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Network pharmacology and molecular dynamics study of the effect of the Astragalus-Coptis drug pair on diabetic kidney disease

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World Journal of Diabetes 2024年第7期15卷 1562-1588页

作者： Mo-Yan Zhang Shu-qin zheng Liaoning University of Traditional Chinese Medicine Liaoning University of Traditional Chinese MedicineShenyang 110847Liaoning ProvinceChina Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110032Liaoning ProvinceChina

BACKGROUND Diabetic kidney disease(DKD)is the primary cause of end-stage renal *** Astragalus-Coptis drug pair is frequently employed in the management of ***,the precise molecular mechanism underlying its therapeutic effect remains *** To investigate the synergistic effects of multiple active ingredients in the Astragalus-Coptis drug pair on DKD through multiple targets and *** The ingredients of the Astragalus-Coptis drug pair were collected and screened using the TCMSP database and the SwissADME *** targets were predicted using the SwissTargetPrediction database,while the DKD differential gene expression analysis was obtained from the Gene Expression Omnibus *** targets were acquired from the GeneCards,Online Mendelian Inheritance in Man database,and DisGeNET databases,with common targets identified through the Venny *** protein-protein interaction network and the“disease-active ingredient-target”network of the common targets were constructed utilizing the STRING database and Cytoscape software,followed by the analysis of the interaction relationships and further screening of key targets and core active *** Ontology(GO)function and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichments were performed using the DAVID *** tissue and organ distributions of key targets were *** and AutoDock software validate the molecular docking between the core ingredients and key ***,molecular dynamics(MD)simulations were conducted to simulate the optimal complex formed by interactions between core ingredients and key target *** A total of 27 active ingredients and 512 potential targets of the Astragalus-Coptis drug pair were *** were 273 common targets between DKD and the Astragalus-Coptis drug *** protein-protein interaction network topology analysis,we identified 9 core active ingredients and 10 key *** and KEGG pathwa

关键词： Astragalus membranaceus Coptis chinensis Franch Diabetic kidney disease Network pharmacology Molecular docking Molecular dynamics simulation

Learning accurate template matching with differentiable coarseto-fine correspondence refinement

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Computational Visual Media 2024年第2期10卷 309-330页

作者： Zhirui Gao Renjiao Yi zheng qin Yunfan Ye Chenyang Zhu Kai Xu College of Computer National University of Defense TechnologyChangsha 410073China

Template matching is a fundamental task in computer vision and has been studied for *** plays an essential role in manufacturing industry for estimating the poses of different parts,facilitating downstream tasks such as robotic *** methods fail when the template and source images have different modalities,cluttered backgrounds,or weak *** also rarely consider geometric transformations via homographies,which commonly exist even for planar industrial *** tackle the challenges,we propose an accurate template matching method based on differentiable coarse-tofine correspondence *** use an edge-aware module to overcome the domain gap between the mask template and the grayscale image,allowing robust *** initial warp is estimated using coarse correspondences based on novel structure-aware information provided by *** initial alignment is passed to a refinement network using references and aligned images to obtain sub-pixel level correspondences which are used to give the final geometric *** evaluation shows that our method to be significantly better than state-of-the-art methods and baselines,providing good generalization ability and visually plausible results even on unseen real data.

关键词： template matching differentiable homography structure-awareness transformers

Photoredox-Catalyzed Metal-Free Regio-&Stereoselective C(sp^(2))-H Amination of Enamides with N-Aminopyridium Salts

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Chinese Journal of Chemistry 2024年第18期42卷 2235-2242页

作者： zheng-Bao qin Kun Ni Li Wang Xiao-Di Wu Yu Zhang Kai Zhao Institute of Advanced Synthesis School of Chemistry and Molecular EngineeringJiangsu National Synergetic Innovation Center for Advanced MaterialsNanjing Tech UniversityNanjingJiangsu211816China college of Chemical Engineering Nanjing Forestry UniversityNanjingJiangsu 210037China

