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In search of a pan-coronavirus vaccine:next-generation vaccine design and immune mechanisms

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Cel.ular & Molecular Immunology 2024年第2期21卷 103-118页

作者： S.Cankat M.u.Demael l.Swadling Division of Infection and Immunity Institute of Immunity and TransplantationUniversity College LondonPears BuildingLondon NW32PPUK

Members of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in recent *** this review,we will discuss the feasibility of and progress toward the ultimate goal.of creating a pan-coronavirus vaccine that can protect against infection and disease by all members of the coronavirus *** will detail the unmet clinical need associated with the continued transmission of SARS-CoV-2,MERS-CoV and the four seasonal coronaviruses(HCoV-oC43,Nl63,HKu1 and 229E)in humans and the potential for future zoonotic *** will highlight how first-generation SARS-CoV-2 vaccines and natural history studies have greatly increased our understanding of effective antiviral immunity to coronaviruses and have informed next-generation vaccine *** will then consider the ideal properties of a pan-coronavirus vaccine and propose a blueprint for the type of immunity that may offer ***,we will describe a subset of the diverse technologies and novel approaches being pursued with the goal.of developing broadly or universally protective vaccines for coronaviruses.

关键词： Vaccine Coronavirus Cross-reactive immunity Cross-protection universal

Exact solutions for magnetohydrodynamic nanofluids flow and heat transfer over a permeable axisymmetric radially stretching/shrinking sheet

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Chinese Physics B 2024年第2期33卷 108-114页

作者： u.S.Mahabaleshwar G.P.Vanitha l.M.Pérez Emad H.Aly I.Pop Department of Studies in Mathematics Davangere UniversityShivagangothriDavangereIndia Departamento de F´ısica FACIUniversidad de Tarapac´aCasilla 7DAricaChile Department of Mathematics Faculty of EducationAin Shams UniversityRoxyCairoEgypt Department of Mathematics Babes-Bolyai University400084 Cluj-NapocaRomania

We report on the magnetohydrodynamic impact on the axisymmetric flow of Al_(2)o_(3)/Cu nanoparticles suspended in H_(2)o past a stretched/shrinked *** the use of partial differential equations and the corresponding thermophysical characteristics of nanoparticles,the physical flow process is *** resultant nonlinear system of partial differential equations is converted into a system of ordinary differential equations using the suitable similarity *** transformed differential equations are solved *** of the magnetic parameter,solid volume fraction and stretching/shrinking parameter on momentum and temperature distribution have been analyzed and interpreted *** skin friction and Nusselt number were al.o *** addition,existence of dual solution was deduced for the shrinking sheet and unique solution for the stretching ***,Al_(2)o_(3)/H_(2)o nanofluid flow has better thermal conductivity on comparing with Cu/H_(2)o ***,it was found that the first solutions of the stream are stable and physically realizable,whereas those of the second ones are unstable.

关键词： magnetohydrodynamic nanofluid stretching/shrinking sheet axisymmetric flow analytical solution suction/injection

Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents

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Neural Regeneration Research 2024年第8期19卷 1835-1841页

作者： Irene Navarro-lobato Mariam Masmudi-Martín Manuel F.lópez-Aranda Juan F.lópez-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero Marta Carretero-Rey Sinforiano Posadas María E.Quiros-ortega Zafar u.Khan laboratory of Neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of Neurobiology University of California-Los AngelesLos AngelesCAUSA

Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(oRM),can induce enhancement of *** this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of oRM in young animals and prevent oRM deficits in rodent models of aging and Alzheimer’s ***,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNF).A knockdown of BDNF gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of oRM *** findings suggest that BDNF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s ***,our findings of RGS14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits.

关键词： behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling

Mechanics and physics under supergravity conditions

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Acta Mechanica Sinica 2024年第6期40卷 1-2页

作者： Chaofeng lü Chao Sun Shengqiang Cai Faculty of Mechanical Engineering and Mechanics Ningbo UniversityNingbo 315211China New Cornerstone Science laboratory Center for Combustion EnergyDepartment of Energy and Power EngineeringTsinghua UniversityBeijing 100084China Department of Mechanical and Aerospace Engineering University of CaliforniaSan DiegoLa Jolla CA 92093USA

"Supergravity"refers to the conditions where the effective gravity is greater than that of *** conditions are generally relevant to stellar evolution,geophysical movement,astrophysical flows,and *** al.o frequently occur in various engineering scenarios involving acceleration,such as the l.unch of space shuttles,operation of rotor engines,impacts and explosions,chemical separation processes,and overloaded testing *** is already demonstrated in physiological experiments that living organisms of animals or plants could be damaged,either temporarily or permanently,when subjected to *** create supergravity conditions for scientific research on the Earth,centrifugal equipment or rapidly rotating devices are omnipresent in various fields,such as aerospace engineering,geophysical science,chemical and biomedical engineering,nuclear engineering,rotating flows,and physical modeling tests.

