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Chronic Diseases and Translational Medicine 2024年第1期10卷 31-39页

作者： zhendong lu Siyun Fu Wei Li Xiang Gao Jinghui Wang Department of Medical Oncology Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing Chest HospitalCapital Medical UniversityBeijingChina Cancer Research Center Beijing Chest HospitalBeijing Tuberculosis and Thoracic Tumor Research InstituteCapital Medical UniversityBeijingChina

Background: C-reactive protein to albumin ratio(CRP/Alb ratio,CAR)has been suggested as a potential prognostic biomarker in lung cancer.This updated systematic review and meta-analysis aimed to assess the association between CAR and lung cancer prognosis in current literature.Methods: A systematic search of databases was conducted to identify relevant studies published up to April 2023.Pooled hazard ratios(HRs)and 95%confidence intervals(CIs)were calculated to assess the association between CAR and overall survival(OS)and progression-free survival(PFS)and recurrence-free survival(RF)in lung cancer patients.Results: This meta-analysis includes 16 studies with a total of 5337 patients,indicating a significant association between higher CAR and poorer OS,PFS,and RFS in lung cancer patients,with a pooled HR of 1.78(95%CI=1.60-1.99),1.57(95%CI=1.36-1.80),and 1.97(95%CI=1.40-2.77),respectively.Conclusions: This updated meta-analysis provides evidence for the potential prognostic role of CAR in lung cancer,suggesting its utility as an effective and noninvasive biomarker for identifying high-risk patients and informing treatment decisions in a cost-effective manner.However,further large-scale studies will be necessary to establish the optimal cut-off value for CAR in lung cancer and confirm the present findings.

关键词： C-reactive protein to albumin ratio inflammation:biomarker lung cancer prognosis

Efficient elimination of carbamazepine using polyacrylonitrile-supported pyridine bridged iron phthalocyanine nanofibers by activating peroxymonosulfate in dark condition

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Journal of Environmental Sciences 2024年第3期137卷 224-236页

作者： Zhexin Zhu Wenjie Qian Zhiguo Shang Xiaoji Ma zhendong Wang Wangyang lu Wenxing Chen National Engineering Lab for Textile Fiber Materials and Processing Technology(Zhejiang) Zhejiang Sci-Tech UniversityHangzhou 310018China

The monoaminotrinitro iron phthalocyanine(FeMATNPc)is used to connect with isonicotinic acid(INA)for amide bonding and axial coordination to synthetic a unique catalyst FeMATNPc-INA,which is loaded in polyacrylonitrile(PAN)nanofibers by electrospinning.The introduction of INA destroys theπ-πconjugated stack structure in phthalocyanine molecules and exposes more active sites.The FeMATNPc-INA structure is characterized by X-ray photoelectron spectroscopy and UV-visible absorption spectrum,and the FeMATNPcINA/PAN structure is characterized by Fourier transform infrared spectroscopy and X-ray diffraction.The FeMATNPc-INA/PAN can effectively activate peroxymonosulfate(PMS)to eliminate carbamazepine(CBZ)within 40 minutes(PMS 1.5 mmol/L)in the dark.The effects of catalyst dosage,PMS concentration,pH and inorganic anion on the degradation of CBZ are investigated.It has been confirmed by electron paramagnetic resonance,gas chromatography–mass spectroscopy and free radical capture experiments that the catalytic system is degraded by·OH,SO4^(·-)and Fe(IV)=O are the major active species,the singlet oxygen(^(1)O_(2))is the secondary active species.The degradation process of CBZ is analyzed by ultra-high performance liquid chromatography-mass spectrometry and the aromatic compounds have been degraded to small molecular acids.

