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Dianwang Jishu/Power System Technology 2025年第1期49卷 306-315页

作者： Zhou, Yang wang, Zhuding Zhang, Man Yang, jie Shu, Dongsheng State Key Laboratory of Power Transmission Equipment & System Security and New Technology Chongqing University Shapingba District Chongqing 400044 China Chongqing Electric Energy Star Inc Jiulongpo District Chongqing 400039 China Economic Research Institute of State Grid Hubei Electric Power Company Hubei Province Wuhan 430000 China

Based upon the existing research findings of distribution network planning，and based on the optimization division of power areas (or grid cells), a heuristic method of distribution network planning, i.e., the grid cell based distribution network planning method, is proposed to adapt to the gradual increase in the penetration rate of distributed resources, wherein the power balancing method involves differential approaches of different space-time-resources and two typical operating modes. The optimization division of grid cells is carried out by the principles of nearby use for distributed power resources and "nearby backup supply", resulting in the regional grid cell, substation grid cell, medium-voltage and low-voltage grid cell in terms of space, and also the energy output type, energy input type and balance type in terms of resources. The real planning example shows that the proposed method has relatively strong operability. © 2025 Power System Technology Press. All rights reserved.

关键词： Power distribution planning

Global Probabilistic Voltage Sensitivity Analysis of Active Distribution Networks Based on the Compound Gaussian Mixture Model

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Dianwang Jishu/Power System Technology 2025年第1期49卷 295-305页

作者： Zhang, Ren wang, Jian Shang, jie Hai, Chen Liu, Haoming School of Electrical and Power Engineering Hohai University Jiangsu Province Nanjing 211100 China College of Artificial Intelligence and Automation Hohai University Jiangsu Province Nanjing 211100 China

The stochasticity of the high penetration of distributed generations (DGs) exacerbates the voltage fluctuation of the active distribution networks (ADNs) and complicates its voltage safety analysis. Therefore, this paper proposes a global probability voltage sensitivity analysis method based on the compound Gaussian mixture model (GMM). Firstly, a shared node path impedance-based global voltage sensitivity analytical model of ADN is derived to quantify the impact of global power fluctuations on node voltage. Considering that the voltage fluctuation has the non-Gaussian characteristic under the superposition influence of power uncertainty injected by multiple nodes, the GMM is used to characterize the probability characteristics of DG and load forecasting errors. Then, based on the affine transformation of the global sensitivity matrix to the GMM of DG and load forecasting error, the probability analytic expression of the voltage fluctuation is constructed, which is caused by the uncertainty of DG and load. Finally, based on the GMM characteristic function, the compound GMM characteristic function of the combined influence of the uncertainty of DG and load on voltage fluctuation is derived, and the global probabilistic voltage sensitivity analysis model based on the compound GMM is established. The case study results show that the proposed method can reflect the probability characteristics of the impact of all node power fluctuations on node voltage, and can quickly and accurately calculate the probability of over-voltage in ADNs. © 2025 Power System Technology Press. All rights reserved.

关键词： Affine transforms

Evaluation of the therapeutic significance of Glehniae Radix polysaccharides on the ulcerative colitis through DSS-induced rat model

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Food Science and Human Wellness 2025年

作者： jie Liu Xufang Geng Yuxin Yang Jiao Xu Haoran Feng Tianshuo Zhang Guangzhao Zhou Man wang Changshun wang Dongsheng Jia Yuting Chen Bin Cong Ding Zhao The Postdoctoral Mobile Station of Basic Medicine， Hebei Medical University The Department of Pharmacognosy， School of Pharmacy， Hebei Medical University Hebei Key Laboratory of Forensic Medicine， College of Forensic Medicine， Hebei Medical University

