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Aflatoxin B1 decreased flesh flavor and inhibited muscle development in grass carp(Ctenopharyngodon idella)

Animal Nutrition 2024年第3期18卷 27-38页

作者： Xiang Ning He zhen zhen zeng Wei Dan Jiang Pei Wu Yang Liu Sheng Yao Kuang Ling Tang Shu Wei Li Lin Feng Xiao Qiu Zhou Animal Nutrition Institute Sichuan Agricultural UniversityChengdu 611130China Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengdu 611130China Key Laboratory for Animal Disease-Resistance Nutrition Ministry of EducationMinistry of Agriculture and Rural AffairsKey Laboratory of Sichuan ProvinceChengdu 611130China Animal Nutrition Institute Sichuan Academy of Animal ScienceChengdu 610066China

In nature,aflatoxins,especially aflatoxin B1(AFB1),are the common mycotoxins,which cause serious health problems for humans and *** paper aimed to study the effects of AFB1 on flesh flavor and muscle development of grass carp(Ctenopharyngodon idella)and its *** were 1440 individual fish in total,with 6 treatments and each treatment replicated 3 *** 6 treatments were fed a control diet with different doses of AFB1(0.04,29.48,58.66,85.94,110.43 and 146.92μg/kg diet)for 60 ***1 increased myofiber diameter,as well as decreased myofiber density of grass carp muscle(P<0.05).The contents of free amino acid decreased gradually(P<0.05)as dietary AFB1 increased in the muscle of grass *** levels of reactive oxygen species,malonaldehyde and protein carbonyl(PC)were increased(P<0.05)with the dietary AFB1 *** levels of antioxidant enzyme(glutathione peroxidase,glutathione,glutathione reductase,total antioxidant capacity,anti-superoxide anion,and anti-hydroxyl radical)were decreased(P<0.05)with the dietary AFB1 *** addition,dietary AFB1 decreased the content of collagen,and downregulated the mRNA and protein levels of transforming growth factor-β(TGF-β)/Smads signaling pathway in grass carp muscle(P<0.05).The mRNA and protein levels of myogenic regulatory factors were downregulated in grass carp muscle(P<0.05).Furthermore,the activities of matrix metalloproteinase-2(MMP-2)and matrix metalloproteinase-9(MMP-9)were increased(P<0.05),and the protein levels of phosphorylate-38 mitogen-activated protein kinase(p-p38MAPK),phosphorylate-c-Jun N-terminal kinase,urokinase-type plasminogen activator(uPA),MMP-2 and MMP-9 were upregulated(P<0.05),but collagenⅠ,lamininβ1 and fibronectin were downregulated(P<0.05)with the dietary AFB1 increased in the muscle of grass *** on the results of this study,we can draw the following conclusion:dietary AFB1 might damage flesh flavor and inhibit the muscle development through MAPK/uPA/MMP/extrac

关键词： Aflatoxin B1 Flesh flavor Muscle development Grass carp

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Understand the Temperature Sensing Behavior of Solid-state Polymerized PEDOT Hybrid Based on X-ray Scattering Studies

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Chinese Journal of Polymer Science 2024年第1期42卷 105-112,I0010页

作者： zhen-Hang He Guang-Feng Liu Ze-Kun Zhou zhen Liu Yi-Shu zeng Peng Zhang School of Materials Science and Engineering Key Laboratory for Polymeric Composite and Functional Materials of Ministry of EducationSun Yat-sen UniversityGuangzhou 510275China Shanghai Advanced Research Institute(Zhangjiang Laboratory) Chinese Academy of SciencesShanghai 201204China

Poly(3,4-ethylenedioxythiophene)(PEDOT) is one of the most successful conductive polymers that recently has been used in wearable sensors for human health monitoring. In this work, we prepared a series of PEDOT hybrids consisting of PEDOT, sodium poly(styrene sulfonate)(PSSNa) and polyethylene oxide(PEO), and their preparation could be scaled-up via an adapted solid-state polymerization process. The resistance of the as-prepared PEDOT:PSS/PEO hybrid shows clear temperature response, i.e., it decreases almost linearly with the temperature increase. To understand this phenomenon, the in situ synchrotron radiation wide-and small-angle X-ray scattering(WAXS/SAXS) characterizations were undertaken to study the temperature-dependent microstructure change of the PEDOT:PSS/PEO hybrid. It demonstrated that PEDOT formed conductive paths in the hybrids, which were not destroyed by the PEO crystallization. As temperature increased, the PEO crystals' melting and the accompanying reorganization of PEDOT chains endowed the hybrid sample temperature responsiveness. Based on these fundamental knowledges, the hybrid materials were used to fabricate flexible wearable sensor that showing temperature sensing performance with an accuracy of 1 ℃. These findings shed lights on the scalable manufacturing of wearable sensors for body temperature monitoring.

