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Effects of palbociclib on oral squamous cell carcinoma and the role of PIK3CA in conferring resistance

Cancer Biology & Medicine 2019年第2期16卷 264-275页

作者： Nur Syafinaz Zainal Bernard Kok Bang Lee zheng wei wong Iuan Sheau Chin Pei San Yee Chai Phei Gan Kein Seong Mun Zainal Ariff Abdul Rahman J. Silvio Gutkind Vyomesh Patel Sok Ching Cheong Head and Neck Team Cancer Research Malaysia Selangor 47500 Malaysia Department of Oral & Maxillofacial Clinical Sciences Faculty of Dentistry University of Malaya Kuala Lumpur 50603 Malaysia Department of Pathology Faculty of Medicine University of Malaya Kuala Lumpur 50603 Malaysia Oral Cancer Research and Co-ordinating Centre (OCRCC) Faculty of Dentistry University of Malaya Kuala Lumpur 50603 Malaysia Department of Pharmacology University of California San Diego 92093-5004 CA USA

Objective: Lack of effective therapies remains a problem in the treatment of oral squamous cell carcinoma(OSCC), especially in patients with advanced tumors. OSCC development is driven by multiple aberrancies within the cell cycle pathway, including amplification of cyclin D1 and loss of p16. Hence, cell cycle inhibitors of the CDK4/6-cyclin D axis are appealing targets for OSCC treatment. Here, we determined the potency of palbociclib and identified genetic features that are associated with the response of palbociclib in ***: The effect of palbociclib was evaluated in a panel of well-characterized OSCC cell lines by cell proliferation assays and further confirmed by in vivo evaluation in xenograft models. PIK3CA-mutant isogenic cell lines were used to investigate the effect of PIK3CA mutation towards palbociclib ***: We demonstrated that 80% of OSCC cell lines are sensitive to palbociclib at sub-micromolar ***, palbociclib was effective in controlling tumor growth in mice. We identified that palbociclib-resistant cells harbored mutations in PIK3CA. Using isogenic cell lines, we showed that PIK3CA mutant cells are less responsive to palbociclib as compared to wild-type cells with concurrent upregulation of CDK2 and cyclin E1 protein levels. We further demonstrated that the combination of a PI3 K/mTOR inhibitor(PF-04691502) and palbociclib completely controlled tumor growth in ***: This study demonstrated the potency of palbociclib in OSCC models and provides a rationale for the inclusion of PIK3CA testing in the clinical evaluation of CDK4/6 inhibitors and suggests combination approaches for further clinical studies.

关键词： OSCC palbociclib CDK4/6 inhibitors PIK3CA

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Aerodynamic Optimization and Flow Mechanism for a Compressor Cascade at Low Reynolds Number

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Journal of Thermal Science 2025年第1期34卷 92-109页

作者： LI Lin ZHANG Jianshe CHEN Caiyan TAN wei ZHANG Yanfeng Key Laboratory of Light-Duty Gas-Turbine Institute of Engineering ThermophysicsChinese Academy of Sciences University of Chinese Academy of Sciences National Key Laboratory of Science and Technology on Advanced Light-duty Gas-turbine

Low-Reynolds-number effect is an important factor affecting the performance of compressors and other main components of high-altitude long-endurance unmanned aerial *** improve the flow condition and reduce flow loss under the condition of high altitude and low Reynolds number(Re),this paper proposes an optimization process based on a surrogate model,which combines the class-shape transformation method(CST),the Latin hypercube sampling(LHS) method,the light gradient-boosting machine algorithm(LightGBM),and a genetic algorithm(GA) to optimize a high-subsonic compressor *** surrogate model is verified to be accurate and can be used in the optimization *** accuracy of the GA is higher than the other algorithms under common test *** optimization results are verified by numerical simulation,and the flow differences before and after optimization are compared,especially the flow within the boundary *** changing the blade shape,the optimization process adjusts the loading distribution to delay the transition of the optimized blade on the suction surface,which changes the turbulent reattachment in the laminar separation bubble(LSB) into laminar ***,the mixing loss induced by the turbulent reattachment of the LSB and the wake loss of turbulent separation at the trailing edge are significantly reduced,and the performance of the compressor profile is finally *** addition,turbulent separation of the optimized profile is delayed reducing the range of the wake region on the suction *** this optimization process,the reduction of total pressure loss coefficient at Re of 2.5×10～5,3.5×10～5,and 4.5×10～5 are 16.32%,20.76%,and 22.16%,respectively.