关键词： geophysical Earth stellar

Water quality, habitat, and fish assemblage relationships in middle-order agricul.ure and forest streams of the Mississippi Al.uvial Plain

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Ecological Processes 2024年第01期13卷 217-236页

作者： Matthew l.Skoog Michael A.Eggleton Yushun Chen Department of Aquacul.ure and Fisheries University of Arkansas at Pine Bluff Minnesota Department of Natural Resources State Key laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology Chinese Academy of Sciences university of Chinese Academy of Sciences

Background Agricul.ure has greatly influenced water quality, habitats, and fish assemblages in streams of the Mississippi Al.uvial Plain(MAP) ecoregion. However, MAP streams have historically been understudied compared to streams in other agricul.ural regions of the uSA. In this study, water quality, habitat, and fish assemblage composition were assessed seasonally(spring, summer, and fall) in eight representative MAP streams located across three u.S. states. The study design included four streams containing highly agricul.ural watersheds(herein termed “agricul.ure” streams) and four streams containing mostly forested watersheds(herein termed “forest” streams), which were intended to represent reference conditions for MAP *** In general, forest streams contained significantly better instream and riparian habitats than agricul.ure streams(P = 0.010–0.040) whereas agricul.ure streams contained significantly greater levels of primary nutrients(P ul.ure and forest streams with respect to other physical and chemical variables were intermittent and season dependent. Fish assemblages in agricul.ure and forest streams were structured primarily along an environmental gradient reflecting instream habitat conditions, water nutrient concentrations, and benthic chlorophyll-a production. Structurally, fish assemblages in both stream types contained many regionally common species, though some species appeared to exhibit affinities for a particular stream type. Functionally, fish assemblages in agricul.ure streams contained more tolerant species, more omnivores, and fewer insectivores compared to forest stream assemblages, which were nearly all insectivores. overall, one-third of the fish specimens collected in forest streams classified as intolerant *** our results suggested that stream water quality, habitat, and fish assemblages differed between agricul.ure and forest streams in the MAP, with fish assemblages e

关键词： Agricul.ure Stream land use Water quality Habitat Fish Multivariate statistics Mississippi Al.uvial Plain

基于背景噪声反演华南块体岩石圈三维S波速度结构

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北京大学学报（自然科学版） 2024年第3期60卷 442-452页

作者：吕杰陈永顺郭震北京大学地球与空间科学学院北京100871 南方科技大学海洋科学与工程系深圳518055

利用背景噪声方法,对布设在华南块体及其周边区域数个流动地震台阵中共704个地震台站的连续数据进行分析,反演得到华南岩石圈的三维S波速度结构。结果表明,地表附近S波速度结构与华南块体的地表构造高度相关,低速异常区集中在四川盆地... 详细信息

利用背景噪声方法,对布设在华南块体及其周边区域数个流动地震台阵中共704个地震台站的连续数据进行分析,反演得到华南岩石圈的三维S波速度结构。结果表明,地表附近S波速度结构与华南块体的地表构造高度相关,低速异常区集中在四川盆地和江汉盆地等沉积层较厚的区域。江南造山带的中上地壳呈现明显的高速异常,该高速异常即为华夏块体与扬子块体的分界区域。华夏块体中地壳低速异常区与该区域广泛分布的中生代花岗岩对应较好。华南上地幔岩石圈的东部与西部存在显著的速度差异,西部呈现显著的高速异常,反映西部四川盆地底部稳固的克拉通结构;上地幔的低速异常揭示华南东部岩石圈因太平洋板块俯冲的影响而明显减薄(<70km)。推测华夏块体以琼州海峡为中心的上地幔显著低速区可能对应海南地幔柱的热物质上涌。

关键词：华南块体 S波速度结构江南造山带板块俯冲

Fusion and one-neutron stripping process for ^(6)li+^(94)Zr system around the Coulomb Barrier

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Chinese Physics C 2024年第9期48卷 133-141页

作者： Xuedou Su Guangxin Zhang Shipeng Hu Peiwei Wen H.o.Soler Gaolong Zhang Boshuai Cai Cenxi Yuan J.l.Ferreira zhenwei Jiao Mingli Wang Xiaoyu Wang zhen Huang Huanqiao Zhang Chunlei Zhang Xiaoguang Wu Yun zheng Congbo li Tianxiao liand J.lubian School.of Physics Beihang UniversityBeijing 100191China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute for Advanced Study in Nuclear Energy&Safety Shenzhen UniversityShenzhen 518060China Shenzhen Key laboratory of Research and Manufacture of High Purity Germanium Materials and Fetectors Shenzhen UniversityShenzhen 518060China China Institute of Atomic Energy Beijing 102413China Instituto de Física Universidade Federal FluminenseNiterói 24210-340Rio de JaneiroBrazil State Key laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China The Key laboratory of Beam Technology and Material Modification of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China

