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Homogenous strength-toughness match for 20Mn2SiCrMoV bainitic large-size parts via processing of VC particles and quenching control

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Rare Metals 2023年第10期42卷 3485-3496页

作者： Yu Tian Zhun-Li Tan Jin-Zhou Zhang zheng-yuan yuan Min Zhang Bing-Zhe Bai Material Science&Engineering Research Center School of MechanicalElectronic and Control EngineeringBeijing Jiaotong UniversityBeijing100044China Key Laboratory of Advanced Materials of Ministry of Education School of Materials Science and EngineeringTsinghua UniversityBeijing100084China

The problem of insufficient hardenability in general large-size parts always occurs in product manufacturing because of their large size,*** is restricted mainly by its own alloy composition with micro-alloy and key quenching and partitioning(Q&P) *** relationship between the cooling rate and properties of small samples was analyzed as the basis of the initial cooling rate at different positions corresponding to large-size parts combined with controlled austenization temperature in this *** as-treated micro structure after a fast cooling rate is mainly composed of lath bainite,martensite,and retained austenite(RA),while bainite and RA after a slow cooling *** showed that cooling control via decreasing spray intensity,meeting higher strength at the surface,and good strength and toughness match can be obtained both at the surface and in the ***-treated large ring part has~1330 MPa tensile strength and~95 J impact energy at the surface,and meantime,~1191 MPa tensile strength and~70 J impact energy in the center,which narrows the property difference.

关键词： Large-size parts Property homogeneity Cooling control Bainite VC

Association between physiological responses after exercise at low altitude and acute mountain sickness upon ascent is sex-dependent

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Military Medical Research 2021年第2期8卷 174-182页

作者： Yang Shen yuan-Qi Yang Chuan Liu Jie Yang Ji-Hang Zhang Jun Jin Hu Tan Fang-zheng-yuan yuan Jing-Bin Ke Chun-Yan He Lai-Ping Zhang Chen Zhang Jie Yu Lan Huang Institute of Cardiovascular Diseases of PLA the Second Affiliated HospitalArmy Medical UniversityChongqing 400037China Department of Cardiology the Second Affiliated HospitalArmy Medical UniversityChongqing 400037China

Background:Acute mountain sickness(AMS)is the mildest form of acute altitude illnesses,and consists of nonspecific symptoms when unacclimatized persons ascend to elevation of≥2500 *** factors of AMS include:the altitude,individual susceptibility,ascending rate and degree of *** the current study,we examined whether physiological response at low altitude could predict the development of ***:A total of 111 healthy adult healthy volunteers participated in this trial;and 99(67 men and 32 women)completed the entire study *** were asked to complete a 9-min exercise program using a mechanically braked bicycle ergometer at low altitude(500 m).Heart rate,blood pressure(BP)and pulse oxygen saturation(SpO2)were recorded prior to and during the last minute of *** ascent from 500 m to 4100 m was completed in 2 *** was defined as≥3 points in a 4-item Lake Louise Score,with at least one point from headache wat 6–8 h after the ***:Among the 99 assessable subjects,47(23 men and 24 women)developed AMS at 4100 *** comparison to the subjects without AMS,those who developed AMS had lower proportion of men(48.9%vs.84.6%,P<0.001),height(168.4±5.9 cm vs.171.3±6.1 cm,P=0.019),weight(62.0±10.0 kg vs.66.7±8.6 kg,P=0.014)and proportion of smokers(23.4%vs.51.9%,P=0.004).Multivariate regression analysis revealed the following independent risks for AMS:female sex(odds ratio(OR)=6.32,P<0.001),SpO2 change upon exercise at low altitude(OR=0.63,P=0.002)and systolic BP change after the ascent(OR=0.96,P=0.029).Women had larger reduction in SpO2 after the ascent,higher AMS percentage and absolute AMS *** reduction of SpO2 after exercise was associated with both AMS incidence(P=0.001)and AMS score(P<0.001)in men but not in ***:Larger SpO2 reduction after exercise at low altitude was an independent risk for AMS upon *** an association was more robust in men than in *** registration:Chinese Clinical

