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人面弓形格铜剑研究

东南文化 2024年第3期 124-134页

作者：彭长林付珍湖南师范大学历史学与人类学研究所湖南长沙410081 广西文物保护与考古研究所广西南宁530001

通过对人面弓形格铜剑的综合分析,可以看出它是流行于战国至西汉中期的一种形制特殊的兵器。各地发现的这类铜剑应该都是由滇东南、桂西北地区的句町文化制作并传播到其他地区,其纹饰包含着太阳神鸟崇拜的宗教信仰。

关键词：人面弓形格铜剑型式年代句町文化太阳神崇拜

Immunotherapeutic hydrogel for co-delivery of STAT3 siRNA liposomes and lidocaine hydrochloride for postoperative comprehensive management of NSCLC in a single application

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Asian Journal of Pharmaceutical Sciences 2024年第3期19卷 115-130页

作者： Xianglei fu Yanbin Shi Zili Gu Hengchang Zang Lian Li Qingjie Wang Yongjun Wang Xiaogang Zhao Hang Wu Shengnan Qiu Yankun Zhang Jiamin Zhou Xiangqin Chen hua Shen Guimei Lin Department of Pharmaceutics School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China School of Mechanical and Automotive Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China Department of Radiology Leiden University Medical CenterAlbinusdreef 22333 ZA LeidenNetherlands NMPA Key Laboratory for Technology Research and Evaluation of Drug Products School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Laboratory of Basic Medical Sciences Qilu HospitalShandong UniversityJinan 250063China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China Department of Thoracic Surgery The Second Hospital of Shandong UniversityJinan 250033China

Despite standard treatment for non-small cell lung cancer(NSCLC)being surgical resection,cancer recurrence and complications,such as induction of malignant pleural effusion(MPE)and significant postoperative pain,usually result in treatment *** this study,an alginate-based hybrid hydrogel(SOG)is developed that can be injected into the resection surface of the lungs during ***,endoplasmic reticulum-modified liposomes(MSLs)pre-loaded with the signal transducer and activator of transcription 3(STAT3)small interfering RNA and lidocaine hydrochloride are encapsulated in *** applied,MSLs strongly downregulated STAT3 expression in the tumor microenvironment,resulting in the apoptosis of lung cancer cells and polarization of tumor-associated macrophages towards the M1-like ***,the release of lidocaine hydrochloride(LID)was beneficial for pain relief and natural killer cell *** data demonstrated MSL@LID@SOG not only efficiently inhibited tumor growth but also potently improved the quality of life,including reduced MPE volume and pain relief in orthotopic NSCLC mouse models,even with a single ***@LID@SOG shows potential for comprehensive clinical management upon tumor resection in NSCLC,and may alter the treatment paradigms for other cancers.

关键词： Liposome Hydrogel Signal transducer and activator of transcription 3 Non-small cell lung cancer Macrophage

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论新质生产力的生成体系

毛泽东邓小平理论研究 2024年第3期 1-13,108页

作者：赵振华中央党校(国家行政学院)经济学部

生产力理论是马克思主义政治经济学的最重要内容之一,“新质生产力”的提出,对推进中国式现代化、加快我国经济高质量发展意义重大。理论上看,发展新质生产力遵循生产力成长的内在规律;历史上看,生产力水平和实力是全球竞争、大国博弈... 详细信息

生产力理论是马克思主义政治经济学的最重要内容之一,“新质生产力”的提出,对推进中国式现代化、加快我国经济高质量发展意义重大。理论上看,发展新质生产力遵循生产力成长的内在规律;历史上看,生产力水平和实力是全球竞争、大国博弈的决定性力量;实践上看,新质生产力是服务于党和国家工作大局的战略选择。当下,发展新质生产力,要加快培育新质生产力生成机制,建设完善技术进步形成机制、生产要素创新型配置机制、产业深度转型升级机制;要加快建设新质生产力生成的政策体系,深化科研体制改革、构建有利于科研成果转化为现实生产力的生态系统、加快从传统产业向新兴产业和未来产业的政策转型。

