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Leukocyte-Specific Morrbid Promotes Leukocyte Differentiation and Atherogenesis

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Research 2024年第2期2023卷 123-137页

作者： Di xiang Lei Jiang Qiong Yuan Yang Yu Ruiming liu Meiting Chen {2. Kuai Wendy Zhang Fan Yang Tingting Wu Zhiyu He Zuhui Ke Wanzi Hong Pengcheng He Ning Tan Yeying Sun zhen Shi Xuebiao Wei Jianfang Luo Xiaoqiu Tan Yuqing Huo Gangjian Qin Chunxiang Zhang department of cardiology Key Laboratory of Medical ElectrophysiologyMinistry of EducationInstitute of Cardiovascular ResearchThe Affiliated Hospital of Southwest Medical UniversitySouthwest Medical UniversityLuzhouSichuan 646000China department of Biomedical Engineering School of Medicine The University of Alabama at BirminghamBirminghamAL 35233USA department of cardiology.Guangdong Cardiovascular Institute Guangdong Provincial Key Laboratory of Coronary Heart Disease PreventionGuangdong Provincial Institute of Geriatric MedicineGuangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510100China Vascular Biology Center Medical College of GeorgiaAugusta UniversityAugustaGA 30912USA

Monocyte-to-M0/M1 macrophage differentiation with unclear molecular mechanisms is a pivotal cellular event in many cardiovascular diseases including *** non-coding RNAs(lncRNAs)are a group of protein expression regulators;however,the roles of monocyte-lncRNAs in macrophage differentiation and its related vascular diseases are still *** study aims to investigate whether the novel leukocyte-specific lncRNA Morrbid could regulate macrophage differentiation and *** identified that Morrbid was increased in monocytes and arterial walls from atherosclerotic mouse and from patients with *** cultured monocytes,Morrbid expression was markedly increased during monocyte to M0 macrophage differentiation with an additional increase during M0 macrophage-to-M1 macrophage *** differentiation stimuli-induced monocyte-macrophage differentiation and the macrophage activity were inhibited by Morrbid ***,overexpression of Morrbid alone was sufficient to elicit the monocyte-macrophage *** role of Morrbid in monocyte-macrophage differentiation was also identified in vivo in atherosclerotic mice and was verified in Morrbid knockout *** identified that PI3-kinase/Akt was involved in the up-regulation of Morrbid expression,whereas s100a10 was involved in Morrbid-mediated effect on macrophage *** provide a proof of concept of Morrbid in pathogenesis of monocyte/macrophage-related vascular disease,we applied an acute atherosclerosis model in *** results revealed that overexpression of Morrbid enhanced but monocyte/macrophage-specific Morrbid knockout inhibited the monocytes/macrophages recruitment and atherosclerotic lesion formation in *** results suggest that Morrbid is a novel biomarker and a modulator of monocyte-macrophage phenotypes,which is involved in atherogenesis.

关键词： inhibited Mor markedly

Vonoprazan-amoxicillin dual therapy for Helicobacter pylori eradication in Chinese population:A prospective,multicenter,randomized,two-stage study

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World Journal of Gastroenterology 2024年第27期30卷 3304-3313页