关键词： Solid-state polymerization PEDOT hybrid Structure-property correlation X-ray scattering

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Printed Biosensors for the Detection of Alzheimer’s Disease Based on Blood Biomarkers

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Journal of Analysis and Testing 2024年第2期8卷 133-142页

作者： Yu zeng zhen Huang Yibiao Liu Tailin Xu Longgang Central Hospital of Shenzhen Shenzhen518116China School of Biomedical Engineering Shenzhen UniversityShenzhen518060China

Alzheimer’s disease(AD)is a chronic neurodegenerative disorder,and early diagnosis plays a crucial role in its prevention and *** recent years,blood-based biomarkers for early AD diagnosis have gained attention due to their non-invasiveness and minimal adverse reactions,which make them an attractive *** the onset of the COVID-19 pandemic,visiting large medical examination centers for blood tests has become increasingly *** trend is shifting towards community or home-based sampling,which relies on the development and application of portable,miniaturized,and highly sensitive *** the various sensors used for detecting blood biomarkers in AD,printed sensors demonstrate great potential in AD blood biomarker detection due to their ease of miniaturization,scalability for mass production,and compatibility with various detection *** this review,we focus on discussing the application of printed sensors in the analysis of blood biomarkers for *** also explore the challenges faced by printed sensors in early diagnosis based on AD blood biomarkers and propose potential solutions to address these challenges.

关键词： Printed biosensors Alzheimer’s disease Blood biomarkers Printing technology

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Capacitor Voltage Imbalance Mechanism and Balancing Control of MMC When Riding Through PTG Fault

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 778-785页

作者： zhen He Maozeng Lu Lijun Hang Pingliang zeng Yanhua Liu Hangzhou Dianzi University Hangzhou 310018China Shandong University of Technology Zibo 255000China State Grid Hangzhou Power Supply Company State GridHangzhou 310000China

Modular multilevel converter (MMC) based fault ride through (FRT) control is a promising solution to deal with the pole-to-ground (PTG) fault in high voltage direct current (HVDC) system. However, when MMC switches to the FRT control, capacitor voltage imbalance between upper and lower arms will occur, resulting in the deterioration of FRT performance. This letter provides a comprehensive analysis for the imbalance issue from the perspective of fundamental frequency circulating current (FFCC). It is found the imbalance during FRT stage will not expand continuously, but converge to a certain value gradually. The specific imbalance degree is closely associated with the amplitude of FFCC. In order to solve the imbalance issue, an open-loop balancing control is proposed. By introducing a fundamental frequency feedforward item to the inherent circulating current control, the proposed method can not only balance the capacitor voltages, but also minimize the amplitude of FFCC, and consequently the power loss of MMC during FRT process can be reduced. Finally, simulation results of PSCAD/ EMTDC verify the validity of theoretical analysis.

关键词： Balancing control capacitor voltage imbalance FFCC FRT control HVDC system PTG fault

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The 2022 Extreme Heatwave in Shanghai,Lower Reaches of the Yangtze River Valley:Combined Influences of Multiscale Variabilities

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Advances in Atmospheric Sciences 2024年第4期41卷 593-607页

作者： Ping LIANG Zhiqi ZHANG Yihui DING zeng-zhen HU Qi CHEN Key Laboratory of Cities’Mitigation and Adaptation to Climate Change in Shanghai Shanghai Regional Climate CenterChina Meteorological AdministrationShanghai 200030China National Climate Center China Meteorological AdministrationBeijing 100081China Climate Prediction Center NCEP/NWS/NOAACollege ParkMD 20740USA