关键词：新质生产力生成体系生产力理论

Prediction model for hepatitis B e antigen seroconversion in chronic hepatitis B with peginterferon-alfa treated based on a responseguided therapy strategy

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World Journal of Hepatology 2024年第3期16卷 405-417页

作者： Pei-Xin Zhang Xiao-Wei zheng Ya-Fei Zhang Jun Ye Wei Li Qian-Qian Tang Jie Zhu Gui-Zhou Zou zhen-hua Zhang Department of Infectious Diseases The Second Affiliated Hospital of Anhui Medical UniversityHefei 230601Anhui ProvinceChina Department of Infectious Diseases Anhui Provincial HospitalHefei 230000Anhui ProvinceChina Department of Hepatology The Second People’s Hospital of Fuyang CityFuyang 236000Anhui ProvinceChina

BACKGROUND Models for predicting hepatitis B e antigen(HBeAg)seroconversion in patients with HBeAg-positive chronic hepatitis B(CHB)after nucleos(t)ide analog treatment are *** To establish a simple scoring model based on a response-guided therapy(RGT)strategy for predicting HBeAg seroconversion and hepatitis B surface antigen(HBsAg)*** In this study,75 previously treated patients with HBeAg-positive CHB underwent a 52-week peginterferon-alfa(PEG-IFNα)treatment and a 24-wk *** regression analysis was used to assess parameters at baseline,week 12,and week 24 to predict HBeAg seroconversion at 24 wk *** two best predictors at each time point were used to establish a prediction model for PEG-IFNαtherapy *** at each time point that met the corresponding optimal cutoff thresholds were scored as 1 or *** The two most meaningful predictors were HBsAg≤1000 IU/mL and HBeAg≤3 S/CO at baseline,HBsAg≤600 IU/mL and HBeAg≤3 S/CO at week 12,and HBsAg≤300 IU/mL and HBeAg≤2 S/CO at week *** a total score of 0 vs 2 at baseline,week 12,and week 24,the response rates were 23.8%,15.2%,and 11.1%vs 81.8%,80.0%,and 82.4%,respectively,and the HBsAg clearance rates were 2.4%,3.0%,and 0.0%,vs 54.5%,40.0%,and 41.2%,*** We successfully established a predictive model and diagnosis-treatment process using the RGT strategy to predict HBeAg and HBsAg seroconversion in patients with HBeAg-positive CHB undergoing PEG-IFNαtherapy.

关键词： Chronic hepatitis B Hepatitis B e antigen-positive Peginterferon-alfa Prediction model Response-guided therapy strategy

反旋双色椭圆偏振激光场中Ar原子的非序列双电离

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物理学报 2024年第9期73卷 78-87页

作者：葛振杰苏旭白丽华上海大学理学院物理系上海200444

利用经典系综方法研究了不同椭偏率的反旋双色椭圆偏振(two-color elliptically polarized,TCEP)激光场中Ar原子非序列双电离(nonsequential double ionization,NSDI)的电子关联特性和再碰撞动力学.不同于反旋双色圆偏振激光场,反旋TCE... 详细信息

利用经典系综方法研究了不同椭偏率的反旋双色椭圆偏振(two-color elliptically polarized,TCEP)激光场中Ar原子非序列双电离(nonsequential double ionization,NSDI)的电子关联特性和再碰撞动力学.不同于反旋双色圆偏振激光场,反旋TCEP激光场不再具有空间对称性,返回电子主要从一个方向返回母离子,从而导致电子动量分布表现出很强的不对称性.数值结果显示随着椭偏率的增大,Ar原子NSDI的产量逐渐减小,并且电子对在椭圆偏振激光场长轴方向上的关联电子动量分布,从主要位于第一和第三象限的正相关逐渐演变为主要位于第二和第四象限的反相关.通过对不同特征时间的统计分析表明,随着椭偏率的增大,旅行时间和返回电子的重碰撞能量逐渐减小,而延迟时间却增大,这是电子对关联特性发生变化的主要原因.此外,进一步分析发现,无论是“短轨迹”还是“长轨迹”,椭偏率的增大都会使两个电子由同向出射逐渐转变为反向出射,这表明椭偏率和旅行时间都影响着电子的出射方向.