作者： Xue-Ping Huang Zhi-Hui Lin Yi-Juan liu Shao-Wei Lin Yan-Feng Shao Feng Qiu Qing-Wu Qiu Zhang-Kun Xu Jin-Xian Chen Liang-Huo Chen zhen-Qun Lin Wen-Hua Dai Ming-Qing Zhang Qi Jiang {2.-Qin Xiao Xian-Xing Cheng xiang-Fei Zhang Wen-Bin You Wei Chen Long-Qin Li Wei-Xing Lin Yong-Fu Wang Fu-Jin Lai Long-Qun Chen {2.-Hua Huang Wen-Qi zheng Jin-Qi Wei department of Gastroenterology Shengli Clinical Medical College of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina department of Gastroenterology Fujian Provincial HospitalFuzhou 350001Fujian ProvinceChina department of Gastroenterology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina School of Public Health Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina department of Gastroenterology The Third People’s Hospital of Fujian ProvinceFuzhou 350000Fujian ProvinceChina department of Gastroenterology Fujian Provincial Hospital North Brance Fujian Provincial Geriatric HospitalFuzhou 350000Fujian ProvinceChina department of Gastroenterology Xiaoao HospitalFuzhou 350000Fujian ProvinceChina department of Gastroenterology The General Hospital of Fujian Energy GroupFuzhou 350000Fujian ProvinceChina department of Gastroenterology The Second Hospital of ZhangzhouZhangzhou 363000Fujian ProvinceChina department of Gastroenterology Anxi Country HospitalQuanzhou 362000Fujian ProvinceChina department of Gastroenterology Zhangzhou Municipal Hospital of TCMZhangzhou 363000Fujian ProvinceChina department of Gastroenterology Zhangpu HospitalZhangzhou 363000Fujian ProvinceChina department of Gastroenterology The Affiliated Dongnan Hospital of Xiamen UniversityZhangzhou 363000Fujian ProvinceChina department of Gastroenterology First Hospital of Nanping CityNanping 353000Fujian ProvinceChina department of Gastroenterology Fujian Nanping Second HospitalNanping 353000Fujian ProvinceChina department of Gastroenterology Wuyishan Municipal HospitalNanping 353000Fujian ProvinceChina department of Gastroenterology Fuzhou Changle District HospitalFuzhou 350000Fujian ProvinceChina department of Gastroenterology Changle City Second HospitalFuzhou 350000Fujian ProvinceChina department of Gastroenterology Jinjiang Municipal HospitalQuanzhou 362000Fujian ProvinceChina department of Gastroenterology Fuding Hospital Affiliated to Fuj

BACKGROUND The efficacy of Vonoprazan-amoxicillin dual therapy(VAT)in the treatment of Helicobacter pylori(***)is *** To evaluate the efficacy of VAT in the Chinese *** This prospective,multicenter,randomized,open-label,and two-stage study was conducted at 2. centers in Fujian,china(May 2.2.-April 2.2.).***-infected patients were randomized to bismuth quadruple therapy(BQT),BQT-Vonoprazan(BQT-V),seven-day VAT(VAT-7),ten-day VAT(VAT-10),and fourteen-day VAT(VAT-14)*** primary endpoint was the *** eradication *** secondary endpoint was the frequency of adverse *** study was registered with the Chinese Clinical Trial Registry,*** In the first stage,VAT-7 and BQT-V groups were selected for early termination because less than 2. among 2. cases were *** the second stage,the eradication rates for BQT,VAT-10,and VA-14 were 80.2.[95%confidence interval(95%CI):71.4%-86.8%],93.2.(86.6%-96.7%),92.2.(85.3%-96.0%)in the intention-to-treat(ITT)analysis,and 80.9%(95%CI:71.7%-87.5%),94.0%(87.5%-97.2.),and 93.9%(87.4%-97.2.)in the per-protocol *** ITT analysis showed a higher eradication rate in the VAT-10 and VAT-14 groups than in the BQT group(P=0.02. and P=0.046,respectively).The incidence of adverse events in the VAT-10 and VAT-14 groups was lower than in the BQT group(2..2.%and 13.73%vs 37.62.,respectively;P<0.001).CONCLUSION VAT with a duration of 10 or 14 days achieves a higher eradication rate than the BQT,with a more tolerable safety profile in ***-infected patients in *** XP et *** for *** eradication.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Bismuth quadruple therapy

Searching for^(76)Ge neutrinoless double beta decay with the CDEX-1B experiment

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Chinese Physics C 2024年第10期48卷 11-22页

