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Relationship between Levels of Testosterone and Cortisol in Saliva and Aggressive Behaviors of Adolescents

Biomedical and Environmental Sciences 2009年第1期22卷 44-49页

作者： yi-zhen YU AND JUN-XIA SHI Department of Child and Adolescent Health and Maternal Care School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei China Xiamen Maternity and Child Hospital Xiamen 361003 Fujian China

Objective To explore the endocfinal factors which influence the aggressive behavior of adolescents. Methods The levels of cortisol （CORT）, testosterone （T）, prolactin （PRL）, and growth hormone （GH） in saliva from 20 aggressive students and 20 non-aggressive control students were measured by radioimmunoassay （RIA）. The students were matched for their gender, age, grade, stage of pubertal development, and economic status of their families. Results The salivary T levels were 22.20±14.50 pg/mL and 19.54±12.52 pg/mL in aggressive male and female students, 13.20±6.85 pg/mL and 5.24±3.03 pg/mL in non-aggressive male and female students （P〈0.05）. The male aggressive students had a lower level of CORT in saliva than non-aggressive male students （P〈0.05）. There were no significant differences in the salivary levels of PRL or GH between the aggressive and non-aggressive groups. Correlation analysis revealed a negative relationship in male students between the salivary CORT levels and the aggression factor scores of the child behavior checklist （CBCL）. In addition, the data also showed a positive relationship between the salivary T levels and the aggression factor scores of CBCL in female students. Multiple linear regression analysis showed that the salivary CORT level was an independent predictive factor for aggressive behaviors in adolescent boys. The higher the CORT level, the less aggressive the boys were. Conclusion CORT and T levels may play a certain role in adolescent aggressive behaviors.

关键词： Adolescents Aggressive behavior Testosterone (T) Cortisol (CORT)

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Influence of excavation schemes on slope stability: A DEM study

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Journal of Mountain Science 2020年第6期17卷 1509-1522页

作者： WANG zhen-yu gu Dong-ming ZHANG Wen-gang Key Laboratory of New Technology for Construction of Cities in Mountain Area Chongqing UniversityChongqing 400045China School of Civil Engineering Chongqing UniversityChongqing 400045China National Joint Engineering Research Center of Geohazards Prevention in the Reservoir Areas Chongqing UniversityChongqing 400045China

Slope failure due to improper excavation is one of common engineering disasters in *** explore the failure mechanism of soil slope induced by toe excavation,especially to investigate the influence of excavation unloading path and rate on slope stability,a numerical slope model was built via particle flow code PFC2 *** development of crack and strain during excavation were obtained and used to evaluate the deformation ***,excavation types representing different unloading paths and rates were compared in terms of crack number and strain *** indicate that crack number and strain level induced by horizontal column excavation are much greater than those of vertical column excavation and oblique *** crack number and strain level increase with excavation unloading ***,the feasibility of taking the average strain of slope surface and the average value of maximum strain along monitoring lines to represent the global deformation characteristics were *** study can provide a theoretical guidance for slope monitoring and preliminary optimal selection of excavation scheme in the design and construction of slope engineering.

关键词： Slope toe excavation Unloading path Unloading rate Strain distribution Slope stability Discrete element method

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Detection and significance of higher thiadiamondoids and diamondoidthiols in oil from the Zhongshen 1C well of the Tarim Basin, NW China

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Science China Earth Sciences 2018年第10期61卷 1440-1450页

作者： Anlai MA Zhijun JIN Cuishan ZHU yi gu Sinopec Petroleum Exploration & Production Research Institute Beijing 100083 China State Key Laboratory of Organic Geochemistry Guangzhou 510640 China College of Resources and Environment Yangtze UniversityWuhan 430100 China

