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An Efficient Deselenenylation Reaction to the Synthesis of 3, 5-Disubstituted Isoxazoline and Isoxazole

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Chinese Chemical Letters 2005年第8期16卷 995-996页

作者： Wei Ming XU Yu Guang WANG zhen hua chen Xian huaNG Department of Chemistry Zhejiang University （Xixi Campus） Hangzhou 310028

A mild deselenenylation reaction protocol for the preparation of 3, 5-disubstituted isoxazolines and their further application to 3-methyl-5-substituted isoxazoles both in solution phase and solid phase was reported.

关键词： Deselenenylation reaction isoxazoline isoxazole.

Single-cell transcriptomic profiling of the hypothalamic median eminence during aging

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Journal of Genetics and Genomics 2022年第6期49卷 523-536页

作者： zhen-hua chen Si Li Mingrui Xu Candace CLiu Hongying Ye Ben Wang Qing-Feng Wu State Key Laboratory of Molecular Development Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100101China Department of Pathology Stanford University School of MedicineStanfordCA 94305USA Department of Endocrinology and Metabolism Huashan HospitalFudan UniversityShanghai 200040China Department of Obstetrics and Gynecology Baoding Second Central HospitalBaodingHebei 072750China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesBeijing 100101China Chinese Institute for Brain Research Beijing 102206China Beijing Children’s Hospital Capital Medical UniversityBeijing 100045China

Aging is a slow and progressive natural process that compromises the normal functions of cells,tissues,organs,and *** aging of the hypothalamic median eminence(ME),a structural gate linking neural and endocrine systems,may impair hormone release,energy homeostasis,and central sensing of circulating molecules,leading to systemic and reproductive ***,the molecular and cellular features of ME aging remain largely ***,we describe the transcriptional landscape of young and middleaged mouse ME at single-cell resolution,revealing the common and cell type-specific transcriptional changes with *** transcriptional changes in cell-intrinsic programs,cell-cell crosstalk,and cellextrinsic factors highlight five molecular features of ME aging and also implicate several potentially druggable targets at cellular,signaling,and molecular ***,our results suggest that vascular and leptomeningeal cells may lead the asynchronized aging process among diverse cell types and drive local inflammation and cellular senescence via a unique ***,our study uncovers how intrinsic and extrinsic features of each cell type in the hypothalamic ME are changed by the aging process,which will facilitate our understanding of brain aging and provide clues for efficient anti-aging intervention at the middle-aged stage.

关键词： Hypothalamic median eminence Single-cell transcriptomic analysis Vascular and leptomeningeal cells Aging

Preparation and properties of GAGG:Ce/glass composite scintillation material

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Chinese Physics B 2021年第7期30卷 274-282页

作者： Wei-Jie Zhang Qin-hua Wei Xiao Shen Gao Tang zhen-hua chen Lai-Shun Qin Hong-Sheng Shi College of Materials and Chemistry China Jiliang UniversityHangzhou 310018China Xinjiang Technical Institute of Physics&Chemistry Chinese Academy of SciencesUrumqi 830011China

The translucent GGAG:Ce/glass composites are prepared successfully by ball-milling,tableting,and pressureless *** thickness of composites is about 400μ*** x-ray diffraction(XRD),differential scanning calorimetry(DSC),density of composite materials are measured and discussed *** scanning electron microscopy(SEM)and energy dispersive spectrometer(EDS)elemental mapping are employed to analyze the particle size,the shape of powders,and the distribution of GGAG:Ce particles in the glass matrix,*** decay time,ultraviolet,(UV),x-ray excitation luminescence spectra,and temperature spectra are *** results show that the composite materials have high light output,good thermostability,and short decay *** method adopted in this work is an effective method to reduce the preparation time and cost of the *** ultralow afterglow indicates that the composite materials have an opportunity to be used for x-ray detection and imaging.