作者： Bing-Tao Zhang Jun-zheng Wang Li-Tao Yang Qian Yue Ke-Jun Kang Yuan-Jing Li Hai-Peng An C.Greeshma Jian-Ping Chang Yun-Huan Chen Jian-Ping Cheng Wen-Han Dai Zhi Deng Chang-Hao Fang Xin-Ping Geng Hui Gong Qiu-Ju Guo Xu-Yuan Guo Li He Sheng-Ming He Jin-Wei Hu Han-Xiong Huang Tu-Chen Huang Hai-Tao Jia Xi Jiang S.Karmakar Hao-Bin Li Jian-Min Li Jin Li Qian-Yun Li Ren-Ming-Jie Li Xue-Qian Li Yu-Lan Li Yi-Fan Liang Bin Liao Fong-Kay Lin Shin-Ted Lin Jia-Xuan liu Shu-Kui liu Yan-Dong liu Yu liu Yuan-Yuan liu zhong-Zhi liu Hao Ma Yu-Cai Mao Qi-Yuan Nie Jin-Hua Ning Hui Pan Ning-Chun Qi Jie Ren Xi-Chao Ruan Ze She Manoj Kumar Singh Tian-Xi Sun Chang-Jian Tang Wei-You Tang Yang Tian Guang-Fu Wang Li Wang Qing Wang Yu-Feng Wang Yun-xiang Wang Henry-Tsz-King Wong Shi-Yong Wu Yu-Cheng Wu Hao-Yang Xing Rui Xu Yin Xu Tao Xue Yu-Lu Yan Nan Yi Chun-Xu Yu Hai-Jun Yu Jian-Feng Yue Ming Zeng Zhi Zeng Feng-Shou Zhang Lei Zhang zhen-Hua Zhang zhen-Yu Zhang Kang-Kang Zhao Ming-Gang Zhao Ji-Fang Zhou Zu-Ying Zhou Jing-Jun Zhou Key Laboratory of Particle and Radiation Imaging(Ministry of Education)and department of Engineering Physics Tsinghua UniversityBeijing 100084 department of Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaTaipei 11529 NUCTECH Company Beijing 100084 YaLong River Hydropower Development Company Chengdu 610051 college of Nuclear science and Technology Beijing Normal UniversityBeijing 100875 college of Physics Sichuan UniversityChengdu 610065 School of Physics Peking UniversityBeijing 100871 department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French Institute of Nuclear and Technology Sun Yat-sen UniversityZhuhai 519082 School of Physics Nankai UniversityTianjin 300071 department of Physics Banaras Hindu UniversityVaranasi 221005 department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEX-1B,1.008 kg)in the china Jinping Underground Laboratory(CJPL)for 500.3 days to search for neutrinoless double beta(0νββ)decay of^(76)Ge.A total of 504.3 kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discrimination methods were used to suppress the background in the energy region of interest(ROI,1989–2.89 keV for this work)with a factor of 2..A background level of 0.33 counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as T_(1/2.^(0ν)>1.0×10^(2.)yr(90%C.L.),corresponding to the upper limits on the effective Majorana neutrino mass:2.7.5 eV.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector ^(76)Ge

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH university of science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing Beijing Computational science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal university Beijing Brown university ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal university WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced science and Technology Beijing china Institute of Atomic Energy Beijing china Jiliang university HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china university of Geo{2.s Beijing china university of Geo{2.s WuhanHubei china university of Mining and Technology XuzhouJiangsu china West Normal university NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu university DalianLiaoning Dalian university of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East china university Of {2. And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2.s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2.15)and the Conceptual Design Report(CDR,2.18),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2.2.-2.2.,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2.30s.