In the summer of 2022,China(especially the Yangtze River Valley,YRV)suffered its strongest heatwave(HW)event since *** this study,we examined the influences of multiscale variabilities on the 2022 extreme HW in the lower reaches of the YRV,focusing on the city of *** found that about 1/3 of the 2022 HW days in Shanghai can be attributed to the long-term warming trend of global *** mid-summer of 2022,an enhanced western Pacific subtropical high(WPSH)and anomalous double blockings over the Ural Mountains and Sea of Okhotsk,respectively,were associated with the persistently anomalous high pressure over the YRV,leading to the extreme *** Pacific Decadal Oscillation played a major role in the anomalous blocking pattern associated with the HW at the decadal time ***,the positive phase of the Atlantic Multidecadal Oscillation may have contributed to regulating the formation of the double-blocking *** warming of both the warm pool of the western Pacific and tropical North Atlantic at the interannual time scale may also have favored the persistency of the double blocking and the anomalously strong *** the subseasonal time scale,the anomalously frequent phases 2-5 of the canonical northward propagating variability of boreal summer intraseasonal oscillation associated with the anomalous propagation of a weak Madden-Julian Oscillation suppressed the convection over the YRV and also contributed to the ***,the 2022 extreme HW originated from multiscale forcing including both the climate warming trend and air-sea interaction at multiple time scales.

关键词： extreme heatwave multiscale variability air-sea interaction warming trend Yangtze River Valley Shanghai

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Influence of filler characteristics on particle removal in fluid catalytic cracking slurry under an alternating electric field

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Petroleum Science 2024年第3期21卷 2102-2111页

作者： Qiang Li Hui-zhen Yang Can Yang Qing-Zhu Qiu Wei-Wei Xu Zhao-zeng Liu College of New Energy China University of Petroleum(East China)Qingdao266580ShandongChina

The characteristics of the packing material under an alternating electric field are an important factor in the removal of FCCS *** this study,the electric field distribution of a separation unit consisting of packed spheres under an alternating electric field is simulated,and the movement mechanism of catalyst particles is ***"effective contact point"model is derived to predict the adsorption of filler contact points on catalyst particles under the alternating electric field,and the model is validated by simulations and *** numerical calculation and experimental results indicate that the electrical properties of the filler spheres,the filler angleθ,and the frequency f of the alternating electric field affect the adsorption of catalyst *** the frequency of the electric field increases,the particle removal efficiency of the high-conductivity filler(silicon carbide)increases and then settles,and the separation efficiency of the low-conductivity filler(glass,zirconia)is not sensitive to the change in electric field frequency.

关键词： Fluid catalyticcracking slurry(FCCS) Particle AC electric field Fillers Removal

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Solitons and Their Biperiodic Pulsation in Ultrafast Fiber Lasers Based on CB/GO

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Chinese Physics Letters 2024年第8期41卷 28-32页

作者： zhen-Tao Ju Zhi-zeng Si Xin Yan Chao-Qing Dai College of Optical Mechanical and Electrical EngineeringZhejiang A&F UniversityLin’an 311300China

The carbon black(CB)is introduced to manufacture CB/graphene oxide(GO)composite material to mitigate limitations of GO as a saturable absorber with the excellent performance in ultrafast fiber *** a central wavelength of 1555.5 nm,the stable mode-locked pulse with width of 656 fs,repetition rate of 20.16 MHz,and high signal-to-noise ratio of 82.07 dB is experimentally ***,experimental observations for pulsation phenomena of vector biperiodic solitons combining period-1 and period-17,period-2 and period-32,period-3 and period-36 are verified via simulations.

关键词： fiber periodic absorber

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Microstructure and Mechanical Property of the Large Cross-Sectioned Mg-Gd-Y-Zn-Zr Alloy Produced by Small Extrusion Ratio

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Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 999-1006页

作者： Sen Wang Hucheng Pan Caixia Jiang Zhihao zeng zhen Pan Weineng Tang Chubin Yang Yuping Ren Gaowu Qin Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) College of Materials Science and EngineeringNortheastern UniversityShenyang110819China Mg and Mg Alloy Institute Technology CenterBaosteel Metal Co.LtdChina Baowu Steel GroupShanghai200940China Jiangxi Provincial Engineering Research Center for Magnesium Alloy Gannan Normal UniversityGanzhou341000China

In this work,the microstructure and mechanical properties of large cross-sectioned Mg-9Gd-3Y-1.2Zn-0.5Zr(VWZ931)samples produced by the small extrusion ratio has been *** as-extruded VWZ931 sample with diameter of~30 mm can exhibit the high yield strength(YS)of 339 MPa,ultimate tensile strength(UTS)of 387 MPa and elongation of 8.2%,*** peak-aged,the YS and UTS of the Mg samples were significantly increased to 435 MPa and 467 *** small extrusion ratio leads to the low fraction of dynamic recrystallized(DRX)grains in VWZ931 sample,and the texture hardening effect can be fully utilized to achieve high *** combined effect of precipitation strengthening due to the long-period stacking ordered phases and theβ′phase,grain boundary strengthening due to the fine DRX grains,heterogeneous deformation-induced strengthening caused by bimodal microstructure,can together contribute to the high strength of present Mg *** findings can shed light on designing other large-sized Mg wrought alloys with high mechanical performance.

