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Plasmodium yoelii infection inhibits murine leukaemia WEHI-3 cell proliferation in vivo by promoting immune responses

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Infectious Diseases of Poverty 2018年第1期7卷 472-479页

作者： zhen-zhen tong zheng-Ming Fang Qi Zhang Yun Zhan Yue Zhang Wan-Fang Jiang Xiao Hou Yong-Long Li Ting Wang Department of Parasitology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Immunology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina

Background:Leukaemia is a malignant leukocyte disorder with a high fatality rate,and current treatments for this disease are ***,new therapeutic strategies for leukaemia must be *** parasite infection has been shown to be effective at combating certain neoplasms in animal *** study is to demonstrate the anti-leukaemia activity of malaria parasite Plasmodium yoelii(***)infection,.Methods:In this study,the proportion of CD3,CD19,CD11b and Mac-3 cells was analysed by flow cytometry;the levels of IFN-γand TNF-αin individual serum samples were measured by enzyme-linked immunosorbent assay,and the phagocytic activity of macrophages and natural killer(NK)cell activity were measured by flow ***:We found that *** infection significantly attenuated the growth of WEHI-3 cells in *** addition,tumor cell infiltration into the murine liver and spleen was markedly *** also demonstrated that malaria parasite infection elicited anti-leukaemia activity by promoting immune responses,including increasing the surface markers of T cells(CD3)and B cells(CD19);decreasing the surface markers of monocytes(CD11b)and macrophages(Mac-3);inducing the secretion of IFN-γand TNF-α;and increasing NK cell and macrophage ***:Malaria parasite infection significantly decreases the number of myeloblasts and inhibits neoplasm proliferation in *** addition,malaria parasite infection inhibits murine leukaemia by promoting immune responses.

关键词： Leukaemia Plasmodium yoelii WEHI-3 cells Anti-leukaemia

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Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige Jiang Dexiang Liu Tingting Li Chengcheng Gai Danqing Xin Yijing Zhao Yan Song Yahong Cheng tong Li zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

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眼前段生物测量值与2型糖尿病患者视网膜病变程度的相关性研究

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中国现代医学杂志 2021年第21期31卷 8-13页

作者：陈妍鹏仝真真冯建梅赵亭亭李毅河北北方学院附属第一医院眼科河北张家口075000

目的探讨眼前段生物测量值与2型糖尿病(T2DM)患者视网膜病变程度的相关性。方法选取2019年3月—2021年3月河北北方学院附属第一医院收治的T2DM患者156例,根据糖尿病性视网膜病变(DR)程度,将其分为无糖尿病性视网膜病变(NDR)组(51例)、... 详细信息

目的探讨眼前段生物测量值与2型糖尿病(T2DM)患者视网膜病变程度的相关性。方法选取2019年3月—2021年3月河北北方学院附属第一医院收治的T2DM患者156例,根据糖尿病性视网膜病变(DR)程度,将其分为无糖尿病性视网膜病变(NDR)组(51例)、非增殖型糖尿病性视网膜病变(NPDR)组(54例)、增殖型糖尿病性视网膜病变(PDR)组(51例)。比较各组患者眼前段生物测量值;采用Spearman法分析角膜厚度、前房深度、眼轴长度与DR程度的相关性;比较不同程度DR患者的一般资料;采用Logistic回归分析PDR的影响因素。结果与NDR组比较,NPDR组和PDR组球镜屈光度增大,角膜厚度增厚,前房深度变浅,眼轴长度缩短(P0.05)。Spearman相关性分析结果显示,角膜厚度与DR程度呈正相关(rs=0.882,P=0.000);前房深度、眼轴长度与DR程度呈负相关(rs=-0.921和-0.886,均P=0.000)。与NPDR组比较,PDR组T2DM病程延长,糖尿病周围神经病变(DPN)占比及尿微量白蛋白(mALB)水平升高(P<0.05)。Logistic回归分析结果显示,T2DM病程长[O^R=6.404(95%CI:3.358,9.451)]、DPN占比高[O^R=2.591(95%CI:1.153,4.029)]、mALB水平高[O^R=3.353(95%CI:2.365,4.342)]、角膜厚度厚[O^R=3.200(95%CI:2.086,4.313)]、前房深度浅[O^R=0.384(95%CI:0.124,0.645)]、眼轴长度短[O^R=0.408(95%CI:0.245,0.571)]是PDR的危险因素(P<0.05)。结论角膜厚度、前房深度、眼轴长度与DR程度有相关性,且角膜厚度厚、前房深度浅、眼轴长度短是PDR的危险因素。

