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Bovine Serum Albumin Loaded Solid lipid Nanoparticles Prepared by Double Emulsion Method

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Chemical Research in Chinese Universities 2010年第1期26卷 136-141页

作者： li zhen li xin-wei zhenG li-qiang liN Xiao-hong GENG Fei YU li Key Laboratory of Colloid and Interface Chemistry Ministry of Education Shandong University Jinan 250100 P. R. China

Solid lipid nanoparticles loaded with bovine serum albumin（BSA） were prepared by a double emulsion method. As the mass fraction of the model drug BSA increased from 0 to 15%, the particle size gradually increased. The physical stability of the nanoparticles was investigated by zeta potential measurement and they were shown to be quite stable. Fluorescence spectroscopy confirmed that the loaded position of BSA was on the interface between the inner aqueous phase and the solid lipid phase. Both Fourier-transform infrared spectroscopy and circular dichroism spectra indicate that BSA in the nanoparticles was not destroyed, but the secondary structure was disrupted slightly.

关键词： Solid lipid nanoparticle Double emulsion Bovine serum albumin Drug model

Surgical treatment ofpatients with severe non-flail chest rib fractures

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World Journal of Clinical Cases 2019年第22期7卷 3718-3727页

作者： Jian-Peng Zhang lin Sun Wei-Qiang li Yan-Yu Wang xin-zhen li Yang liu Department of Thoracic Surgery Beijing Luhe Hospital Capital Medical University

BACKGROUND Many patients have inadequate long-term analgesia,respiratory distress,and hypoxemia due to a long-standing substantial smoking history or the presence of primary pulmonary diseases;analgesic treatment is not valid in these *** if the imaging findings of rib fractures are relatively mild,rib fractures may cause severe position limitation,respiratory distress,and *** To investigate the curative effect of surgical treatment for patients with severe non-flail chest rib *** A total of 78 patients from our hospital with severe noncontinuous thoracic rib fractures from September 2016 to September 2018 were enrolled in our ***-nine patients underwent surgical treatment,and 39 underwent conservative *** surgical treatment group received surgery performed with titanium plates,and the screws were inserted with open reduction and internal *** conservative treatment group received analgesia and symptomatic *** pain scores at 72 h,1 wk,2 wk,4 wk,6 wk,3 mo,and 6 mo were compared,and the SF-36 quality of life scores were compared atthe 3rd and 6th *** Pain relief in the surgical group was significantly better than that in the conservative group at each time point(72 h,1 wk,2 wk,4 wk,6 wk,3 mo,and 6 mo after surgery,Plity of life following surgical treatment than following conservative treatment,and surgical treatment is also useful for relieving *** should pay more attention to the physiological functions and clinical manifestations of patients with severe rib *** patients with non-flail chest rib fractures,surgical treatment is feasible and effective.

关键词： Severe Non-flail chest rib fractures Treatment Conservative surgery Internal fixation Quality of life

Quantification of radiation damage in natural and synthetic zircon by Raman spectroscopy:application to low-temperature thermochronology

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Acta Geochimica 2023年第4期42卷 673-688页

作者： Ke Su Shao-Bing Zhang John MHanchar zhen-xin li Fang-Yuan Sun Ting liang Xiao-Ying Gao CAS Key Laboratory of Crust-Mantle Materials and Environments School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Center of Excellence for Comparative Planetology Chinese Academy of Sciences(CAS)Hefei 230026China Frontiers Science Center for Planetary Exploration and Emerging Technologies University of Science and Technology of ChinaHefei 230026China Department of Earth Sciences Memorial University of NewfoundlandSt John’sNL A1B 3X5Canada