关键词：反旋双色椭圆偏振激光场非序列双电离椭偏率电子关联

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Aurora B promotes the CENP-T–CENP-W interaction to guide accurate chromosome segregation in mitosis

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Journal of Molecular Cell Biology 2024年第2期16卷 11-23页

作者： Wei Liu zhen Dou Chunyue Wang Gangyin Zhao Fengge Wu Chunli Wang Felix Aikhionbare Mingliang Ye Divine Mensah Sedzro zhenye Yang Chuanhai fu Zhikai Wang Xinjiao Gao Xuebiao Yao Xiaoyu Song Xing Liu MOE Key Laboratory for Cellular Dynamics Center for Advanced Interdisciplinary Science and Biomedicine of IHMUniversity of Science and Technology of China School of Life SciencesHefei 230027China Keck Center for Cellular Dynamics and Organoids Plasticity AtlantaGA 30310USA Anhui Key Laboratory for Cellular Dynamics and Chemical Biology Hefei National Research Center for Interdisciplinary Sciences at the MicroscaleHefei 230026China National Chromatographic Research and Analysis Center Chinese Academy of SciencesDalian 116023China

Accurate chromosome segregation in mitosis depends on kinetochores that connect centromeric chromatin to spindle *** are captured by individual microtubules via a kinetochore constitutive centromere-associated network(CCAN)during chromosome *** contains 16 subunits,including CENP-W and ***,the molecular recognition and mitotic regulation of the CCAN assembly remain ***,we revealed that CENP-W binds to the histone fold domain and an uncharacterized N-terminal region of *** B phosphorylates CENP-W at threonine 60,which enhances the interaction between CENP-W and CENP-T to ensure robust metaphase chromosome alignment and accurate chromosome segregation in *** findings delineate a conserved signaling cascade that integrates protein phosphorylation with CCAN integrity for the maintenance of genomic stability.

关键词： mitosis kinetochore Aurora B CENP-T CENP-W phosphorylation

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现象溢出与意识的分离主义

科学技术哲学研究 2024年第1期41卷 31-37页

作者：王振华山东大学哲学与社会发展学院济南250013

现象意识与取用意识在经验上是否可分离?现象溢出命题认为现象意识内容超出了取用意识容量,所以它们有着不同的神经实现,从而支持了分离主义;现象稀疏命题则认为可以通过对盲视、注意与错觉的解释消解了溢出命题,意识本质上其实是稀疏的... 详细信息

现象意识与取用意识在经验上是否可分离?现象溢出命题认为现象意识内容超出了取用意识容量,所以它们有着不同的神经实现,从而支持了分离主义;现象稀疏命题则认为可以通过对盲视、注意与错觉的解释消解了溢出命题,意识本质上其实是稀疏的,因此,它支持了反分离主义。文章认为,现象稀疏命题虽然拒绝承认溢出命题,但它所提供的论据并没有将其驳倒。相反,现象溢出是更为合理的,从而支持了分离主义。

关键词：现象意识取用意识现象溢出现象稀疏分离主义

Mental health and insomnia problems in healthcare workers after the COVID-19 pandemic:A multicenter cross-sectional study

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World Journal of Psychiatry 2024年第5期14卷 704-714页

