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Long-term clinical effects of intravitreal injections of conbercept for the treatment of choroidal neovascularization in patients with pathological myopia

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International Journal of Ophthalmology(English edition) 2022年第12期15卷 1971-1977页

作者： Si Zhang Zi-Fang He Fei-Fei Chen Wen-Wen Zhang Ya-Jun Liu Hui Chen zheng-gao xie Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008Jiangsu ProvinceChina

AIM:To observe the long-term clinical efficacy of intravitreal injections of conbercept,a novel vascular growth factor inhibitor,for the treatment of pathological myopia choroidal neovascularization(PM-CNV).METHODS:A total of 67 eyes(from 67 patients;mean age,54.90±12.7y)with PM-CNV were retrospectively *** on the different schemes used for the administration of the drug,the patients were divided into two groups:group A(n=35;average age,53.31±13.6y;average diopter,9.25±1.72 D),which received only one injection of pro re nata(PRN;1+PRN regimen),and group B(n=32;average age,56.49±11.8y;average diopter,9.63±2.24 D),which received one injection per month for 3mo(3+PRN regimen).Best-corrected visual acuity(BCVA)analysis,intraocular pressure(IOP)examination,slit-lamp microscopy,fundus examination and optical coherence tomography were per formed at each *** recurrence and treatment times of CNV were *** patients were followed up for at least ***:The BCVA was increased in 29 eyes(82.9%)in group A and 30 eyes(93.75%)in group B;no increase or decrease was observed in 6(17.1%)and 2(6.25%)eyes in groups A and B,*** BCVA(log MAR)values before treatment(0.67±0.48 and 0.71±0.56)were significantly higher than those 12mo after treatment(0.31±0.26 and 0.33±0.17)in groups A and B,respectively(P<0.05).The mean central macular thickness(CMT)values had significantly decreased from 346.49±65.99 and 360.10±82.31μm at baseline to 257.29±40.47 and 251.97±48.26μm in groups A and B,respectively,after 12mo of treatment.A total of 21 eyes in group A needed reinjection(60%;average number of injections,2.51±0.98);the corresponding values in group B were 6 eyes(18.75%;average number of injections,3.74±1.22).There were no adverse ocular and systemic complications during the treatment and ***:Intravitreal injection of conbercept with 1+PRN or 3+PRN improve the visual acuity,reduce macular edema and reduce the level of CMT in patie

关键词： pathological myopia choroidal neovascularization conbercept best-corrected visual acuity central macular thickness

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Orthogonal Combinatorial Raman Codes Enable Rapid High-Throughput-Out Library Screening of Cell-Targeting Ligands

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Research 2024年第1期2023卷 199-208页

作者： Yuchen Tang Xingxing zheng Tingjuan gao China Key Laboratory of Pesticide and Chemical Biology of Ministry of Education College of ChemistryCentral China Normal UniversityWuhan 430079China

High-throughput assays play an important role in the fields of drug discovery,genetic analysis,and clinical *** super-capacity coding strategies may facilitate labeling and detecting large numbers of targets in a single assay,practically,the constructed large-capacity codes have to be decoded with complicated procedures or are lack of survivability under the required reaction *** challenge results in either inaccurate or insufficient decoding ***,we identified chemical-resistant Raman compounds to build a combinatorial coding system for the high-throughput screening of cell-targeting ligands from a focused 8-mer cyclic peptide *** accurate in situ decoding results proved the signal,synthetic,and functional orthogonality for this Raman coding *** orthogonal Raman codes allowed for a rapid identification of 63 positive hits at one time,evidencing a high-throughput-out capability in the screening *** anticipate this orthogonal Raman coding strategy being generalized to enable efficient high-throughput-out screening of more useful ligands for cell targeting and drug discovery.