A visible-light-induced photoredox-catalyzed regioselective and stereoselective C(sp')-H amination of enamides with bench-stable and A visible-light-induced photoredox-catalyzed regioselective and stereoselective C(sp)-H amination of enamides with bench-stable and easily accessible N-aminopyridium salts is developed,affording synthetically and biologically prominent vicinal 1,2-diamine scaffolds with broad substrate scope and excellent functional group *** transformation proceeded through a radical pathway involving the Giese addition of the relatively electrophilic N-centered sulfonamidyl radical species to nucleophilicβ-olefinic position of enamides followed by the ensuing single electron oxidation andβ-H elimination,delivering geometrically-defined Z-configuredβ-sulfonamidylated *** operational simplicity,environmental friendliness and cost efficiency of this methodology allowed it to pave a new avenue to enrich the arsenal of synthetically crucial functionalized enamides and their related derivatives.

关键词： Enamides Amination Photoredox catalysis Regioselective Stereoselective Metal-free

Application value of indocyanine green fluorescence imaging in guiding sentinel lymph node biopsy diagnosis of gastric cancer: Meta-analysis

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1883-1893页

作者： Qi-Jia Zhang Zhi-Cheng Cao qin Zhu Yu Sun Rong-Da Li Jin-Long Tong qin zheng Department of Oncology The Second Hospital of NanjingAffiliated to Nanjing University of Chinese MedicineNanjing 210003Jiangsu ProvinceChina Department of Gastrointestinal Surgery Qilu Hospital of Shandong UniversityJinan 250063Shandong ProvinceChina

BACKGROUND Gastric cancer is a common malignant tumor of the digestive system worldwide,and its early diagnosis is crucial to improve the survival rate of *** green fluorescence imaging(ICG-FI),as a new imaging technology,has shown potential application prospects in oncology *** meta-analysis to study the application value of ICG-FI in the diagnosis of gastric cancer sentinel lymph node biopsy is helpful to comprehensively evaluate the clinical effect of this technology and provide more reliable guidance for clinical *** To assess the diagnostic efficacy of optical imaging in conjunction with indocya-nine green(ICG)-guided sentinel lymph node(SLN)biopsy for gastric *** Electronic databases such as PubMed,Embase,Medline,Web of Science,and the Cochrane Library were searched for prospective diagnostic tests of optical imaging combined with ICG-guided SLN *** 12.0 software was used for analysis by combining the"bivariable mixed effect model"with the"midas"*** true positive value,false positive value,false negative value,true negative value,and other information from the included literature were extracted.A literature quality assessment map was drawn to describe the overall quality of the included literature.A forest plot was used for heterogeneity analysis,and P50%),meta-regression analysis and subgroup analysis were *** were *** Optical imaging involves two methods:Near-infrared(NIR)imaging and fluorescence imaging.A combination of optical imaging and ICG-guided SLN biopsy was useful for *** positive likelihood ratio was

关键词： Gastric neoplasms Sentinel lymph nodes Near infrared imaging Fluorescence imaging Indocyanine green Meta-analysis

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后伊斯兰主义的特征及其宗教主张

世界宗教文化 2024年第1期 102-109页

作者：秦政中国人民大学哲学院

伊斯兰主义作为一种政治意识形态,在近30年中已经发生了重大变化。“后伊斯兰主义”概念的出现,就是对这种变化的描述。本文梳理了不同研究者对于后伊斯兰主义概念的使用,并依据后伊斯兰主义思想家的著作,阐述了后伊斯兰主义的概念史、... 详细信息

伊斯兰主义作为一种政治意识形态,在近30年中已经发生了重大变化。“后伊斯兰主义”概念的出现,就是对这种变化的描述。本文梳理了不同研究者对于后伊斯兰主义概念的使用,并依据后伊斯兰主义思想家的著作,阐述了后伊斯兰主义的概念史、主要特征及宗教主张。相对于伊斯兰主义而言,后伊斯兰主义不仅在实践上放弃了伊斯兰主义的行动纲领,在宗教主张上也有相应的变化,但不同的宗教主张间存在质的差异。在某种程度上,后伊斯兰主义更多是一个描述性和时间性概念,因此能够包含不同的宗教主张和思想。本文希望通过不同角度的分析,呈现伊斯兰主义的具体变化,进而理解这些变化背后的思想动因。

