Immunotherapeutic hydrogel for co-delivery of STAT3 siRNA liposomes and lidocaine hydrochloride for postoperative comprehensive management of NSCLC in a single application

作     者：Xianglei Fu Yanbin Shi Zili Gu Hengchang Zang Lian Li Qingjie Wang Yongjun Wang Xiaogang Zhao Hang Wu Shengnan Qiu Yankun Zhang Jiamin Zhou Xiangqin Chen Hua Shen Guimei Lin Xianglei Fu;Yanbin Shi;Zili Gu;Hengchang Zang;Lian Li;Qingjie Wang;Yongjun Wang;Xiaogang Zhao;Hang Wu;Shengnan Qiu;Yankun Zhang;Jiamin Zhou;Xiangqin Chen;Hua Shen;Guimei Lin

作者机构：Department of PharmaceuticsSchool of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China School of Mechanical and Automotive EngineeringQilu University of Technology(Shandong Academy of Sciences)Jinan 250353China Department of RadiologyLeiden University Medical CenterAlbinusdreef 22333 ZA LeidenNetherlands NMPA Key Laboratory for Technology Research and Evaluation of Drug ProductsSchool of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Laboratory of Basic Medical SciencesQilu HospitalShandong UniversityJinan 250063China Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China Department of Thoracic SurgeryThe Second Hospital of Shandong UniversityJinan 250033China 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2024年第19卷第3期

页      面：115-130页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China[grant numbers 21873057,22373059] the Natural Science Foundation of Shandong Province[grant numbers ZR2023MB082] 

主　　题：Liposome Hydrogel Signal transducer and activator of transcription 3 Non-small cell lung cancer Macrophage 

摘      要：Despite standard treatment for non-small cell lung cancer(NSCLC)being surgical resection,cancer recurrence and complications,such as induction of malignant pleural effusion(MPE)and significant postoperative pain,usually result in treatment *** this study,an alginate-based hybrid hydrogel(SOG)is developed that can be injected into the resection surface of the lungs during ***,endoplasmic reticulum-modified liposomes(MSLs)pre-loaded with the signal transducer and activator of transcription 3(STAT3)small interfering RNA and lidocaine hydrochloride are encapsulated in *** applied,MSLs strongly downregulated STAT3 expression in the tumor microenvironment,resulting in the apoptosis of lung cancer cells and polarization of tumor-associated macrophages towards the M1-like ***,the release of lidocaine hydrochloride(LID)was beneficial for pain relief and natural killer cell *** data demonstrated MSL@LID@SOG not only efficiently inhibited tumor growth but also potently improved the quality of life,including reduced MPE volume and pain relief in orthotopic NSCLC mouse models,even with a single ***@LID@SOG shows potential for comprehensive clinical management upon tumor resection in NSCLC,and may alter the treatment paradigms for other cancers.