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Comparison of corneal biological parameters between transepithelial and epithelium-off corneal cross-linking in keratoconus

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International Journal of Ophthalmology(English edition) 2021年第7期14卷 998-1005页

作者： Bo-Wen Ouyang Hui Ding Han Wang zhen-duo yang Tan Zhong Hong-Ming Fan Xing-Wu Zhong Zhongshan Ophthalmic Center State Key Laboratory of OphthalmologySun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina Hainan Eye Hospital Zhongshan Ophthalmic CenterSun Yat-sen UniversityHaikou 570311Hainan ProvinceChina

AIM:To evaluate the differences in corneal biological parameters between transepithelial and epithelium-off corneal cross-linking in ***:In our prospective clinical trial,40 patients(60 eyes)with progressive keratoconus were randomized to undergo corneal cross-linking with transepithelial(TE group,n=30)or epithelium-off(EO group,n=30)*** comprised topography,corneal biomechanical analysis and specular microscopy at 6 mo ***:The keratometer values were not significantly different between the TE and EO corneal cross-linked groups in different periods(each P>0.05).The corneal thickness of the EO group was greater than that of the TE group at 1 wk after the operation(each P<0.05).Regarding corneal biomechanical responses,the EO group showed a longer second applanation length than TE group(P=0.003).Regarding the corneal endothelial function,standard deviation of the endothelial cell size,and coefficient of variation in the cell area,the values of EO group were larger than those of TE group at 1 wk(P=0.011,0.026),and the percentage of hexagonal cells in EO group was lower than that in TE group at 1 and 6 mo(P=0.018,0.019).CONCLUSION:Epithelium-off corneal cross-linking may strengthen corneal biomechanics better than TE procedure ***,the TE procedure with a lower ultraviolet-A irradiation intensity would be safer for corneal endothelial function.

关键词： keratoconus corneal cross-linking transepithelial epithelium-off corneal biomechanics corneal topography

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Treatment of superficial corneal opacities with corneal stromal lenticule obtained through SMILE surgery

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International Journal of Ophthalmology(English edition) 2024年第12期17卷 2221-2228页

作者： Shi-Si Hu Hui Ding Xu-Yun Meng Bo-Wen Ouyang zhen-duo yang Xiao-Dan Chen Xing-Wu Zhong Hainan Eye Hospital and Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityHaikou 570311Hainan ProvinceChina State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060Guangdong ProvinceChina

AIM:To evaluate the clinical efficacy and feasibility of superficial corneal opacities treated by excimer laser phototherapeutic keratectomy(PTK)combined with small incision lenticule extraction(SMILE)-derived corneal stromal lenticule ***:A retrospective interventional case series of nine patients aged 12-59y with superficial corneal opacity caused by different pathologies who underwent standardized PTK combined with SMILE-derived corneal stromal lenticule transplantation was *** patches were fixed with fibrin *** patients underwent pre-and post-operative clinical assessments at different times for up to *** lamp microscopy,corneal density,uncorrected distance visual acuity(UDVA),corrected distance visual acuity(CDVA),and anterior segment optical coherence tomography(AS-OCT)were ***:The patients’mean age was 36.00±5.80(12-59)*** eyes(77.8%)gained UDVA and CDVA at the last measurement compared to their preoperative *** densities of the total cornea,the total anterior corneal layer,and the anterior corneal layers of 0-2 and 2-6 mm decreased significantly by 12.4%,27.5%,46.7%,and 32.8%,*** human allogeneic transplantation,the implanted lenticules of all eyes were clearly visible by AS-OCT and remained transparent without displacement or graft *** thickness of the central cornea and corneal lenticule transplants were stable throughout the entire postoperative *** case experienced the postoperative complication of delayed corneal epithelial ***:PTK combined with SMILE-derived corneal lenticule transplantation improves long-term visual ***,it is a new,safe,and effective method for treating superficial corneal opacity.

