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Effects of acupuncture on hypothalamic–pituitary–adrenal axis:Current status and future perspectives

Journal of Integrative Medicine 2024年第4期22卷 445-458页

作者： Jia-yuan zheng Jing Zhu Yu wang Zhan-zhuang Tian Department of Integrative Medicine and Neurobiology School of Basic Medical SciencesState Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceInstitutes of Brain ScienceInstitute of Acupuncture ResearchAcademy of Integrative MedicineShanghai Key Laboratory for Acupuncture Mechanism and Acupoint FunctionShanghai Medical CollegeFudan UniversityShanghai 200032China Department of Human Anatomy School of Integrative MedicineShanghai University of Traditional Chinese MedicineShanghai 201203China

The hypothalamic–pituitary–adrenal(HPA) axis is a critical component of the neuroendocrine system,playing a central role in regulating the body's stress response and modulating various physiological processes. Dysregulation of HPA axis function disrupts the neuroendocrine equilibrium, resulting in impaired physiological functions. Acupuncture is recognized as a non-pharmacological type of therapy which has been confirmed to play an important role in modulating the HPA axis and thus favorably targets diseases with abnormal activation of the HPA axis. With numerous studies reporting the promising efficacy of acupuncture for neuroendocrine disorders, a comprehensive review in terms of the underlying molecular mechanism for acupuncture, especially in regulating the HPA axis, is currently in need. This review fills the need and summarizes recent breakthroughs, from the basic principles and the pathological changes of HPA axis dysfunction, to the molecular mechanisms by which acupuncture regulates the HPA axis. These mechanisms include the modulation of multiple neurotransmitters and their receptors, neuropeptides and their receptors, and microRNAs in the paraventricular nucleus,hippocampus, amygdala and pituitary gland, which alleviate the hyperfunctioning of the HPA *** review comprehensively summarizes the mechanism of acupuncture in regulating HPA axis dysfunction for the first time, providing new targets and prospects for further exploration of acupuncture.

关键词： Acupuncture Electroacupuncture Hypothalamic-pituitary-adrenal axis Mechanism Neurotransmitter microRNA

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Experimental study on workability and permeability of sandy soils conditioned with thickened foam

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 532-544页

作者： Zhiyao Feng Shuying wang Tongming Qu Xiangcou zheng Fanlin Ling School of Civil Engineering Central South UniversityChangsha410075China Tunnel and Underground Engineering Research Center Central South UniversityChangsha410075China Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyClearwater BayKowloon999077Hong KongChina Geo-Engineering Section Delft University of TechnologyDelft999025Netherlands

Water spewing and muck plugging often occur during earth pressure balance(EPB)shield machines tunnelling in water-rich sandy strata,even though the conventional foam has been employed to condition sandy *** this study,a novel thickened foaming agent suitable for EPB shield tunnelling in water-rich sandy strata is *** contrast to conventional foam-conditioned sands,the thickened foam-conditioned sand has a low permeability due to the consistent filling of soil pores with the thickened foam,and the initial permeability coefficient decreases by approximately two orders of *** also exhibits a suitable workability,which is attributed to the enhanced capability of the thickened foam to condition sandy *** addition,the effect of concentration on the stability of the foam is explained by the Gibbs-Marangoni effect,and conditioning mechanisms for the thickened foam on sands are discussed from the evolution of foam bubbles.

关键词： Earth pressure balance(EPB)shield Thickened foam Foam-conditioned sand Permeability Workability

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Monitoring seismicity in the southern Sichuan Basin using a machine learning workflow

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Earthquake Research Advances 2024年第1期4卷 59-66页

作者： kang wang Jie Zhang Ji Zhang Zhangyu wang Huiyu Zhu School of Earth and Space Sciences University of Science and Technology of ChinaHefei230026China

