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Emerging roles of bile acids in chronic hepatitis,liver cirrhosis,and hepatocellular carcinoma

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Cellular & Molecular Immunology 2023年第9期20卷 1087-1089页

作者： zhen xun Xiaobao Yao Qishui Ou Department of Laboratory Medicine Fujian Key Laboratory of Laboratory MedicineGene Diagnosis Research CenterFujian Clinical Research Center for Clinical Immunology Laboratory TestThe First Affiliated HospitalFujian Medical UniversityFuzhouChina Department of Laboratory Medicine National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouChina

Bile acids(BAs)are cholesterol-derived molecules that are produced in the liver,secreted into the duodenum,absorbed by the small intestine and recycled back to the liver[1].BAs regulate cholesterol metabolism,promote bile secretion,and emulsify and facilitate the digestion and absorption of dietary fats;in addition,there is growing evidence that BAs also act as endocrine cell signaling mediators that activate nuclear or membrane-localized receptors to trigger specific signaling pathways and regulate various biological processes,including immunity[2,3].Findings from studies in patients and cell or mouse models support the notion that BAs are critical regulators of the development of liver diseases,including chronic hepatitis B(CHB)[4],liver cirrhosis(LC)[5],and hepatocellular carcinoma(HCC)[6].Here,we discuss the emerging roles of BAs in the progression of CHB,LC,and HCC.

关键词： bile cirrhosis metabolism

生物炭施加垄沟集雨种植对水土流失及紫花苜蓿草产量的影响

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草地学报 2024年第5期32卷 1314-1326页

作者：朱进辉赵武成 Erastus Mak-Mensah 王琦张登奎周旭姣赵晓乐戚文佳马文崔循臻李旭春刘冰甘肃农业大学草业学院甘肃兰州730070 甘肃省定西市水利科学研究所甘肃定西743000 甘肃省定西市水土保持科学研究所甘肃定西743000 中国科学院西北生态环境资源研究院临泽内陆河流域研究站/中国科学院内陆河流域生态水文重点实验室甘肃兰州730000

为缓解我国黄土高原区干旱胁迫和控制水土流失,本研究采用裂区设计,生物炭施加模式(生物炭施加和无生物炭施加)为主区,耕作模式(打结垄、开敞垄和平作)为副区,研究不同生物炭施加模式和耕作模式对土壤水分、径流、泥沙流失、养分流失、... 详细信息

为缓解我国黄土高原区干旱胁迫和控制水土流失,本研究采用裂区设计,生物炭施加模式(生物炭施加和无生物炭施加)为主区,耕作模式(打结垄、开敞垄和平作)为副区,研究不同生物炭施加模式和耕作模式对土壤水分、径流、泥沙流失、养分流失、紫花苜蓿(Medicago sativa L.)干草产量和水分利用效率的影响。试验结果表明,在2019和2020年紫花苜蓿生育期,与平作处理相比,开敞垄和打结垄处理的径流量、泥沙、全氮、全磷、有机质流失量分别减少20.1%~37.7%和60.1%~64.7%,54%~75.5%和77.1%~87.6%,44.4%~65.5%和49.0%~81.8%,36.7%~75.3%和48.6%~87.3%,48.2%~72.9%和58.6%~85.4%,土壤贮水量、紫花苜蓿干草产量和水分利用效率分别增加39.5~52.1和31.2~60.5 mm,26.2%~31.7%和26.5%~35.2%,10.07~14.86和12.14~16.55 kg·hm^(-2)·mm^(-1)。与无生物炭施加处理相比,生物炭施加处理的径流量、泥沙、全氮、全磷和有机质流失量分别减少48%~69%,94%~125%,12%~24%,28%~46%和35%~48%,土壤贮水量、紫花苜蓿干草产量和水分利用效率分别增加42.93~26.09 mm,106%~111%和1.96~6.90 kg·hm^(-2)·mm^(-1)。本研究表明,生物炭施加打结垄沟集雨种植是该区域适宜耕作模式。

关键词：生物炭添加模式耕作模式径流水土流失养分流失坡地

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A decoupled procedure for convection-radiation simulation in scramjets

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Science China(Technological Sciences) 2014年第12期57卷 2551-2566页

作者： WANG Jing Ying GAO zhen xun LEE Chun Hian ZHANG Hui Qiang School of Aeronautical Science and Engineering Beihang University School of Aerospace Tsinghua University