关键词： initiated exceeding precise

基于人工智能的全自动化一站式CT血流储备分数在冠心病患者中的诊断与预后价值

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science Bulletin 2024年第10期69卷 1472-1485页

作者：郭邦俊姜孟春郭翔唐春香钟健陆梦洁刘春雨张晓蕾乔红艳周帆许棚棚薛艺郑敏文侯阳王怡宁张佳胤张波张代民徐磊胡秀华周长圣李建华杨志文毛新生卢光明张龙江 department of Radiology Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210002China department of Radiology Affiliated Hospital of Jining Medical UniversityJining 272007China department of Radiology Xijing HospitalFourth Military Medical UniversityXi’an 733399China department of Radiology Shengjing Hospital of China Medical UniversityShenyang 110022China department of Radiology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Institute of Diagnostic and Interventional Radiology and Department of CardiologyShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200235China department of Radiology Jiangsu Taizhou People’s HospitalTaizhou 225399China department of cardiology Nanjing First HospitalNanjing Medical UniversityNanjing 210012China department of Radiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China department of Radiology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310020China department of cardiology Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210002China Shukun(Beijing)Network Technology Co. Ltd.Beijing 102200China

Currently,clinically available coronary CT angiography(CCTA)derived fractional flow reserve(CT-FFR)is time-consuming and *** propose a novel artificial intelligence-based fully-automated,on-site CT-FFR technology,which combines the automated coronary plaque segmentation and luminal extraction model with reduced order 3 dimentional(3D)computational fluid dynamics.A total of 463 consecutive patients with 600 vessels from the updated china CT-FFR study in Cohort 1 undergoing both CCTA and invasive fractional flow reserve(FFR)within 90 d were collected for diagnostic performance *** Cohort 2.a total of 901 chronic coronary syndromes patients with index CT-FFR and clinical outcomes at 3-year follow-up were retrospectively *** Cohort 3,the association between index CT-FFR from triple-rule-out CTA and major adverse cardiac events in patients with acute chest pain from the emergency department was further *** diagnostic accuracy of this CT-FFR in Cohort 1 was 0.82.with an area under the curve of 0.82.on a per-patient *** with the manually dependent CT-FFR techniques,the operation time of this technique was substantially shortened by 3 times and the number of clicks from about 60 to *** CT-FFR technique has a highly successful(>99%)calculation rate and also provides superior prediction value for major adverse cardiac events than CCTA alone both in patients with chronic coronary syndromes and acute chest ***,the novel artificial intelligencebased fully automated,on-site CT-FFR technique can function as an objective and convenient tool for coronary stenosis functional evaluation in the real-world clinical setting.

关键词： Artificial intelligence Coronary CTA CT-derived fractional flow reserve Fully-automated Outcomes

A double-blind,randomized,placebo-and positive-controlled phase III trial of 1% benvitimod cream in mild-to-moderate plaque psoriasis

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Chinese medical Journal 2020年第24期133卷 2905-2909页

作者： Lin Cai Gen-Hui Chen Qian-Jin Lu Min zheng Yu-zhen Li Jin Chen Jie zheng Fu-Ren Zhang Jian-Bin Yu Sen Yang Fu-Qiu Li Sheng-xiang Xiao Qiu-Ning Sun Jin-Hua Xu Xing-Hua Gao Hong Fang Tian-Wen Gao Fei Hao Quan-zhong liu Ya-Ting Tu Ruo-Yu Li Bao-Xi Wang Dan-Qi Deng Qing-Shan zheng Hong-Xia liu Jian-zhong Zhang department of Dermatology Peking University People’s HospitalBeijing 100044China Beijing Wenfeng Tianji Pharma Ltd. Beijing 100044China department of Dermatology The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China department of Dermatology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310009China department of Dermatology Harbin Medical University Second HospitalHarbinHeilongjiang 150001China department of Dermatology Sichuan Provincial People’s HospitalChengduSichuan 610072China department of Dermatology Shanghai JiaoTong University School of Medicine Ruijin HospitalShanghai 213002China Shandong Provinical Institute of Dermatology and Venereology JinanShandong 250022China department of Dermatology The First Affiliated HospitalZhengzhou UniversityZhengzhouHenan 450052China department of Dermatology The First Affiliated HospitalAnhui Medical UniversityHefeiAnhui 230022China department of Dermatology The Second Hospital of Jilin UniversityChangchunJilin 130041China department of Dermatology The Second Affiliated HospitalXi’an Jiaotong UniversityXi’anShaanxi 710004China department of Dermatology Peking Union Medical College HospitalBeijing 100730China department of Dermatology Fudan University Huashan HospitalShanghai 200041China department of Dermatology The First Hospital of China Medical UniversityShenyangLiaoning 110001China department of Dermatology The First Affiliated HospitalZhejiang UniversityHangzhouZhejiang 310006China department of Dermatology Xijing HospitalAir Force Medical University of People’s Liberation ArmyXi’anShaanxi 710032China department of Dermatology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China department of Dermatology Tianjin Medical University General HospitalTianjin 300052China department of Dermatology Wuhan Union HospitalWuhanHubei 430022China department of Dermatology Peking University First HospitalBeijing