关键词： Reynolds number

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An improved parallel contrast-aware halftoning

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Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第12期14卷 918-929页

作者： Ling-yue LIU wei CHEN Tien-tsin wong Wen-ting zheng wei-dong GENG State Key Lab of CAD & CG Zhejiang University Department of Computer Science and Engineering The Chinese University of Hong Kong

Digital image halftoning is a widely used technique. However, achieving high fidelity tone reproduction and structural preservation with low computational time cost remains a challenging problem. This paper presents a highly parallel algorithm to boost real-time application of serial structure-preserving error diffusion. The contrast-aware halftoning approach is one such technique with superior structure preservation, but it offers only a limited opportunity for graphics processing unit(GPU) acceleration. Our method integrates contrast-aware halftoning into a new parallelizable error-diffusion halftoning framework. To eliminate visually disturbing artifacts resulting from parallelization, we propose a novel multiple quantization model and space-filling curve to maintain tone consistency, blue-noise property, and structure consistency. Our GPU implementation on a commodity personal computer achieves a real-time performance for a moderately sized image. We demonstrate the high quality and performance of the proposed approach with a variety of examples, and provide comparisons with state-of-the-art methods.

关键词： Digital image halftoning Error diffusion GPU Quantization Space-filling curve

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Hydrodynamical self-interference of a scattered polariton quanta

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Light(Science & Applications) 2020年第1期9卷 541-542页

作者： Jiahui Huang wei Liu Chee wei wong Mesoscopic Optics and Quantum Electronics Laboratory University of CaliforniaLos AngelesCA 90095USA

Researchers have observed the free-propagation of a single microcavity polariton directly and its self-interference when scattering upon a *** experimental observations of quantum hydrodynamics in the single polariton limit test the wave-particle duality and aid in the development of polariton-based photonic circuits in quantum information processing.

关键词： defect polar quantum

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Error Bounds for Uniform Asymptotic Expansions-Modified Bessel Function of Purely Imaginary Order

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Chinese Annals of Mathematics,Series B 2010年第5期31卷 759-780页

作者： wei SHI Roderick wong Wuhan Institute of Physics and Mathematics The Chinese Academy of Sciences Wuhan 430071 China. Department of Mathematics City University of Hong Kong Tat Chee Avenue Kowloon Hong Kong China.

The authors modify a method of Olde Daalhuis and Temme for representing the remainder and coefficients in Airy-type expansions of *** using a class of rational functions,they express these quantities in terms of Cauchy-type integrals;these expressions are natural generalizations of integral representations of the coe?cients and the remainders in the Taylor expansions of analytic *** using the new representation,a computable error bound for the remainder in the uniform asymptotic expansion of the modified Bessel function of purely imaginary order is derived.

关键词： Modified Bessel function of purely imaginary order Airy function Uniform asymptotic expansion Error bound

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Extreme high reversible capacity with over 8.0 wt% and excellent hydrogen storage properties of MgH2 combined with LiBH4 and Li3AlH6

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Journal of Energy Chemistry 2020年第11期29卷 296-306页

作者： Wenping Lin Xuezhang Xiao Xuancheng Wang Jie-wei wong Zhendong Yao Man Chen Jiaguang zheng Zhencan Hu Lixin Chen State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027ZhejiangChina Key Laboratory of Advanced Materials and Applications for Batteries of Zhejiang Province.Hangzhou 310013 ZhejiangChina Guangdong Provincial Key Laboratory of Advance Energy Storage Materials South China University of TechnologyGuangzhou 510640GuangdongChina