Following an order analysis of key parameters, a decoupled procedure for simulation of convection-radiation heat transfer problems in supersonic combustion ramjet(scramjet) engine was developed. The radiation module of the procedure consisted of Perry 5GG weighted sum gray gases model for spectral property calculation and discrete ordinates method S4 scheme for radiative transfer computation, while the flow field was computed using the Favrè average conservative Navier-Stokes(N-S) equations, in conjunction with Menter's k-ω SST two-equation model. A series of 2D supersonic nonreactive turbulent channel flows of radiative participants with selective parameters were simulated for validation purpose. Radiative characteristics in DLR hydrogen fueled and NASA SCHOLAR ethylene fueled scramjets were numerically studied using the developed procedure. The results indicated that the variations of spatial distributions of the radiative source and total absorption coefficient are highly consistent with those of the temperature and radiative participants, while the spatial distribution of the incident radiation spreads wider. It also demonstrated that the convective heating is significantly affected by the complexity of the flow field, such as the shock wave/boundary layer interactions, while the radiative heating is simply an integral effect of the whole flow field. Although the radiative heating in the combustion chambers reaches a certain level, an order of magnitude of 10 k W/m2, it still contributes little to the total heat transfer(<7%).

关键词：超燃冲压发动机辐射传热数值模拟对流加热解耦方法计算模型方程模型空间分布

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新兴分子诊断技术在即时检验中的应用与展望

中华检验医学杂志 2023年第10期46卷 1104-1108页

作者：黄群芳荀振欧启水福建医科大学附属第一医院检验科、福建省检验医学重点实验室、福建医科大学基因诊断研究中心、福建省临床免疫学检验临床医学研究中心福州350005

分子诊断技术是临床实验中的重要诊断手段。即时检验便携、快速、准确、低成本,有助于及时发现传染源,控制传染病蔓延。本文介绍了可用于即时检验的新兴分子诊断技术,包含数字环介导等温扩增技术和规律成簇的间隔短回文重复序列及其相... 详细信息

分子诊断技术是临床实验中的重要诊断手段。即时检验便携、快速、准确、低成本,有助于及时发现传染源,控制传染病蔓延。本文介绍了可用于即时检验的新兴分子诊断技术,包含数字环介导等温扩增技术和规律成簇的间隔短回文重复序列及其相关蛋白系统的相关进展,同时对其未来前景进行了展望。

关键词：基因扩增规律成簇的间隔短回文重复序列及其相关蛋白系统即时检验

Association between MTHFR c.677C>T variant and erectile dysfunction among males attending fertility clinic

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Asian Journal of Andrology 2024年第1期26卷 41-45页

作者： Shun Bai Ming-zhen Li Yang-Yang Wan Xue-Chun Hu Yi-xun Liu Xian-Hong Tong Tong-Hang Guo Lu Zong Ran Liu Yuan-Qi Zhao Ping Xiang Bo Xu Xiao-Hua Jiang Department of Gynecology and Obstetrics Reproductive and Genetic HospitalThe First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China NHC Key Laboratory of Male Reproduction and Genetics Guangdong Provincial Reproductive Science Institute(Guangdong Provincial Fertility Hospital)Guangzhou 510600China Department of Urology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Wannan Medical College Wuhu 241002China

Genetic risk factors have been shown to contribute to the development of sexual ***,the role of methylenetetrahydrofolate reductase(MTHFR)gene variants in the risk of erectile dysfunction(ED)remains *** this study,we recruited 1254 participants who underwent ED assessed by the International Index of Erectile *** MTHFR c.677C>T variant was also measured by fluorescence polymerase chain reaction(PCR).No significant difference in the genotypic frequency of the MTHFR C677T polymorphism(CC,CT,and TT)was observed between men from the ED and non-ED *** addition,on binary logistic regression analysis,both crude and adjusted models showed that the risk of ED was not significantly associated with the C677T ***,a significantly higher frequency of the 677TT polymorphism was found in severe and moderate ED(P=O.02).The positive correlation between the MTHFR 677TT polymorphism and severe ED was confirmed by logistic regression analysis,even after adjusting for potential confounders(odds ratio[OR]=2.46,95%confidence interval[CI]:1.15-5.50,P=0.02).These findings suggest a positive correlation between the MTHFR 677TT polymorphism and the risk of severe *** of MTHFR gene polymorphisms may provide complementary information for ED patients during routineclinicaldiagnosis.

关键词： erectile dysfunction gene variant genetic risk factors methylenetetrahydrofolate reductase sexual function

Association between mitochondrial DNA content and baseline serum levels of HBsAg in chronic hepatitis B infection

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Association between mitochondrial DNA content and baseline s...

