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Journal of Iron and Steel Research International 2024年第4期31卷 810-827页

作者： zheng-jian Liu Hui-qing Jiang Yao-zu Wang Jian-liang Zhang Hong-mei Qiao An-yang zheng Fang-yu Guo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China School of Intelligence Science and Technology University of Science and Technology BeijingBeijing 100083China Beijing Shougang Co. Ltd.Qian'an 064404HebeiChina department of Physics National University of Defense TechnologyChangsha 410128HunanChina

At high temperature,the chemical reaction mechanism at the interface of magnetite and the influence mechanism of gangue element Al on the oxidation performance of magnetite are not *** addition,due to the limitation of existing experimental equipment,it is difficult to clarify the interface reaction mechanism in the oxidation process and the influence mechanism of Al on the surface oxidation reaction of Fe_(3.O_(4) at an atomic scale at high *** surface oxidation reaction mechanism of magnetite and the influence mechanism of Al on the oxidation of magnetite were studied by experiments and AIMD(ab initio molecular dynamics).The experimental results show that the existence of Al_(2.O_(3. will reduce the initial oxidation temperature and comprehensive oxidation performance of *** AIMD results show that aluminum can accelerate the interface reaction rate of Fe_(3.O_(4) in the high-temperature oxidation atmosphere,but the strong Al-O binding ability is not conducive to the transfer of O atoms in the oxidation process.

关键词： Ironmaking Magnetite oxidation Interface reaction Adsorption-Gangue aluminum AIMD

Targeted drug approvals in 2.2.:breakthroughs by the FDA and NMPA

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Signal Transduction and Targeted Therapy 2024年第3期9卷 813-821页

作者： Lang zheng Wenjing Wang Qiu Sun department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China West china Medical Publishers West China HospitalSichuan UniversityChengdu 610041China

According to the official website of china’s National Medicines and Pharmaceutical Administration(NMPA),a total of 87 novel drugs were approved in china in 2.2.,with targeted drugs accounting for 67.8%of the total,amounting to 59 drugs(Fig.1a;Table 1)[https://***/yaopin/ypjgdt/***].Notably,domestic innovation is flourishing,with five first-in-class drugs,including Glumetinib,a c-Met inhibitor from Haihe Biopharma;Leritrelvir,a 3.L protease inhibitor from Raynovent;Anaprazole,a proton pump inhibitor from Xuanzhu Biopharm;Pegol-Sihematide,an EPO drug from Hansoh Pharma;and Zuberitamab from BioRay Biopharmaceutical Co.,***,the world’s first allosteric inhibitor targeting TYK2.Sotyktu(deucravacitinib),has been approved for the treatment of psoriasis and Selumetinib,a MEK inhibitor co-developed by AstraZeneca and Merck Sharp&Dohme(MSD),became the first approved drug in china for the treatment of neurofibromatosis type I(NF1).Beyond these drugs,the approval of novel drug types such as CAR-T cell products,siRNA,monoclonal antibodies,dual antibodies,and ADCs in china is a significant development in the country’s pharmaceutical industry(Fig.1a).

关键词： drugs Merck approval

TFEL of Ce^(3.) in zine sulpho-oxide

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Chinese Science Bulletin 1998年第14期43卷 1179-1183页

作者： YU Lei\+1, LOU Zhidong\+1, XU Chunxiang\+1, XU zheng\+2.and XU Xurong\+2.1. Institute of Material Physics, Tianjin Institute of Technology, Tianjin 3.0191,{3. 2. {2. of Physics, Northern Jiaotong {3., Beijing 100044,{3. Institute of Material Physics Tianjin Institute of Technology Tianjin China department of Physics Northern Jiaotong University Beijing China

A new TFEL material ZnS X O 1-X : Ce 3. is prepared. The EL brightness of ZnS X O 1-X : Ce 3. is at least one order higher than that of ZnS: Ce 3. at the same doping concentration of Ce 3. . The EL emission wavelength of ZnS X O 1-X : Ce 3. (\%X\%=0.5) ranges from 400 to 600 nm. The emission of ZnS X O 1-X : Ce 3. may be used as the blue part of white TFEL.

关键词： thin_film electroluminescence (TFEL) filter layered optimization zine sulpho_oxide.

Quantum and Non-Causal Stochastic Calculus

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Acta Mathematica Sinica,English Series 1998年第3期14卷 289-294页

作者： Liang Zongxia zheng Mingli department of Applied {2., Tsinghua {3., Beijing 100084, china department of Applied mathematics Tsinghua University 100084 Beijing China

In this paper, using the Guichardet space technique, the relationship between Fermion quantum stochastic calculus and non-causal calculus in Segal space L^2.H) is discussed, and an anticipating quantum stochastic calc... 详细信息

关键词： Non-causal stochastic analysis Quantum stochastic analysis Guichardet space

Urotensin Ⅱ accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol

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Acta Pharmacologica Sinica 2007年第1期28卷 36-43页