Due to its ubiquitous occurrence in igneous,metamorphic,and sedimentary rocks and its wide application in geochronology and geochemistry,zircon has become the most widely used accessory mineral in the geological ***,the decay of U and Th causes radiation damage to the zircon structure,resulting in various degrees of metamictization,which can affect the accuracy of U–Pb dates and Hf and O isotope *** the degree of zircon radiation damage can be quantified,the influence on geochemical analyses can be evaluated,and the results can be corrected more *** this paper,synthetic and natural zircon crystals with different crystallization ages were selected for Raman spectroscopy analysis,cathodoluminescence imaging,and determination of the U and Th *** results show that Raman FWHM(full width at half bandmaximum)and Raman shift correlate with alpha dose(Da)ofzirconsfollowingtheseequations,FWHM=44.36(±2.32)×[1-exp(-2.74×Da)]-+1.7(±0.19),Raman Shift=-6.53×Da+*** of synthetic zircon crystals shows that doped REEs(rare earth elements and P)can also lead to an increase in the ***,this effect can be ignored for natural zircon samples with REE contents at a normal level of hundreds to a few thousand *** FWHM and Raman shift can be used as proxies to measure the degree of zircon radiation *** the updated equations to calculate the latest age when zircon began to accumulate radiation damage,a more accurate and more meaningful“radiation damage age”can be obtained.

关键词： Zircon Radiation damage Raman spectroscopy FWHM(full width at half-maximum) Raman shift Raman isochron age

Influence of alloy ingredients on mechanical properties of ternary boride hard alloy clad materials

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中国有色金属学会会刊：英文版 2004年第z1期14卷 482-486页

作者： liU Fu-tian SONG Shi-xue YANG Jun-ru HUANG Wei-ling HUANG Chuan-zhen CHENG xin li Zhao-qian School of Materials Science and Engineering Ji''nan University Ji''nan 250022 China School of Mechanical Engineering Shandong University Ji''nan 250061 China Techinal Center Ji''nan Iron & Steel Group Corporation Ji''nan 250101 China School of Materials Science and Engineering Ji''nan University Ji''nan 250022 China School of Mechanical Engineering Shandong University Ji''nan 250061 China School of Mechanical Engineering Shandong University Ji''nan 250061 China School of Mechanical Engineering Shandong University Ji''nan 250061 China School of Materials Science and Engineering Ji''nan University Ji''nan 250022 China School of Mechanical Engineering Shandong University Ji''nan 250061 China

Using Mo, B-Fe alloy and Fe powders as raw materials, and adding C, Cr and Ni ingredients, respectively, or C, Cr and Ni mixed powders, ternary boride hard alloy clad materials was prepared on Q235 steel substrate by means of in-situ reaction and vacuum liquid phase sintering technology. The influence of alloy ingredients on the mechanical properties of ternary boride hard alloy clad materials was investigated. The results indicate that a mixture of 0.8% C, 5% Cr and 2% Ni ingredients gives a ternary boride hard alloy clad material with optimal mechanical properties, such as high transverse rupture strength, high hardness and good wear resistance.

关键词： hard alloy cladding liquid phase sintering alloying ingredient transverse rupture strength hardness wear resistance

Variants in the promoter region of CYP7A1 are associated with neuromyelitis optica but not with multiple sclerosis in the Han Chinese population

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Neuroscience Bulletin 2013年第5期29卷 525-530页

作者： Gui-Xian Zhao Ying liu zhen-xin li Chuan-zhen Lv Anthony Traboulsee A.Dessa Sadovnick Zhi-Ying Wu Department of Neurology and Institute of Neurology Huashan Hospital Institute of Brain Science and State Key Laboratory of Medical Neurobiology Shanghai Medical College Fudan University Shanghai Key Laboratory of Signaling and Disease Research Department of Neurology and Institute of Neurology First Affiliated Hospital Fujian Medical University Faculty of Medicine Division of Neurology University of British Columbia Department of Medical Genetics University of British Columbia