The complete and incomplete fusion cross section as well as one-neutron stripping process of ^(6)li+^(94)Zr system were measured at the energies around the Coulomb barrier by onlineγ-ray *** addition to a 30%suppression factor when compared with the measured total fusion process,the complete fusion cross section in ^(6)li+^(94)Zr system was observed to be significantly lower than those in the nearby ^(6)li+^(90,96)Zr *** new experimental result implies that the coupling with breakup channel in the ^(6)li-induced fusion processes can be affected by the inner structure of the target,which is still not clear in any available model *** the one-neutron stripping process,the direct production cross sections for each level in 95Zr were extracted and compared with the coupled reaction channel cal.ulation,offering a unique opportunity to examine the single-particle nature of the produced excited *** the fact that an overall.overestimation of the production cross section for 954-keV and1618-keV levels was observed in the comparison,further investigation is highly demanded in order to understand the full reaction mechanism for the one-neutron stripping process induced by ^(6)li.

关键词： weakly bound nuclei complete fusion incomplete fusion transfer reaction

Novel process for facile preparation of mesoporous silica-based materials with controllable pore structure from coal fly ash Author links open overlay panel

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Particuology 2024年第8期91卷 128-137页

作者： Jian-ming Gao zhen li Shujia Ma Yuanyuan Zhang Fangqin Cheng Institute of Resources and Environment Engineering State Environmental Protection Key Laboratory of Efficient Utilization Technology of Coal Waste ResourcesShanxi Collaborative Innovation Center of High Value-added Utilization of Coal-related WastesShanxi UniversityTaiyuan 030006China

Extraction of silica from fly ash to produce mesoporous silica materials is one of the most important utilization *** silica could not be synthesized on a large-scale by conventional sol-gel *** this paper,facile preparation of mesoporous silica with controllable pore structure from fly ash by the template-free process via two steps of mineral phase transformation and selective acid etching was *** influence of crystalline structure and acid etching degree on structure of as-synthesized mesoporous silica materials was revealed,as well as mechanism of crystalline structure transformation and pore structure *** results show that mullite and quartz could be transformed into acid-soluble kal.ophilite when fly ash reacted with K_(2)Co_(3)at temperature of 800-1100℃.The hexagonal kal.ophilite would be transformed into orthorhombic KAlSio_(4)-o1 phase when the temperature is controlled at 1100℃.Mesoporous silica with specific surface area of 475.93 m^(2)/g and 642.57 m^(2)/g could be synthesized from activated fly ash with kal.ophilite and KAlSio_(4)-o1 phase crystalline *** controlling the degree of acid etching,mesoporous silica materials with different pore structures can be *** paper provides a cost-effective and large-scale process for the preparation of mesoporous silica materials with controllable pore structure from solid waste fly ash.

关键词： Fly ash Mesoporous silica Crystal transformation Acid etching Controllable pore structure

Noncoding RNAs：＇our turn＇ to join the p53 networ

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Journal.of Molecular Cell Biology 2014年第3期8卷 179-180页

作者： Yong li Hua l.u Department of Biochemistry and Molecular Biology School of Medicine University of Louisville 319 Abraham Flexner Way Louisville KY40202 USA E-mail: yong.ti@louisviUe.edu Department of Biochemistry& Molecular Biology andTulane Cancer Center TulaneUniversity School ofMedicine New Orleans LA70112 USA

The p53 tumor suppressor is the guardian of the rrr- o human genome. Since ,ts discovery in pS3 has been the most studied molecule in the field of cancer. Recently, its role has al.o been extended to other biological and pathological processes, p53 functions primarily as a transcription factor to regulate target genes that encode proteins crucial for promot- ing apoptotic cell death, cell cycle arrest, senescence, and so on in response to diverse upstream stressors. Interestingly, some of the p53 targets are noncoding RNAs. Noncoding RNAs can be functional without being translated into proteins and are often independent RNA molecules or noncoding parts of messenger RNAs. The past decade has witnessed bur- geoning intensive investigation on the interplay of noncoding RNAs with p53, its regulators, and effectors during the development of cancer and/or other dis- eases. This issue of Journal.of Molecular Cell Biology presents five essays to review the rapid progress in this area from five different angles and to offer new insight into the role of noncoding RNAs in the p53 signaling web with updated information.

关键词：非编码RNA BP网络分子细胞生物学 P53 编码蛋白质细胞周期阻滞 p53 人类基因组