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17β-estradiol inhibits TGF-β-induced collagen gel contraction mediated by human Tenon fibroblasts via Smads and MAPK signaling pathways

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International Journal of Ophthalmology(English edition) 2023年第9期16卷 1441-1449页

作者： Cheng-Cheng Yang Meng-Jie Liu Yun-Ze-Peng Li zheng-hua xu Yang Liu Zi-Han Guo Bin-Hui Li Xiu-Xia Yang Department of Ophthalmology the Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Eye Institute of Xiamen University Fujian Provincial Key Laboratory of Ophthalmology and Visual ScienceSchool of MedicineXiamen UniversityXiamen 361000Fujian ProvinceChina

AIM:To investigate the impact of 17β-estradiol on the collagen gels contraction(CGC)and inflammation induced by transforming growth factor(TGF)-βin human Tenon fibroblasts(HTFs).METHODS:HTFs were three-dimensionally cultivated in type I collagen-generated gels with or without TGF-β(5 ng/mL),17β-estradiol(12.5 to 100μmol/L),or progesterone(12.5 to 100μmol/L).Then,the collagen gel diameter was determined to assess the contraction,and the development of stress fibers was analyzed using immunofluorescence *** and gelatin zymography assays were used to analyze matrix metalloproteinases(MMPs)and tissue inhibitors of metalloproteinases(TIMPs)being released into culture ***-linked immunosorbent assay(ELISA)and reverse transcription-quantitative polymerase chain reaction(RT-PCR)were used to detect interleukin(IL)-6,monocyte chemoattractant proteins(MCP)-1,and vascular endothelial growth factor(VEGF)in HTFs at the translational and transcriptional *** phosphorylation levels of Sma-and Mad-related proteins(Smads),mitogen-activated protein kinases(MAPKs),and protein kinase B(AKT)were measured by *** analysis was performed using either the Tukey-Kramer test or Student’s unpaired t-test to compare the various ***:The CGC caused by TGF-βin HTFs was significantly inhibited by 17β-estradiol(25 to 100μmol/L),and a statistically significant difference was observed when comparing the normal control group with 17β-estradiol concentrations exceeding 25μmol/L(P<0.05).The suppressive impact of 17β-estradiol became evident 24h after administration and peaked at 72h(P<0.05),whereas progesterone had no ***,17β-estradiol attenuated the formation of stress fibers,and the production of MMP-3 and MMP-1 in HTFs stimulated by TGF-β.The expression of MCP-1,IL-6,and VEGF mRNA and protein in HTFs were suppressed by 100μmol/L 17β-estradiol(P<0.01).Additionally,the phosphorylation of Smad2 Smad3,p38,and extracellula

关键词： Tenon fibroblasts transforming growth factor-β 17β-estradiol fibrosis wound healing

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Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

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Neural Regeneration Research 2025年第5期20卷 1495-1504页

作者： Yunting Xiang Xiangxin Xing xuyun hua Yuwen Zhang Xin xue Jiajia Wu Mouxiong zheng He Wang Jianguang xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected ***,differences among reconstruction strategies at the brain network level have not been *** study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve ***–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper ***-state brain functional magnetic resonance imaging was obtained 7 months after *** independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the *** in intra-network resting-state functional connectivity were compared among the *** muscle reinnervation was assessed by behavioral observation(elbow flexion)and *** results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural *** repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor *** thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve *** areas related to cognition and emotion were enhanced after end-to-side nerve *** study revealed important brain networks related to different nerve *** networks may be potential targets for enhancing motor recovery.

关键词： brain functional networks end-to-end nerve transfer end-to-side nerve transfer independent component analysis nerve repair peripheral plexus injury resting-state functional connectivity

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Pyroptosis,ferroptosis,and autophagy in spinal cord injury:regulatory mechanisms and therapeutic targets

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Neural Regeneration Research 2025年第10期20卷 2787-2806页

作者： Qingcong zheng Du Wang Rongjie Lin Weihong xu Department of Spinal Surgery the First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Arthritis Clinical and Research Center Peking University People’s HospitalBeijingChina Department of Orthopedic Surgery Fujian Medical University Union HospitalFuzhouFujian ProvinceChina

Regulated cell death is a form of cell death that is actively controlled by *** studies have shown that regulated cell death plays a key role after spinal cord *** and ferroptosis are newly discovered types of regulated cell deaths that have been shown to exacerbate inflammation and lead to cell death in damaged spinal ***,a complex form of cell death that is interconnected with various regulated cell death mechanisms,has garnered significant attention in the study of spinal cord *** injury triggers not only cell death but also cellular survival *** signaling pathways play pivotal roles in influencing the processes of both deterioration and repair in spinal cord injury by regulating pyroptosis,ferroptosis,and ***,this review aims to comprehensively examine the mechanisms underlying regulated cell deaths,the signaling pathways that modulate these mechanisms,and the potential therapeutic targets for spinal cord *** analysis suggests that targeting the common regulatory signaling pathways of different regulated cell deaths could be a promising strategy to promote cell survival and enhance the repair of spinal cord ***,a holistic approach that incorporates multiple regulated cell deaths and their regulatory pathways presents a promising multi-target therapeutic strategy for the management of spinal cord injury.