关键词： Mg-RE alloy Mechanical property Bimodal grains Texture hardening

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Evaluation of the binding affinity and antioxidant activity of phlorizin to pepsin and trypsin

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Food Science and Human Wellness 2024年第1期13卷 392-400页

作者： Jing Zhang Lan Tang Xia Hu zhen zeng Wen Wu Fang Geng Hui Li Di Wu Meat Processing Key Laboratory of Sichuan Province School of Food and Biological EngineeringChengdu UniversityChengdu 610106China School of Chemical Engineering Sichuan UniversityChengdu 610065China

Phlorizin(PHL)is a natural compound with strong antioxidant properties mainly found in *** this paper,the interaction mechanism of PHL with pepsin and trypsin was comparatively evaluated by computer simulation,fluorescence spectra,circular dichroism(CD),and Fourier transform infrared(FT-IR)spectra at a molecular *** spectra showed that PHL quenches the pepsin/trypsin by static *** parameters indicated that PHL binds to pepsin mainly through hydrogen bonds and van der Waals forces,and that of trypsin was electrostatic *** ground state complexes PHL and protease have a moderate affinity of 105 L/mol PHL binds more strongly to trypsin than to *** and FT-IR spectra results showed that pepsin/trypsin decreased theβ-sheet content and slightly changed its secondary structure upon *** experimental results are mutually verified with the predicted computer-aid simulation *** PHL and trypsin binding,the antioxidant capacity of PHL was ***,the antioxidant capacity of PHL was decreased after binding to *** work elucidates the binding of PHL binding mechanisms to pepsin/trypsin and provides useful information for the digestion of PHL to improve the application of PHL in food processing.

关键词： Interaction Phlorizin Pepsin Trypsin Antioxidation

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Shi-pi-xiao-ji formula suppresses hepatocellular carcinoma by reducing cellular stiffness through upregulation of acetyl-coA acetyltransferase 1

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2727-2741页

作者： Hui-Ying Jian Zi-Cheng Liang Huan Wen zhen Zhang Pu-Hua zeng Graduate School Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Provincial Hospital of Integrated Traditional Chinese and Western Cancer Research Institute of Hunan Academy of Traditional Chinese MedicineHunan Academy of Chinese MedicineChangsha 410006Hunan ProvinceChina

BACKGROUND Previous studies have shown that the Shi-pi-xiao-ji(SPXJ)herbal decoction formula is effective in suppressing hepatocellular carcinoma(HCC),but the underlying mechanisms are not ***,this study investigated whether the antitumor effects of the SPXJ formula in treating HCC were mediated by acetyl-coA acetyltransferase 1(ACAT1)-regulated cellular *** a series of experiments,we concluded that SPXJ inhibits the progression of HCC by upregulating the expression level of ACAT1,lowering the level of cholesterol in the cell membrane,and altering the cellular stiffness,which provides a new idea for the research of traditional Chinese medicine against *** To investigate the anti-tumor effects of the SPXJ formula on the malignant progression of *** HCC cells were cultured in vitro with SPXJ-containing serum prepared by injecting SPXJ formula into wild-type *** apoptotic rate and proliferative,invasive,and migratory abilities of control and SPXJ-treated HCC cells were *** force microscopy was used to determine the cell surface morphology and the Young’s modulus values of the control and SPXJ-treated HCC *** membrane cholesterol levels in HCC cells were detected using the Amplex Red cholesterol detection ***1 protein levels were estimated using western *** Compared with the vehicle group,SPXJ serum considerably reduced proliferation of HCC cells,increased stiffness and apoptosis of HCC cells,inhibited migration and invasion of HCC cells,decreased plasma membrane cholesterol levels,and upregulated ACAT1 protein ***,treatment of HCC cells with the water-soluble cholesterol promoted proliferation,migration,and invasion of HCC cells as well as decreased cell stiffness and plasma membrane cholesterol levels,but did not alter the apoptotic rate and ACAT1 protein expression levels compared with the vehicle *** SPXJ formula inhibited proliferation,invasion,and migration

关键词： Shi-pi-xiao-ji formula Hepatocellular carcinoma Cellular stiffness Plasma membrane cholesterol level AcetylcoA acetyltransferase 1

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