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Taxuchin B,a New Chlorine-Containing Taxoid

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Chinese Chemical Letters 1997年第3期8卷 231-232页

作者： fang, WS fang, QC Liang, XT Lu, Y wu, N zheng, QT CHINESE ACAD MED SCI INST MAT MEDBEIJING 100050PEOPLES R CHINA BEIJING UNION MED COLL BEIJING 100050PEOPLES R CHINA

A new taxoid, taxuchin B[1], has been isolated from twigs and needles of Taxus chinensis. It is the first chlorine-containing taxoid reported to date.

关键词： Zhang Chen

Carboxylic Esterase and Its Associations With Long-term Effects of Organophosphorus Pesticides

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Biomedical and Environmental Sciences 2007年第4期20卷 284-290页

作者： ZHI-JUN ZHOU JIE zheng QIANG-EN wu fang XIE Department of Occupational Health and Toxicology School of Public Health WHO Collaborating Center for Occupational HealthShanghai Key Laboratory of Public Health and Safety Ministry of Education Fudan University Shanghai 200032 China

To examine a） the effect of organophosphorus pesticide exposure on activity of carboxylic esterases, namely butyrylcholinesterase （BChE）, carboxylesterase （CarbE） and paraoxonase （PonE）; and b） the association of polymorphisms of BChE and PonE with individual genetic susceptibility to organophosphorus pesticide exposure. Methods A cross-sectional study was conducted in 75 workers exposed to organophosphorus pesticides and 100 non-exposed controls. The serum activity of these enzymes was measured. Variant forms of BCHE-K, PON-192, and PON-55 were detected. A symptom score was developed as a proxy measure of clinical outcomes. Results Activities of both BChE and CarbE were lower in exposed workers （27.3±21.65 ***^-l and 235.6±104.03 nmol-min^-***^-l） than in non-exposed workers （78.313±30.354 nmol.h^-***^-1 and 362.681_＋194.997 ***^-***^-1）. The activity of PonE was not associated with exposure status. The AChE activity in the exposed workers with BCHE-K genotype UU （61 cases）, genotype UK （12 cases） and genotype KK （2 cases） was 105.05, 84.42 and 79.00 mmol-h^-***^-1, respectively and the accumulative symptom scores were 3.74, 9.17, and 12.50 accordingly. The AChE activity in the exposed workers with PON-192 genotype BB （37）, genotype AB （27） and genotype AA （11） was 116.8, 91.2, and 72,3 mmol-h^-***^-1, respectively and the symptom scores were 2.00, 6.74, and 9.73 accordingly. The AChE activity in those with PON-55 genotype LL （70） and genotype LM （5） was 102.4 and 82.8 mmol-h^-***^-1 and the symptom scores were 4.53 and 9.20. The symptom score was the highest in individuals with abnormal homozygote for each of the three gene loci. Condusions Long-term exposure to organophosphorus pesticides can inhibit BChE and CarbE activity, but exerts no inhibitory effect on PonE activity. Different genotypes of BCHE-K, PON-192, and PON-55 may be related to the severity of adverse health effects of organophosphorus pesticide exposure. Implications of potential

关键词： Carboxylic esterases Organophosphorus pesticides Polymorphism Susceptibility

An Effective RAID Data Layout for Object-Based De-duplication Backup System

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Chinese Journal of Electronics 2016年第5期25卷 832-840页

作者： YAN fang TAN Yu'an ZHANG Quanxin wu Fei CHENG Zijing zheng Jun School of Computer Science and Technology Beijing Institute of Technology School of Information Beijing Wuzi University Beijing Engineering Research Center of Massive Language Information Processing and Cloud Computing Application wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Space Star Technology CO. LtdChina Academy of Space Technology

We propose an alternative Redundant array of independent disks(RAID) data layout, Asymmetrical grouping data organization(AGDO), for object-based data de-duplication backup system. Object-based data deduplication is an effective solution for detecting duplicate data for compound files. We designed an asymmetrical grouping strategy, the disk in the array are partitioned into different groups, and in each group parallelism data access scheme is adopted, different types of objects are stored in different groups with maybe different group size, it can set and manage dynamic group size by using dynamic disk group adjustment algorithms. The performance of AGDO is evaluated and proved to be sufficient for the continuous storage application. The result is that disk accesses are concentrated in a part of the disks over a long time period and reduces the power consumption to 25% in a 10-disk configuration. Moreover, object-based de-duplication combined with AGDO has great potential in increasing data restoration speed for compound files. We have shown that this combination makes average restoration speed improved 11%.

