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Evaluation of the Effectiveness of“5E”Comprehensive Injury Prevention Strategy for Fall Prevention Among the Rural Elderly—Six Pilot Villages,Yunnan Province and Chongqing Municipality,China,2018–2023

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China CDC weekly 2024年第14期6卷 277-281页

作者： Fujin sun Rong Luo Hui Han National Center for Women and Children’s Health Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?The mortality rate and disease burden associated with falls among the elderly in China are on the *** can play a crucial role in preventing and managing *** is added by this report?The application of the“5E”injury prevention strategy led to a decrease in both the occurrence of falls and the likelihood of subsequent *** physical activity and maintaining a positive outlook were identified as protective measures against falls,while sleep issues and hearing impairment were found to increase the risk of *** are the implications for public health practice?The group-based comprehensive intervention strategy is crucial as it offers an innovative intervention model and empirical evidence for decreasing fall rates among elderly individuals living in rural areas.

关键词： Chongqing Rural prevention

Stem cell-based ischemic stroke therapy:Novel modifications and clinical challenges

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Asian Journal of Pharmaceutical Sciences 2024年第1期19卷 18-34页

作者： Yuankai sun Xinchi Jiang Jianqing Gao Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative Medicine Zhejiang UniversityHangzhou 310058China Department of Pharmacy The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China

Ischemic stroke(IS)causes severe disability and high mortality *** cell(SC)therapy exhibits unique therapeutic potential for IS that differs from current ***’s cell homing,differentiation and paracrine abilities give hope for *** studies on SC modification have enhanced therapeutic effects for IS,including gene transfection,nanoparticle modification,biomaterial modification and *** improve survival rate,homing,neural differentiation,and paracrine abilities in ischemic ***,many problems must be resolved before SC therapy can be clinically *** issues include production quality and quantity,stability during transportation and storage,as well as usage ***,we reviewed the brief pathogenesis of IS,the“multi-mechanism”advantages of SCs for treating IS,various SC modification methods,and SC therapy *** aim to uncover the potential and overcome the challenges of using SCs for treating IS and convey innovative ideas for modifying SCs.

关键词： Ischemic stroke Stem cell therapy Stem cell modification Cell therapy challenge

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Targeted drug approvals in 2023:breakthroughs by the FDA and NMPA

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Signal Transduction and Targeted Therapy 2024年第3期9卷 813-821页

作者： Lang Zheng Wenjing Wang Qiu sun Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China West China Medical Publishers West China HospitalSichuan UniversityChengdu 610041China

According to the official website of China’s National Medicines and Pharmaceutical Administration(NMPA),a total of 87 novel drugs were approved in China in 2023,with targeted drugs accounting for 67.8%of the total,amounting to 59 drugs(Fig.1a;Table 1)[https://***/yaopin/ypjgdt/***].Notably,domestic innovation is flourishing,with five first-in-class drugs,including Glumetinib,a c-Met inhibitor from Haihe Biopharma;Leritrelvir,a 3CL protease inhibitor from Raynovent;Anaprazole,a proton pump inhibitor from Xuanzhu Biopharm;Pegol-Sihematide,an EPO drug from Hansoh Pharma;and Zuberitamab from BioRay Biopharmaceutical Co.,***,the world’s first allosteric inhibitor targeting TYK2,Sotyktu(deucravacitinib),has been approved for the treatment of psoriasis and Selumetinib,a MEK inhibitor co-developed by AstraZeneca and Merck Sharp&Dohme(MSD),became the first approved drug in China for the treatment of neurofibromatosis type I(NF1).Beyond these drugs,the approval of novel drug types such as CAR-T cell products,siRNA,monoclonal antibodies,dual antibodies,and ADCs in China is a significant development in the country’s pharmaceutical industry(Fig.1a).

关键词： drugs Merck approval

Value Recognition:The International Communication of Shared Human Values and Aesthetics:A Case Study of the Overseas Dissemination and Reception of Chinese Literature

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Social Sciences in China 2024年第3期45卷 130-143页

作者： sun Dehong School of Journalism and Communication Nankai University

International communication should fundamentally aim at promoting the exchange and mutual learning of civilizations,achieving a transformation from"cultural clashes"to""civilizational exchange and mutual learning."The manifestation of international communication that facilitates this exchange and mutual learning is that the values contained in the communication texts ultimately become integrated into the culture of the receiving party and even into human culture as a whole due to this exchange and mutual *** civilizational exchange and mutual learning in international communication requires"value recognition"efforts between the disseminating and receiving parties,focusing on the universal values of human happiness for all,which is the"greatest common divisor"of value recognition among different receiving *** communication that facilitates the exchange and mutual learning of civilizations must take the inevitable route of such international communication:the path of aesthetic communication.

