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Recent advances on thermosensitive hydrogels-mediated precision therapy

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Asian Journal of Pharmaceutical Sciences 2024年第3期19卷 1-21页

作者： Hao Chen jiangmei Xu jiangwei Sun Yongxin jiang Wang zheng Wei Hu Haisheng Qian Department of Clinical Pharmacology The Second Hospital of Anhui Medical UniversityAnhui Medical UniversityHefei 230032China Department of Dermatology and Rheumatology Immunology Xinqiao HospitalArmy Medical UniversityChongqing 400037China School of Biomedical Engineering Anhui Provincial Institute of Translational MedicineAnhui Medical UniversityHefei 230032China

Precision therapy has become the preferred choice attributed to the optimal drug concentration in target sites,increased therapeutic efficacy,and reduced adverse *** the past few years,sprayable or injectable thermosensitive hydrogels have exhibited high therapeutic *** can be applied as cell-growing scaffolds or drug-releasing reservoirs by simply mixing in a free-flowing sol phase at room *** by their unique properties,thermosensitive hydrogels have been widely applied as drug delivery and treatment platforms for precision *** this review,the state-of-theart developments in thermosensitive hydrogels for precision therapy are investigated,which covers from the thermo-gelling mechanisms and main components to biomedical applications,including wound healing,anti-tumor activity,osteogenesis,and periodontal,sinonasal and ophthalmic *** most promising applications and trends of thermosensitive hydrogels for precision therapy are also discussed in light of their unique features.

关键词： Thermosensitive hydrogels Injectable Sprayable Stimuli-responsive Precision therapy

Ultra-high-temperature application of MXene: Stabilization of 2D Ti_(3)C_(2)T_(x) for cross-scale strengthening and toughening of 3D TiC

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Journal of Advanced Ceramics 2024年第1期13卷 1-10页

作者： Lu Liu Guobing Ying Quanguo jiang Dong Wen Peng Wang Meng Wu Ziying Ji Yongting zheng xiang Wang Department of Materials Science and Engineering College of Mechanics and MaterialsHohai UniversityNanjing 211100China Key Laboratory of Superlight Materials&Surface Technology Ministry of EducationHarbin Engineering UniversityHarbin 150001China Shenzhen Key Laboratory for Advanced Materials School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China Center for Composite Materials and Structures Harbin Institute of TechnologyHarbin 150001China

Transition metal carbide/nitride cores within MXenes make them considerably useful for ultra-high-temperature ***,extensive research on Ti_(3)C_(2)T_(x) MXene has revealed its tendency to undergo a phase transition to TiCy at temperatures above 800℃due to high activity of a superficial Ti atomic ***,spark plasma sintering of Ti_(3)C_(2)T_(x) and TiC is performed to prevent the Ti_(3)C_(2)T_(x) phase transition at temperatures up to 1900℃through the fabrication of composites at a pressure of 50 *** a focused ion beam scanning electron microscope to separate layered substances in the composites and examining selected area diffraction spots in a transmission electron microscope enabled identification of non-phase-transitioned ***-principles calculations based on density functional theory indicated the formation of strong chemical bonding interfaces between Ti_(3)C_(2)T_(x) and TiC,which imposed a stability constraint on the Ti atomic layer at the Ti_(3)C_(2)T_(x) *** performance tests,such as three-point bending and fracture toughness analysis,demonstrated that the addition of Ti_(3)C_(2)T_(x) can effectively improve the cross-scale strengthening and toughening of the TiC matrix,providing a new path for designing and developing two-dimensional(2D)carbides cross-scale-enhanced three-dimensional(3D)carbides with the same elements relying on a wide variety of MXenes.

关键词： MXene ultra-high-temperature phase stability interface bonding cross-scale strengthening and toughening structural ceramic composites

Evaluation of the injection and plugging ability of a novel epoxy resin in cement cracks

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Petroleum Science 2024年第2期21卷 1211-1220页

作者： Guang-Yao Leng Wei Yan Hai-Mu Ye Er-Dong Yao Ji-Bin Duan zheng-xian Xu Ke-Pei Li Jing-Ru Zhang Zhong Li State Key Laboratory of Petroleum Resource&Prospecting China University of Petroleum(Beijing)Beijing102249China CNPC Liaohe Oilfield Gas Storage Co.LTD Panjin124000LiaoningChina CNOOC Research Institute Co. Ltd.Beijing100028China