Monitoring seismicity in real time provides significant benefits for timely earthquake warning and *** this study,we propose an automatic workflow based on machine learning(ML)to monitor seismicity in the southern Sichuan Basin of *** workflow includes coherent event detection,phase picking,and earthquake location using three-component data from a seismic *** combining Phase Net,we develop an ML-based earthquake location model called Phase Loc,to conduct real-time monitoring of the local *** approach allows us to use synthetic samples covering the entire study area to train Phase Loc,addressing the problems of insufficient data samples,imbalanced data distribution,and unreliable labels when training with observed *** apply the trained model to observed data recorded in the southern Sichuan Basin,China,between September 2018 and March *** results show that the average differences in latitude,longitude,and depth are 5.7 km,6.1 km,and 2 km,respectively,compared to the reference *** Loc combines all available phase information to make fast and reliable predictions,even if only a few phases are detected and *** proposed workflow may help real-time seismic monitoring in other regions as well.

关键词： Earthquake monitoring Machine learning Local seismicity Gaussian waveform Sparse stations

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A modified 3D mean strain energy density criterion for predicting shale mixed-mode Ⅰ/Ⅲ fracture toughness

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2411-2428页

作者： Kun zheng Chaolin wang Yu Zhao Jing Bi Haifeng Liu College of Civil Engineering Guizhou UniversityGuiyang550025China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China

The fracture toughness of rocks is a critical fracturing parameter in geo-energy exploitation playing a significant role in fracture mechanics and hydraulic *** edge-notched disk bending(ENDB)specimens are employed to measure the entire range of mixed-modeⅠ/Ⅲfracture toughness of Longmaxi *** theoretically interpret the fracture mechanisms,this research first introduces the detailed derivations of three established fracture *** distinguishing the volumetric and distortional strain energy densities,an improved three-dimensional mean strain energy density(MSED)criterion is *** the critical volumetric to distortional MSED ratio decreases,the transition from tensiondominated fracture to shear-dominated fracture is *** results indicate that both peak load and applied energy increase significantly with the transition from pure mode I(i.e.,tension)to pure modeⅢ(i.e.,torsion or tearing)since mode-Ⅲcracking happens in a twisted manner and mode-Ⅰcracking occurs in a coplanar *** macroscopic fracture signatures are consistent with those of triaxial hydraulic *** average ratio of pure mode-Ⅲfracture toughness to pure mode-Ⅰfracture toughness is 0.68,indicating that the obtained mode-Ⅲfracture resistance for a tensionbased loading system is apparent rather than *** to the three mainstream fracture criteria,the present fracture criterion exhibits greater competitiveness and can successfully evaluate and predict mixed-modeⅠ/Ⅲfracture toughness of distinct materials and loading methods.

关键词： Longmaxi shale Hydraulic fracturing Fracture mechanisms Fracture criteria Mixed-modeⅠ/Ⅲfracture toughness Edge-notched disk bending

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NbB_(2)Modified Al-Cu Alloys Fabricated by Freeze-Ablation Casting under High Cooling Rate Solidification

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Acta Metallurgica Sinica(English Letters) 2024年第5期37卷 921-938页

作者： Xiang Kong Yu wang Hong Xu Haotian Fan Yuewu zheng Beibei Xie School of Materials Science and Engineering North University of ChinaTaiyuan 030051China

At present,improving the properties of aluminum alloys is generally achieved by increasing the cooling rate of the melt and adding micro-nano *** the cooling rate of the melt to improve the refining effect of grain refiner is still a difficult problem in the aluminum alloy casting *** innovative and environmentally friendly casting process,known as freeze ablation,was introduced during the preparation of an Al–NbB_(2) intermediate *** process significantly enhanced the cooling rate of the *** results indicated that the Al–NbB_(2) intermediate alloy produced under high cooling rates had a noticeable refining effect on Al–Cu alloys,with smaller NbB2 particles demonstrating superior refining *** average grain size of the refined Al–Cu alloy decreased from 154 to 69μm,the tensile strength increased by 12%,the fluidity increased by 18.4%,and the hot tearing index decreased from 144 to *** matching degree between NbB_(2) andα-Al was calculated using high-resolution transmission electron microscopy and the edge-to-edge *** was found that the atomic interplanar spacing and the interatomic spacing mismatch between NbB_(2)’splane and Al were both less than 10%,which further proved that NbB2 could serve as an effective nucleation site forα-Al grains to achieve grain refinement.