关键词： High altitude Exercise testing Sex differences Acute mountain sickness Individual susceptibility

Transcriptome sequencing and metabolome analysis reveal the mechanism of Shuanghua Baihe Tablet in the treatment of oral mucositis

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Chinese Journal of Natural Medicines 2021年第12期19卷 930-943页

作者： GENG Qi-Shun LIU Rui-Juan SHEN Zhi-Bo WEI Qian zheng yuan-yuan JIA Lan-Qi WANG Long-Hao LI Li-Feng LI Jun XUE Wen-Hua Department of Pharmacy the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Engineering Laboratory for Digital Telemedicine Service The first Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Oral mucositis(OM) caused by cancer therapy is the most common adverse reaction in the radiotherapy of head and neck tumors. In severe cases, it can lead to the interruption of treatment, which affects the control of the disease and the quality of *** Baihe Tablet(SBT) is a traditional Chinese medicine(TCM) formula, which is administerd to treat OM in China. It has been clinically effective for more than 30 years, but the underlying mechanism is not completely understood. With the development of multiple omics, it is possible to explore the mechanism of Chinese herbal compound prescriptions. Based on transcriptomics and metabolomics, we explored the underlying mechanism of SBT in the treatment of OM. An OM model of rats was established by 5-FU induction, and SBT was orally administered at dosages of 0.75 and 3 g·kg;·d;. In order to search for SBT targets and related metabolites, the dysregulated genes and metabolites were detected by transcriptomics and metabolomics. Immune related indicators such as interleukin-17(IL-17) and tumor necrosis factor-α(TNF-α) were detected by ELISA. Treg cell disorders was analyzed by flow cytometry. Our results showed that SBT significantly alleviated the symptoms of OM rats and the inflammatory infiltration of ulcer *** SBT administration, inflammatory related metabolic pathways including linoleic acid metabolism, valine, leucine and isoleucine biosynthesis were significantly altered. Furthermore, the production of proinflammatory factors like IL-17 and TNF-α, were also dramatically reduced after SBT administration. Besides, the infiltration degree of Treg cells in the spleen of OM modeling rats was significantly improved by SBT administration, thus maintaining the immune balance of the body. The current study demonstrates that SBT regulates inoleic acid metabolism, glycerophospholipid metabolism and amino acid metabolism, and inhibits IL-17/TNF signal transduction to restore Treg and Th17 cell homeostasis in OM

关键词： Oral mucositis Shuanghua Baihe tablet Transcriptomics Metabolomics IL-17/TNF signal pathway

EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study

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Military Medical Research 2021年第1期8卷 25-36页

作者： Ji-Hang Zhang Yang Shen Chuan Liu Jie Yang yuan-Qi Yang Chen Zhang Shi-Zhu Bian Jie Yu Xu-Bin Gao Lai-Ping Zhang Jing-Bin Ke Fang-zheng-yuan yuan Wen-Xu Pan Zhi-Nian Guo Lan Huang Institute of Cardiovascular Diseases Department of CardiologyXinqiao HospitalArmy Medical UniversityChongqing 400037China

Background: More people ascend to high altitude(HA) for various activities, and some individuals are susceptible to HA illness after rapidly ascending from plains. Acute mountain sickness(AMS) is a general complaint that affects activities of daily living at HA. Although genomic association analyses suggest that single nucleotide polymorphisms(SNPs) are involved in the genesis of AMS, no major gene variants associated with AMS-related symptoms have been ***: In this cross-sectional study, 604 young, healthy Chinese Han men were recruited in June and July of 2012 in Chengdu, and rapidly taken to above 3700 m by plane. Basic demographic parameters were collected at sea level, and heart rate, pulse oxygen saturation(Sp O2), systolic and diastolic blood pressure and AMS-related symptoms were determined within 18–24 h after arriving in Lhasa. AMS patients were identified according to the latest Lake Louise scoring system(LLSS). Potential associations between variant genotypes and AMS/AMS-related symptoms were identified by logistic regression after adjusting for potential confounders(age, body mass index and smoking status).Results: In total, 320 subjects(53.0%) were diagnosed with AMS, with no cases of high-altitude pulmonary edema or high-altitude cerebral edema. Sp O2 was significantly lower in the AMS group than that in the non-AMS group(P=0.003). Four SNPs in hypoxia-inducible factor-related genes were found to be associated with AMS before multiple hypothesis testing correction. The rs6756667(EPAS1) was associated with mild gastrointestinal symptoms(P=0.013), while rs3025039(VEGFA) was related to mild headache(P=0.0007). The combination of rs6756667 GG and rs3025039 CT/TT further increased the risk of developing AMS(OR=2.70, P<0.001).Conclusions: Under the latest LLSS, we find that EPAS1 and VEGFA gene variants are related to AMS susceptibility through different AMS-related symptoms in the Chinese Han population;this tool might be useful for screenin