Glehniae Radix has a wide range of pharmaceutical applications， and research on its main components has mainly focused on coumarins， alkaloids， lignans， and flavonoids， while neglecting the research on polysaccharides. Literature reports and our previous studies have shown that polysaccharides have certain therapeutic significance in immune regulation， antioxidant， anti-inflammatory and other aspects. Herein， the rat model of ulcerative colitis (UC) was established to evaluate the anti-inflammatory efficacy of the prepared Glehniae Radix polysaccharide (GLP) from the perspectives of inflammatory factors， intestinal tissue morphology， and microflora changes. The polysaccharides are mainly composed of galacturonic acid， rhamnose， glucose， galactose， and arabinose in molar ratios of 1.4:9.2:33.3:2.5:2.9， and GLP could downregulate the expression pro-inflammatory factors (interleukin-6， tumor necrosis factor-α， and interferon-γ) and significantly upregulate the expression of anti-inflammatory factor (interleukin-10). In addition， Glehniae Radix aqueous extract (GLA)， GLP with low dosage (GLPL) and GLP with high dosage (GLPH) could increase the number of goblet cells， enhance the integrity of crypt structure， and reverse the status of inflammatory infiltrating cells. Moreover， GLA and GLPH could upregulate Lactobacillus and Lachnoclostridium in UC rats， and appropriately downregulate Lachnospiraceae＿NK4A136＿group， thereby optimizing the proportion of bacterial flora and improving the intestinal microbial environment. Our findings not only be valuable as theoretical materials for the further clinical applications of GLP， but the identified biomarkers and metabolic pathways also provide new clues for the diagnosis of UC.

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Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期68卷 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui Wei Shu-Hui Fan Li Chen jie wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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一氧化氮供体型双水杨酸酯衍生物的合成及降血糖活性

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中国药科大学学报 2008年第4期39卷 301-305页

作者：余文颖张奕华赖宜生接振旺张玉彬彭司勋中国药科大学新药研究中心南京210009 中国药科大学生命科学与技术学院南京210009

目的:研究一氧化氮(NO)供体型双水杨酸酯衍生物的合成和降血糖活性,寻找治疗糖尿病的有效药物。方法:以双水杨酸酯为先导化合物,通过各种连接基团,将硝酸酯类NO供体与双水杨酸酯的2′位羧基连接,分别制得目标物2a-2e、4a、4b、6a、6b。... 详细信息

目的:研究一氧化氮(NO)供体型双水杨酸酯衍生物的合成和降血糖活性,寻找治疗糖尿病的有效药物。方法:以双水杨酸酯为先导化合物,通过各种连接基团,将硝酸酯类NO供体与双水杨酸酯的2′位羧基连接,分别制得目标物2a-2e、4a、4b、6a、6b。应用GOD-POD法测定目标物增加HepG2细胞耗糖量的作用,应用Griess法测定目标物体外NO释放量。结果:合成了9个目标物,其结构经IR、1HNMR、MS等确证;所有目标物均有不同程度的降血糖活性,其中化合物2a、2b、4b的活性优于双水杨酸酯。结论:NO供体型双水杨酸酯衍生物可能通过释放NO,增强了双水杨酸酯的降血糖活性。其中,化合物2a的活性较强,值得进一步研究。

关键词：双水杨酸酯硝酸酯一氧化氮供体合成降血糖活性

Metastable seed-crystals: epitaxial growth of branched-array organic heterostructure nanowires

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Science China Chemistry 2025年

作者： Jin Feng zhen-Yu Geng Ting-Yao Song Ying-Xin Ma Chuan-Zeng wang Wei Zhang Hong-Tao Lin Jin Zhou Shu-Ping Zhuo Shu-Hai Chen Xue-Dong wang School of Chemistry and Chemical Engineering Shandong University of Technology Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & DevicesSoochow University College of Chemistry and Chemical Engineering Hunan Normal University

Tunable light–matter interactions are exhibited by organic low-dimensional crystals, making these crystals a promising platform for organic photonics. However, the precise synthesis of organic low-dimensional crystals remains challenging due to the stochastic nature of molecular nucleation processes. Herein, the directed nucleation process is driven by the introduction of metastable seed-crystals as the trunk, which ultimately leads to branched-array organic heterostructures. The successful formation of organic heterostructures with high-density branched arrays is attributed to the highest attachment energy (Eatt（023）=-104.25 kcal mol-1) of the exposed （023） crystal plane during the seed-crystal growth route. Significantly, these as-prepared heterostructures inherently have an ultralow lattice mismatch ratio η of 0.7%between trunk and branch, which contributes to the multi-channel photon transportation. Therefore, this work provides valuable insights into a versatile synthetic strategy for accessing low-dimensional heterostructures for integrated optoelectronics.