关键词： GGAG:Ce composite material scintillator glass matrix luminescence properties

Experimental observation of the significant difference between surface and bulk Kondo processes in Kondo lattice YbCu_(2)Si_(2)

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 154-160页

作者： Yin-Zou Zhao Jiao-Jiao Song Qi-Yi Wu Hao Liu chen Zhang Bo chen Hong-Yi Zhang zhen-hua chen Yao-Bo huang Xue-Qing Ye Ya-hua Yuan Yu-Xia Duan Jun He Jian-Qiao Meng School of Physics Central South UniversityChangsha 410083China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201204China

Synchrotron-based angle-resolved photoemission spectroscopy was employed to investigate the temperature evolution of the Yb 4 f spectral for surface and bulk in the Kondo lattice YbCu_(2)Si_(2).Our study quantitatively distinguishes between the surface and bulk hybridization processes,revealing that the onset temperatures for both surface and bulk hybridization processes are significantly higher than the Kondo ***,we found that the effective surface Kondo temperature is much lower than that of the *** findings offer valuable insights into the understanding of heavy fermion physics.

关键词： Kondo lattice angle-resolved photoemission spectroscopy electronic structure hybridization surface state

Design of wide-range energy material beamline at the Shanghai Synchrotron Radiation Facility

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Nuclear Science and Techniques 2018年第2期29卷 91-102页

作者： zhen-hua chen Fan-Fei Sun Ying Zou Fei Song Shuo Zhang zheng Jiang Yong Wang Ren-Zhong Tai Shanghai Institute of Applied Physics Chinese Academy of Sciences

We report the design of a wide-range energy material beamline(E-line) with multiple experimental techniques at the Shanghai Synchrotron Radiation *** undulators consisted of an elliptically polarizing undulator and in-vacuum undulator that generate the soft and hard X-rays, respectively. The beamline covered a wide energy range from 130 to 18 ke V with both a high photon flux([ 10^(12) phs/s with exit silt 30 lm in soft X-ray and [ 5 9 10^(12) phs/s in hard X-ray within 0.1%BW bandwidth) and promising resolving power(maximum E/DE [ 15,000 in soft X-ray with exit silt 30 lm and [6000 in hard X-ray). Moreover, the beam spots from the soft and hard X-rays were focused to the same sample position with a high overlap ratio, so that the surfaces, interfaces, and bulk properties were characterized in situ by changing the probing depth.

关键词： Synchrotron radiation Beamline Wide energy range E-line Shanghai Synchrotron Radiation Facility

Fluoxetine Ameliorates the Aggravation of UC Symptoms in C57BL/6 Mice Induced by CUMS

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Current Medical Science 2023年第5期43卷 1033-1042页

作者： Teng ZHAO Yu-xin ZHOU Rong-jie WANG Ping WAN Ying LI Liang-liang ZHOU zhen-hua chen Jiangxi Province Key Laboratory of Drug Design and Evaluation School of PharmacyJiangxi Science and Technology Normal UniversityNanchang 330013China Department of Liver Disease the Ninth Hospital of NanchangNanchang 330006China

Objective Patients with chronic ulcerative colitis(UC)often have mental symptoms such as depression and anxiety,and stress can lead to gastrointestinal ***,the correlation between mental stress and UC is *** this paper,chronic unpredictable mild stress(CUMS)was utilized to evaluate the involvement of mental factors in the pathogenesis of *** The CUMS model was used to evaluate the direct/indirect involvement of mental factors in the pathogenesis of *** behavior was evaluated by the open field,forced swimming,and tail suspension *** weight,the disease activity index(DAI)score,colon length,and HE staining of colon tissue were used to evaluate the action of CUMS and *** The results showed that weight loss and the DAI score increased in CUMS mice,but they had no meaningful effect on colon length and morphological structure of colon ***,CUMS aggravated dextran sulfate sodium(DSS)-induced colon length shortening and colon morphological structure *** significantly improved the DAI score,shortened colon length,and damaged morphology and structure of the colons induced by CUMS combined with DSS in *** also decreased the level of IL-6 in the serum and the TNF-αand IFN-γlevels of colon *** simultaneously improved behavioral abnormalities induced by CUMS combined with DSS in *** CUMS aggravated the UC symptoms induced by DSS,and fluoxetine could improve the UC symptoms due to its improvement in the inflammatory level and behavioral abnormalities.