Sustained casing pressure(SCP)is a crucial issue in the oil and gas production *** resins,exhibiting exceptional compressive strength,ductility,and shear bonding strength,have the potential to form reliable *** injectivity and sealing capacity of the epoxy resin is crucial parameters for the success of shallow remediation *** study aimed to develop and assess a novel solid-free resin sealant as an alternative to Portland cement for mitigating fluid *** investigation evaluated the viscosity,compressive strength,and brittleness index of the epoxy resin sealant,as well as its tangential and normal shear strengths in conjunction with casing *** flow characteristics and sealing abilities of conventional cement and epoxy resin were comparatively analyzed in *** results showed that the application of a viscosity reducer facilitated control over the curing time of the epoxy resin,ranging from 1.5 to 6 h,and reduced the initial viscosity from 865.53 to 118.71 m Pa,*** mechanical properties of the epoxy resin initially increased with a rise in curing agent content before experiencing a minor *** epoxy resin containing 30%curing agent exhibited optimal mechanical *** a 14-day curing period,the epoxy resin's compressive strength reached81.37 MPa,2.12 times higher than that of cement,whereas the elastic modulus of cement was 2.99 times greater than that of the epoxy *** brittleness index of epoxy resin is only 3.42,demonstrating high flexibility and *** tangential and normal shear strengths of the epoxy resin exceeded those of cement by 3.17 and 2.82 times,*** a 0.5 mm-wide crack,the injection pressure of the epoxy resin remained below 0.075 MPa,indicating superior injection and flow ***,the injection pressure of cement surged dramatically to 2.61 MPa within 5 *** breakthrough pressure of0.5 PV epoxy resin reached 7.53 MPa,decreasing the crack's perme

关键词： Sustained casing pressure Epoxy resin sealant Curing agent Viscosity reducer Mechanical properties Crack sealing

Characteristics and influencing factors of greenhouse gas emissions from reservoirs in the Yellow River Basin:A Meta-analysis

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Science China Earth Sciences 2024年第7期67卷 2210-2225页

作者： Shurui HUANG Peijia ZHANG Wenxiu zheng Jiajia ZHANG Yang LI Yuanjian WANG Enhui jiang Shaoda LIU Xinghui XIA State Key Laboratory of Water Environment Simulation School of EnvironmentBeijing Normal UniversityBeijing 00875China Yellow River Institute of Hydraulic Research Yellow River Conservancy CommissionZhengzhou 450003China

Reservoir construction and operation profoundly alter the hydrological,hydrodynamic,and carbon and nitrogen cycling processes of ***,current research still lacks a systematic understanding of the characteristics of greenhouse gas(GHG)emissions from reservoirs in arid/semi-arid *** study integrates existing monitoring data to discuss the characteristics of GHG emissions from reservoirs in the Yellow River Basin and illustrate the controlling factors and underlying mechanism of these *** results indicate that while CO_(2) emission flux from reservoirs is lower than that from river channels,the emission fluxes of CH_(4) and N_(2)O are 1.9 times and 10 times those from rivers,respectively,indicating that the emission of GHG with stronger radiative effect is significantly enhanced in *** to the reservoirs in humid climates(e.g.,the Three Gorges Reservoir),reservoirs in the Yellow River Basin exhibit relatively lower emissions of CO_(2) and CH_4 due to lower organic matter concentrations,but significantly higher N_(2)O emissions due to higher nitrogen *** Carlo simulations for 237 reservoirs in the Yellow River Basin showed that total emission of the three GHGs is 3.05 Tg CO_(2)-eq yr^(-1),accounting for 0.39% of the total emission from global reservoirs and lower than the area percentage of the basin(0.53%).This study has important implications on revealing the GHG emission characteristics and control mechanisms of reservoirs in arid/semi-arid regions.