关键词： Pyridine bridged iron phthalocyanine Isonicotinic chloride hydrochloride Efficient elimination Peroxymonosulfate activation Degradation pathway

坝基缓坡预裂开挖中不同布孔方式下的爆破扰动比较分析

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岩土工程学报 2024年第5期46卷 1018-1029页

作者：高启栋张宸范勇周海孝卢文波冷振东长安大学公路学院陕西西安710064 三峡大学湖北省水电工程施工与管理重点实验室湖北宜昌443002 武汉大学水资源与水电工程科学国家重点实验室湖北武汉430072 中国葛洲坝集团易普力股份有限公司重庆401121

在坝基缓坡预裂开挖中,为解决传统主爆孔或缓冲孔顺坡布设时(称之为顺坡布孔)钻孔效率低的问题,工程建设者尝试采用了反坡钻孔的方式(称之为反坡布孔),有必要对两种布孔方式下坝基保留岩体扰动情况进行比较分析,以指导工程实践。依托白... 详细信息

在坝基缓坡预裂开挖中,为解决传统主爆孔或缓冲孔顺坡布设时(称之为顺坡布孔)钻孔效率低的问题,工程建设者尝试采用了反坡钻孔的方式(称之为反坡布孔),有必要对两种布孔方式下坝基保留岩体扰动情况进行比较分析,以指导工程实践。依托白鹤滩水电站坝基缓坡开挖,分别开展了顺坡布孔与反坡布孔两种开挖方式下的现场爆破试验,同时借助LS-DYNA三维动力有限元模拟,比较分析了两种布孔方式下保留岩体的爆破损伤演化特性与振动分布规律,并揭示了不同布孔方式下的内在力学作用机制,最后综合考虑开挖成型效果与施工速率,对坝基缓坡开挖方案的选择进行了探讨。结果表明:两种布孔方式下由预裂孔引起的保留岩体扰动情况基本一致,区别在于主爆孔或缓冲孔引起的累积损伤效应与爆破振动,内在原因在于炮孔与保留岩体轮廓面夹角的变化。相对顺坡布孔,反坡布孔因增大了主爆孔或缓冲孔与轮廓面的夹角,减少了传输至保留岩体的爆炸能量,有利于减轻对保留岩体的扰动,可减小损伤深度约11.6%~13.9%,降低爆破振动约6.4%~53.7%。

关键词：坝基缓坡预裂爆破顺坡布孔反坡布孔爆破扰动

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罗氏沼虾胞质锰超氧化物歧化酶的功能

水产学报 2024年第1期48卷 158-165页

作者：李亚男陆霖青张鹏张博林蠡秦真东仲恺农业工程学院动物科技学院广东省水环境与水产品安全工程技术研究中心广州市水产病害与水禽养殖重点实验室中国水产科学研究院南海水产研究所

为了解超氧化物歧化酶(SOD)分子生物学特性和免疫功能，实验克隆了罗氏沼虾胞质锰SOD基因(MrcMnSOD)，制备多克隆抗体，并分析在嗜水气单胞菌感染下该基因的表达模式。结果显示，嗜水气单胞菌感染可显著诱导MrcMnSOD在转录水平和蛋白质... 详细信息

为了解超氧化物歧化酶(SOD)分子生物学特性和免疫功能，实验克隆了罗氏沼虾胞质锰SOD基因(MrcMnSOD)，制备多克隆抗体，并分析在嗜水气单胞菌感染下该基因的表达模式。结果显示，嗜水气单胞菌感染可显著诱导MrcMnSOD在转录水平和蛋白质水平进行高表达。为探究MrcMnSOD参与免疫应答的机制，进一步的抑菌实验表明，该蛋白质可显著抑制3种革兰氏阴性细菌(大肠杆菌、副溶血性弧菌、嗜水气单胞菌)和2种革兰氏阳性细菌(无乳链球菌、金黄色葡萄球菌)的生长，且抑制作用与蛋白质浓度的关系不显著。研究表明，MrcMnSOD可能作为一种免疫相关分子参与免疫应答反应。本研究初步探讨了MrcMnSOD的免疫生物学功能，旨在为深入研究罗氏沼虾SOD的功能奠定相关基础。

关键词：罗氏沼虾 MnSOD 表达模式抑菌

Buckling analysis of functionally graded nanobeams under non-uniform temperature using stress-driven nonlocal elasticity

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Applied Mathematics and Mechanics(English Edition) 2022年第3期43卷 355-370页