关键词： international communication ideal benchmark value recognition aesthetic communication

New Algebraic Attacks on Grendel with the Strategy of Bypassing SPN Steps

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Chinese Journal of Electronics 2024年第3期33卷 635-644页

作者： Wenxiao QIAO Siwei sun Lei HU State Key Laboratory of Information Security Institute of Information Engineering Chinese Academy of Sciences School of Cyber Security University of Chinese Academy of Sciences School of Cryptology University of Chinese Academy of Sciences State Key Laboratory of Cryptology

The rapid development of modern cryptographic applications such as zero-knowledge,secure multiparty computation,fully homomorphic encryption has motivated the design of new so-called arithmetization-oriented symmetric *** designing ciphers in this domain is relatively new and not well-understood,the security of these new ciphers remains to be completely *** this paper,we revisit the security analysis of arithmetizat ionoriented cipher *** uses the Legendre symbol as a component,which is tailored specifically for the use in zero-knowledge and efficiently-varifiable proof *** FSE 2022,the first preimage attack on some original full GrendelHash instances was *** a countermeasure,the designer adds this attack into the security analysis and updates the formula to derive the secure number of *** our work,we present new algebraic attacks on *** the preimage attack,we can reduce the complexity or attack one more round than previous attacks for some *** addition,we present the first collision attack on some round-reduced instances by solving the constrained input/constrained output problem for the underlying permutations.

关键词： Ciphers Symbols Multi-party computation Complexity theory Homomorphic encryption

Stability and Time-Step Constraints of Implicit-Explicit Runge-Kutta Methods for the Linearized Korteweg-de Vries Equation

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Communications on Applied Mathematics and Computation 2024年第1期6卷 658-687页

作者： Joseph Hunter Zheng sun Yulong Xing Department of Mathematics The Ohio State UniversityColumbusOH43210USA Department of Mathematics The University of AlabamaTuscaloosaAL35487USA

This paper provides a study on the stability and time-step constraints of solving the linearized Korteweg-de Vries(KdV)equation,using implicit-explicit(IMEX)Runge-Kutta(RK)time integration methods combined with either finite difference(FD)or local discontinuous Galerkin(DG)spatial *** analyze the stability of the fully discrete scheme,on a uniform mesh with periodic boundary conditions,using the Fourier *** the linearized KdV equation,the IMEX schemes are stable under the standard Courant-Friedrichs-Lewy(CFL)conditionτ≤λ***,λis the CFL number,τis the time-step size,and h is the spatial mesh *** study several IMEX schemes and characterize their CFL number as a function ofθ=d/h^(2)with d being the dispersion coefficient,which leads to several interesting *** also investigate the asymptotic behaviors of the CFL number for sufficiently refined meshes and derive the necessary conditions for the asymptotic stability of the IMEX-RK *** numerical experiments are provided in the paper to illustrate the performance of IMEX methods under different time-step constraints.

关键词： Linearized Korteweg-de Vries(KdV)equation Implicit-explicit(IMEX)Runge-Kutta(RK)method Stability Courant-Friedrichs-Lewy(CFL)condition Finite difference(FD)method Local discontinuous Galerkin(DG)method

Mechanics and physics under supergravity conditions

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Acta Mechanica Sinica 2024年第6期40卷 1-2页

作者： Chaofeng Lü Chao sun Shengqiang Cai Faculty of Mechanical Engineering and Mechanics Ningbo UniversityNingbo 315211China New Cornerstone Science Laboratory Center for Combustion EnergyDepartment of Energy and Power EngineeringTsinghua UniversityBeijing 100084China Department of Mechanical and Aerospace Engineering University of CaliforniaSan DiegoLa Jolla CA 92093USA

"Supergravity"refers to the conditions where the effective gravity is greater than that of *** conditions are generally relevant to stellar evolution,geophysical movement,astrophysical flows,and *** also frequently occur in various engineering scenarios involving acceleration,such as the launch of space shuttles,operation of rotor engines,impacts and explosions,chemical separation processes,and overloaded testing *** is already demonstrated in physiological experiments that living organisms of animals or plants could be damaged,either temporarily or permanently,when subjected to *** create supergravity conditions for scientific research on the Earth,centrifugal equipment or rapidly rotating devices are omnipresent in various fields,such as aerospace engineering,geophysical science,chemical and biomedical engineering,nuclear engineering,rotating flows,and physical modeling tests.