关键词： corneal opacity corneal lenticule transplant phototherapeutic keratectomy

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气囊着陆缓冲过程仿真分析

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载人航天 2018年第4期24卷 529-535页

作者：卫剑征王滢甄铎谭惠丰杨知寒哈尔滨工业大学复合材料与结构研究所哈尔滨150080

针对气囊着陆缓冲与反弹问题,以对称的胶囊状双气囊缓冲系统为研究对象,提出了气囊的等效弹簧刚度和阻尼模型,讨论了着陆速度与气囊等效阻尼的变化关系。建立了双缓冲气囊的有限元模型,基于显式计算方法对双气囊有无排气孔的着陆缓冲过... 详细信息

针对气囊着陆缓冲与反弹问题,以对称的胶囊状双气囊缓冲系统为研究对象,提出了气囊的等效弹簧刚度和阻尼模型,讨论了着陆速度与气囊等效阻尼的变化关系。建立了双缓冲气囊的有限元模型,基于显式计算方法对双气囊有无排气孔的着陆缓冲过程进行了仿真,表明有排气孔气囊能实现软着陆。建立了有排气孔的芳纶织物双气囊缓冲试验系统,通过电磁快速释放装置完成了双气囊被动式排气孔的测试。结果表明,被动式排气孔的胶囊状气囊能有效起到缓冲作用,无侧翻和明显反弹,并验证了设计方法的正确性。

关键词：陆缓冲气囊排气孔着陆反弹

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姜黄素纳米粒对人视网膜色素上皮细胞的示踪研究

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国际眼科杂志 2022年第3期22卷 373-377页

作者：郑海生蓝育青李芳梁晓茜杨镇朵钟兴武中山大学中山眼科中心海南眼科医院海南省眼科医院海南省眼科学重点实验室中国海南省海口市570311 中山大学附属孙逸仙纪念医院眼科中国广东省广州市510120

目的:探讨脱氧胆酸基接枝的壳聚糖衍生物负载姜黄素纳米粒的合成方法及该药物纳米粒对人视网膜色素上皮(hRPE)细胞的作用。方法:合成姜黄素/壳聚糖-脱氧胆酸纳米粒并分析其性能。将负载荧光染料异硫氰酸荧光素的壳聚糖-脱氧胆酸及姜黄素... 详细信息

目的:探讨脱氧胆酸基接枝的壳聚糖衍生物负载姜黄素纳米粒的合成方法及该药物纳米粒对人视网膜色素上皮(hRPE)细胞的作用。方法:合成姜黄素/壳聚糖-脱氧胆酸纳米粒并分析其性能。将负载荧光染料异硫氰酸荧光素的壳聚糖-脱氧胆酸及姜黄素/壳聚糖-脱氧胆酸作用于hRPE细胞24h后,于倒置荧光显微镜下观察避光培养1、3、5d后二者与hRPE细胞的相互关系。结果:通过将姜黄素与壳聚糖-脱氧胆酸混合制成负载药的壳聚糖衍生物纳米粒为淡黄色;药物从纳米粒中的释放在96h后达到平衡,累积释放药物量为31.6%。异硫氰酸/壳聚糖-脱氧胆酸与hRPE细胞作用1d后,壳聚糖-脱氧胆酸纳米粒大部分仍位于近细胞膜的部位;作用3d后,纳米粒逐渐向细胞核会聚,且大部分位于细胞核周围;作用5d后,可看到壳聚糖-脱氧胆酸纳米粒已进入细胞核,且纳米粒可能在细胞内溶酶体的作用下有部分降解。姜黄素/壳聚糖-脱氧胆酸纳米粒和hRPE细胞作用的关系与壳聚糖-脱氧胆酸大致相同。结论:通过壳聚糖-脱氧胆酸包载的姜黄素纳米粒能持续释放出姜黄素,具有较持久的缓释功能。

关键词：姜黄素纳米粒壳聚糖视网膜色素上皮细胞

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环孢素A联合抗真菌药物体外抗茄病镰刀菌效果研究

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国际眼科杂志 2020年第9期20卷 1567-1572页

作者：陈晓莲杨镇朵丁辉何宏吴娇婵胡献铝钟兴武中山大学中山眼科中心海南眼科医院(海南省眼科医院) 海南省眼科学重点实验室中国海南省海口市570311

目的:研究免疫抑制剂环孢素A联合使用抗真菌药物对镰刀菌体外抗真菌药物敏感性的影响。方法:采用美国临床实验室标准化委员会(CLSI)M27-Ed4及M38-A3方法测定伏立康唑(voriconazole)、那他霉素(NAT)和两性霉素B(Amphotericin B)及氟康唑(... 详细信息

