Single-cell transcriptomic profiling of the hypothalamic median eminence during aging

作     者：Zhen-Hua Chen Si Li Mingrui Xu Candace CLiu Hongying Ye Ben Wang Qing-Feng Wu Zhen-Hua Chen;Si Li;Mingrui Xu;Candace C.Liu;Hongying Ye;Ben Wang;Qing-Feng Wu

作者机构：State Key Laboratory of Molecular Development BiologyInstitute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of SciencesBeijing 100101China Department of PathologyStanford University School of MedicineStanfordCA 94305USA Department of Endocrinology and MetabolismHuashan HospitalFudan UniversityShanghai 200040China Department of Obstetrics and GynecologyBaoding Second Central HospitalBaodingHebei 072750China Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesBeijing 100101China Chinese Institute for Brain ResearchBeijing 102206China Beijing Children’s HospitalCapital Medical UniversityBeijing 100045China 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2022年第49卷第6期

页      面：523-536页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学] 

基　　金：supported by the National Key R&D Program of China(2019YFA0801900 and 2018YFA0801104) the National Natural Science Foundation of China(31771131,81891002,31921002,and 32070972) the Strategic Priority Research Program of Chinese Academy of Sciences(XDB32020000) the Hundred-Talent Program(Chinese Academy of Sciences) the Beijing Municipal Science&Technology Commission(Z210010 and Z181100001518001) the Baoding Technical Program(2141ZF027) 

主　　题：Hypothalamic median eminence Single-cell transcriptomic analysis Vascular and leptomeningeal cells Aging 

摘      要：Aging is a slow and progressive natural process that compromises the normal functions of cells,tissues,organs,and *** aging of the hypothalamic median eminence(ME),a structural gate linking neural and endocrine systems,may impair hormone release,energy homeostasis,and central sensing of circulating molecules,leading to systemic and reproductive ***,the molecular and cellular features of ME aging remain largely ***,we describe the transcriptional landscape of young and middleaged mouse ME at single-cell resolution,revealing the common and cell type-specific transcriptional changes with *** transcriptional changes in cell-intrinsic programs,cell-cell crosstalk,and cellextrinsic factors highlight five molecular features of ME aging and also implicate several potentially druggable targets at cellular,signaling,and molecular ***,our results suggest that vascular and leptomeningeal cells may lead the asynchronized aging process among diverse cell types and drive local inflammation and cellular senescence via a unique ***,our study uncovers how intrinsic and extrinsic features of each cell type in the hypothalamic ME are changed by the aging process,which will facilitate our understanding of brain aging and provide clues for efficient anti-aging intervention at the middle-aged stage.