Oil and gas breakthroughs have been achieved in the Zhongshen 1(ZS1) and 1 C(ZS1 C) wells in Cambrian pre-salt from the Tarim Basin in northwest China. However, Middle and Lower Cambrian reservoirs reveal substantial differences in the geochemistry and secondary alteration characteristics between the oils collected from the two wells. High concentrations of thiadiamondoids and diamondoidthiols, including thiatetramantanes, tetramantanethiols, thiapentamantanes, and pentamantanethiols, are detected in the organic sulfur compound fraction of concentrated oil collected from the ZS1 C well, which samples the Lower Cambrian Xiaoerbulake Formation. Higher diamondoids, such as tetramantanes, pentamantanes, hexamantanes, and cyclohexamantane, also occur in the saturate fractions of the concentrated ZS1 C oil. The presence of these compounds is verified by mass spectra analysis and comparison with previous studies. During thermochemical sulfate reduction(TSR), the cage of higher diamondoids is interpreted to open because of sulfur radicals forming open-cage higher diamondoid-like thiols, followed by cyclization that leads to the formation of high thiadiamondoids. Using D_(16)-adamantane as an internal standard, the concentrations of lower diamondoids and thiadiamondoids of non-concentrated Cambrian oil from well ZS1 C are 83874 and8578 μg/g, respectively, which are far higher than Cambrian oil from well ZS1 and most Ordovician oils in the Tarim Basin. The high concentrations of lower thiadiamondoids and occurrence of higher thiadiamondoids and diamondoidthiols support that the oil from well ZS1 C is a product of severe TSR alteration.

关键词： Tarim Basin Cambrian Well Zhongshen 1C Higher thiadiamondoid Higher diamondoidthiol Higher diamondoid,Therrnochemical sulfate reduction (TSR)

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Effect of dislocation structure evolution on low-angle grain boundary formation in 7050 aluminum alloy during aging

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International Journal of Minerals,Metallurgy and Materials 2015年第7期22卷 721-728页

作者： Wei gu Jing-yuan Li yi-de Wang School of Materials Science and Engineering University of Science and Technology Beijing

The effect of dislocation structure evolution on low-angle grain boundary formation in 7050 aluminum alloy during aging was studied by using optical microscopy, transmission electron microscopy, and electron backscatter diffraction analysis of misorientation angle distribution, cumulative misorientation and geometrically necessary dislocation （GND） density. Experimental results indicate that coarse spindle-shaped grains with the dimension of 200 μm- 80 μm separate into fine equiaxed grains of 20μm in size as a result of newborn low-angle grain boundaries formed during the aging process. More specifically, the dislocation arrays, which are rearranged and formed due to scattered dislocations during earlier quenching, transform into low-angle grain boundaries with aging time. The relative frequency of 3°-5° low-angle grain boundaries increases to over 30%. The GND density, which describes low-angle grain boundaries with the misorientation angle under 3°, tends to decrease during initial aging. The inhomogeneous distribution of GNDs is affected by grain orientation. A decrease in GND density mainly occurs from 1.83 × 10^13 to 4.40 × 10^11 m^-2 in grains with 〈111〉 fiber texture. This is consistent with a decrease of unit cumulative misorientation. Precipitation on grain boundaries and the formation of a precipitation free zone （PFZ） are facilitated due to the eroding activity of the Graft etchant. Consequently, low-angle grain boundaries could be readily viewed by optical microscopy due to an increase in their electric potential difference.

关键词： aluminum alloys low-angle grain boundaries dislocation structure aging dislocation density

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Testosterone replacement therapy： dilemmas and challenges in China and Asia

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Asian Journal of Andrology 2018年第2期20卷 149-151页

作者： Qi An yi-Qun gu Graduate School Peking Union Medical College Beijing 100730 China Nationa Health and Family Planning Key Laboratory of Male Reproductive Health National Research Institute for Family Planning Beijing 100081 China

Late-onset hypogonadism （LOH） has been described as a clinical syndrome comprising symptoms consistent with androgen deficiency and a circulating concentration of testosterone in the low-to-normal range in some middle-aged and elderly men. The presence of symptoms may affect the health and quality of life in aging men and it has become a hot spot in global medical research, diagnosis, and treatment in the recent years.