作者： Wei Ding Min-Zhong Wang Xian-Wei Zeng zhen-hua Liu Yao Meng Hui-Ting Hu Yuan Zhang Yu-Guang Guan Fan-Gang Meng Jian-Guo Zhang Shu Wang Department of Public Health Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina Department of Neurology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Neurosurgery Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Sleep Medicine Center Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Neurology The First Affiliated Hospital of Shandong First Medical UniversityJinan 250014Shandong ProvinceChina Department of Neurology Heze Mudan People’s HospitalHeze 274000Shandong ProvinceChina Neonatal Center Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Neurosurgery SanBo Brain HospitalCapital Medical UniversityBeijing 100093China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

BACKGROUND Healthcare workers(HCWs)are at increased risk of contracting coronavirus disease 2019(COVID-19)as well as worsening mental health problems and *** problems can persist for a long period,even after the ***,less is known about this *** To analyze mental health,insomnia problems,and their influencing factors in HCWs after the COVID-19 *** This multicenter cross-sectional,hospital-based study was conducted from June 1,2023 to June 30,2023,which was a half-year after the end of the COVID-19 ***-stratified population-based cluster sampling was applied at the provincial level for Chinese *** such as anxiety,depression,and insomnia were evaluated by the Generalized Anxiety Disorder-7,Patient Health Questionnaire-9,and Insomnia Severity *** influencing the symptoms were identified by multivariable logistic *** A total of 2000 participants were invited,for a response rate of 70.6%.A total of 1412 HCWs[618(43.8%)doctors,583(41.3%)nurses and 211(14.9%)nonfrontline],254(18.0%),231(16.4%),and 289(20.5%)had symptoms of anxiety,depression,and insomnia,respectively;severe symptoms were found in 58(4.1%),49(3.5%),and 111(7.9%)of the ***,female sex,and hospitalization for COVID-19 were risk factors for anxiety,depression,and insomnia symptoms;moreover,death from family or friends was a risk factor for insomnia *** the COVID-19 outbreak,most[1086(76.9%)]of the participating HCWs received psychological interventions,while nearly all[994(70.4%)]of them had received public psychological *** 102(7.2%)of the HCWs received individual counseling from *** Although the mental health and sleep problems of HCWs were relieved after the COVID-19 pandemic,they still faced challenges and greater risks than did the general *** risk factors would help in providing targeted *** addition,although a major proportion of

关键词： COVID-19 Mental health Psychological symptoms Insomnia Sleep disorders Cross-sectional study Epidemiological study

Transparent cap adjusted the stent placed for stenosis after endoscopic injection of esophageal varices:A case report

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World Journal of Clinical Cases 2024年第15期12卷 2614-2620页

作者： fu-Long Zhang Jing Xu Yuan-Dong Zhu Qian-Neng Wu Yan Shi Lei Fang Dan Zhou Hai Wang Chao-Junhuang Chun-hua Zhou Qun Zhu Department of Gastroenterology Hangzhou Xixi hospitalHangzhou 310023Zhejiang ProvinceChina Department of Hepatopathy Hangzhou Xixi hospitalHangzhou 310023Zhejiang ProvinceChina

BACKGROUND The stent embedded in the esophageal mucosa is one of the complications after stenting for esophageal *** present a case of stent adjustment with the aid of a transparent cap after endoscopic injection of an esophageal varices *** SUMMARY A 61-year-old male patient came to the hospital with discomfort of the chest after the stent implanted for the stenosis because of endoscopic injection of esophageal *** gastroscopy was performed,and the stent embedded into the esophageal *** first,we pulled the recycling line for shrinking the stent,however,the mucosa could not be removed from the *** a forceps was performed to remove the mucosa in the stent,nevertheless,the bleeding form the mucosa was *** then,we used a transparent cap to scrape the mucosa along the stent,and the mucosa were removed successfully without *** A transparent cap helps gastroscopy to remove the mucosa embedded in the stent after endoscopic injection of the esophageal varices stent.

关键词： Stent Transparent cap Stenosis Endoscopic injection Esophageal varices Case report