关键词： enable throughput allowed

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Puerarin enhances superoxide dismutase activity and inhibits RAGE and VEGF expression in retinas of STZ-induced early diabetic rats

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Asian Pacific Journal of Tropical Medicine 2012年第11期5卷 891-896页

作者： Fang Chen Hong-Quan Zhang Jun Zhu Kai-Yang Liu Hong Cheng Guo-Li Li Shan Xu Wei-Hong Lv zheng-gao xie Department of Ophthalmology Clinical Medicine CollegeYangzhou University Institute of Pharmacy School of MedicineYangzhou University Department of Biochemistry School of MedicineYangzhou University Department of Pathology School of MedicineYangzhou University

Objective:To investigate the effects of puerarin on the activity of superoxide dismutase(SOD), and expressions of advanced glycation end-product(AGE) receptor(RAGE) and vascular endothelial growth factor(VEGF) in retinas of streptozotocin(STZ)-induced early diabetic rats. Methods:Diabetic rat models were established by inducing diabetes via intra-peritoneal injection of *** were randomly divided into normal(control),diabetic(DM),and DM+ puerarin *** intra-gastric administration of puerarin(500 mg/kg/day for 4 weeks),levels of SOD and malondialdehyde(MDA) were determined in serum and *** and protein expression levels of RAGE and VEGF in retinas were determined by real-lime polymerase chain reaction(RT-PCR)(mRNA) and Western blot analysis(protein levels).Results:There was significantly lower SOD activity and significantly higher MDA in serum and retinas of the DM group compared with the two other groups(P<0.05).After treatment with puerarin,SOD activity increased and MDA content decreased in this group(P<0.05).mRNA and protein expression levels of RACE and VECF in the DM group were significantly higher than those of the other groups (P<0.05),and decreased after puerarin treatment(P<0.05).Conclusions:Puerarin is able to enhance SOD activity,and inhibit RAGE and VEGF expressions in retinas of STZ-induced early diabetic ruts.

关键词： Diabetic retinopathy Puerarin Oxidative stress Receptor for advanced glycation end products Vascular endothelial growth factor

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An Integrated External Archive Local Disturbance Mechanism for Multi-Objective Snake Optimizer

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Chinese Journal of Electronics 2024年第4期33卷 989-996页

作者： Leifu gao zheng LIU Institute for Optimization and Decision Analytics Liaoning Technical University

It is an interesting research direction to develop new multi-objective optimization algorithms based on meta-heuristics. Both the convergence accuracy and population diversity of existing methods are not *** paper proposes an integrated external archive local disturbance mechanism for multi-objective snake optimizer(IMOSO) to overcome the above shortcomings. There are two improved strategies. The adaptive mating between subpopulations strategy introduces the special mating behavior of snakes with multiple husbands and wives into the original snake optimizer. Some positions are updated according to the dominated relationships between the newly created individuals and the original individuals. The external archive local disturbance mechanism is used to re-search partial non-inferior solutions with poor diversities. The perturbed solutions are non-dominated sorting with the generated solutions by the next iteration to update the next external archive. The main purpose of this mechanism is to make full use of the non-inferior solution information to better guide the population evolution. The comparison results of the IMOSO and 7 state-of-the-art algorithms on WFG benchmark functions show that IMOSO has better convergence and population diversity.

关键词： Accuracy Sociology Metaheuristics Diversity methods Benchmark testing Statistics Convergence

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Adaptive Trajectory Tracking Control for Nonholonomic Wheeled Mobile Robots:A Barrier Function Sliding Mode Approach

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 1007-1021页

作者： Yunjun zheng Jinchuan zheng Ke Shao Han Zhao Hao xie Hai Wang the School of Mechanical Engineering Hefei University of TechnologyHefei 230009China the School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyHawthorn VIC 3122Australia the School of Civil Aviation Northwestern Polytechnical UniversityXi’an 710072China the Shanghai Aerospace Control Technology Institute Shanghai 201109 the School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China the College of Science HealthEngineering and EducationMurdoch UniversityPerth WA6150Australia

The trajectory tracking control performance of nonholonomic wheeled mobile robots(NWMRs)is subject to nonholonomic constraints,system uncertainties,and external *** paper proposes a barrier function-based adaptive sliding mode control(BFASMC)method to provide high-precision,fast-response performance and robustness for *** with the conventional adaptive sliding mode control,the proposed control strategy can guarantee that the sliding mode variables converge to a predefined neighborhood of origin with a predefined reaching time independent of the prior knowledge of the uncertainties and disturbances *** advantage of the proposed algorithm is that the control gains can be adaptively adjusted to follow the disturbances amplitudes thanks to the barrier *** benefit is that the overestimation of control gain can be eliminated,resulting in chattering ***,a modified barrier function-like control gain is employed to prevent the input saturation problem due to the physical limit of the *** stability analysis and comparative experiments demonstrate that the proposed BFASMC can ensure the prespecified convergence performance of the NWMR system output variables and strong robustness against uncertainties/disturbances.