Background:Benvitimod cream,a novel synthetic small molecule,was effective in treating mild-to-moderate plaque *** conducted a phase III clinical trial to assess the efficacy and safety of benvitimod cream in patients with mild-to-moderate plaque ***:We randomly assigned 686 patients(2.1:1)to receive 1%benvitimod cream,0.005%calcipotriol ointment or placebo twice a day for 12.*** primary efficacy end points were the percentage of patients with a 75%or greater reduction from baseline in the psoriasis area and severity index(PASI 75)score and with a score of 0 or 1 in static physician’s global assessment(sPGA)at week ***:The results showed that 50.4%of patients in the benvitimod group achieved PASI 75,which was significantly higher than that in the calcipotriol(38.5%,P2.week study,benvitimod cream was demonstrated with high effectiveness and safety in patients with mild-to-moderate plaque psoriasis.

关键词： Psoriasis Benvitimod Immune modulator Drug discovery 3,5-dihydroxy-4-isopropylstilbene

Neuroprotectants attenuate hypobaric hypoxia-induced brain injuries in cynomolgus monkeys

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Zoological Research 2020年第1期41卷 3-19页

作者： Pei Zhang Jie-Si Chen Qi-Ye Li Long-xiang Sheng Yi-Xing Gao Bing-zheng Lu Wen-Bo Zhu Xiao-Yu Zhan Yuan Li Zhi-Bing Yuan Gang Xu Bi-Tao Qiu Min Yan Chun-Xue Guo You-Qiong Wang Yi-Jun Huang Jing-Xia Zhang Fu-Yu {2. zhong-Wei Tang Sui-zhen Lin David NCooper Huan-Ming Yang Jian Wang Yu-Qi Gao Wei Yin Guo-Jie Zhang Guang-Mei Yan State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China BGI-Shenzhen ShenzhenGuangdong 518083China Section for Ecology and Evolution Department of BiologyUniversity of CopenhagenCopenhagen DK-2100Denmark department of Pharmacology Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhouGuangdong 510080China Institute of Medicine and Hygienic Equipment for High Altitude Region College of High Altitude Military MedicineThird Military Medical UniversityChongqing 400038China Key Laboratory of High Altitude Medicine of People's Liberation Army Chongqing 400038China Key Laboratory of High Altitude Environmental Medicine Third Military Medical UniversityMinistry of EducationChongqing 400038China School of Pharmaceutical sciences Sun Yat-Sen UniversityGuangzhouGuangdong 510006China Guangzhou Cellprotek Pharmaceutical Co.Ltd. GuangzhouGuangdong 510663China Institute of medical Genetics School of MedicineCardiff UniversityCardiff CF144XNUK James D.Watson Institute of Genome sciences HangzhouZhejiang 310058China department of Biochemistry Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhouGuangdong 510080China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China china National Genebank BGI-ShenzhenShenzhenGuangdong 518120China