关键词：后伊斯兰主义伊斯兰主义概念史宗教主张教法创制

Unraveling adaptive changes in electric vehicle charging behavior toward the postpandemic era by federated meta-learning

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The Innovation 2024年第2期5卷 21-23页

作者： Linlin You Rui Zhu Mei-Po Kwan Min Chen Fan Zhang Bisheng Yang Man Sing Wong zheng qin School of Intelligent Systems Engineering Sun Yat-Sen UniversityShenzhen 518107China Institute of High Performance Computing(IHPC) Agency for ScienceTechnology and Research(A*STAR)1 Fusionopolis WaySingapore 138632Republic of Singapore Institute of Space and Earth Information Science Chinese University of Hong KongHong KongChina Key Laboratory of Virtual Geographic Environment(Ministry of Education) Nanjing Normal UniversityNanjing 210023China Institute of Remote Sensing and Geographical Information System School of Earth and Space SciencesPeking UniversityBeijing 100871China State Key Laboratory of Information Engineering in Surveying Mappingand Remote SensingWuhan UniversityWuhan 430079China Department of Land Surveying and Geo-Informatics The Hong Kong Polytechnic UniversityHong KongChina

Dear Editor,Electric vehicle(EV)sales have significantly grown over the years to fulfill growing demands for economic travel and greenhouse gas mitigation.1 However,the surge in the number of EVs has led to charging anxiety as users struggle to find an available charging station before running out of electricity,resulting in longer reserve and waiting times.2 Moreover,severe mobility restrictions caused by infectious diseases,such as coronavirus disease 2019(COVID-19),have greatly affected people’s travel behavior3,4 and hindered their willingness to use EVs,given that charging in public spaces consumes time and increases the risk of contracting the virus.5 This implies that in the postpandemic era,in which individuals coexist with the virus,the interplay between the two important trends,namely vehicle electrification and mobility restrictions,can extensively affect people’s daily commuting by using EVs.

关键词： travel behavior charging

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双肩壁凹槽叶顶冷却传热性能的优化研究

西安交通大学学报 2024年第1期58卷 68-80页

作者：秦正何坤晏鑫西安交通大学能源与动力工程学院西安710049

为改善航空发动机透平第一级凹槽叶顶的冷却传热性能,利用自编程序搭建了凹槽叶顶的优化设计平台。采用三阶多项式响应面模型和Hooke-Jeeves模式搜索算法的组合优化策略,获得了一种具有优良气热性能的透平级双肩臂凹槽叶顶结构,并将优... 详细信息

为改善航空发动机透平第一级凹槽叶顶的冷却传热性能,利用自编程序搭建了凹槽叶顶的优化设计平台。采用三阶多项式响应面模型和Hooke-Jeeves模式搜索算法的组合优化策略,获得了一种具有优良气热性能的透平级双肩臂凹槽叶顶结构,并将优化结果与传统凹槽叶顶、4种典型双肩臂凹槽叶顶的传热和冷却性能进行了对比,分析了内肩臂的几何参数对凹槽叶顶流场结构和冷却传热性能的影响,评估了双肩臂凹槽叶顶冷却传热性能对设计变量的敏感性。结果表明:优化后的内肩臂分为上下两层;合理的内肩臂几何参数可有效降低泄漏流的冲击作用,有利于冷却流在内外凹槽区域形成良好的覆盖;与传统凹槽叶顶相比,优化后的双肩臂凹槽叶顶的平均传热系数下降了24.96%,平均气膜冷却效率上升了5.38%;叶顶平均传热系数对内肩臂下层的高度最为敏感,叶顶平均气膜冷却效率对内肩臂上层的起始位置更加敏感,而内肩臂上层的高度对双肩臂凹槽叶顶的冷却传热性能影响相对较小。

关键词：航空发动机凹槽叶顶双肩壁优化传热冷却

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透平级小翼-凹槽叶顶冷却传热性能研究

工程热物理学报 2024年第2期45卷 401-409页

作者：吴琛琦秦正何坤晏鑫西安交通大学能源与动力工程学院陕西西安710049

采用数值方法研究了发动机工况下含内冷通道的透平级小翼-凹槽叶顶的冷却传热性能,分析了叶顶型式、吹风比对叶顶传热系数和气膜冷却效率分布的影响。结果表明:带压力侧小翼凹槽叶顶可有效消除叶顶刮削涡,改善凹槽底部冷气覆盖的均匀性... 详细信息