关键词： Adaptive sliding mode barrier function nonholonomic wheeled mobile robot(NWMR) trajectory tracking control

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Stimulating Start-up Investment Through Government-Sponsored Venture Capital:Theory and Chinese Evidence

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Journal of Systems Science & Complexity 2024年第5期37卷 2021-2053页

作者： NI Xuanming zheng Tiantian gao Feng ZHAO Huimin School of Software and Microelectronics Peking UniversityBeijing 100871China School of Economics and Management Tsinghua UniversityBeijing 100084China School of Business Sun Yat-sen UniversityGuangzhou 510275China

Government-sponsored venture capital(GVC)has been used to support financially constrained start-ups as an important policy tool in ***,to motivate the social capital to invest in start-ups,GVC provides subsidies for them to bridge the funding gap in the early-stage venture capital ***,the effect and mechanism of GVC affecting social capital investment have not been clearly *** this paper,the authors not only develop a game model to analyze this issue in theory,but conduct an empirical study by analyzing the 14741 records matched by propensity score matching(PSM)of Chinese venture capital market data from 2011 to *** proposed findings are as the ***,the subsidies offered by GVC will simultaneously increase the returns and risks of investments in start-ups of social capital with more volatile incentive effect of *** incentive effect of GVC is only effective when the returns resulting from the subsidies outweigh the risks they *** the context of the Chinese venture capital market,the incentive effect of GVC is ***,the incentive effect of GVC is more pronounced in high-tech industries,which can be attributed to the signaling effect facilitated by *** this context,the subsidy mainly helps social capital to bear the costs associated with screening potential ***,the incentive effect of GVC is more significant in underdeveloped venture capital markets,which can be explained by the“virtuous cycle”effect,in which GVC plays a pioneering role in establishing a more robust early-stage market trading *** examining these three points,this study contributes to a better understanding of how GVC can effectively guide social capital investment,especially in the Chinese landscape.

关键词： Government-sponsored venture capital fund incentive effect social capital subsidy venture capital

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On-surface synthesis and characterization of polyynic carbon chains

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National Science Review 2024年第3期11卷 192-199页

作者： Wenze gao Wei zheng Luye Sun Faming Kang zheng Zhou Wei Xu Interdisciplinary Materials Research Center School of Materials Science and Engineering Tongji University

Carbyne, an elusive sp-hybridized linear carbon allotrope, has fascinated chemists and physicists for decades. Due to its high chemical reactivity and extreme instability, carbyne was much less explored in contrast to the sp2-hybridized carbon allotropes such as graphene. Herein, we report the on-surface synthesis of polyynic carbon chains by demetallization of organometallic polyynes on the Au（111） surface;the longest one observed consists of ～60 alkyne units（120 carbon atoms）. The polyynic structure of carbon chains with alternating triple and single bonds was unambiguously revealed by bond-resolved atomic force microscopy. Moreover, an atomically precise polyyne, C14, was successfully produced via tip-induced dehalogenation and ring-opening of the decachloroanthracene molecule(C14Cl10) on a bilayer NaCl/Au（111） surface at 4.7 K, and a band gap of 5.8 eV was measured by scanning tunnelling spectroscopy,in a good agreement with the theoretical HOMO–LUMO gap（5.48 eV）.