关键词： geophysical Earth stellar

A Wideband High-Gain Sawtooth Slot Array Antenna with Frequency-Scanning at Lower Frequency and Fixed-Beam at Higher Frequency

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Chinese Journal of Electronics 2024年第2期33卷 463-471页

作者： Qiang sun Yongling BAN Jun HU School of Electronic Science and Engineering University of Electronic Science and Technology of China

Exploring the multifunctional array antenna suitable for complex communication environment has very important research value. In this paper, a millimeter wave(mm-wave) double longitudinal sawtooth slot array antenna(DLSA) based on substrate integrated waveguide(SIW) technology is proposed, which has wideband, highgain and novel beam characteristics. Two irregular longitudinal slots are etched on the SIW conductor surface as the radiation structure. To improve the bandwidth of the DLSA, the metallized vias are added at the transition point of the slots to construct multiple resonant frequency points. By adjusting the size of the slots and the position of the metallized vias, the phase constant can be regulated, and the unusual beam characteristics can be obtained. That is to say, in the lower frequency band, the beam pointing angle increases with frequency. In the higher frequency band,the beam pointing angle is maintained at a fixed angle. Finally, to improve the antenna gain, a 16 × 8 DLSA is fabricated, measured and discussed. The proposed antenna has an impedance matching bandwidth close to 9.7 *** 27 to 33 GHz, the beam pointing angle changes from 8° to 29°. From 33 to 37 GHz, the beam pointing angle is fixed at 29°, and the pointing angle error range is ±1°. In addition, the measured maximum gain is 22.9 d Bi at32 GHz.

关键词： Antenna measurements Slot antennas Surface waves Resonant frequency Gain measurement Conductors Frequency measurement

A multi-parameter-induced activation of gas therapeutic platform to remarkably amplify photodynamic therapy efficacy

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Science China Chemistry 2024年第7期67卷 2403-2411页

作者： Jie sun Ziwen Zhang Hongyu Wu Xuemei Dong Chengjun Dong Lixin sun Zhiqian Guo Yingchao Liu Xianfeng Gu Chunchang Zhao Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center Institute of Fine ChemicalsSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China Department of Medicinal Chemistry School of PharmacyFudan UniversityShanghai 201203China Shandong Provincial Hospital Affiliated to Shandong First Medical University Shandong First Medical University&Shandong Academy of Medical ScienceJinan 250021China

Gas therapy(GT)combined with photodynamic therapy(PDT)is an effective strategy to compensate for the PDT limitation caused by the hypoxic tumor microenvironment,which can greatly improve PDT *** uncontrolled leakage of gas molecules during delivery seriously hinders its practical biological ***,we report a multifunction nanomedicine that enables precise gas therapy(including carbon monoxide(CO)release and H_(2)S depletion)using a multi-parameter-induced activation gas release strategy,enlarging the PDT *** nanomedicine uses a disulfide bond to covalently link a photosensitizer with the CO donor 3-hydroxyflavone(3-HF).The disulfide bond can be specifically consumed in H_(2)S-rich tumor areas,releasing the CO donor(3-HF),and also depleting H_(2)*** importantly,the photo-controlled production of^(1)O_(2)can induce 3-HF precise release of CO in the tumor *** H_(2)S,light,and^(1)O_(2)multi-parameter-induced activation of gas release strategy ensures the accuracy of GT to amplify PDT *** expected,in vitro and in vivo investigations show that GT makes up for the PDT limitation,exhibiting the highest tumor therapeutic *** multi-parameter-activated design strategy provides a new way to improve the precision and efficacy of multimodal synergistic therapy of tumors.

关键词： gas therapy precision gas release hydrogen sulfide depletion photodynamic therapy multimodal synergistic therapy

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