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大豆种间杂交F_2代主要品质性状遗传研究初报

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大豆科学 2016年第6期35卷 1032-1036页

作者：曹永强王雅珍董丽杰王文斌宋书宏辽宁省农业科学院作物研究所辽宁沈阳110161

以栽培大豆铁豆67为母本,半野生大豆YZ1621为父本,进行有性杂交,构建大豆种间杂交F2代遗传群体,对群体蛋白质含量、脂肪含量及蛋脂总量等遗传参数进行了分析。结果表明:大豆种间杂交F2代蛋白质含量、脂肪含量及蛋脂总量的遗传分离为连... 详细信息

以栽培大豆铁豆67为母本,半野生大豆YZ1621为父本,进行有性杂交,构建大豆种间杂交F2代遗传群体,对群体蛋白质含量、脂肪含量及蛋脂总量等遗传参数进行了分析。结果表明:大豆种间杂交F2代蛋白质含量、脂肪含量及蛋脂总量的遗传分离为连续离散分布,符合正态分布,其中,脂肪含量和蛋脂总量表现出倾向高值亲本的正态分布;三性状超中亲遗传普遍存在,蛋脂总量超高亲遗传显著,超高亲比例达到66.7%;三性状的遗传方差、标准差均较小,变异系数分别为4.04%、5.13%、2.67%,表明群体内个体间的变异度不高;三性状广义遗传力均达到了55.0%以上。

关键词：大豆种间杂交品质性状遗传

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting wang Xia Wu Ling-jie Zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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FAST地锚基础工程中的若干问题探讨

科学技术与工程 2017年第2期17卷 251-255页

作者：沈志平孙洪杨振杰吴斌王鸿付君宜贵州正业工程技术投资有限公司、贵州省岩溶地基工程技术研究中心贵阳550003

FAST工程主动反射面为一半径300 m、口径500 m的球冠面,是一种基于柔性基底的预应力整体索网结构,索网包括2225个主索节点及下拉索驱动装置和地锚。由于台址岩土单元复杂,地锚点多、分布范围广、定位精度要求高、与场地其他基础设施的... 详细信息

FAST工程主动反射面为一半径300 m、口径500 m的球冠面,是一种基于柔性基底的预应力整体索网结构,索网包括2225个主索节点及下拉索驱动装置和地锚。由于台址岩土单元复杂,地锚点多、分布范围广、定位精度要求高、与场地其他基础设施的相互干涉大,给地锚基础的设计带来了一定的难题。本文针对FAST地锚基础中的特殊问题一一展开研究:以工程地质调查和测绘为基础,通过抓台址区主控因素,集合影响台址岩土性质的自然因素,对岩土单元进行了合理的分区;通过建立台址开挖后的BIM模型,利用极射投影技术实现了地锚中心点的精确定位;利用极射投影结果,对设备之间的相互干涉情况进行了调节和处理。研究成果最终确保了FAST地锚基础工程的顺利竣工。

关键词： FAST工程地锚基础岩土分区极射投影

Electro-optic tuning in ferroelectric capacitor with photonic crystal nanobeam cavity

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Science China(Information Sciences) 2025年

作者： Tongtong wang Yong ZHANG Danyang YAO Zhi JIANG Dongxin TAN jie WEN Qiyu YANG Xuetao GAN Yan LIU Yue HAO Genquan HAN State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology School of MicroelectronicsXidian University Key Laboratory of Light Field Manipulation and Information Acquisition Ministry of Industry and Information TechnologyShaanxi Key Laboratory of Optical Information Technology School of Physical Science and TechnologyNorthwestern Polytechnical University Hangzhou Institute of Technology Xidian University

Silicon photonics has provided a platform for the convergency of photonic devices and electronic circuits, facilitating the development of optical telecommunications and optical interconnects on chip[1]. As the basic building block of optical communication systems, electro-optic tuning is expected to be more compact, high bandwidth, energy efficient, and allow for CMOS-compatible fabrication in the future[2]. Resonator-based electro-optic tuning has attracted more and more interest due to the small footprint, enhanced light-matter interactions and high energy efficiency. Compared with microring and microdisk resonators, photonic crystal nanobeam cavities （PCNBCs） realize higher quality factors, stronger light-matter interactions, ultrasmall mode volume and a much larger free spectral range （FSR）[3].

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