目的:研究免疫抑制剂环孢素A联合使用抗真菌药物对镰刀菌体外抗真菌药物敏感性的影响。方法:采用美国临床实验室标准化委员会(CLSI)M27-Ed4及M38-A3方法测定伏立康唑(voriconazole)、那他霉素(NAT)和两性霉素B(Amphotericin B)及氟康唑(FLU)对22株镰刀菌的最低抑菌浓度(MIC),棋盘法测定四种抗真菌药物单独及联合环孢素A使用抗真菌作用。结果:那他霉素、伏立康唑、两性霉素B和氟康唑对镰刀菌(22株)MIC范围分别是2~8、1~8、1~8和8~512μg/mL。体外联合用药时,环孢素A与氟康唑对64%菌株(14/22)有协同效应,与两性霉素B对41%菌株(9/22)有协同效应,对所有菌株无拮抗效应。联合使用环孢素A后,镰刀菌对两性霉素B药物敏感性由4.5%提升至68.2%(P<0.001)。结论:镰刀菌在体外对那他霉素敏感,对伏立康唑部分敏感。与环孢素A联合应用时,可与氟康唑及两性霉素B产生协同效应,并显著提高镰刀菌对两性霉素B药物敏感性。

关键词：真菌性角膜溃疡抗真菌药物微生物敏感试验镰刀菌环孢素A

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How to identify dislocations in molecular dynamics simulations?

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Science China(Physics,Mechanics & Astronomy) 2014年第12期57卷 2177-2187页

作者： LI duo WANG Feng Chao yang zhen Yu ZHAO Ya Pu State Key Laboratory of Nonlinear Mechanics (LNM) Institute of Mechanics Chinese Academy of Sciences Department of Modern Mechanics University of Science and Technology of China Institute of Solid Mechanics Beihang University

Dislocations are of great importance in revealing the underlying mechanisms of deformed solid *** the development of computational facilities and technologies,the observations of dislocations at atomic level through numerical simulations are *** dynamics(MD)simulation suggests itself as a powerful tool for understanding and visualizing the creation of dislocations as well as the evolution of crystal ***,the numerical results from the large-scale MD simulations are not very illuminating by themselves and there exist various techniques for analyzing dislocations and the deformed crystal ***,it is a big challenge for the beginners in this community to choose a proper method to start their *** this review,we summarized and discussed up to twelve existing structure characterization methods in MD simulations of deformed crystal solids.A comprehensive comparison was made between the advantages and disadvantages of these typical *** also examined some of the recent advances in the dynamics of dislocations related to the hydraulic *** was found that the dislocation emission has a significant effect on the propagation and bifurcation of the crack tip in the hydraulic fracturing.

关键词： dislocations defects MD simulation structural characterization hydraulic fracturing (fracking)

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Preparation of hydroxyapatite layer on Ti-based bulk metallic glasses by acid and alkali pre-treatment

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Rare Metals 2015年第1期34卷 22-27页

作者： Hao Hu zhen-duo Cui Sheng-Li Zhu Zhao-yang Li Yan-Qin Liang Xian-Jin yang School of Materials Science and Engineering Tianjin University Tianjin Key Laboratory of Composite and Functional Materials

In this paper, a thin calcium phosphate layer was prepared on the surface of Ti4oZr10Cu36Pd14 bulk metallic glasses （BMGs）. All samples were dipped in HNO3 aqueous solution and boiled in 1.2 mol-L-I NaOH aqueous solution. After the two preliminary treatment steps, they were soaked in simulated body fluid （SBF） to form an apatite layer on the surface. After immersion for 12 days, a coating composed mainly of Ca-P particles was rapidly deposited on the surface of Ti40Zr10Cu36Pd14 bulk metallic glasses. The surfaces of chemically treated sam- ples and the samples after immersion in SBF were char- acterized by X-ray diffraction （XRD）, X-ray photoemission spectroscopy （XPS）, field emission scanning electron microscopy （FESEM）, and energy dispersive spectroscopy （EDS）. Analysis results indicate that this apatite coating consists of Ca-P particles with different diameters. In addition, the Ca/P ratio of the apatite coatings immersed for 14 days is 1.62, which is close to that of hydroxyapatite （HA）.

