构成的体系。在我国西南民族地区,由于少数民族文化与传统文化浓厚、经济贫困、民众居住相对分散、地势崎岖、交通闭塞等特点,因此,在公共服务活动中,根据该地区公共... 详细信息

公共服务系统是公共部门提供公共产品和公共服务所依赖的各个环节及其构成的体系。在我国西南民族地区,由于少数民族文化与传统文化浓厚、经济贫困、民众居住相对分散、地势崎岖、交通闭塞等特点,因此,在公共服务活动中,根据该地区公共服务环境与运行特点,在决策中注重培养和引入少数民族精英,发动和组织群众,营造与西南民族地区文化相适应的"熟人"服务理念等,是与民众面对面的西南民族地区基层政府公共服务系统建设的必需。

关键词：西南民族地区基层公共服务系统探析

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