关键词： Data layout Object-based deduplication Backup Energy aware Redundant array of independent disks(RAID)

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小麦TaGPX8基因的克隆与表达分析

农业生物技术学报 2023年第2期30卷 232-241页

作者：张华东李雅倩董飞燕丁芳草刘孟伟许嘉盛高春保王晓玲刘易科方正武长江大学农学院/农业农村部长江中游作物绿色高效生产重点实验室(部省共建) 湖北省农业科学院粮食作物研究所/粮食作物种质创新与遗传改良湖北省重点实验室/农业农村部华中地区小麦病害生物学科学观测实验站武汉生物工程学院

谷胱甘肽过氧化物酶(glutathione peroxidase, GPX)作为植物最主要的抗氧化酶之一，在植物逆境胁迫应答中发挥着重要作用。本课题组前期对小麦(Triticum aestivum) GPX基因家族的转录组数据进行分析时发现，TaGPX8(IWGSC数据库登录号:Tr... 详细信息

谷胱甘肽过氧化物酶(glutathione peroxidase, GPX)作为植物最主要的抗氧化酶之一，在植物逆境胁迫应答中发挥着重要作用。本课题组前期对小麦(Triticum aestivum) GPX基因家族的转录组数据进行分析时发现，TaGPX8(IWGSC数据库登录号:TraesCS4D02G162000.1)基因具有受逆境诱导表达的特性，本研究对TaGPX8进行了克隆，并对其编码蛋白进行了生物信息学分析和亚细胞定位，同时对盐和干旱胁迫下根和叶中TaGPX8的表达进行了分析。基因结构分析显示，TaGPX8全长14 754 bp，包含6个外显子和5个内含子，CDS全长564 bp，编码187个氨基酸残基，编码蛋白相对分子质量是21.330 kD，理论等电点为6.62，亲水性平均值为-0.664；启动子序列分析发现TaGPX8的启动子序列中含有多个参与激素反应、光反应和响应胁迫的顺式作用元件；qPCR结果显示，TaGPX8基因响应干旱胁迫和盐胁迫，干旱胁迫12 h时TaGPX8在叶片中的表达量与对照无显著差异，干旱胁迫24 h时被显著诱导，表达量上调，为对照的12倍，48 h时表达量降低，与对照无显著差异，且干旱胁迫48 h时在根部的表达也有所上升；TaGPX8在盐胁迫12 h叶片中表达受到一定程度抑制，但在处理24 h表达量升高，之后又降低与对照无显著差异，而在根中的表达受到抑制。酵母转录激活活性分析显示TaGPX8基因没有转录自激活活性。亚细胞定位显示TaGPX8定位于细胞核和细胞膜。本研究为深入探究TaGPX8基因的功能提供了参考。

关键词：小麦 TaGPX8 生物信息学分析 qPCR 自激活亚细胞定位

Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan Yang Zhi-Cheng Zhang Qi Dai Xiao-Yan Bao Lin-Jie wu Ya-Xin Qin Xin Tan Xiao-Yan Sun Xu-fang Ying Zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

A Data-Driven Clustering Recommendation Method for Single-Cell RNA-Sequencing Data

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Tsinghua Science and Technology 2021年第5期26卷 772-789页

作者： Yu Tian Ruiqing zheng Zhenlan Liang Suning Li fang-Xiang wu Min Li the Hunan Provincial Key Lab on Bioinformatics School of Computer Science and EngineeringCentral South UniversityHunan 410083China the Division of Biomedical Engineering and Department of Mechanical Engineering University of SaskatchewanSKS7N5A9Canada