作者： Chi XU Yang LI Mingyue lu zhendong DAI College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Jiangsu Provincial Key Laboratory of Bionic Functional Materials Nanjing University of Aeronautics and AstronauticsNanjing 210016China

In this work,the size-dependent buckling of functionally graded(FG)Bernoulli-Euler beams under non-uniform temperature is analyzed based on the stressdriven nonlocal elasticity and nonlocal heat conduction.By utilizing the variational principle of virtual work,the governing equations and the associated standard boundary conditions are systematically extracted,and the thermal effect,equivalent to the induced thermal load,is explicitly assessed by using the nonlocal heat conduction law.The stressdriven constitutive integral equation is equivalently transformed into a differential form with two non-standard constitutive boundary conditions.By employing the eigenvalue method,the critical buckling loads of the beams with different boundary conditions are obtained.The numerically predicted results reveal that the growth of the nonlocal parameter leads to a consistently strengthening effect on the dimensionless critical buckling loads for all boundary cases.Additionally,the effects of the influential factors pertinent to the nonlocal heat conduction on the buckling behavior are carefully examined.

关键词： size effect stress-driven nonlocal model constitutive boundary condition nonlocal heat conduction functionally graded(FG)beam buckling load

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高速列车转向架区域气动发声尺度特征研究

中南大学学报（自然科学版） 2024年第5期55卷 1734-1744页

作者：卢鑫源刘翰林杨志刚吕镇东袁思齐中南大学交通运输工程学院轨道交通安全教育部重点实验室湖南长沙410075 中南大学轨道交通安全关键技术国际合作联合实验室湖南长沙410075 轨道交通列车安全保障技术国家地方联合工程研究中心湖南长沙410075

基于大涡模拟(LES)和声学有限元法,在400 km/h车速条件下,对1:8缩比尺度简化转向架模型进行数值模拟研究,并仿真对比同一模型在1:4、1:8、1:16和1:25缩比下的流场扰动特征及气动发声特征。研究结果表明:转向架区域内前缘剪切流与转向架... 详细信息

基于大涡模拟(LES)和声学有限元法,在400 km/h车速条件下,对1:8缩比尺度简化转向架模型进行数值模拟研究,并仿真对比同一模型在1:4、1:8、1:16和1:25缩比下的流场扰动特征及气动发声特征。研究结果表明:转向架区域内前缘剪切流与转向架本体以及转向架舱之间的耦合作用明显,可见L1和L2两种典型的循环反馈扰动模式;转向架本体结构间也存在次一级扰动,这些扰动增强了剪切流动的不稳定性;这些扰动循环反馈模式即为该区域气动发声的主要模式。尺度变化较显著改变了转向架区域的流场扰动特征,尤其是L2反馈模式;随着尺度减小,表面脉动压力及声源能量向高频迁移,声源能量先减小后增大(变化范围在2 dB内),且构架和后轮对的声源能量占比有所增加;在缩比为1:4、1:8、1:16和1:25时,频率修正后的标准点平均声压级分别为105.5、103.9、104.3、105.1 dB(A)(变化范围在1.6 dB内)。对于全尺寸模型,这种差距将进一步扩大。

关键词：高速列车转向架尺度效应气动噪声大涡模拟声学有限元

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代森锰锌对异色瓢虫雌虫生殖毒性初探

中国生物防治学报 2024年第2期40卷 477-483页

作者：朱莉陈鑫蒲占湑吕佳黄振东鹿连明周兴苗浙江省柑橘研究所台州318020 华中农业大学武汉430070

在农林业生产中,化学农药的使用成为了生物防治实施的制约因素之一。为了促进化学防治和生物防治的协调应用,评估农药对天敌昆虫的影响是天敌昆虫推广应用中的重要环节。异色瓢虫Harmonia axyridis是我国农业生产中常用的捕食性天敌之一... 详细信息

