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Impact of adverse childhood experiences on the symptom severity of different mental disorders: a cross-diagnostic study

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General Psychiatry 2022年第2期35卷 127-136页

作者： Wenjie gu Qing Zhao Chengmei Yuan zhenghui yi Min Zhao zhen Wang Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai China

Background Adverse childhood experiences have a significant impact on different mental *** To compare differences in adverse childhood experiences among those with different mental disorders and their relationships in a cross-disorder *** The study included 1513 individuals aged≥18 years:339 patients with substance use disorders,125 patients with schizophrenia,342 patients with depression,136 patients with bipolar disorder,431 patients with obsessive-compulsive disorder(OCD),and 140 healthy *** Early Trauma Inventory Self Report-Short Form was used to investigate childhood traumatic experiences,and the Addiction Severity Index,Positive and Negative Syndrome Scale,Hamilton Depression Scale,Young Mania Rating Scale,and Yale-Brown Obsessive-Compulsive Scale were used to assess mental disorder *** and multivariate logistic regression were analysed between adverse childhood experiences and clinical *** Levels of adverse childhood experiences were significantly different among different mental ***,25.8%of patients with substance use disorders reported childhood trauma,which was significantly higher than found in the other four psychiatric disorder *** abuse scores were positively correlated with disease severity:the higher the total trauma score,the more severe the mental *** Adverse childhood experiences are a common phenomenon in those with mental disorders,and the level of trauma affects mental disorder *** abuse is closely related to many mental *** incidence or severity of mental disorders can be reduced in the future by reducing the incidence of adverse childhood experiences or by timely intervention in childhood trauma.

关键词： severity disorders childhood

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Cargo-encapsulated cells for drug delivery

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Science China(Life Sciences) 2020年第4期63卷 599-601页

作者： Zhaowei Chen Di Wen zhen gu MOE Key Laboratory for Analytical Science of Food Safety and Biology College of ChemistryFuzhou UniversityFuzhou 350108China Department of Bioengineering University of CaliforniaLos AngelesCA 90095USA California NanoSystems Institute University of CaliforniaLos AngelesCA 90095USA Jonsson Comprehensive Cancer Center University of CaliforniaLos AngelesCA 90095USA Center for Minimally Invasive Therapeutics University of CaliforniaLos AngelesCA 90095USA

Synthetic micro-/nanoparticle(MNP)carriers,either organic or inorganic ones,have advanced considerably in recent years for drug delivery with the aim of enhancing drug solubility/stability,reducing systemic toxicity and increasing dosing at pathological sites(Chen and Liang,2018;Xiang et al.,2018).Specially,the properties of MNPs,such as size,morphology,or surface groups,can be easily modulated to maximize their potency in delivering drugs to the targeted areas(Ran and Xue,2018).Nevertheless,till now,only a handful of MNPs have been approved by the US Food and Drug Administration for clinical *** numerous proof-of-concept studies of MNPs in animal models are in progress or are being clinically evaluated,synthetic MNPs are still struggling to reach the clinical expectations.

关键词： proof solubility inorganic

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Evaluation of perceived value and behavioral intentions of citizens in Chinese commercially open communities:A case study of Liuyun Community

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Frontiers of Architectural Research 2024年第5期13卷 1022-1038页

作者： Yuanyi Xie Zijian Miao Xinyue gu Wenchu Zhang Zipei zhen yi Huang Department of Urban Planning College of Architecture and Urban PlanningTongji UniversityShanghai 200092China School of Architecture South China University of TechnologyGuangzhou 510641China Department of Land Surveying and Geo-Informatics The Hong Kong Polytechnic UniversityHong Kong 999077China Graduate School of Design Harvard UniversityCambridgeMA 02138USA School of Architecture Southeast UniversityNanjing 210096China State Key Laboratory of Subtropical Building and Urban Science South China University of TechnologyGuangzhou 510641China

