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Iontophoresis-assisted corneal crosslinking using 0.1% riboflavin for progressive keratoconus

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International Journal of Ophthalmology(English edition) 2017年第5期10卷 717-722页

作者： Hong-Zhen Jia Xu Pang zheng-jun fan Na Li Gang Li Xiu-jun Peng Chinese PLA Medical School Beijing 100853 China Department of Ophthalmology Chinese PLA Navy General Hospital Beijing 100048 China

AIM：To report the clinical results of iontophoresis-assisted epithelium-on corneal crosslinking（I-CXL） using 0.1% riboflavin in distilled water for progressive keratoconus. METHODS：In this prospective clinical study, we examined 94 eyes of 75 patients with progressive keratoconus who were treated with I-CXL using 0.1% riboflavin in distilled water. Best correct visual acuity（BCVA）, Scheimpflug tomography, corneal topography, anterior segment optical coherence tomography, intraocular pressure, and endothelial cell density were evaluated at baseline and 1, 3, 6, 12, and 24 mo after ***：After 24 mo I-CXL, compared to the level at baseline, BCVA significantly improved 0.14±0.07（P=0.010）; mean keratometry signifi cantly decreased 0.72±1.97（P=0.021）; maximum keratometry significantly reduced 2.30±5.01（P=0.014）; central keratoconus index significantly reduced 0.04±0.08（P=0.007）. The demarcation line was visible in 83.1% of eyes at 1mo after treatment, with a depth of 298.95±51.97 μm, and gradually indistinguishable. One eye had repeat treatment. Intraocular pressure and endothelial cell density did not change ***：I-CXL using 0.1% riboflavin halts keratoconus progression within 24 mo, resulting in a significant improvement in visual and topographic parameters. Moreover, the depth of the demarcation line is similar to that previously reported in standard epithelium-off CXL procedures.

关键词： corneal cross-linking iontophoresis keratoconus distilled water riboflavin

Riboflavin concentration in corneal stroma after intracameral injection

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International Journal of Ophthalmology(English edition) 2015年第3期8卷 470-475页

作者： Na Li Xiu-jun Peng zheng-jun fan Xu Pang Yu Xia Teng-Fei Wu Chinese PLA Medical School & Chinese PLA General Hospital Department of Ophthalmology Navy General Hospital of Chinese PLA

AIM: To evaluate the enrichment of riboflavin in the corneal stroma after intracameral injection to research the barrier ability of the corneal endothelium to riboflavin in ***: The right eyes of 30 New Zealand white rabbits were divided into three groups. Different concentrations riboflavin-balanced salt solutions(BSS)were injected into the anterior chamber(10 with 0.5%, 10 with 1%, and 10 with 2%). Eight corneal buttons of 8.5mm in diameter from each group were dissected at 30 min after injection and the riboflavin concentrations in the corneal stroma were determined using high-performance liquid chromatography(HPLC) after removing the epithelium and endothelium. The other two rabbits in every group were observed for 24 h and sacrificed. As a comparison, the riboflavin concentrations from 16 corneal stromal samples were determined using HPLC after instillation of 0.1% riboflavin-BSS solution for30 min on the corneal surface(8 without epithelium and 8with intact epithelium).RESULTS: The mean riboflavin concentrations were11.19, 18.97, 25.08, 20.18, and 1.13 μg/g for 0.5%, 1%, 2%,de-epithelialzed samples, and the transepithelial groups,respectively. The color change of the corneal stroma and the HPLC results showed that enrichment with riboflavin similar to classical de-epithelialized corneal collagen crosslinking(CXL) could be achieved by intracameral 1%riboflavin-BSS solution after 30min; the effect appeared to be continuous for at least 30 ***: Riboflavin can effectively penetrate the corneal stroma through the endothelium after an intracameral injection in vivo, so it could be an enhancing method that could improve the corneal riboflavin concentration in transepithelial CXL.

关键词： riboflavin cornea intracameral injection high-performance liquid chromatography endothelium

Iontophoresis-assisted versus standard corneal crosslinking for progressive keratoconus

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Annals of Eye Science 2017年第1期2卷 28-34页

作者： Hong-Zhen Jia Xu Pang zheng-jun fan Xiu-jun Peng Department of Ophthalmology Chinese PLA Navy General HospitalBeijing 100048China

Background:To compare the safety and efficacy of iontophoresis-assisted epithelial-on corneal crosslinking(I-CXL)using 0.1%riboflavin-distilled water solution with standard epithelium-off corneal crosslinking(S-CXL)for progressive ***:In a retrospective analysis,progressive keratoconus patients treated with I-CXL(17 eyes of 17 patients)or S-CXL(13 eyes of 13 patients)were *** patients were followed up at least 12 *** patients underwent detailed ophthalmologic examinations involving pre-and postoperative visual acuity,topographic parameters and ***-and postoperative complications were ***:No statistically significant differences were observed between the two groups at baseline with respect to visual acuity,age and thinnest corneal thickness(TCT).The postoperative decreases of K1 and Kmean in the S-CXL group represented statistically significantly better results than in the I-CXL group(t=2.093 and 2.123,P=0.046 and 0.043,respectively).Alterations of other parameters showed no significant differences between the two *** were no failure cases in the two ***:I-CXL using 0.1%riboflavin-distilled water solution provided effective treatment for progressive keratoconus at 12-month ***,the decreases of K1 and Kmean caused by I-CXL were less than those by *** treatment time,postoperative patient pain and risk of infection in I-CXL are all less than those in S-CXL,I-CXL is unable to completely replace S-CXL for progressive keratoconus temporarily.