Multiple sclerosis（MS）and neuromyelitis optica（NMO）are common autoimmune demyelinating disorders of the central nervous *** exact etiology of each remains ***7A1was reported to be associated with NMO in Korean patients,but this is yet to be confirmed in other *** this study,we used Sanger sequencing to detect SNPs in the promoter region of CYP7A1 in a population consisting of unrelated patients and controls from the Han Chinese population（129 MS;89 NMO;325 controls）.Two known SNPs,204A〉C（rs3808607）and 469T〉C（rs3824260）,and a novel SNP（208G〉C）were identified in the 5＇-UTR of *** 204A〉C was in complete linkage with 469T〉C and both were associated with NMO but not with *** suggest that the CYP7A1 allele was associated with *** and MS have different genetic risk *** further supports the emerging evidence that MS and NMO are distinct disorders.

关键词： multiple sclerosis neuromyelitis optica CYP7A1 association Chinese

No association between identified multiple sclerosis non-MHC risk loci and neuromyelitis optica

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Neuroscience Bulletin 2014年第6期30卷 1036-1044页

作者： Qi-Bing liu zhen-xin li Gui-Xian Zhao Hai Yu Zhi-Ying Wu Department of Neurology and Institute of Neurology Huashan HospitalInstitutes of Brain Science and State Key Laboratory of Medical NeurobiologyShanghai Medical CollegeFudan University Department of Neurology and Institute of Neurology First Affiliated HospitalFujian Medical University

Neuromyelitis optica（NMO） and multiple sclerosis（ M S） a r e b o t h a u t o i m m u n e i n f l a m m a t o r y a n d demyelinating disorders of the central nervous system. Recently, more than 50 MS-susceptibility single-nucleotide polymorphisms（SNPs） have been detected outside the major histocompatibility complex（MHC） region. In this study, we aimed to evaluate the association of these identified non-MHC MS risk loci with Chinese patients with NMO. Thirtyfive non-MHC SNPs were selected and genotyped by matrix-assisted laser desorption/ionization timeof-fl ight mass spectrometry（MALDI-TOF MS） in 110 NMO patients and 332 controls from southeastern China. Among the 35 SNPs, only one, rs1800693 in the TNFRSF1 A locus, was nominally associated with NMO（P = 0.045, OR = 1.550, 95% CI = 1.007 – 2.384）. However, none of the 35 SNPs was associated with NMO after Bonferroni correction. Our results showed no association between these identified non-MHC MS risk loci and NMO, suggesting there are genetic differences in the etiology of NMO and MS.

关键词： neuromyelitis optica major histocompatibility complex association Chinese

Variants of Interleukin-7/Interleukin-7 Receptor Alpha are Associated with Both Neuromyelitis Optica and Multiple Sclerosis Among Chinese Han Population in Southeastern China

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Chinese Medical Journal 2015年第22期128卷 3062-3068页

作者： Jing-Cong Zhuang Lei Wu Mei-zhen Qian Ping-Ping Cai Qi-Bing liu Gui-Xian Zhao zhen-xin li Zhi-Ying Wu Department of Neurology Institute of Neurology First Affiliated Hospital Fujian Medical University Fuzhou Fujian 350004 China Department of Neurology Research Center of Neurology Second Affiliated Hospital The Collaborative Innovation Center for Brain Science Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China Department of Neurology Institute of Neurology Huashan Hospital Shanghai Medical College Fudan University Shanghai 200040 China