关键词： autophagy cell death ferroptosis inflammation pathological mechanisms pyroptosis regulated cell death regulatory pathways spinal cord injury therapeutic targets

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基于圆锥截线的高超前体气动设计及特性分析

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推进技术 2017年第8期38卷 1717-1725页

作者：袁化成陈文芳刘君华正旭南京航空航天大学能源与动力学院江苏省航空动力系统重点实验室江苏南京210016

为了探究前体典型几何参数对高超声速前体/进气道气动特性的影响,在相同的前体外压缩角度和几何长度下,对基于圆锥截线参数控制横向截面的高超声速前体流动特性开展了三维数值模拟分析。采用控制变量法研究了高超声速前体宽度比、形状... 详细信息

为了探究前体典型几何参数对高超声速前体/进气道气动特性的影响,在相同的前体外压缩角度和几何长度下,对基于圆锥截线参数控制横向截面的高超声速前体流动特性开展了三维数值模拟分析。采用控制变量法研究了高超声速前体宽度比、形状参数、形状角度参数以及水平半宽控制曲线次数对高超声速前体/进气道气动性能的影响。结果显示:上述四个几何参数对前体横向压力梯度的构建均产生一定的影响,导致前体横向溢流,进而影响前体/进气道的气动性能。增大前体宽度比、形状参数、水平半宽控制线次数,减小形状角度参数,可减小前体展向压力梯度及横向溢流,提高前体/进气道流量捕获特性,在本文研究范围内,上述参数变化对应的前体/进气道流量系数分别增加了25.1%,13.7%,20.3%及12.2%。

关键词：前体构型圆锥曲线横向溢流流量系数升阻比

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一种基于横向压力控制的前体流动特性分析

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推进技术 2017年第1期38卷 8-15页

作者：陈文芳袁化成华正旭刘君南京航空航天大学能源与动力学院江苏省航空动力系统重点实验室江苏南京210016

为了探究前体构型对进气道气动特性的影响,在相同的压缩角度及几何长度下,设计了升力体前体和类乘波体前体两种构型方案。就不同构型对前体/进气道气动特性的影响开展了三维数值模拟研究,并与进气道二维流动进行了对比分析。结果显示,... 详细信息

为了探究前体构型对进气道气动特性的影响,在相同的压缩角度及几何长度下,设计了升力体前体和类乘波体前体两种构型方案。就不同构型对前体/进气道气动特性的影响开展了三维数值模拟研究,并与进气道二维流动进行了对比分析。结果显示,相比于进气道二维流动,三维升力体和类乘波体前体构型在设计状态和不同来流攻角下均存在一定的横向压力梯度,导致进气道流量捕获能力降低,与二维流动差异较大,前者流量系数下降20.3%,后者下降9.0%。相比较而言,类乘波体前体在流量捕获能力及升阻比等方面性能更优。增大类乘波体前体宽度比和前缘角度,可以减小前体横向压力梯度,提高前体/进气道的流量捕获能力,前者提高了升阻比,而后者则降低了升阻比。

关键词：前体构型攻角横向压力梯度流量捕获升阻比高超声速进气道

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Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai xu Zhen Gu hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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Role of iron ore in enhancing gasification of iron coke:Structural evolution,influence mechanism and kinetic analysis

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 58-69页

作者： Jie Wang Wei Wang xuheng Chen Junfang Bao Qiuyue Hao Heng zheng Runsheng xu School of Chemistry and Materials Science Hubei Engineering UniversityXiaogan 432000China Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China Institue of Ironmaking Technology Baosteel Central Research InstituteShanghai 201999China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The utilization of iron coke provides a green pathway for low-carbon *** uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the microstructure of iron coke was ***,a comparative study of the gasification reactions between iron coke and coke was conducted through non-isothermal thermogravimetric *** findings indicate that compared to coke,iron coke exhibits an augmentation in micropores and specific surface area,and the micropores further extend and *** provides more adsorption sites for CO_(2) molecules during the gasification process,resulting in a reduction in the initial gasification temperature of iron *** the heating rate in non-isothermal gasification can enhance the reactivity of iron *** metallic iron reduced from iron ore is embedded in the carbon matrix,reducing the orderliness of the carbon structure,which is primarily responsible for the heightened reactivity of the carbon *** kinetic study indicates that the random pore model can effectively represent the gasification process of iron coke due to its rich pore ***,as the proportion of iron ore increases,the activation energy for the carbon gasification gradually decreases,from 246.2 kJ/mol for coke to 192.5 kJ/mol for iron coke 15wt%.