Recently,the emergence of single-cell RNA-sequencing(scRNA-seq)technology makes it possible to solve biological problems at the single-cell *** of the critical steps in cellular heterogeneity analysis is the cell type *** scRNA-seq clustering methods have been proposed to partition cells into *** all the methods,hierarchical clustering and spectral clustering are the most popular approaches in the downstream clustering analysis with different preprocessing strategies such as similarity learning,dropout imputation,and dimensionality *** this study,we carry out a comprehensive analysis by combining different strategies with these two categories of clustering methods on scRNA-seq datasets under different biological *** analysis results show that the methods with spectral clustering tend to perform better on datasets with continuous shapes in two-dimension,while those with hierarchical clustering achieve better results on datasets with obvious boundaries between clusters in *** by this finding,a new strategy,called QRS,is developed to quantitatively evaluate the latent representative shape of a dataset to distinguish whether it has clear boundaries or ***,a data-driven clustering recommendation method,called DDCR,is proposed to recommend hierarchical clustering or spectral clustering for scRNA-seq *** perform DDCR on two typical single cell clustering methods,SC3 and RAFSIL,and the results show that DDCR recommends a more suitable downstream clustering method for different scRNA-seq datasets and obtains more robust and accurate results.

关键词： single-cel RNA-sequencing(sc RNA-seq) cel ular heterogeneity cel type identification data latent shape clustering

Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua Jianhong Dong Zheyu fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

不同热处理蛋黄脂质对小鼠学习认知能力下降的缓解能力

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食品工业科技 2025年第1期46卷 367-376页

作者：吴瑶刘铭坤方冰张明合肥工业大学食品与生物工程学院安徽合肥230061 中国农业大学营养与健康系北京100083 北京工商大学食品与健康学院北京100048

为探讨不同温度处理下蛋黄脂质对小鼠学习认知能力下降的缓解能力的差异。本研究利用小鼠认知障碍模型,比较95℃(水浴30 min)和121℃(灭菌锅加热30 min)热处理蛋黄脂质组分改善小鼠学习认知能力的差异。研究结果表明,相较于121℃热处理... 详细信息

为探讨不同温度处理下蛋黄脂质对小鼠学习认知能力下降的缓解能力的差异。本研究利用小鼠认知障碍模型,比较95℃(水浴30 min)和121℃(灭菌锅加热30 min)热处理蛋黄脂质组分改善小鼠学习认知能力的差异。研究结果表明,相较于121℃热处理的蛋黄脂质,95℃热处理的蛋黄脂质更有效地降低了Tau蛋白的磷酸化和Aβ1-40、GSK-3β表达,下调了促炎因子的表达,其提升小鼠的学习记忆能力的效果更好。95℃热处理蛋黄脂质中的多不饱和脂肪酸以及DHA较121℃热处理的蛋黄脂质显著增加(P<0.05)。因此,过度的加热条件,会破坏蛋品中DHA等多不饱和脂肪酸,削弱蛋黄脂质的改善认知的生物活性。本研究为蛋制品的热加工工艺的优化提供参考依据。

关键词：蛋黄脂质热处理学习和记忆

Rapid and robust initialization for monocular visual inertial navigation within multi-state Kalman filter

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Chinese Journal of Aeronautics 2018年第1期31卷 148-160页

作者： Wei fang Lianyu zheng School of Mechanical Engineering and Automation Beihang University

Sensor-fusion based navigation attracts significant attentions for its robustness and accuracy in various applications. To achieve a versatile and efficient state estimation both indoor and outdoor, this paper presents an improved monocular visual inertial navigation architecture within the Multi-State Constraint Kalman Filter （MSCKF）. In addition, to alleviate the initialization demands by appending enough stable poses in MSCKF, a rapid and robust Initialization MSCKF （I-MSCKF） navigation method is proposed in the paper. Based on the trifocal tensor and sigmapoint filter, the initialization of the integrated navigation can be accomplished within three consecutive visual frames. Thus, the proposed I-MSCKF method can improve the navigation performance when suffered from shocks at the initial stage. Moreover, the sigma-point filter is applied at initial stage to improve the accuracy for state estimation. The state vector generated at initial stage from the proposed method is consistent with MSCKF, and thus a seamless transition can be achieved between the initialization and the subsequent navigation in I-MSCKF. Finally, the experimental results show that the proposed I-MSCKF method can improve the robustness and accuracy for monocular visual inertial navigations.

关键词： Estimator initialization Navigation Kalman filter Pose estimation Visual inertial fusion