Magnesium hydride has attracted great attention because of its high theoretical capacity and outstanding reversibility, nevertheless, its practical applications have been restricted by the disadvantages of the sluggish kinetics and high thermodynamic stability. In this work, an unexpected high reversible hydrogen capacity over 8.0 wt% has been achieved from MgH2 metal hydride composited with small amounts of LiBH4 and Li3AlH6 complex hydrides, which begins to release hydrogen at 276 ℃ and then completely dehydrogenates at 360 ℃. The dehydrogenated MgH2+LiBH4/Li3AlH6 composite can fully reabsorb hydrogen below 300 ℃ with an excellent cycling stability. The composite exhibits a significant reduction of dehydrogenation activation energy from 279.7 kJ/mol(primitive MgH2) to 139.3 kJ/mol(MgH2+LiBH4/Li3AlH6),as well as a remarkable reduction of dehydrogenation enthalpy change from 75.1 k J/mol H2(primitive MgH2) to 62.8 kJ/mol H2(MgH2+LiBH4/Li3AlH6). The additives of LiBH4 and Li3AlH6 not only enhance the cycling hydrogen capacity, but also simultaneously improve the reversible de/rehydrogenation kinetics, as well as the dehydrogenation thermodynamics. This notable improvement on the hydrogen absorption/desorption behaviors of the MgH2+LiBH4/Li3AlH6 composite could be attributed to the dehydrogenated products including Li3Mg7, Mg17Al12 and MgAlB4, which play a key role on reducing the dehydrogenation activation energy and increasing diffusion rate of hydrogen. Meanwhile, the LiBH4 and Li3AlH6 effectively destabilize MgH2 with a remarkable reduction on dehydrogenation enthalpy change in terms of thermodynamics. In particular, the Li3Mg7, Mg17Al12 and MgAlB4 phases can reversibly transform into MgH2, Li3AlH6 and LiBH4 after rehydrogenation, which contribute to maintain a high cycling *** constructing strategy can further promote the development of high reversible capacity Mg-based materials with suitable de/rehydrogenation properties.

关键词： Magnesium hydride Complex hydride Hydrogen storage High reversible capacity Synergistic effect

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Specific protein-urea interactions

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Magnetic Resonance Letters 2022年第3期2卷 131-138页

作者： Zhi wei wong Daiwen Yang Department of Biological Sciences National University of Singapore14 Science Drive 4Singapore117543Singapore

The mechanism of urea's action in protein denaturation remains largely *** provide an experimental basis for molecular dynamics(MD)simulations on urea-protein interactions,we investigated the effect of urea on human intestinal fatty acid binding protein(hIFABP)by nuclear magnetic resonance(NMR).Hydrogen-deuterium exchange(HDX)rates at2 M urea indicate that urea affects hIFABP in a residue-specific manner via direct urea-protein interactions and preferentially weakens hydrogen bonds between highly protected ***-specific effects of urea on NMR peak intensities and chemical shifts further support the presence of direct urea-protein ***(2D)water-rotating frame Overhauser enhancement(ROE)data shows one protein-bound water molecule in contact with Val66 and Trp82,one putative bound water molecule in interaction with Thr76 and E-F loop,and that urea at low concentrations cannot displace these protein-bound water *** urea-nuclear Overhauser effect(NOE)experiments using 15N-urea further show no tightly protein-bound urea *** results thus suggest specific,but weak or transient,urea-protein interactions,supporting the direct interaction model of urea denaturation.

关键词： Protein denaturation Protein-folding Fatty acid binding protein Hydrogen-deuterium exchange

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Multi-line code: A low complexity revocable fingerprint template for cancelable biometrics

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Journal of Central South University 2013年第5期20卷 1292-1297页

作者： wong wei-jing wong Mou-ling Dennis KHO Yau-hee Faculty of Engineering Computing and ScienceSwinburne University of Technology(Sarawak Campus)

A low computational cost cancelable fingerprint template, namely the multi-line codes was proposed. The formulation of a single-line code involves the inspection of minutiae distribution along a straight line constructed based on the reference minutia. Multi-line code is introduced to elevate the performance by combining several single-line codes. Experiments were carried out on a few FVC databases. It has been proven that the proposed method yields relatively low computational complexity as compared to existing minutiae distribution-based methods, while preserving the performance. The equal error rate obtained for FVC2002 DB1 is 4.69% in stolen-key case, and the total arithmetic operations utilized are 14 520 additions and zero multiplication.