关键词： low-carbon ironmaking iron coke gasification structural evolution kinetic model

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后掠唇口对二元高超声速进气道起动特性的影响研究

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推进技术 2017年第2期38卷 241-248页

作者：华正旭袁化成王金刚陈文芳南京航空航天大学能源与动力学院江苏省航空动力系统重点实验室江苏南京210016 沈阳飞机设计研究所辽宁沈阳110035

为深入探究唇罩侧板后掠对二元高超声速进气道起动性能的影响规律,采用风洞试验与三维数值模拟分析相结合的方法,对比分析了侧板不同后掠状态下的不起动流场特征,细致地研究了后掠角度影响进气道起动的流动机理。研究结果表明:唇罩后掠... 详细信息

为深入探究唇罩侧板后掠对二元高超声速进气道起动性能的影响规律,采用风洞试验与三维数值模拟分析相结合的方法,对比分析了侧板不同后掠状态下的不起动流场特征,细致地研究了后掠角度影响进气道起动的流动机理。研究结果表明:唇罩后掠能够提高进气道的起动能力,来流Ma=5.0和Ma=4.0时,进气道的最小起动后掠角分别为75°和82.5°。Ma=5.0来流条件下,不起动的分离包前缘形态在一定范围内基本不受后掠角影响。唇罩后掠角度增大时主要通过侧板的展向溢流,改变分离包的位置及形态,进而通过降低分离包内的逆压梯度来影响进气道的起动性能。

关键词：高超声速进气道后掠角不起动溢流分离包

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概念喷雾机底盘双侧液压马达自抗扰同步控制研究

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中国农业大学学报 2017年第6期22卷 135-143页

作者：张华郑加强徐幼林南京林业大学机械电子工程学院南京210037 安徽科技学院机械工程学院安徽凤阳233100

针对复杂农林环境下植保喷雾作业对底盘智能化、柔性化等的需求问题,采用双侧液压马达同步回转系统数学模型分析法和外层自抗扰控制,内层PID协调控制的同步控制策略,提出一种液压直驱的概念喷雾机底盘,以离散化形式设计了3阶自抗扰控制... 详细信息

针对复杂农林环境下植保喷雾作业对底盘智能化、柔性化等的需求问题,采用双侧液压马达同步回转系统数学模型分析法和外层自抗扰控制,内层PID协调控制的同步控制策略,提出一种液压直驱的概念喷雾机底盘,以离散化形式设计了3阶自抗扰控制器,并对双侧液压马达同步控制问题进行研究。通过SIMULINK仿真和试验台试验,结果表明:1)所制定的自抗扰同步控制策略相比传统的PID控制,系统响应更快速,其上升时间为1.2s,稳定时间3s;2)扰动工况下的双马达同步控制误差更低,其中,在马达2内部参数摄动下,双马达的试验同步误差峰值仅为-0.016rad,同步控制精度高于0.060%,而采用PID控制,双马达同步误差峰值可达-0.850rad,同步控制精度低于2.000%;3)自抗扰同步控制器具有更高的控制精度和扰动误差补偿能力,能满足喷雾机底盘直线行驶需求。该研究可为复杂农林环境下作业的行走机械底盘设计和液压系统同步控制提供理论参考。

关键词：液压直驱喷雾机底盘双侧液压马达自抗扰同步控制同步误差

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Chitosan/Konjac Glucomannan Blend Antibacterial Fibers

Chitosan/Konjac Glucomannan Blend Antibacterial Fibers

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2006年度学术研讨会

作者： LIHONG FAN,hua zheng,YONGMEI xu College of Chemical Engineering, Wuhan University of Technology, Wuhan 430070, China

Chitosan and konjac glucomannan (KGM) blend fibers were prepared by spinning their solution through a viscose-type spinneret into a coagulating bath containing aqueous sodium hydroxide and ethanol. The structure and properties of the blend fibers were studied with the aids of infrared spectra (IR), scanning electron micrography (SEM) and X-ray diffraction (XRD). The structure analysis indicated that there were strong interaction and good miscibility between alginate and gelatin molecular resulted from intermolecular hydrogen bonds. Mechanical properties and water-retention properties were measured. Through controlling blend conditions, blend fibers can obtain better mechanical properties than the pure chitosan fiber. The water-retention values (WRV) of blend fibers increase as the amount of KGM is raised. The fibers treated with alcoholic solution of acetic acid have good antibacterial activity to Staphylococcus aureus.

关键词： chitosan konjac glucomannan blend fibers miscibility mechanical properties water-retention properties

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