关键词： Yellow River Basin Reservoir Greenhouse gas Emission flux Water quality

Loss of GATA6-mediated up-regulation of UTX promotes pancreatic tumorigenesis and progression

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Genes & Diseases 2024年第2期11卷 921-934页

作者： Hui-Qing Zhang Fanyang Kong xiangyu Kong Tingting jiang Muyuan Ma Shaojiang zheng Junli Guo Keping Xie The Third Department of Medical Oncology Jiangxi Cancer HospitalNanchangJiangxi 330006China Departments of Gastroenterology Changhai HospitalSecond Military Medical UniversityShanghai 200433China Center for Pancreatic Cancer Research The South China University of Technology School of MedicineGuangzhouGuangdong 510006China Hainan Clinical Medical Research Center of the First Affiliated Hospital Hainan Women and Children's Medical CenterHainan Medical UniversityHaikouHainan 570102China Key Laboratory of Tropical Cardiovascular Diseases Research of Hainan Province Key Laboratory of Emergency and Trauma of Ministry of EducationHainan Medical UniversityHaikouHainan 571199China

Ubiquitously transcribed tetratricopeptide repeat on chromosome X(UTX),also known as lysine(K)-specific demethylase 6A(KDM6A),functions as a tumor suppressor gene or oncogene depending on the tumor type and ***,its tumor-suppressive mechanisms remain largely ***,we investigated the clinical significance and biological effects of UTX expression in pancreatic ductal adenocarcinoma(PDA)and determined the potential mechanisms of its *** expression and its association with clinicopathologic characteristics of PDA patients were analyzed using *** mRNA and protein expression and their regulation in PDA cell lines were measured using quantitative polymerase chain reaction and Western blot *** biological functions of UTX in PDA cell growth,migration,and invasion were determined using gain-and loss-of-function assays with both in vitro and in vivo animal *** expression was reduced in human PDA cell lines and *** UTX expression was associated with poor differentiation and prognosis in *** UTX expression inhibited PDA proliferation,migration,and invasion in vitro and PDA growth and metastasis in vivo,whereas knockdown of UTX expression did the ***,UTX expression was trans-activated by GATA6 ***6-mediated PDA progression could be blocked,at least partially,by silencing UTX *** conclusion,loss of GATA6-mediated UTX expression was evident in human PDA and restored UTX expression suppressed PDA growth and ***,UTX is a tumor suppressor in PDA and may serve as a prognostic biomarker and therapeutic target.

关键词： Growth Invasion Metastasis Pancreatic cancer UTX

Thermodynamics-directed bulk/grain-boundary engineering for superior electrochemical durability of Ni-rich cathode

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Journal of Energy Chemistry 2024年第10期97卷 321-331页

作者： Kangyu Zou Mingzhu jiang Tianxiang Ning Lei Tan Junchao zheng Jiexi Wang Xiaobo Ji Lingjun Li School of Materials Science and Engineering Changsha University of Science and Technology School of Metallurgy and Environment Central South University National Engineering Research Centre of Advanced Energy Storage Materials College of Chemistry and Chemical Engineering Central South University

Introducing high-valence Ta element is an essential strategy for addressing the structu ral deterioration of the Ni-rich LiNi1-x-yCoxMnyO2（NCM） cathode,but the enlarged Li/Ni cation mixing leads to the inferior rate capability originating from the hindered Li+*** that the non-magnetic Ti4+ion can suppress Li/Ni disorder by removing the magnetic frustration in the transition metal ***,it is still challenging to directionally design expected Ta/Ti dual-modification,resulting from the complexity of the elemental distribution and the uncertainty of in-situ formed coating compounds by introducing foreign ***,a LiTaO3grain boundary（GB） coating and bulk Ti-doping have been successfully achieved in LiNi0.834Co0.11Mn0.056O2cathode by thermodynamic guidance,in which the structural formation energy and interfacial binding energy are employed to predict the elemental diffusion discrepancy and thermodynamically stable coating *** to the coupling effect of strengthened structural/interfacial stability and improved Li+diffusion kinetics by simultaneous bulk/GB engineering,the Ta/Ti-NCM cathode exhibits outstanding capacity retention,reaching 91.1% after 400 cycles at 1 *** elaborate work contributes valuable insights into rational dual-modification engineering from a thermodynamic perspective for maximizing the electrochemical performances of NCM cathodes.