关键词： Metallic glass Titanium alloy Hydroxyapatite Thin film

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Flower-like CuS/graphene oxide with photothermal and enhanced photocatalytic effect for rapid bacteria-killing using visible light

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Rare Metals 2022年第2期41卷 639-649页

作者： Rui Lv Yan-Qin Liang Zhao-yang Li Sheng-Li Zhu zhen-duo Cui Shui-LinWu School of Materials Science&Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of ChinaTianjin UniversityTianjin 300072China The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China Tianjin UniversityTianjin 300072China

Pathogenic bacteria have been threatening the daily life of human *** effective methods without causing drug-resistance of bacteria need to be developed to fight against these ***,flower-like CuS/-graphene oxide(GO)hybrids have been successfully synthesized via simple one-pot hydrothermal *** worked as an excellent electron acceptor to transport the photogenerated electrons from CuS,which can suppress the recombination of hole–electron pairs efficiently,thus enhancing the photocatalytic *** addition,the morphology of CuS and GO with high specific surface area and the increased defect in GO also improved photocatalytic performance of the *** to the synergy of photothermal,enhanced photocatalytic effect and released Cu ions,CuS/GO exhibited outstanding antibacterial efficacy under visible light irradiation for 15 ***,the hybrid showed great biocompatibility to L929 ***,the synthesized CuS/GO would be a promising antibacterial material for daily life including rapid water disinfection and wounds sterilization.

关键词： Antibacterial Photocatalytic CuS Graphene oxide Photoresponsive

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Microstructure and mechanical properties of TC4 joints brazed with Ti-Zr-Cu-Sn amorphous filler alloy

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Rare Metals 2021年第7期40卷 1881-1889页

作者： Hui-Hui Zhang zhen-duo Cui Sheng-Li Zhu Shi-Wei Guo Xian-Jin yang Akihisa Inoue School of Materials Science and Engineering Tianjin UniversityTianjin 30007China Key Laboratory of Advanced Ceramics and Machining Technology Ministry of EducationTianjin 300072China Tianjin Key Laboratory of Composite and Functional Materials Tianjin 300072China Department of Physics King Abdulaziz UniversityJeddah 22254Saudi Arabia

The Ti_(51.44)Zr_(16.26)Cu_(30)Sn_(2.3)(at%)amorphous filler alloy in a ribbon form was prepared by melt *** Ti-6 Al-4 V alloy was brazed in vacuum furnace by using the Ti_(51.44)Zr_(16.26)Cu_(30)Sn_(2.3)amorphous filler *** effects of brazing temperature and holding time on the interfacial microstructure and mechanical properties of the Ti-6 Al-4 V brazed joints were *** brazed joints are composed ofα-Ti,β-Ti,and(Ti,Zr)_(2)Cu *** shear strength of the joints increases with brazing temperature increasing from 1153 to 1193 K and holding time from 10 to 15 min,while decreases with brazing temperature and time further *** temperature brazing results in the formation of microcracks and voids in the seams,which are harmful for the shear strength of the *** the joint brazed at 1193 K for 15 min,a fineα+βWidmansta¨tten structure beneficial to the mechanical property is formed,and the joint exhibits relatively high joint strength of 180 MPa.

关键词： Amorphous alloy Brazing Titanium alloy Microstructure Mechanical property

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Zr_(55)Al_(10)Ni_(5)Cu_(30)amorphous alloy film prepared by magnetron sputtering method

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Rare Metals 2021年第8期40卷 2237-2243页

作者： Dong-Mei Mi Sheng-Li Zhu Yan-Qin Liang Zhao-yang Li zhen-duo Cui Xian-Jin yang Akihisa Inoue School of Materials Science and Engineering Tianjin UniversityTianjin300072China Tianjin Key Laboratory of Composite and Functional Materials Tianjin300072China Key Laboratory of Advanced Ceramics and Machining Technology Ministry of EducationTianjin300072China Department of Physics Kings Abudulaziz UniversityJeddah22254Saudi Arabia

In this work,amorphous Zr_(55)Al_(10)Ni_(5)Cu_(30)alloy thin film was prepared on D36 steel substrate by magnetron sputtering *** film was characterized by scanning electron microscopy(SEM),X-ray diffraction(XRD),atomic force microscopy(AFM),hardness tester and nano *** behavior of the film was investigated in 3.5%NaCl aqueous solutions by an electrochemical *** room temperature,the amorphous alloy film was formed completely after sputtering for 5 *** surface morphology of the amorphous alloy film was uniform and *** of the amorphous alloy film improved the microhardness and corrosion resistance of the D36 *** amorphous alloy film(prepared at room temperature for 5 h)exhibited good adhesion strength with the *** as-sputtered sample exhibited a crevice corrosion trend when the sputtering time was too short(1 h)or too long(10 h).

关键词： Magnetron sputtering Amorphous alloy Thin film Corrosion resistance Zr_(55)Al_(10)Ni_(5)Cu_(30)

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