作者： Yong-gang ZHANG~(2.5) Yu-guang LI~2.Bao-guo LIU~3.Rui-hong WEI~2.Dong-ming WANG~2.Xue-rui TAN~2.Ding-fang BU~4 Yong-zheng PANG~4 Chao-shu TANG~42.department of Cardiovascular Diseases,First Affiliated Hospital,Shantou {2. Medical College,Shantou 515041,{3. 3.The Affiliated Hospital,Medical School of Hebei {2. of Engineering,Hebei 05602.,{3.,4 Institute of Cardiovascular Research,Peking {2. First Hospital,Beijing 10003.,{3. department of Cardiovascular Diseases First Affiliated Hospital Shantou University Medical College Shantou China The Affiliated Hospital Medical School of Hebei University of Engineering Hebei China Institute of Cardiovascular Research Peking University First Hospital Beijing China

Aim:To study whether urotensin II（UII）,a potent vasoconstrictive peptide,isinvolved in the development of cardiac hypertrophy and fibrogenesis of ratsinduced by isoproterenol（ISO）.Methods:Thirty male Wistar rats were randomlydivided into 3.*** 1 was the healthy control group,group 2.was the ISOgroup,and group 3.was the ISO+UII *** groups 2.and 3.ISO(5 mg-kg-1.d-1)wasgiven（sc）once daily for 7 *** 3.was also given UII in the first day [3.nmol/kg（5μg/kg）,iv],followed by sc（1.5 μg/kg）twice *** 1 received 0.9% *** receptor（UT）mRNA expression was determined by *** contents ofUII and angiotensin II（Ang II）were determined by *** vitro,the effects of UII on DNA/collagen synthesis of cardiac fibroblasts were deter-mined by [3.]thymidine/[3.]proline ***:The ratio of heartweight/body weight,plasma lactate dehydrogenase activity,myocardialmalondialdehyde and hydroxyproline concentration increased significantly in theISO group,as well as UT mRNA expression,plasma and cardiac UII and ventricu-lar Ang II,compared with the control group（P3.]thymidine/[3.]proline incorporation into cardiac fibroblasts in a dose-dependent manner（P<0.01）.Conclusion:These results suggest that UII was involved in the development ofcardiac fibrosis and hypertrophy by synergistic effects with ISO.

关键词： cardiac remodeling cardiac fibrosis GPR14 receptor urotensin II collagen

EXAFS Studies on Local Atomic Structure in the Amorphous Mg_(65)Cu_(2.)Gd_(10) Alloy

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Journal of Wuhan university of Technology(Materials Science) 2011年第1期26卷 98-101页

作者：李国强 Business Development department China Perfect Machinery Industry Corp. Ltd

Local atomic structures of an amorphous Mg65Cu2.Gd10 alloy and the structural changes by thermal annealing have been studied by extended X-ray absorption fine structure （EXAFS）. The correlation between structural changes and mechanical properties for the Mg65Cu2.Gd10 alloy has also been discussed. Results showed that Cu atoms around Gd in Mg65Cu2.Gd10 lost rapidly during annealing , resulting in the segregation of Cu atoms. The coordination number NGd-Mg of Mg65Cu2.Gd10 annealed at 3.3.K first diminished and then augmented with the increase of annealing time. The formation of polyhedral short-range order unit with coordination number of nearly 12.around Gd atoms is in favor of the improvement of mechanical properties. The chemical short-range order, not topological short-range order in the amorphous Mg65Cu2.Gd10 alloy had obvious changes during annealing.

关键词： magnesium alloy amorphous alloy short-range EXAFS mechanical properties annealing

Utility and Application of a Versatile Analytical Method for MMF Calculation in AC Machines

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CES Transactions on Electrical Machines and Systems 2024年第1期8卷 22-31页

作者： Ze-zheng Wu Robert Nilssen Jian-Xin Shen IEEE the College of Electrical Engineering Zhejiang UniversityHangzhou 310027China the department of Electric Energy Norwegian University of Science and TechnologyTrondheimNorwayand also affiliated with the College of Electrical EngineeringZhejiang UniversityHangzhou 310027China

A versatile analytical method(VAM) for calculating the harmonic components of the magnetomotive force(MMF) generated by diverse armature windings in AC machines has been proposed, and the versatility of this method has been established in early literature. However, its practical applications and significance in advancing the analysis of AC machines need further elaboration. This paper aims to complement VAM by augmenting its theory, offering additional insights into its conclusions, as well as demonstrating its utility in assessing armature windings and its application of calculating torque for permanent magnet synchronous machines(PMSM). This work contributes to advancing the analysis of AC machines and underscores the potential for improved design and performance optimization.