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Molecular Modeling of the Chain Structures of Polybenzoxazines

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Chemical Research in Chinese Universities 2002年第3期18卷 367-369页

作者： LIU Xin gu yi State Key Laboratory of Polymer Materials Engineering Department of Polymer Materials Science and EngineeringSichuan UniversityChengdu 610065P.R.China

The structures and properties of benzoxazines were investigated by virtue of molecular modeling at a molecular level. By means of Cerius software(version 4.0) supplied by Molecular Simulations Inc., the molecular mechanics and the molecular dynamics were performed under a PCFF force field. Five kinds of the polymeric chains of benzoxazines were created by using polymer builder and energy minimization. The relaxation process was conducted with both energy minimization and molecular dynamics.

关键词： Polybenzoxazines Chain structure Molecular mechanics Molecular dynamics Quantum dynamics

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MEASUREMENT AND ANALYSIS OF LASER GENERATED RAYLEIGH AND LAMB WAVES CONSIDERING ITS PULSE DURATION

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Acta Mechanica Solida Sinica 2015年第5期28卷 441-452页

作者： zhen Zhang Yongdong Pan yi Xiao zheng Zhong School of Aerospace Engineering and Applied Mechanics Tongji University

In this article, laser generated Rayleigh and Lamb waves are studied by taking into account its pulse duration. The physical model and theoretical solution are presented to predict the corresponding waveforms for aluminum samples under the ablation generation regime. The waveforms of the excited Rayleigh and Lamb waves by laser with selected pulse duration were measured by laser interferometer and analyzed theoretically, and the agreement between measurement and analysis is demonstrated for the validation of the theoretical model and solution. The broadening of the Rayleigh wave and the disappearing of high order Lamb wave modes can be found with the increase of the pulse duration by the laser ultrasonic technique.

关键词： Rayleigh wave Lamb wave pulse duration laser ultrasonic technique

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碱-酶水解结合分散式固相萃取提高大豆异黄酮活性总量测定的准确性

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分析测试学报 2025年第1期44卷 106-115页

作者：顾文黎晨曼孙震庞月红冯永巍沈晓芳江南大学食品科学与资源挖掘全国重点实验室江苏无锡214122 无锡市食品安全检验检测中心国家市场监管技术创新中心(特殊食品)江苏无锡214142

通过碱性甲醇溶液超声提取,结合杏仁来源β-葡萄糖苷酶水解及聚酰胺分散式固相萃取步骤,建立了超高效液相色谱测定大豆异黄酮活性总量的方法。样品中的丙二酰及乙酰类大豆异黄酮苷在碱性条件下水解成基本型苷,并在β-葡萄糖苷酶的作用... 详细信息

通过碱性甲醇溶液超声提取,结合杏仁来源β-葡萄糖苷酶水解及聚酰胺分散式固相萃取步骤,建立了超高效液相色谱测定大豆异黄酮活性总量的方法。样品中的丙二酰及乙酰类大豆异黄酮苷在碱性条件下水解成基本型苷,并在β-葡萄糖苷酶的作用下进一步脱去糖基转变为相应的苷元。样品中12种不同形式的大豆异黄酮转变为仅含3种大豆异黄酮苷元(大豆苷元、黄豆黄素、染料木素)后,以聚酰胺粉进行分散式固相萃取,C_(18)反相色谱柱(2.1 mm i.d.×50 mm,1.8μm)分离。结果显示,大豆苷元、黄豆黄素及染料木素在3 min内实现基线分离,3种异黄酮苷元的标准曲线相关系数(r^(2))均大于0.999,总异黄酮的回收率为94.3%~102%,相对标准偏差(RSD,n=6)小于5.0%,具有较高的准确度和精密度。该方法通过检测样品中的全部苷元来计算异黄酮总量,有助于降低异黄酮检测在分离度、准确度及检测成本上带来的挑战;考虑异黄酮在体内的转化吸收机制和生理效应,以苷元总量计能更科学地反映实际的异黄酮活性水平,避免因通过苷和苷元的简单加和而造成对异黄酮含量水平的高估。