关键词： polyyne scanning probe microscopy carbon allotrope on-surface synthesis organometallic polyyne

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Experiment and Analysis of Compatibility between New Phase Change Mixed Molten Salt and 316L Stainless Steel

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Journal of Thermal Science 2024年第06期33卷 2259-2273页

作者： REN Chenxing zheng Chenghang gao Xiang State Key Laboratory of Clean Energy Utilization Zhejiang University Institute of Carbon Neutrality Zhejiang University Baima Lake Laboratory Zhejiang University

Molten salt is considered as a promising heat storage and heat transfer medium due to its efficient thermophysical *** order to study the compatibility of five new mixed molten salts obtained with KNO3,NaNO3,K2CO3,Ca（NO3）2·4H2O,ZnCl2,NaF,Na2CO3,NaCl and MgO as materials and 316L stainless steel,corrosion weight loss,scanning electron microscopy,elemental analysis and XRD were used to analyze the compatibility of 316L stainless steel in the new mixed molten salt at different time and *** corrosion behavior under the conditions was studied and *** compatibility data was obtained,and the corrosion mechanism of 316L stainless steel in mixed molten salts was *** results show that the corrosion weight of 316L stainless steel increases,and the corrosion degree of grain,crystal crack depth and oxidation degree increase gradually with the increase of temperature and *** corrosion of molten salt on alloy is mainly caused by the selective diffusion loss and corrosion of Cr,Fe and other elements,and is accompanied by the formation of different metal *** formation of metal oxides can slow down metal corrosion and loss to a certain *** corrosion results under different working conditions show that 316L stainless steel has good compatibility with the new mixed molten salt,and has certain application value in the field of heat transfer and energy storage.

关键词： 316L stainless steel corrosion resistance heat treatment molten salt

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Effects of orientation on the fatigue crack growth behaviors of the ZK60 magnesium alloy in air and PBS

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Journal of Magnesium and Alloys 2024年第1期12卷 281-294页

作者： Jiaqi Hu zheng Liu Zuoliang Ning Hong gao School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China Tianjin Key Laboratory of Chemical Process Safety and Equipment Technology Tianjin 300072China

Strong anisotropic corrosion and mechanical properties caused by specimen orientations greatly limit the applications of wrought magnesium *** investigate the influences of specimen orientation,the corrosion tests and(corrosion)fatigue crack growth tests were *** rolled and transverse surfaces of the materials show distinct corrosion rate differences in the stable corrosion stage,but the truth is the opposite for the initial stage of *** air,specimen orientations have a significant influence on the plastic deformation mechanisms near the crack tip,which results in different fatigue fracture surfaces and cracking *** with R-T specimens,N-T specimens show a slower fatigue crack growth(FCG)rate in air,which can be attributed to crack closure effects and deformation twinning near the crack *** corrosion environment will not significantly change the main plastic deformation mechanisms for the same type of ***,the FCG rate in phosphate buffer saline(PBS)is one order of magnitude higher than that in air,which is caused by the combined effects of hydrogen-induced cracking and anodic *** to the similar corrosion rates at crack tips,the specimens with different orientations display close FCG rates in PBS.

关键词： Magnesium alloy Orientation Corrosion Fatigue crack growth

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Chirality transfer induced circularly polarized luminescence of achiral dye molecules by plasmonic nanohelicoid

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Nano Research 2024年第9期17卷 8408-8414页

作者： Han gao ChunLian Zhan Tianqi Zhao Jianzhong zheng College of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018China School of Environmental Science and Engineering Nanjing Tech UniversityNanjing 211816China

Optical materials with circularly polarized luminescence(CPL)features have attracted a growing interest due to their crucial role in biological sensing,display,spintronics,information storage,and so ***,CPL emissions in hybrid nanoparticle systems,in particular,chirality transfer induced CPL from chiral plasmonic nanoparticles,have rarely been explored due to a lack of effective bottom-up synthesis ***,we creatively take advantage of the newly introduced chiral plasmonic nanoparticles-gold nanohelicoid(GNH)to excite the CPL of achiral Rhodamine 6G(R6G).The fabricated GNH@R6G-SiO_(2)shows obvious CPL signals with|g_(lum)|up to *** with the single GNH,the photoluminescence(PL)dissymmetry factor of the single GNH@R6G-SiO_(2)is similar,but with 25 folds higher PL intensities under different circular *** research not only offers an effective and feasible method to fabricate single-particle level CPL-active materials,but also provides guidelines on how to regulate the CPL of achiral luminophores from chiral plasmonic nanostructures,thereby enlarging the category and quantity of CPL-active materials that can be applied for photonic technologies and visualization biosensing,especially some intracellular chirality related detection.

关键词： circularly polarized luminescence gold nanohelicoids chiral plasmonic

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