Hypobaric hypoxia (HH) exposure can cause serious brain injury as well as life-threatening cerebral edema in severe cases. Previous studies on the mechanisms of HH-induced brain injury have been conducted primarily using non-primate animal models that are genetically distant to humans, thus hindering the development of disease treatment. Here, we report that cynomolgus monkeys (Macaca fascicularis) exposed to acute HH developed human-like HH syndrome involving severe brain injury and abnormal behavior. Transcriptome profiling of white blood cells and brain tissue from monkeys exposed to increasing altitude revealed the central role of the HIF-1 and other novel signaling pathways, such as the vitamin D receptor (VDR) signaling pathway, in co-regulating HH-induced inflammation processes. We also observed profound transcriptomic alterations in brains after exposure to acute HH, including the activation of angiogenesis and impairment of aerobic respiration and protein folding processes, which likely underlie the pathological effects of HH-induced brain injury. Administration of progesterone (PROG) and steroid neuroprotectant 5α-androst-3β,5,6β-triol (TRIOL) significantly attenuated brain injuries and rescued the transcriptomic changes induced by acute HH. Functional investigation of the affected genes suggested that these two neuroprotectants protect the brain by targeting different pathways, with PROG enhancing erythropoiesis and TRIOL suppressing glutamate-induced excitotoxicity. Thus, this study advances our understanding of the pathology induced by acute HH and provides potential compounds for the development of neuroprotectant drugs for therapeutic treatment.

关键词： Acute hypobaric hypoxia Cynomolgus monkeys Brain injury Neuroprotectant Gene regulatory networks

Chinese guideline for the application of rectal cancer staging recognition systems based on artificial intelligence platforms (2.2. edition)

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Chinese medical Journal 2021年第11期134卷 1261-1263页

作者： Yuan Gao Yun Lu Shuai Li Yong Dai Bo Feng Fang-Hai Han Jia-Gang Han Jing-Jing He Xin-xiang Li Guo-Le Lin Qian liu Gui-Ying Wang Quan Wang {2.-Ning Wang zheng Wang Ai-Wen Wu Bin Wu Ying-Chi Yang Hong-Wei Yao Wei Zhang Jian-Ping Zhou Ai-Min Hao zhong-Tao Zhang Colorectal Surgery Group of the Surgery Branch in the Chinese medical Association Beihang university State Key Laboratory of Virtual Reality Technology and Systems department of General Surgery The Affiliated Hospital of Qingdao UniversityQingdaoShandong 266555China Beihang university State Key Laboratory of Virtual Reality Technology and Systems Beijing 100191China department of General Surgery Qilu Hospital of Shandong UniversityJinanShandong 250012China department of General Surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Minimally Invasive Surgery Center Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China department of Gastrointestinal Surgery Sun Yat-sen UniversityGuangzhouGuangdong 510120China department of General Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Institute of International Law Chinese Academy of Social SciencesBeijing 100732China department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghai 201321China department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 201321China department of General Surgery Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China National Cancer Center/National Clinical Research Center for Cancer/Cancer hospital Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100021China Third hospital of Hebei medical {2. ShijiazhuangHebei 050051China department of Colon and Rectum Surgery The First Hospital of Jilin UniversityChangchunJilin 130021China department of Surgical Oncology and General Surgery Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal TumorsMinistry of EducationThe First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110001China department of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China department of Unit III&Ostomy Service Key laboratory of Carcinogenesis and Translational Research(Ministry of Education)Gastrointest

Development and Application of Artificial Intelligence Recognition Systems in Rectal Cancer Staging Whether for surgical treatment or for neoadjuvant chemoradiotherapy,imaging evaluation has become an important basis to perform the treatment plans.[1]The reading of imaging results requires a large number of experienced radiologists to complete,but shortages and uneven distributions of personnel cause delays and biases in imaging ***,independent research and development of automatic recognition systems of rectal cancer staging based on artificial intelligence(AI)platforms aim to partially replace practitioners’work and achieve rapid and accurate identification of rectal cancer staging.

关键词： staging artificial replace

Author Correction: Neuroprotectants attenuate hypobaric hypoxia-induced brain injuries in cynomolgus monkeys

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Zoological Research 2021年第2期42卷 250-251页

Open Access This is an open-access article distributed under the terms of theCreative Commons Attribution Non-Commercial License(http:1/***/licenses/by-nc/4.0/).which permits unrestrictednon-commercial use,*** reprodu... 详细信息

关键词： Open Creative Access