关键词： Grain refinement Freeze ablation Particle size control Mechanical properties Process properties

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Food nutrition and toxicology targeting on specific organs in the era of single-cell sequencing

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Food Science and Human Wellness 2024年第1期13卷 75-89页

作者： Xiaofei wang Xiaowen Cheng Huiling Liu Xiaohuan Mu Hao zheng National Engineering Technology Research Center for Fruit and Vegetable Processing Key Open Laboratory of Fruit and Vegetable ProcessingMinistry of Agriculture and Rural AffairsBeijing Key Laboratory of Food Non-Thermal ProcessingCollege of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China

Due to the complex natures of dietary food components,it is difficult to elucidate how the compounds affect host *** food often selectively presents its mechanism of action on different cell types,and participates in the modulation of targeted cells and their microenvironments within ***,the limitations of traditional in vitro assays or in vivo animal experiments cannot comprehensively examine cellular heterogeneity and the tissue-biased ***-cell RNA sequencing(sc RNA-seq)has emerged as an indispensable methodology to decompose tissues into different cell types for the demonstration of transcriptional profiles of individual *** RNA-seq applications has been summarized on three typical organs(brain,liver,kidney),and two representative immune-and tumor related health *** everincreasing role of sc RNA-seq in dietary food research with further improvement can provide sub-cellular information and the coupling between other cellular *** this review,we propose utilizing sc RNAseq to more effectively capture the subtle and complex effects of food chemicals,and how they may lead to health problems at single-cell *** novel technique will be valuable to elucidate the underlying mechanism of both the health benefits of food nutrients and the detrimental consequences food toxicants at the cellular level.

关键词： Dietary food Cellular heterogeneity Single-cell RNA sequencing Food nutrients Food toxicants

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Tube-based robust reinforcement learning for autonomous maneuver decision for UCAVs

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Chinese Journal of Aeronautics 2024年第7期37卷 391-405页

作者： Lixin wang Sizhuang zheng Haiyin PIAO Changqian LU Ting YUE Hailiang LIU School of Aeronautical Science and Engineering Beihang UniversityBeijing 100191China Shenyang Aircraft Design&Research Institute Shenyang 110035China

Reinforcement Learning(RL)algorithms enhance intelligence of air combat AutonomousManeuver Decision(AMD)policy,but they may underperform in target combat environmentswith *** enhance the robustness of the AMD strategy learned by RL,thisstudy proposes a Tube-based Robust RL(TRRL)***,this study introduces a tube todescribe reachable trajectories under disturbances,formulates a method for calculating tubes basedon sum-of-squares programming,and proposes the TRRL algorithm that enhances robustness byutilizing tube size as a quantitative ***,this study introduces offline techniques forregressing the tube size function and establishing a tube library before policy learning,aiming toeliminate complex online tube solving and reduce the computational burden during ***,an analysis of the tube library demonstrates that the mitigated AMD strategy achievesgreater robustness,as smaller tube sizes correspond to more cautious *** finding highlightsthat TRRL enhances robustness by promoting a conservative *** effectively balanceaggressiveness and robustness,the proposed TRRL algorithm introduces a“laziness factor”as aweight of ***,combat simulations in an environment with disturbances confirm thatthe AMD policy learned by the TRRL algorithm exhibits superior air combat performance comparedto selected robust RL baselines.