在农林业生产中,化学农药的使用成为了生物防治实施的制约因素之一。为了促进化学防治和生物防治的协调应用,评估农药对天敌昆虫的影响是天敌昆虫推广应用中的重要环节。异色瓢虫Harmonia axyridis是我国农业生产中常用的捕食性天敌之一,为了确保异色瓢虫在应用中的安全性,保障其持续发挥控害作用,本文采用毒蚜饲喂法,以卵巢发育情况为指标,评价了常用杀菌剂代森锰锌对异色瓢虫雌成虫的生殖毒性。试验结果表明,不同发育阶段的异色瓢虫在摄入代森锰锌后均会出现雌成虫卵巢发育受抑制的现象。主要表现为卵巢管长度下降、卵巢发育指数降低、Vg1和Vg2相对表达量降低。并且摄入代森锰锌的时间越长,对卵巢发育的抑制作用也越明显。此外,通过解剖观察未发现代森锰锌对异色瓢虫卵巢具有致畸作用。因此,推测代森锰锌对异色瓢虫具有较弱的生殖抑制作用。本文研究结果将增强代森锰锌与捕食性天敌昆虫应用的兼容性,提高代森锰锌与天敌昆虫的使用效率。

关键词：代森锰锌异色瓢虫卵巢发育安全性评价

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基于中西医临床特点的感染后肠易激综合征动物模型分析

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中药新药与临床药理 2024年第1期35卷 92-102页

作者：谢璐安张扬雨陈小霞潘震东杨贻铃黄适广西中医药大学广西南宁530001 广西中医药大学附属瑞康医院广西南宁530001

目的基于感染后肠易激综合征的中西医临床诊断标准及症状特点,对现有的感染后肠易激综合征动物模型进行总结归纳及模型评价,以期寻找中西医临床吻合度高的动物模型,为感染后肠易激综合征的中医药防治提供精准动物模型。方法通过查阅... 详细信息

目的基于感染后肠易激综合征的中西医临床诊断标准及症状特点,对现有的感染后肠易激综合征动物模型进行总结归纳及模型评价,以期寻找中西医临床吻合度高的动物模型,为感染后肠易激综合征的中医药防治提供精准动物模型。方法通过查阅整理感染后肠易激综合征动物实验及其动物模型制备相关文献,基于感染后肠易激综合征的临床诊断特点及症状特征,将现有感染后肠易激综合征动物模型的动物品系、造模方法及机制进行归纳总结,并进行吻合度评价、分析模型制备的优缺点。结果综合评价后发现,中西医临床吻合度相对较高的是空肠弯曲杆菌感染模型、旋毛虫感染模型以及病症结合模型中的肝郁脾虚证模型。结论现有的感染后肠易激综合征模型普遍西医吻合度高于中医吻合度,造模过程中普遍对中医四诊及证候的体现及信息收集较少,中医诊断中的主症主要依靠观察动物表观行为,而对次症表现的观察则相对较少,导致中医证型的判断欠准确。因此,仍需进一步规范病证结合动物模型的症状评价标准和辨证方法。具备中西医临床病证特点的感染后肠易激综合征动物模型在未来具有较大的应用价值及应用前景,采用西医病理损伤+中医病因刺激的多因素复合方法造模可建立吻合度更高的感染后肠易激综合征模型,可为研究感染后肠易激综合征发病机制、证候差异、中西医结合防治提供理论支持,对指导感染后肠易激综合征的临床诊断和治疗具有重要意义。

关键词：感染后肠易激综合征(PI-IBS) 病证结合动物模型中西医临床特点

Early Paleoproterozoic Post-Collisional Basaltic Magmatism in Quanji Massif:Implications for Precambrian Plate Tectonic Regime in NW China

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Journal of Earth Science 2022年第3期33卷 706-718页

作者： Hassan Abdelslam Mustafa Fanxi Liao Nengsong Chen zhendong You Meshaal Abdelgadir Salih lu Wang lu Zhang School of Earth Sciences China University of GeosciencesWuhan 430074China Faculty of Science University of KordofanEL ObeidP.O.160Sudan International Research Center for Geology and Resources along the Silk Roads China University of GeosciencesWuhan 430074China College of Earth Sciences University of Science and Technology of ChengduChengdu 610059China State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesWuhan 430074China