关键词： 2型糖尿病糖尿病性视网膜病变眼前段生物测量值病变程度

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正常人眼全角膜点扩散函数的分析(英文)

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国际眼科杂志 2015年第4期15卷 577-583页

作者：陈妍鹏郭旭郭俊红王芳仝真真齐天梅李毅河北北方学院附属第一医院眼科中国河北省张家口市075000 张家口市第二医院骨科中国河北省张家口市075000

目的:探讨不同瞳孔直径下正常人眼全角膜总像差的斯特列尔比(strehl ratio,SR)与总高阶像差SR的正常值及其与调制传递函数(modulation transfer function,MTF)的关系。方法:应用SIRIUS 3D角膜地形图仪对200例(400眼)进行全角膜总像差的S... 详细信息

目的:探讨不同瞳孔直径下正常人眼全角膜总像差的斯特列尔比(strehl ratio,SR)与总高阶像差SR的正常值及其与调制传递函数(modulation transfer function,MTF)的关系。方法:应用SIRIUS 3D角膜地形图仪对200例(400眼)进行全角膜总像差的SR和总高阶像差的SR检查,并分析相对应的均方根值(root-mean-square,RMS)。结果:在不同瞳孔直径组下(3.0,5.0,6.0,7.0mm)全角膜总像差100'SR值为0.45±0.12,0.25±0.06,0.17±0.05,0.13±0.04;总高阶像差100'SR值为0.69±0.14,0.34±0.07,0.24±0.05,0.16±0.04;全角膜总像差200'SR值为0.45±0.12,0.24±0.06,0.20±0.04,0.16±0.03;总高阶像差200'SR值为0.70±0.13,0.35±0.07,0.27±0.06,0.20±0.04,各组均逐渐变小;全角膜总像差SR值和总高阶像差SR值与对应的RMS值之间均存在负相关性。当瞳孔直径小时,总像差SR值与MTF值的高频区相关性较高,而当瞳孔直径大时,总像差SR值与MTF值的低频区相关性较高。结论:正常人全角膜总像差的SR值和总高阶像差的SR值能够很好地反映其视觉质量。

关键词：点扩散函数斯特列尔比瞳孔直径均方根值调制

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2D/2D heterostructured MoS_(2)/PtSe_(2) promoting charge separation in FTO thin film for efficient and stable photocatalytic hydrogen evolution

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Rare Metals 2022年第5期41卷 1735-1742页

作者： Shu-tong Wan Hao-tong Li zhen-Hui Ma He-Chuan Zhang Yan-zhen zheng Beijing Key Laboratory of Green Recovery and Extraction of Rare and Precious Metals University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Department of Physics Beijing Technology and Business UniversityBeijing 100037China

Exploiting stable photocatalytic films is of practical significance for solar energy-hydrogen conversion and pollutant degradation, yet remains a big challenge so far. In this work, we report a highly stable photocatalytic film, i.e.,MoS_(2)/PtSe_(2)/FTO by sequential growing PtSe_(2) and MoS_(2) onto commercially fluorine-doped tin oxide(FTO) substrates using two round thermal evaporation and chemical vapor deposition(CVD) process.

关键词： film FTO separation

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Studies of internal magnetic fluctuation in the HL-1M tokamak

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核聚变与等离子体物理 2005年第1期25卷 42-48页

作者： zhenGYong-zhen DINGXuan-tong LIWen-zhong SouthwesternInstituteofPhysics Chengdu610041

The transport of runaway electrons in a hot plasma can be comparatively easily measured in steady state or perturbation experiments, which provide runaway electron diffusivity Dr. The diffusivity can be interpreted in terms of the magnetic fluctuation level. The runaway electron diffusion coefficient is determined by internal magnetic fluctuations. The internal magnetic fluctuations level （r/BT） is estimated to be about （2～4） ×10-4 in the HL-1M plasma. The results demonstrate the effectiveness of using runaway transport techniques for determining internal magnetic fluctuations. A profile of the magnetic fluctuation level in the HL-1M tokamak can be estimated from Dr.