As urban development shifts from the incremental era to the stock era,urban design is becoming increasingly focused on high-quality living and human ***,the opening of traditional communities has been insufficiently *** study took Liuyun Community,a typical open community in guangzhou(China)that has undergone a transformation from residential to commercial use,as its research ***,more than 300 residents,tourists,and merchants were surveyed via questionnaires administered in field investigations and ***,the data from the completed questionnaires were used to construct a structural equation model consisting of five dimensions,namely commercial service value,cost value,risk value,perceptual value,and social *** data were then analyzed to determine the correlations between perceived value and behavioral intention,satisfaction,and other psychological *** following results were obtained:(1)As commercial activities in the community increased,the influence of social value,cost value,and commercial service value on behavioral intention decreased.(2)The open community inevitably had negative impacts on its ***,these negative impacts were mitigated to some extent by high levels of social value.(3)Perceptions of commercial service value varied between groups.

关键词： Residential area Commercial activity Perceived value Citizens’behavioral intentions Open community Liuyun Community

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On Subsonic and Subsonic-Sonic Flows with General Conservatives Force in Exterior Domains

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Acta Mathematicae Applicatae Sinica 2023年第1期39卷 3-16页

作者： Xumin gu Tian-yi WANG Department of Mathematics Shanghai University of Finance and EconomicsShanghai 200433China Department of Mathematics School of ScienceWuhan University of TechnologyWuhan 430070China The Institute of Mathematical Sciences the Chinese University of Hong KongShatinN.T.Hong Kong Gran Sasso Science Institute viale Francesco Crispi767100 L'AquilaItaly

In this paper, we study the irrotational subsonic and subsonic-sonic fows with general conservative forces in the exterior domains. The conservative forces indicate the new Bernoulli law naturally. For the subsonic case, we introduce a modified cut-off system depending on the conservative forces which needs the varied Bers skill, and construct the solution by the new variational formula. Moreover, comparing with previous results, our result extends the pressure-density relation to the general case. Afterwards we obtain the subsonic-sonic limit solution by taking the extract subsonic solutions as the approximate sequences.

关键词： steady fow homentropic irrotation subsonic fow subsonic-sonic limit

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Engineering platelet-mimicking drug delivery vehicles

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Frontiers of Chemical Science and Engineering 2017年第4期11卷 624-632页

作者： Quanyin Hu Hunter N. Bomba zhen gu Joint Department of Biomedical Engineering University of North Carolina at Chapel Hill and North Carolina State University Raleigh USA Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill USA Department of Medicine University of North Carolina School of Medicine Chapel Hill USA

Platelets dynamically participate in various physiological processes, including wound repair, bacterial clearance, immune response, and tumor metastasis. Recreating the specific biological features of platelets by mimicking the structure of the platelet or translocating the platelet membrane to synthetic particles holds great promise in disease treatment. This review highlights recent advancements made in the platelet-mimicking strategies. The future opportunities and translational challenges are also discussed.

关键词： drug delivery platelets nanomedicine,bio-inspired biomimetic

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Generation of double pulses at the Shanghai soft X-ray free electron laser facility

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Nuclear Science and Techniques 2017年第3期28卷 7-12页

作者： zhen Wang Chao Feng Qiang gu Li-Hua Yu zhen-Tang Zhao Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China Shanghai Sciences Research Center Chinese Academy of Sciences Shanghai 201204 China Graduate University of Chinese Academy of Sciences Beijing 100049 China National Synchrotron Light Source Brookhaven National Laboratory Upton NY 11973 USA

In this article, we present the promise of a new method generating double electron pulses in picosecondscale pulse length and tunable interpulse spacing at several picoseconds. This has witnessed an impressive potential of application in pump–probe techniques, two-color X-ray free electron laser, high-gradient witness bunch acceleration in a plasma, etc. Three-dimensional simulations are carried out to analyze the dynamic of the electron beam in a linear accelerator. Comparisons are made between the new method and existing ways.