关键词： AC machine Analytical method Harmonic analysis MMF Magnetic field Torque calculation

ASYMPTOTIC THEORY FOR THE CIRCUIT ENVELOPE ANALYSIS

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Journal of Computational mathematics 2024年第4期42卷 955-978页

作者： Chunxiong zheng Xianwei Wen Jinyu Zhang Zhenya Zhou College of mathematics and Systems Science Xinjiang UniversityUrumqi 830046China department of Mathematical Sciences Tsinghua UniversityBeijing 100084China Empyrean Software Empyrean Technology Co.Ltd.Beijing 100102China

Asymptotic theory for the circuit envelope analysis is developed in this paper.A typical feature of circuit envelope analysis is the existence of two significantly distinct timescales:one is the fast timescale of carrier wave,and the other is the slow timescale of modulation *** first perform pro forma asymptotic analysis for both the driven and autonomous *** resorting to the Floquet theory of periodic operators,we make a rigorous justification for first-order asymptotic *** turns out that these asymptotic results are valid at least on the slow *** speed up the computation of asymptotic approximations,we propose a periodization technique,which renders the possibility of utilizing the NUFFT *** experiments are presented,and the results validate the theoretical findings.

关键词： Asymptotic analysis Circuit envelope analysis Floquet theory Singularly perturbed problem

Clinical observation on 90 cases of primary dysmenorrhea treated by buccal acupuncture therapy:a randomized controlled study

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Journal of Traditional Chinese Medicine 2024年第1期44卷 172-181页

作者： YANG Yi YE Huijun zheng Huiling JIN Lihua department of Obstetrics and Gynecology the Second Affiliated Hospital of Zhejiang Chinese Medical UniversityXinhua Hospital of Zhejiang ProvinceHangzhou 310005China

OBJECTIVE:To explore the short-term and long-term efficacy of buccal acupuncture therapy in the treatment of patients with primary dysmenorrhea(PD).METHODS:A total of 90 patients with PD who were admitted to the Second Affiliated Hospital of Zhejiang university of Traditional Chinese Medicine from January 2.2. to December 2.2. were included in this study and randomly divided into three groups,including the observation group,the control group,and the placebo group,with 3. patients in each *** in the observation group were treated according to the syndrome types of Traditional Chinese Medicine,those in the control group were treated with Saridon,and those in the placebo group received a *** visual analog scale(VAS)scores of these patients were evaluated at different time points(before treatment,5 min after needle retention,3. min after needle retention,1 h after treatment,2.h after treatment,1 d after treatment,and 2.d after treatment).The Cox Menstrual Symptom Scale(CMSS)scores were assessed before the treatment and after three courses of ***,these two scales were also evaluated during ***,the pain score and adverse reactions of these patients were assessed during ***:After treatment,the VAS and CMSS scores in the observation group decreased significantly(P3. min after needle retention and after ***:Buccal acupuncture therapy is verified to have short-term efficacy in the treatment of *** addition,this therapy has an immediate analgesic effect and long-term efficacy in reducing the severity and frequency of PD.

关键词： buccal acupuncture therapy primary dysmenorrhea pain score randomized controlled trial

Assessing the Performance of CMIP6 Models in Simulating Droughts across Global Drylands

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Advances in Atmospheric Sciences 2024年第2期41卷 193-208页

作者： Xiaojing YU Lixia ZHANG Tianjun ZHOU Jianghua zheng LASG Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science&TechnologyNanjing 210044China university of Chinese Academy of Sciences Beijing 100049China College of Geography&Remote Sensing Sciences Xinjiang UniversityUrumqi 830046China

Both the attribution of historical change and future projections of droughts rely heavily on climate modeling. However,reasonable drought simulations have remained a challenge, and the related performances of the current state-of-the-art Coupled Model Intercomparison Project phase 6(CMIP6) models remain unknown. Here, both the strengths and weaknesses of CMIP6 models in simulating droughts and corresponding hydrothermal conditions in drylands are *** the general patterns of simulated meteorological elements in drylands resemble the observations, the annual precipitation is overestimated by ~3.%(with a model spread of 2.3.–77.2.), along with an underestimation of potential evapotranspiration(PET) by ~3.0}(17.5%–47.2.). The water deficit condition, measured by the difference between precipitation and PET, is 50%(2..1%–71.7%) weaker than observations. The CMIP6 models show weaknesses in capturing the climate mean drought characteristics in drylands, particularly with the occurrence and duration largely underestimated in the hyperarid Afro-Asian areas. Nonetheless, the drought-associated meteorological anomalies, including reduced precipitation, warmer temperatures, higher evaporative demand, and increased water deficit conditions, are reasonably reproduced. The simulated magnitude of precipitation(water deficit) associated with dryland droughts is overestimated by 2.%(2.%) compared to observations. The observed increasing trends in drought fractional area,occurrence, and corresponding meteorological anomalies during 1980–2.14 are reasonably reproduced. Still, the increase in drought characteristics, associated precipitation and water deficit are obviously underestimated after the late 1990s,especially for mild and moderate droughts, indicative of a weaker response of dryland drought changes to global warming in CMIP6 models. Our results suggest that it is imperative to employ bias correction approaches in drought-related studies over drylands by using CMIP6 o

关键词： droughts hydrothermal conditions drylands CMIP6 model evaluation