Basaltic magmas can provide important information about mantle source nature,tectonic settings and tectonic evolution for a given terrain.This paper reports geology,petrography and geochemistry of whole-rock major and trace elements and Nd-Sr isotopes for a suite of garnet amphibolites from southeastern Wulan(Ulan),Quanji Massif,northwestern China.The garnet amphibolites were likely generated from basaltic lavas,associated with both paragneisses and orthogneisses of the lower Delingha Group.The basaltic protolith of these amphibolites can be broadly constrained to be formed at~2.33 Ga in an extensional setting post-collision.The geochemistry of amphibolites shows subalkaline and highly evolved characteristics.They display high-Fe low-Ti characteristics,with TFeO of 13.1 wt.%-17.9 wt.%and TiO_(2) of 1.42 wt.%-3.09 wt.%(in most samples TiO_(2)≤2.5 wt.%).The chondrite-normalized REE patterns show enrichment of LREE and LILE and the primitive-mantle-normalized incompatible element patterns display negative P,Ti,Nb-Ta and Zr-Hf anomalies.The(^(87)Sr/^(86)Sr)t values of 0.6978-0.7123 andε_(Nd)(t)values of-2.81-5.08 respond to depleted mantle model ages(T_(DM))of 2.33-3.30 Ga.These suggest that the precursor magmas of the protolith of the garnet amphibolites were probably derived from the Early Paleoproterozoic depleted sub-continental lithospheric mantle that had been metasomatized by subduction-induced fluids and melts.The precursor basaltic magmas were contaminated by the older crustal components during magma ascending.This post-collisional basaltic magmatic event at~2.33 Ga in Quanji Massif thus enhanced the subduction shutdown or slowdown tectonic regime both in NW China and coevally with those plate tectonics in some important domains worldwide during the Early Paleoproterozoic.

关键词： amphibolite geochemistry NW China post-collisional magmatism Precambrian tectonic evolution

Occurrence Models of Movable Fluid in Lacustrine Sandstone Reservoir of Chang 7 Member in the Heshui Block， Ordos Basin， China

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Journal of Earth Science 2021年

作者： Qibiao Zang Chenglin Liu Rizwan Sarwar Awan Xiya Yang zhendong lu Guoxiong Li Yuping Wu Dehao Feng State Key Laboratory of Petroleum Resource and Prospecting， China University of Petroleum College of Geosciences， China University of Petroleum

The Chang 7 sandstone is characterized by complex micro-pore structures， strong heterogeneity， and differential fluid distribution. These characteristics result in low oil recovery. In this paper， various techniques， including high-pressure mercury intrusion， nuclear magnetic resonance， scanning electron microscope， thin section， and X-ray diffraction， are employed to quantitatively evaluate the occurrence characteristics and influencing factors of movable fluids in Chang 7 sandstone reservoirs from the Heshui Block with different fractal structures. Results show that the dominant sandstone type is feldspar lithic fragment sandstone. Chang 7 reservoir has been divided into three types (types I， Ⅱ， and Ⅲ) based on capillary pressure curves and pore structure parameters. These reservoirs are characterized by various fractal structures and different movable fluids distribution. Multiple possible factors affecting the movable fluid distribution are analyzed， including physical properties， pore structure， pore size distribution， mineral content， and heterogeneity. Movable fluid saturation is positively correlated with physical properties， weighted average pore-throat radius， median pore-throat radius， final residual mercury saturation， and maximum mercury withdrawal saturation. In contrast， it is negatively correlated with displacement pressure and has no obvious correlation with the sorting coefficient. Micron- and submicron-scale pores are beneficial to the movable fluid occurrence， while nano-scale pores are vice versa. The influence of mineral content on movable fluid occurrence varies with mineral types. Quartz is conducive to the movable fluid occurrence in submicron-scale pores， while carbonate cementation inhibits the movable fluid occurrence in submicron-scale pores. The inhibition of clay on the movable fluid occurrence is mainly reflected in submicron- and nano-scale pores and varies with clay mineral types. The influence of heterogeneity on the movable fluid occurrence is mainly reflected in submicron-scal

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