关键词： Acute mountain sickness Hypoxia Single nucleotide polymorphism Endothelial PAS domain protein 1 Vascular endothelial growth factor

Mouse strain differences in selective serotonin reuptake inhibitors sensitivity correlates with serotonin transporter binding and function

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中国药理学与毒理学杂志 2018年第9期32卷 710-711页

作者： JIN Zeng-liang CHEN Xiao-fei LI Xiao-rong XIONG Jie zheng yuan-yuan GAO Na-na LI Yun-feng Beijing Key laboratory of Neuropsychopharmacology Beijing Institute of Pharmacology and Toxicology Department of Pharmacology School of Basic Medical SciencesCapital Medical University

OBJECTIVE Selective serotonin reuptake inhibitors(SSRIs) bind 5-HT transporters,leading to the accumulation of 5-HT and amelioration of *** different mouse strain showed different sensitivity to SSRIs in mouse models of depression,the reason for these strain differences remains ***,therefore,in the present study,we examined immobility time and locomotor activity in two mouse strains,namely,C57BL/6 J and DBA/2 J mice,and the effects of the SSRIs ***,we analyzed 5-HT transporter binding and reuptake inhibition in both strains to explore their relationship with the immobility and locomotor activity effects of the three SSRIs in these two mouse *** Strain differences in SSRI effects in the tail suspension test(TST) and forced swimming test(FST).To initiate our studies,we sought to confirm that SERT strain variation did not alter SERT protein expression,5-HT recognition,or uptake activity when expressed in C57BL/6 J and DBA/2 J *** binding assays were conducted to determine the affinity of the SSRIs for the 5-HT transporters in the two mouse *** SSRI citalopram dose-dependently reduced immobility time in both the FST and TST in DBA/2 J but not C57BL/6 J mouse strains,whereas fluoxetine showed opposite *** reduced immobility time similarly in both *** affinity of citalopram for the 5-HT transporter in DBA/2 J mice was 700-fold higher than that for in C57BL/6 J mice,whereas the affinity of fluoxetine in C57BL/6 J mice was 100-fold higher than that in the DBA/2 J ***,High citalopram concentrations were required to [3 H]5-HT uptake in C57BL/6 J but not DBA/2 J mouse cortical synaptosomes,whereas fluoxetine also showed opposite *** Immobility duration depends on 5-HT transporter binding levels,leading to apparent strain differences in immobility time in FST and ***,differences in 5-HT transporter binding may cause variations in SSRI

关键词： antidepressants mouse strains selective serotonin reuptake inhibitors

Robust first two rounds access driven cache timing attack on AES

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通讯和计算机（中英文版） 2009年第6期6卷 20-25页

作者： ZHAO Xin-jie WANG Tao zheng yuan-yuan Department of Computer Engineering Ordnance Engineering College Sho＇iazhuang 050003 China

维普期刊数据库评论

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维普期刊数据库

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阿尔采末病非人灵长类动物模型

中国药理学通报 2005年第6期21卷 649-653页

作者：郑元元孙兰中国医学科学院.中国协和医科大学基础医学院药理室北京100005

阿尔采末病(AD)是一种以进行性认知障碍和记忆力损害为主的中枢神经系统退行性疾病。非人灵长类动物(nonhumanprimate,NHP)模型较啮齿类动物模型更好地模拟了AD的病理变化,其神经生物学特性与人类非常相似,是研究AD等疾病最理想的动物模... 详细信息