采用数值方法研究了发动机工况下含内冷通道的透平级小翼-凹槽叶顶的冷却传热性能,分析了叶顶型式、吹风比对叶顶传热系数和气膜冷却效率分布的影响。结果表明:带压力侧小翼凹槽叶顶可有效消除叶顶刮削涡,改善凹槽底部冷气覆盖的均匀性;相对于传统凹槽叶顶,带压力侧小翼凹槽叶顶的面积平均传热系数减小11.11%、气膜冷却效率增大4.54%。吹风比从1增大到2时,带压力侧小翼凹槽叶顶面积平均传热系数减小48.96%、气膜冷却效率增大154.01%。

关键词：凹槽叶顶小翼传热气膜冷却吹风比

AICAR-based exercise mimetic alleviates aging-induced memory impairment through activating AMPK and improving mitochondrial quality control

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Food Science and Human Wellness 2024年

作者： Bo Liao Yuan-Yuan qin Shan-Yao Pan Gui-Ping Wang Zhi Jiang Bin Li Yao Wang Yu-Long Wang Ming-Chao Zhou Yong Zhang Gang Liu zheng-Hong qin Xue-Feng Xi Li Luo Department of Pharmacology and Laboratory of Aging and Nervous Diseases (SZS0703) Jiangsu Key Laboratory of Translational Research and Therapy for NeuroPsycho-Diseases， Soochow University School of Pharmaceutical Science College of Physical Education， Henan University School of Physical Education and Sports Science， Soochow University Department of Pharmacy， Suzhou Hospital of Traditional Chinese Medicine Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine Laboratory Animal Center， Medical College of Soochow University Center Lab of Ninth People's Hospital of Suzhou Department of Rehabilitation Medicine， Nan‘ao People's Hospital of Dapeng New District Rehabilitation Department， The First Affiliated Hospital of Shenzhen University， Shenzhen Second People's Hospital Tianjin Key Lab of Exercise Physiology and Sports Medicine， Tianjin University of Sport Department of Rehabilitation Medicine， Nanfang Hospital， Southern Medical University

Growing evidence suggests that exercise can provide neuroprotection by improving mitochondrial quality control (MQC) on the aged brain. Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) signaling responsiveness declines with aging. However， whether AMPK plays a role in the exercise-mediated improvement of memory and MQC in the aged hippocampus remains to be established. AICAR (5-Aminoimidazole 4-carboxamide ribonucleoside)， a pharmacological agonist of AMPK， has been proposed to be an exercise mimetic recently. However， it has not been clarified whether AICAR could mimic the effects of exercise on the aged hippocampus through improvement of MQC. In this study， AICAR (AMPK agonist) and Compound C (AMPK inhibitor) were used to investigate if AMPK plays a key role in exercise-induced improvement of MQC and if AICAR could act as an exercise mimetic through improvement of MQC in aged hippocampus. Both exercise and AICAR improved the memory of aged mice and increased AMPK phosphorylation in the aged hippocampus. Exercise， but not AICAR， improved mitochondrial respiratory function in the aged hippocampus and increased the Microtubule associated protein 1 light chain 3 (LC3) II/LC3 I ratio and the protein expression of LC3 II and Autophagy Related Protein 7 (ATG7) in the lysate of whole hippocampal tissue. Both exercise and AICAR increased the ratio of LC3 II/LC3 I and the protein expression of LC3 II in the mitochondrial fractions of the hippocampus. Regarding mitochondrial dynamics， neither exercise training nor AICAR changed the protein level of Mitofusin2 (Mfn2). Exercise， but not AICAR， increased the protein level of Dynamin-related protein 1 (Drp1). Furthermore， both exercise training and AICAR increased the protein level of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α)， a modulator of mitochondrial biogenesis. Compound C abolished the exercise-induced effects on memory in aged mice (Fig. 1)， AMPK phosphorylation， autophagy， mitop

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