关键词：内禀磁波动扩散系数热等离子体稳定性失控电子传输

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Variational Gridded Graph Convolution Network for Node Classification

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IEEE/CAA Journal of Automatica Sinica 2021年第10期8卷 1697-1708页

作者： Xiaobin Hong tong Zhang zhen Cui Jian Yang Key Laboratory of Intelligent Perception and Systems for High-Dimensional Information of Ministry of Education School of Computer Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China

The existing graph convolution methods usually suffer high computational burdens,large memory requirements,and intractable *** this paper,we propose a high-efficient variational gridded graph convolution network(VG-GCN)to encode non-regular graph data,which overcomes all these aforementioned *** capture graph topology structures efficiently,in the proposed framework,we propose a hierarchically-coarsened random walk(hcr-walk)by taking advantage of the classic random walk and node/edge *** hcr-walk greatly mitigates the problem of exponentially explosive sampling times which occur in the classic version,while preserving graph structures *** efficiently encode local hcr-walk around one reference node,we project hcrwalk into an ordered space to form image-like grid data,which favors those conventional convolution *** of the direct 2-D convolution filtering,a variational convolution block(VCB)is designed to model the distribution of the randomsampling hcr-walk inspired by the well-formulated variational *** experimentally validate the efficiency and effectiveness of our proposed VG-GCN,which has high computation speed,and the comparable or even better performance when compared with baseline GCNs.

关键词： Graph coarsening gridding node classification random walk variational convolution

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Synthesis of Octapod Cu-Au Bimetallic Nanocrystal with Concave Structure through Galvanic Replacement Reaction

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Journal of Electronic Science and Technology 2020年第2期18卷 151-158页

作者： zhen-Ni Wang Qiang Li zhen-Huan Zhao Xiao-Mei tong School of Advanced Materials and Nanotechnology Xidian UniversityXi’an 710126

We synthesized octapod Cu-Au bimetallic alloy with a concave structure by employing a replacement reaction between Au PPh3Cl and Cu nanocubes. Using the Cu nanocube as sacrificial templates, we have successfully generated high-active sites on alloy nanocrystals by carefully tuning the replacement reaction and growth. The key is to afford the proper concentration of Au PPh3Cl-TOP to the reaction solution. When the Au precursor with high concentration is injected into the galvanic replacement reaction, the growth dominated the process and hollowed octapod Cu-Au alloy was obtained. In contrast, when the concentration of the Au precursor is low, the replacement reaction can only take place at the nanocrystals, leading to generate Cu-Au nanocages. This work provides an effective strategy for the preparation of hollow bimetallic nanocrystals with high-active sites.

关键词： solution. crystal concave

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Regulation of aging by NELF-A and RNA polymerase Ⅱ elongation

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Neural Regeneration Research 2024年第7期19卷 1415-1416页

作者： Chin-tong Ong zhen-Kai Ngian Temasek Life Sciences Laboratory and Department of Biological Sciences National University of SingaporeSingaporeSingapore Department of Genetics Harvard Medical SchoolBostonMAUSA Institute of Molecular and Cell Biology Agency for ScienceTechnology and ResearchSingaporeSingapore

Epigenetic regulation of aging:Aging is defined as the gradual decline of physiological function and cellular integrity,causing o rganismal vulnerability to age-onset diseases and *** in different animal models have l... 详细信息

关键词： aging twelve integrity

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Tensile properties and fractographs of Ti–2.5Al–1.5Mn foils at different temperatures

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Rare Metals 2017年第4期36卷 247-255页

作者： zhen-Wu Ma Guo-Quan tong Feng Chen College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016China

The tensile properties and fractographs of Ti- 2.5Al-1.5Mn foils at different temperatures were investi- gated. It is observed that material properties closely cor- relate with the thickness （T） to grain size （d） ratio and deformation temperature. Tensile analysis shows that local deformation is the main deformation feature in foils forming at room temperature, which may lead to premature fracture. The causes of inhomogeneous deformation behavior are the limited number of deformable grains contained in deformation zone and the weak transferability of hardening among different grains. Fracture analysis reveals that the size of dimples can represent the ductility of foils at room temperature. With the further increase of deformation temperature, the main plastic deformation mode of foils is transformed from intragranular disloca- tions and twin crystal to grain-boundary gliding and roll- ing. In conclusion, foil forming at elevated temperature can increase the hardening transferability and the number of deformable grains in deformation zone, which is an effective method to improve the formability and reduce the scatter of material properties.

关键词： Size effects Titanium foils Tensile properties Homogeneous deformation Elevated temperature

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