阿尔采末病(AD)是一种以进行性认知障碍和记忆力损害为主的中枢神经系统退行性疾病。非人灵长类动物(nonhumanprimate,NHP)模型较啮齿类动物模型更好地模拟了AD的病理变化,其神经生物学特性与人类非常相似,是研究AD等疾病最理想的动物模型,对筛选治疗老年痴呆药也起着至关重要的作用。恒河猴是目前应用最广泛的非人灵长类实验动物,另外松鼠猴、小猿、短尾猿、猩猩、黑猩猩和狐猴也是AD研究的理想实验动物。本文通过非人灵长类动物模型的胆碱能系统、β淀粉样肽沉积、载脂蛋白E、神经元纤维缠结和tau蛋白等方面的变化,对近年来NHP的自发性、诱发性及自身免疫性痴呆模型的发展分别进行阐述。

关键词：阿尔采末病老年痴呆灵长类动物模型

Camellia访问驱动Cache计时攻击研究

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计算机学报 2010年第7期33卷 1153-1164页

作者：赵新杰王韬郑媛媛军械工程学院计算机工程系石家庄050003

Camellia是NESSIE计划中128位分组密码的最终获胜者.现有的针对Camellia的Cache计时攻击大多基于时序驱动模型,需百万计的样本在几十分钟内完成.文中研究表明,由于频繁的查找表操作,Camellia对访问驱动Cache计时攻击也是脆弱的,攻击所... 详细信息

Camellia是NESSIE计划中128位分组密码的最终获胜者.现有的针对Camellia的Cache计时攻击大多基于时序驱动模型,需百万计的样本在几十分钟内完成.文中研究表明,由于频繁的查找表操作,Camellia对访问驱动Cache计时攻击也是脆弱的,攻击所需样本量比时序驱动要小.首先,基于访问驱动方式,给出了一种通用的针对对称密码S盒的分析模型,指出Camellia加密过程中的轮函数易泄露初始密钥和轮密钥的异或结果值,密钥扩展中的左移函数使得Camellia安全性大大降低.然后,给出了多例针对Camellia-128/192/256的访问驱动Cache计时攻击,实验结果表明:500和900个随机明文样本可恢复Camellia-128、Camellia-192/256密钥,文中的攻击可被扩展到针对已知密文条件下的解密过程或远程环境中进行实施,3000个随机明文可在局域网和校园网环境下恢复Camellia-128/192/256密钥.最后,分析了Camellia易遭受Cache计时攻击的原因,并为密码设计者提出了防御该攻击的一些有效措施.

关键词： Camellia-128/192/256 分组密码访问驱动 Cache计时攻击旁路攻击远程攻击 F函数查找S盒左移函数密钥扩展已知密文

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针对SMS4密码算法的Cache计时攻击

通信学报 2010年第6期31卷 89-98页

作者：赵新杰王韬郑媛媛军械工程学院计算机工程系河北石家庄050003

分别提出并讨论了针对SMS4加密前4轮和最后4轮的访问驱动Cache计时分析方法,设计间谍进程在不干扰SMS4加密前提下采集加密前4轮和最后4轮查表不可能访问Cache组集合信息并转化为索引值,然后结合明文或密文对密钥的不可能值进行排除分析... 详细信息

分别提出并讨论了针对SMS4加密前4轮和最后4轮的访问驱动Cache计时分析方法,设计间谍进程在不干扰SMS4加密前提下采集加密前4轮和最后4轮查表不可能访问Cache组集合信息并转化为索引值,然后结合明文或密文对密钥的不可能值进行排除分析,最终恢复SMS4初始密钥。实验结果表明多进程共享Cache存储器空间方式和SMS4查找表结构决定其易遭受Cache计时攻击威胁,前4轮和最后4轮攻击均在80个样本左右恢复128bit SMS4完整密钥,应采取一定的措施防御该类攻击。

关键词： SMS4 访问驱动 Cache计时攻击 Cache组查表索引