关键词： ulcerative colitis chronic unpredictable mild stress fluoxetine dextran sulfate sodium behavior

A stable and reliable animal model for hepatocellular carcinoma with portal vein tumor thrombus

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Hepatobiliary & Pancreatic Diseases International 2022年第1期21卷 90-93页

作者： Zong-Tao Chai zhen-hua chen Xiu-Ping Zhang Jin-Kai Feng Zong-Han Liu Shu-Qun cheng Department of Hepatic Surgery VI Eastern Hepatobiliary Surgery HospitalSecond Military Medical University225 Changhai RoadShanghai 200433China Faculty of Hepato-Biliary-Pancreatic Surgery the First Medical Center of Chinese People’s Liberation Army(PLA)General HospitalBeijing 100039China

To the Editor:Hepatocellular carcinoma(HCC)is one of the most common cancers worldwide[1,2].Portal vein tumor thrombus(PVTT)has been demonstrated to be a poor prognostic indicator for HCC[3-5].However,effective treatment for the condition is still ***-derstanding the insight into the molecular mechanisms behind PVTT development may help to establish a new therapeutic strat-egy.

关键词： thrombus carcinoma hepatocellular

Study on Oxidation of Pyrite by In Situ Absorption Spectroscopy

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光谱学与光谱分析 2010年第12期30卷 3375-3378页

作者： ZHAO zhen-hua ZHANG Ping chen Yong-heng YAO Yan WU Ying-juan GENG Xin-hua DENG Xiang-zhou School of Chemistry and Chemical Engineering Guangzhou University Guangzhou 510006 China

Pyrite is one of the common natural *** is easily oxidized and brings heavy metal contaminations,therefore it is the main source of acidity mine *** study on the dynamics of pyriteis helpful to comprehending the mechanism of its *** the present paper,an experi mental method was designed that phenanthroline reacts with Fe2+ that is released from pyrite in solution,and produces stable orange-red complex *** can be detected by absorption ***-situ characterization of oxidation of pyrite can be achieved by this *** results showed that the method is reliable and accurate,and it has high sensitivity and little interference;the reaction rate of oxidation increasedl inearly with time,corresponding to the characterization of zero-order reaction;oxidation of pyrite belongs to the surface reaction and the process of surface reactionis rate determining step.

关键词：黄铁矿氧化反应检测方法灵敏度

Serum soluble interleukin-2 receptor levels in patients with chronic hepatitis B virus infection and its relation with antiHBc

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World Journal of Gastroenterology 2006年第3期12卷 482-484页

作者： Ping Xiao Qing-Feng chen Yan-Ling Yang zhen-hua Guo Hong chen Institute of Infectious Diseases the First Hospital ofLanzhou University Lanzhou 730000 Gansu Province China

AIM： To investigate the relationship between serum soluble interleukin-2 receptor （sIL-2R） level and anti-HBc in patients with chronic hepatitis B virus （HBV） infection. METHODS： Sera from 100 patients with chronic HBV infection and 30 healthy controls were included in this study. The patients were divided into group A [HBsAg （＋）, HBeAg （＋） and anti-HBc （＋）, n = 50] and group B [HBsAg （＋）, HBeAg （＋） and anti-HBc （-）, n = 50]. sIL-2R levels were determined using ELISA. HBV DNA and alanine aminotransferase （ALT） were also detected. RESULTS： Serum sIL-2R levels were significantly higher in patients with chronic HBV infection than in healthy controls. Moreover, serum sIL-2R levels were significantly higher in patients with HBsAg （＋）, HBeAg （＋） and antiHBc （＋）（976.56±213.51×10^3 U/L） than in patients with HBsAg （＋）, HBeAg （＋） and anti-HBc （-）（393.41±189.54 ×10^3 U/L, P〈 0.01）. A significant relationship was found between serum sIL-2R and ALT levels （P〈 0.01） in patients with chronic HBV infection, but there was no correlation between sIL-2R and HBV DNA levels. The anti-HBc status was significantly related to the age of patients （P〈 0.01）. CONCLUSION： The high sIL-2R level is related to positive anti-HBc in chronic hepatitis B patients. Positive anti-HBc may be related to T-lymphocyte activation and negative anti-HBc may imply immune tolerance in these patients.

关键词： Chronic hepatitis B Hepatitis B virus AntiHBc Soluble interleukin-2 receptor Immune tolerance