关键词： cancelable fingerprint template multi-line code single-line code stolen-key case

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Fine-tune chiroptical activity in discrete chiral Au nanorods

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Nano Research 2022年第7期15卷 6574-6581页

作者： Guangchao zheng Sulin Jiao wei Zhang Shenli Wang Qinghua Zhang Lin Gu weixiang Ye Junjun Li Xiaochen Ren Zhicheng Zhang Kwok-yin wong School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China State Key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical TechnologyThe Hong Kong Polytechnic UniversityKowloonHong KongChina Institute of Applied Physics and Computational Mathematics Beijing 100088China School of Food Science and Engineering Henan University of TechnologyZhengzhou 450001China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Department of Applied Physics School of ScienceHainan UniversityHaikou 570228China Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of ChemistrySchool of ScienceTianjin University&Collaborative Innovation Center of Chemical Science and EngineeringTianjin 300072China

Accurate researches on the surface plasmon resonance(SPR)-based applications of chiral plasmonic metal nanoparticles(NPs)still remain a great ***,a series of chiral plasmonic metal NPs,e.g.,chiral Au nanorods(c-Au NRs),c-Au@Ag core–shell,and c-Au@TiO_(2) core–shell NRs,with different chiroptical activities have been *** circular dichroism(PCD)bands of c-Au NRs can be precisely tailored by tuning the longitudinal SPR(LSPR)and amount of Au NRs as ***,a shift of PCD bands within ultraviolet–visible–near infrared ray(UV–vis–NIR)region can also be achieved through the functionalization of a shell of another metal or ***,chirality transfer from c-Au core to Ag shell leads to new PCD bands at the near-UV *** tuning of PCD bands and chirality transfer are confirmed by our developed theoretical *** chiral Au NRs-based chiral plasmonic nanomaterials with tunable chiroptical activities will be helpful to understand the structure-direct PCD and to extend circularly polarized-based applications.

关键词： chiral Au nanorods(c-Au NRs) surface plasmon resonance optical activity chirality transfer

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Changes of cell membrane fluidity for mesenchymal stem cell spheroids on biomaterial surfaces

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World Journal of Stem Cells 2022年第8期14卷 616-632页

作者： Chui-wei wong Hao-wei Han Shan-hui Hsu National Taiwan University Institute of Polymer Science and EngineeringTaipei 10617TaiwanChina National Health Research Institutes Institute of Cellular and System MedicineMiaoli 350TaiwanChina National Taiwan University Research and Development Center for Medical DevicesTaipei 10617TaiwanChina

BACKGROUND The therapeutic potential of mesenchymal stem cells(MSCs)in the form of threedimensional spheroids has been extensively *** underlying mechanisms for the altered cellular behavior of spheroids have also been *** membrane fluidity is a critically important physical property for the regulation of cell behavior,but it has not been studied for the spheroid-forming cells to *** To explore the association between cell membrane fluidity and the morphological changes of MSC spheroids on the surface of biomaterials to elucidate the role of membrane fluidity during the spheroid-forming process of *** We generated three-dimensional(3D)MSC spheroids on the surface of various culture substrates including chitosan(CS),CS-hyaluronan(CS-HA),and polyvinyl alcohol(PVA)*** cell membrane fluidity and cell morphological change were examined by a time-lapse recording system as well as a highresolution 3D cellular image *** and normal/cancer cells were prestained with fluorescent dyes and co-cultured on the biomaterials to investigate the exchange of cell membrane during the formation of heterogeneous cellular *** We discovered that vesicle-like bubbles randomly appeared on the outer layer of MSC spheroids cultured on different biomaterial *** average diameter of the vesicle-like bubbles of MSC spheroids on CS-HA at 37℃ was approximately 10μm,smaller than that on PVA substrates(approximately 27μm).Based on time-lapse images,these unique bubbles originated from the dynamic movement of the cell membrane during spheroid formation,which indicated an increment of membrane fluidity for MSCs cultured on these ***,the membrane interaction in two different types of cells with similar membrane fluidity may further induce a higher level of membrane translocation during the formation of heterogeneous *** Changes in cell membrane fluidity may be a novel path to elucidate the

关键词： Cell membrane fluidity Cell-cell interaction Cellular spheroids Chitosan Hyaluronan

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