关键词： Keratoconus corneal crosslinking iontophoresis riboflavin

Analysis of circumferential waves on a water-filled cylindrical shell

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Chinese Journal of Acoustics 2012年第2期31卷 178-188页

作者： fan Wei zheng Guoyin fan jun State Key Laboratory of Ocean Engineering Shanghai Jiao Tong University Shanghai 200240

The formation of scattering field from a water-filled cylindrical shell was studied. The analytic solutions of scattering field are derived using elastic thin shell theory and Sommerfeld-Watson Transformation （SWT） method. Complex wave-number poles of circumferential waves are found numerically, the phase speed and attenuation of circumferential waves between the situation of a hollow cylindrical shell and a water-filled cylindrical shell are compared. The synthesis of backscattering form functions which are sum of specular reflection component and circumferential waves is consistent with normal mode result. The calculated echo sequences of additional fluid circumferential waves are compared with experimental results. The results show that richer resonance peaks appeared in the backscattering form functions of a water-filled cylindrical shell and the formation of echo＇s structure are due to re-radiation effects of additional fluid circumferential waves.

关键词：圆柱壳水填充波分弹性薄壳理论散射场镜面反射比较实验解析解

Acoustic scattering from fluid-filled finite cylindrical shell in water:Ⅱ.Experiment

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Chinese Journal of Acoustics 2011年第3期30卷 301-312页

作者： zheng Guoyin fan jun TANG Weilin State Key Laboratorg of Ocean Engineering Shanghai Jiao Tong University Shanghai 200240

Acoustic scattering from the submerged fluid-filled finite cylindrical shell insonified by an incident plane wave is studied experimentally and theoretically. A monostic broadband transducer with the sharp directivity is used in the experiment. The broadband LFM signal and the single-frequency narrow pulse are used to measure the backscattering field of the cylindrical shell. The measured results have a good agreement with the theory both in time and frequency domain. The theoretical and experimental results show that the resonances of several additional waves which are caused by the internal fluid are presented in the frequency domain. And a series of ＇whispering gallery＇ waves produced by the waves reflected back and forth in the internal fluid filled in the cylindrical shell are added. The reason for the clustering of the bowl-shape resonance curves in the frequency-angle spectrum is explained as the superposition of the first several modes of ＇whispering gallery＇ waves.

关键词：散射实验圆柱壳液体声散射宽带换能器共振频率入射平面波 LFM信号

Acoustic scattering from a fluid-filled finite cylindrical shell in water:Ⅰ.Theory

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Chinese Journal of Acoustics 2011年第3期30卷 288-300页

作者： zheng Guoyin fan jun TANG Weilin State Key Laboratory of Ocean Engineering Shanghai Jiao Tong University Shanghai 200240

Acoustic scattering from a submerged fluid-filled finite cylindrical shell insonified by an incident plane wave was studied. The analytic solutions of the scattering field are derived using the elastic thin shell theory with the boundary conditions. The fluid-filled impedance, due to the effect of internal fluid, must add to the impedance of the system. The results show that in the backscattering field, rigid scattering has a large contribution only on the broadside and elastic scattering play a major role when oblique incidence. The dispersion curves of the phase velocity show that comparing with the internal vacuum condition, except the contribution by longitudinal wave and shear wave near the broadside a series of the additional waves caused by the internal fluid is added which have great contribution to the scattering field. Bowl- shape resonance curves are presented in the frequency-angle spectrum as the contribution of the internal fluid waves.

关键词：声散射圆柱壳液体水下弹性薄壳理论入射平面波散射场边界条件

Effect of a Carbon Fibre-steel Fibre-graphite Conductive Filler on the Electrothermal Properties of Cementitious Materials

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 141-151页

作者： fan Yanan WEI Hong zheng Hongyong DU Hongxiu Department of Architecture and Environmental Engineering Taiyuan UniversityTaiyuan 030032China College of Civil Engineering Taiyuan University of TechnologyTaiyuan 030032China