关键词： Free electron laser Double pulses SXFEL

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An integrated software system for analyzing nanopore data

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Chinese Science Bulletin 2014年第35期59卷 4942-4945页

作者： Na Zhang Yong-Xu Hu zhen gu yi-Lun ying Pin-Gang He yi-Tao Long Department of Chemistry East China Normal University Key Laboratory for Advanced Materials Department of ChemistryEast China University of Science and Technology

We presented an integrated software system for analyzing nanopore *** self-developed software provided rapid processes for accurate location,classification,and evaluation of every individual *** the proposed software,statistical analysis could be achieved easily and *** results of β-Amyloid 42 demonstrated that our data process could rapidly extract duration time and current *** addition,our data process could accurately carry out statistical fittings.

关键词：软件系统数据集成纳米孔统计分析数据处理淀粉样蛋白分析数据自主研发

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Rule-and PSO Algorithm-based Dynamic Spatial Rescheduling Method for Hull Curved Block Construction

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Chinese Journal of Mechanical Engineering 2013年第3期26卷 594-605页

作者： ZHANG Zhiying gu Jiayu XU Chen LI zhen School of Mechanical Engineering Tongji University State Key Laboratory of Estuarine and Coastal Research East China Normal University

Due to no effective rescheduling method in hull curved block construction planning, existing scheduling planning can’t be applied in practical production effectively. Two-dimensional layout and dynamic attributes of block construction planning are considered to develop a spatial rescheduling method, which is based on the spatial points searching rule and the particle swarm optimization(PSO) algorithm. A dynamic spatial rescheduling method is proposed to solve the manufacturing problem of rush-order blocks. Through spatial rescheduling, the rescheduling start time, the current processing information set and rescheduling blocks set can be obtained automatically. By using and updating the data of these sets, the rescheduling method combines the PSO algorithm with the spatial points searching rule to determine the rescheduling start time and layout of the blocks. Three types of dynamic events, including rush-order block delay, existing block delay and existing block position changes, are used to address problems with different function goals by setting different function weights. Finally, simulations based on three types of rush-order block events are performed to validate this method, including single rush-order block, multi rush-order blocks at the same time and multi rush-order blocks at different times. The simulation results demonstrate that this method can solve the rush-order block problems in hull block construction and reduce the interference to the existing manufacturing schedule. The proposed research provides a new rescheduling method and helps instruct scheduler to make production planning in hull block construction.

关键词： spatial scheduling rush-order block event particle swarm optimization dynamic rescheduling

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Hybrid particle swarm optimization for multiobjective resource allocation

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Journal of Systems Engineering and Electronics 2008年第5期19卷 959-964页

作者： yi Yang Li Xiaoxing gu Chunqin Computer Science Dept. Sun Yat-sen Univ. Guangzhou 510275 P. R. China

Resource allocation （RA） is the problem of allocating resources among various artifacts or business units to meet one or more expected goals, such a.s maximizing the profits, minimizing the costs, or achieving the best qualities. A complex multiobjective RA is addressed, and a multiobjective mathematical model is used to find solutions efficiently. Then, all improved particie swarm algorithm （mO_PSO） is proposed combined with a new particle diversity controller policies and dissipation operation. Meanwhile, a modified Pareto methods used in PSO to deal with multiobjectives optimization is presented. The effectiveness of the provided algorithm is validated by its application to some illustrative example dealing with multiobjective RA problems and with the comparative experiment with other algorithm.

关键词： resource allocation multiobjective optimization improved particle swarm optimization.

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Classification of hypersurfaces with two distinct principal curvatures and closed Mbius form in S^(m+1)

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Science China Mathematics 2012年第7期55卷 1463-1478页

作者： LINLiMiao gu0zhen DepartmentofMathematics EastChinaNormalUniversityShanghai200241China DepartmentofMathematics YunnanNormalUniversityKunming650092China

Let x be an m-dimensional umbilic-free hypersurface in an （m＋1）-dimensional unit sphere Sm＋l （m≥3）. In this paper, we classify and explicitly express the hypersurfaces with two distinct princi- pal curvatures and closed MSbius form, and then we characterize and classify conformally flat hypersurfaces of dimension larger than 3.

关键词： moebius geometry principal curvature conformally fiat MSbius form

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