关键词： Bulk doping Dual-modification Grain boundary coating Ni-rich layered cathode Thermodynamic perspective

Analysis of debris flow control effect and hazard assessment in Xinqiao Gully,Wenchuan M_(s)8.0 earthquake area based on numerical simulation

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China Geology 2024年第2期7卷 248-263页

作者： Chang Yang Yong-bo Tie xian-zheng Zhang Yan-feng Zhang Zhi-jie Ning Zong-liang Li Chinese Academy of Geological Sciences Beijing 100037China Chengdu Center of China Geological Survey China Geological SurveyChengdu 610081China Technology innovation center for risk prevention and mitigation of geohazard Ministry of Natural ResourcesChengdu 611734China Observation and Research Station of Chengdu Geological Hazards Ministry of Natural ResourcesChengdu 610000China

Xinqiao Gully is located in the area of the 2008 Wenchuan M_(s)8.0 earthquake in Sichuan province,*** on the investigation of the 2023"6-26"Xinqiao Gully debris flow event,this study assessed the effectiveness of the debris flow control project and evaluated the debris flow *** field investigation and numerical simulation methods,the indicators of flow intensity reduction rate and storage capacity fullness were proposed to quantify the effectiveness of the engineering measures in the debris flow *** simulation results show that the debris flow control project reduced the flow intensity by41.05%to 64.61%.The storage capacity of the dam decreases gradually from upstream to the mouth of the gully,thus effectively intercepting and controlling the debris *** evaluating the debris flow of different recurrence intervals,further measures are recommended for managing debris flow events.

关键词： Landslide Debris flow Hazard assessment Numerical simulation OpenLISEM Prevention and control project Wenchuan M_(s)8.0 earthquake Xinqiao Gully Sichuan province Geological hazards survey engineering

Weatherability and heat resistance enhanced by interaction between AG25 and Mg/AI-LDH

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Rare Metals 2024年第6期43卷 2758-2768页

作者： Pei-Yao Yang xiang-Cui Liu Yu-Chao Wang Huan-Ran zheng Jin-xian Wang Jia-Yi zheng Meng-Jie Liu Dan-Ni Deng Yu Bai Ying-Bi Chen Tong Zhang Zhi-Ming Liu Yong-Peng Lei State Key Laboratory of Powder Metallurgy Powder Metallurgy Research InstituteCentral South UniversityChangsha 410083China Research Institute of Chemical Defense Beijing 102205China

Although inorganic pigments in common spectral tuning materials show good weatherability and heat resistance,the limited color choices,weak coloring power,poor dispersibility,and a possibility of toxicity limit their *** the basis of organic pigments which possess a wide range of colors,high coloring power,good transparency,and high safety,herein,the modified pigment and biomimetic coating with improved weatherability,especially ultraviolet(UV)resistance(from 2 to 6 days),was achieved by intercalating acid green 25(AG25)pigment into Mg/Al-layered double hydroxides(Mg/Al-LDH).Furthermore,the heat resistance of AG25 was also significantly ***,the spectral stability of pigments after heat treatment is superior with almost unchanged spectral profile and green reflection *** formation of strong N-H bonds and the S-M(Mg,Al)bonds between Mg/Al-LDH laminates and AG25 molecules contributes to the *** work shows potential for biomimetic leaf materials in respect of reflective spectra stability.

关键词： Layered double hydroxide Biomimetic Acid green 25 Interaction Weatherability Heat resistance

具有分流叶片跨声速离心叶轮激波及能量损失分析

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航空动力学报 2016年第12期31卷 3010-3016页

作者：刘正先曹江涛王牧苏赵祎佳天津大学机械工程学院天津300072 天津大学化工学院天津300072

对具有分流叶片跨声速离心叶轮,采用激波基本关系式对数值信息进行分析和判定,理论证实了叶轮流道中激波的存在,并确定流道内高速气流易在主叶片前缘、分流叶片前缘以及主叶片的吸力面与分流叶片的压力面通道位置形成激波.进一步对比分... 详细信息

对具有分流叶片跨声速离心叶轮,采用激波基本关系式对数值信息进行分析和判定,理论证实了叶轮流道中激波的存在,并确定流道内高速气流易在主叶片前缘、分流叶片前缘以及主叶片的吸力面与分流叶片的压力面通道位置形成激波.进一步对比分析了叶顶间隙和运行工况对激波位置分布特征的影响及引起的能量损失.结果表明:固定叶顶间隙下,随着流量减小,激波位置向流道上游移动;叶顶间隙导致激波线位置向流道下游偏移;分流叶片前缘处有最强激波并引起较明显能量损失.

关键词：跨声速离心叶轮分流叶片叶顶间隙激波判定能量损失