关键词： Air combat Autonomous maneuver decision Robust reinforcement learning Tube-based algorithm Combat simulation

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Development of Fixture Layout Optimization for Thin-Walled Parts:A Review

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 15-39页

作者： Changhui Liu Jing wang Binghai Zhou Jianbo Yu Ying zheng Jianfeng Liu School of Mechanical Engineering Tongji UniversityShanghai 201804China Shanghai Jiaotong University Shanghai 200240China Shanghai Waigaoqiao Shipbuilding Co. Ltd.Shanghai 200137China

An increasing number of researchers have researched fixture layout optimization for thin-walled part assembly during the past ***,few papers systematically review these *** analyzing existing literature,this paper summarizes the process of fixture layout optimization and the methods *** process of optimization is made up of optimization objective setting,assembly variation/deformation modeling,and fixture layout *** paper makes a review of the fixture layout for thin-walled parts according to these three ***,two different kinds of optimization objectives are *** usually consider in-plane variations or out-of-plane deformations when designing ***,modeling methods for assembly variation and deformation are divided into two categories:Mechanism-based and data-based *** common methods are discussed *** that,optimization algorithms are reviewed *** are two kinds of optimization algorithms:Traditional nonlinear programming and heuristic ***,discussions on the current situation are *** research direction of fixture layout optimization in the future is discussed from three aspects:Objective setting,improving modeling accuracy and optimization ***,a new research point for fixture layout optimization is *** paper systematically reviews the research on fixture layout optimization for thin-walled parts,and provides a reference for future research in this field.

关键词： Thin-walled parts Assembly quality Fixture layout optimization Modeling methods Optimization algorithms

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Vulnerability assessment of UAV engine to laser based on improved shotline method

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Defence Technology（防务技术） 2024年第3期33卷 588-600页

作者： Le Liu Chengyang Xu Changbin zheng Sheng Cai Chunrui wang Jin Guo Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China University of Chinese Academy of Sciences Beijing 100049China

Laser anti-drone technology is entering the sequence of actual combat,and it is necessary to consider the vulnerability of typical functional parts of *** the concept of"vulnerability"was proposed,a variety of analysis programs for battlefield targets to traditional weapons have been developed,but a comprehensive assessment methodology for targets'vulnerability to laser is still *** on the shotline method,this paper proposes a method that equates laser beam to shotline array,an efficient vulnerability analysis program of target to laser is established by this method,and the program includes the circuit board and the wire into the vulnerability analysis category,which improves the precision of the vulnerability *** the UAV engine part as the target of vulnerability analysis,combine with the"life-death unit method"to calculate the laser penetration rate of various materials of the UAV,and the influence of laser weapon system parameters and striking orientation on the killing probability is quantified after introducing the penetration rate into the vulnerability analysis *** quantitative analysis method proposed in this paper has certain general expansibility,which can provide a fresh idea for the vulnerability analysis of other targets to laser.

关键词： Laser weapon Laser damage Vulnerability UAV Engine Killing probability

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An envelope-based machine learning workflow for locating earthquakes in the southern Sichuan Basin

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Earthquake Research Advances 2024年第2期4卷 45-54页

作者： kang wang Jie Zhang Ji Zhang Zhangyu wang Ziyu Li School of Earth and Space Sciences University of Science and Technology of ChinaHefei230026China

The development of machine learning technology enables more robust real-time earthquake monitoring through automated implementations. However, the application of machine learning to earthquake location problems faces challenges in regions with limited available training data. To address the issues of sparse event distribution and inaccurate ground truth in historical seismic datasets, we expand the training dataset by using a large number of synthetic envelopes that closely resemble real data and build an earthquake location model named ENVloc. We propose an envelope-based machine learning workflow for simultaneously determining earthquake location and origin time. The method eliminates the need for phase picking and avoids the accumulation of location errors resulting from inaccurate picking results. In practical application, ENVloc is applied to several data intercepted at different starting points. We take the starting point of the time window corresponding to the highest prediction probability value as the origin time and save the predicted result as the earthquake location. We apply ENVloc to observed data acquired in the southern Sichuan Basin, China, between September 2018 and March 2019. The results show that the average difference with the catalog in latitude, longitude, depth, and origin time is 0.02°,0.02°, 2 km, and 1.25 s, respectively. These suggest that our envelope-based method provides an efficient and robust way to locate earthquakes without phase picking, and can be used in earthquake monitoring in near-real time.

关键词： Waveform envelope Earthquake location Local seismicity Synthetic data Sparse stations

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