Carbon fibre,steel fibre and graphite were used as conductive fillers to prepare cementitious materials with excellent electrothermal *** electrically conductive cementitious materials with different volume dosages were analysed through compressive and flexural strength,electrochemical impedance spectroscopy and temperature rise *** equivalent circuit model was established to study the electrically conductive heat generation mechanism in the electrically conductive cementitious *** results indicate that the mechanical properties of cementitious composite materials with a ternary conductive phase are better than those of pristine cementitious materials because the fibrous filler improves their mechanical ***,the incorporation of graphite in the material reduces its *** fibrous and point-like conductive phase materials into the cementitious material enhances the overall conductive pathway and considerably reduces the electrical resistance of the cementitious material,enhancing its conductive *** volume ratios of carbon fibre,steel fibre and graphite that achieve an optimal complex doping in the cementitious material were 0.35%,0.6%and 6%,*** was determined using the mutation point of each circuit element parameter as the percolation *** addition,at a certain safety voltage,there is a uniform change between the internal and surface temperatures of the conductive cementitious material,and the heating effect in this materialis is considerably better than that in the pristine cementitious material.

关键词： cementitious composites conductive fillers electrothermal properties electrochemical impedance spectroscopy

Experimental Study on Geometry Characteristics of Turbulent Premixed Flames for Natural Gas/Air Mixtures

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Journal of Thermal Science 2025年第1期34卷 268-282页

作者： zheng Weilin WANG Qijiao XIAO Huahua CHEN Xiaoxiao XIE fan ZENG Wen Liaoning Key Lab of Advanced Test Technology for Aerospace Propulsion System Shenyang Aerospace University State Key Laboratory of Fire Science University of science and Technology of China AVIC Shenyang Aircraft Design and Research Institute

In this study,focusing on the geometry characteristics of spherical expanding flame,the turbulent premixed flames of natural gas/air mixtures were investigated in a fan-stirred turbulent *** effects of initial temperature（T=300-400 K）,initial pressure（P=0.1-0.3 MPa）,turbulence intensity（u'=1.0-2.7 m/s）,oxygen volumetric percentage(φ（O2）=15%-21%) and carbon dioxide volumetric percentage(φ（CO2）=0-20%)were delved *** flame profile under the Cartesian coordinate system was derived from the schlieren images taken by the high-speed ***,from both macroscopic and microscopic perspectives,the influence of experimental conditions on the flame geometry characteristics was explored through flame front extraction,wavelet decomposition and network *** results demonstrate that for significant flame wrinkling,changes in species concentrations and turbulence intensity have more pronounced effects on the flame wrinkling *** wrinkling of the flame front maintains a certain degree of similarity,as evidenced by the locally concentrated distribution of the angles of the maximum fluctuation *** disturbance energy under large-scale（D6-D8） disturbances exhibits relatively high values with a similar trend,exerting a significant impact on the geometry characteristics of the flame *** peaks of correlation degree are scattered either with the decomposition scale or the development of flame radius,indicating no linear correlation between different detail ***,the probability distribution of node degrees in key wrinkled regions exhibits different trends with that of large-scale wrinkling and disturbance energy,especially with changes in initial *** occurs because the number of key wrinkles varies based on the perturbation's strength or the region's ***,an increase in the fluctuation frequency of the flame's local radius may not necessarily lead to an increase in the number of key folded regions.

关键词： fan-stirred turbulent combustor geometry characteristics large-scale wrinkling network topology wavelet decomposition

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溴芬酸钠滴眼液对RPK术后止痛效果的观察

国际眼科杂志 2013年第3期13卷 557-559页

作者：樊郑军海军总医院眼科中国北京市100037

目的:观察溴芬酸钠滴眼液用于PRK术后止痛的临床效果。方法:选取双眼行PRK术患者60例,术前及术后常规局部使用抗菌素、激素。根据局部使用非甾体抗炎药随机分组,溴芬酸钠滴眼液组30例60眼,术前3d开始点用溴芬酸钠滴眼液2次/d,至术后5d;... 详细信息

目的:观察溴芬酸钠滴眼液用于PRK术后止痛的临床效果。方法:选取双眼行PRK术患者60例,术前及术后常规局部使用抗菌素、激素。根据局部使用非甾体抗炎药随机分组,溴芬酸钠滴眼液组30例60眼,术前3d开始点用溴芬酸钠滴眼液2次/d,至术后5d;对照组30例60眼,术前3d开始点用普拉洛芬滴眼液4次/d,至术后5d。采用5级疼痛评估法,即无痛0度,轻痛1度,中度痛2度,重度痛3度,严重痛4度。记录术后3d内最高疼痛数值。结果:疼痛调查表回收率100%。溴芬酸钠组0度20例(66.66%),1度10例(33.33%);对照组0度10例(33.33%),1度10例(33.33%),2度7例(23.33%),3度3例(10.00%)。统计学结果显示溴芬酸钠组与对照组之间有统计学差异(P<0.05)。结论:溴芬酸钠滴眼液用于PRK术后止痛效果优于普拉洛克滴眼液,并且副作用小,依从性好。

关键词：止痛溴芬酸钠准分子激光屈光角膜切削术