Background： Neuromyelitis optica （NMO） and multiple sclerosis （MS） are autoimmune demyelinating diseases of the central nerve system, lnterleukin-7 （IL-7） and interleukin-7 receptor alpha （IL-7Rα） were proved to be important in the pathogenesis of both diseases because of the roles they played in the differentiations of autoimmune lymphocytes. The variants of both genes had been identified to be associated with MS susceptibility in Caucasian, Japanese and Korean populations. However, the association of these variants with NMO and MS has not been well studied in Chinese Southeastern Han population. Here, we aimed to evaluate the association of six IL-7 variants （rsl520333, rs1545298, rs4739140, rs6993386, rs7816065, and rs2887502） and one variant of IL-7RA （rs6897932） with NMO and MS among Chinese Han population in southeastern China. Methods： Matrix-assisted laser desorption/ionization time of flight mass spectrometry （MassARRAY system） and Sanger sequencing were used to determine the variants of IL-7 and IL-7RA in 167 NMO patients, 159 MS patients and 479 healthy controls among Chinese Han population in southeastern China. Samples were excluded if the genotyping success rate 〈90%. Results： Statistical differences were observed in the genotypes of IL-7 rs1520333 in MS patients and IL-7RA rs6897932 in NMO patients, compared with healthy controls （P = 0.035 and 0.034, respectively）. There was a statistically significant difference in the genotypes of IL-7 rs2887502 between MS and NMO patients （P = 0.014）. And there were statistically significant differences in the rs6897932 genotypes （P = 0.004） and alleles （P = 0.042） between NMO-IgG positive patients and healthy controls. Conclusions： The study suggested that among Chinese Hart population in southeastern China, the variant of IL-7RA （rs6897932） was associated with NMO especially NMO-IgG positive patients while the variant of IL-7 （rs1520333） with MS patients. And the genotypic differences of IL-7 rs2887502 between M

关键词： Association lnterleukin-7/Interleukin-7 Receptor Alpha Multiple Sclerosis Neuromyelitis Optica Chinese Han Population

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3Cr2W8V钢膏剂硼铝共渗及生产应用

金属热处理 1988年第3期 33-36页

作者：张振信李凤珍哈尔滨科技大学

本文通过金相、硬度、X射线衍射等方法,测定了3Cr2W8V钢膏剂法硼铝共渗层的组织及相结构。共渗层具有高硬度(HV0.11850～2290)、高的耐磨性和热硬性,用此工艺处理的轴承套圈辗压模的使用寿命延长了3～4倍。

关键词：共渗层相结构表面硬度渗硼层热硬性耐磨性力学性能生产应用膏剂剂型 Cr

Variants of Interferon Regulatory Factor 5 are Associated with Neither Neuromyelitis Optica Nor Multiple Sclerosis in the Southeastern Han Chinese Population

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Chinese Medical Journal 2015年第13期128卷 1743-1747页

作者： Qi-Bing liu Lei Wu Gui-Xian Zhao Ping-Ping Cai zhen-xin li Zhi-Ying Wu Department of Neurology Institute of Neurology First Affiliated Hospital Fujian Medical University Fuzhou Fujian 350005 China Department of Neurology Research Center of Neurology in Second Affiliated Hospital and The Collaborative Innovation Center for Brain Science Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China Department of Neurology Institute of Neurology Huashan Hospital Shanghai Medical College Fudan University Shanghai 200040 China

Background： Neuromyelitis optica （NMO） and multiple sclerosis （MS） are demyelinating disorders of the central nervous system. Interferon regulatory factor 5 （IRF5） is a common susceptibility gene to different autoimmune disorders. However, the association of IRF5 variants with NMO and MS patients has not been well studied. Therefore, we aimed to evaluate whether IRF5 variants were associated with NMO and MS in the Southeastenl Han Chinese population. Methods： Four single nucleotide polymorphisnls （SNPs） were selected and genotyped by matrix-assisted laser desorption/ionization time of flight mass spectrometry in 111 NMO patients, 145 MS patients and 300 controls from Southeastern China. Results： None of these 4 SNPs was associated with NMO or MS patients. Conclusions： Our preliminary study indicates that genetic variants in IRI~ may affect neither NMO nor MS in the Southeastern Han Chinese population. Further studies with a large sample size and diverse ancestry populations are needed to clarify this isstie.

关键词： Association: Chinese: Interferon Regulatory Factor 5: Multiple Sclerosis: Neuromyelitis Optica