关键词：大豆异黄酮聚酰胺(PA) 分散式固相萃取(d-SPE) β-葡萄糖苷酶超高效液相色谱(UPLC)

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Loss of BRCA1 expression leads to worse survival in patients with gastric carcinoma

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World Journal of Gastroenterology 2013年第12期19卷 1968-1974页

作者： Zi-zhen Zhang Yuan Jie Charles Liu Xiao-Lu yin Ping Zhan yi gu Xing-Zhi Ni Department of General Surgery Renji Hospital School of Medicine Shanghai Jiaotong University Astra-Zeneca Innovation Center China

AIM: To investigate the expression deficiency of key molecular markers in the homologous recombination pathway. METHODS: Expression loss of breast cancer type 1 susceptibility protein (BRCA1), ataxia telangiectasia mutated (ATM), ATM-Rad3-related (ATR), mediator of DNA damage checkpoint protein 1 (MDC1) and meiotic recombination 11 (Mre11) were correlated with their clinicopathological parameters in gastric cancer (GC). One hundred and twenty treatment-naive GC samples were formalin-fixed and paraffin-embedded into tissue blocks. Two representative cores from each block were extracted and constructed into tissue microarrays. Expression levels of BRCA1, ATM, ATR, MDC1 and Mre11 were determined using immunohistochemical analysis, and correlated with clinical parameters, including age, gender, Lauren subtype, tumor grades, clinical stage and overall ***: Expression loss of BRCA1, ATM, ATR, MDC1, and Mre11 was found in 21.4%, 20.2%, 21.0%, 11.1% and 4.6%, respectively, of interpretable cases. BRCA1 loss was significantly associated with patients of diffused subtype (intestinal vs diffused, 8.2% vs 31.7%, P = 0.001), higher tumor grade (Ⅰ/Ⅱ vs Ⅲ, 10.7% vs 20.5;Ⅰ/Ⅱ vs Ⅳ, 10.7% vs 54.5%, P = 0.047) and advanced clinical stage (Ⅰ/Ⅱ vs Ⅲ, 12.9% vs 16.9%;Ⅰ /Ⅱ vs Ⅳ, 12.9% vs 45.5%, P = 0.006). MDC1 loss was significantly associated with patients of diffused subtype (intestinal vs diffused, 0% vs 19.7%, P = 0.001) and higher tumor grade (Ⅰ/Ⅱ vs Ⅲ, 0% vs 12%;Ⅰ/Ⅱ vs Ⅳ, 0% vs 30.8%, P = 0.012). In addition, the survival time of the patients with expression loss of BRCA1 was significantly shorter than those with positive expression of BRCA1 (2-year survival rate, 32.4% vs 62.8%, P = 0.015). No correlations were found between clinicopathological parameters and expression loss of ATM, ATR and Mre11. CONCLUSION: Our results support the hypothesis that homologous recombination deficiency plays an important role in the progression of gastric carcinoma. Loss of expression of

关键词： Homologous recombination deficiency Gastric cancer Breast cancer type 1 susceptibility protein Mediator of DNA damage checkpoint protein 1 Ataxia telangiectasia mutated Ataxia telangiectasia mutated-Rad3-related

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Approaches to Pendent Groups' Functionalization of Polyimide

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Chemical Research in Chinese Universities 2002年第1期18卷 95-102页

作者： FAN Hao-jun gu yi The State Key Laboratory of Polymer Engineering Department of Polymer Materials Science and EngineeringSichuan UniversityChengdu 610065P.R.China

Pendent groups' functionalization of polyimide is an optimum approach to improve its processability and achieve functionalized polyimide materials. There are two types of modification routes for pendent groups' functionalization of polyimide: monomer route and macromolecular route. In this paper, various approaches for pendent groups' functionalization of polyimide are introduced. At the same time, a new method to achieve functional polyimide materials without decreasing its thermal stability and mechanical properties is mentioned.

关键词： Polyimide Functional pendent group Approach

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