对《慢性乙型肝炎防治指南(2022年版)》的商榷

第二届中国临床分子诊断大会

作者： zhen xun Qishui Ou The 1st affiliated Hospital Fujian Medical University

Recent studies have demonstrated a potential link between mitochondrial DNA（mtDNA） content and cirrhosis or hepatocellular carcinoma（HCC）. However, there are few studies evaluating mtDNA content as a noninvasive marker of chronic hepatitis B infection（CHB）. In this study, we conducted a case-control study to determine mtDNA content in peripheral blood leukocyte（PBL） samples from 76 CHB cases na?ve to antivirus therapy and 96 healthy controls, and then evaluated the association between mtDNA content and baseline serum concentration of HBV markers. Consequently, CHB cases had significantly higher mtDNA content than healthy controls（1052.85 vs 618.98, P＜0.001）. Pearson’s correlation analysis revealed that mtDNA content was negatively correlated with the baseline levels of hepatitis B surface antigen（HBsAg）（r=-0.291, P=0.011） in CHB patients. In a trend analysis, a statistically significant association was detected between lower mtDNA content and increasing levels of HBsAg（P=0.015）. In conclusion, our study provides the first epidemiological evidence that mtDNA content of CHB cases na?ve to antivirus therapy is significantly higher than healthy controls and the levels of mtDNA content is negatively associated with HBsAg. mtDNA content may serve as a potential noninvasive biomarker of CHB which may need more researches to validate.

关键词： Mitochondrial DNA Chronic hepatitis B infection Peripheral blood leukocyte HBsAg Noninvasive biomaker

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中华肝脏病杂志 2023年第10期31卷 1099-1100页

作者：荀振傅亚叶宇宸刘灿欧启水福建医科大学附属第一医院检验科福建省检验医学重点实验室福建医科大学基因诊断研究中心福建省临床免疫学检验临床医学研究中心福州350005 福建医科大学附属第一医院滨海院区国家区域医疗中心检验科福州350212

最近中华医学会肝病学分会和中华医学会感染病学分会联合发布了《慢性乙型肝炎防治指南(2022年版)》(以下简称《指南》)[1], 该《指南》较好地帮助临床医生在慢性乙型肝炎(chronic hepatitis B, CHB)的预防、诊断和治疗实践中做出合理... 详细信息

最近中华医学会肝病学分会和中华医学会感染病学分会联合发布了《慢性乙型肝炎防治指南(2022年版)》(以下简称《指南》)[1], 该《指南》较好地帮助临床医生在慢性乙型肝炎(chronic hepatitis B, CHB)的预防、诊断和治疗实践中做出合理决策。本着学术争鸣原则, 从实验工作者的角度现对该《指南》提出一些商榷意见, 与作者和读者探讨。

关键词：慢性乙型肝炎抗病毒治疗实验诊断

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大学评价活动的基本逻辑与价值选择

清华大学教育研究 2021年第3期42卷 39-46,64页

作者：荀振芳华北电力大学高教研究所北京102206

评价是一种基于事物认知的价值判断活动,好的评价活动是评价活动的目标性、科学性、有效性和效益性的完美契合。研究从WSP(物理-事理-人理)社会系统方法以及价值分析的双重维度出发,剖析大学评价活动的评价状态与价值事实,同时以学科评... 详细信息

评价是一种基于事物认知的价值判断活动,好的评价活动是评价活动的目标性、科学性、有效性和效益性的完美契合。研究从WSP(物理-事理-人理)社会系统方法以及价值分析的双重维度出发,剖析大学评价活动的评价状态与价值事实,同时以学科评估为例分析探讨大学评价体系的"价值建构",反思其成就、经验与存在问题,在此基础上提出"双一流"建设中大学评价的价值选择:评价活动要把关注人的进步与发展体现渗透在评价过程的每一环节,倡导发挥大学评价的教育价值与社会价值,以高质量内涵发展为核心推动大学评价思想、理念、技术、方法的全方位进步与持续的改革创新。

关键词：大学评价 WSR分析评价体系学科评估价值建构

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大学教学评价的制度干预与学术自由

清华大学教育研究 2005年第6期26卷 44-49页

作者：荀振芳华北电力大学高等教育研究所北京102206

大学教学评价作为国家对高等教育监督、调控、管理的重要形式,彰显着一种政府的干预力量,与大学的学术自由形成了矛盾、冲突,实质上体现了学术发展力量和政府管理力量的最终博弈。评价干预必须保持一个合理的尺度,评价的行政管理化走向... 详细信息

大学教学评价作为国家对高等教育监督、调控、管理的重要形式,彰显着一种政府的干预力量,与大学的学术自由形成了矛盾、冲突,实质上体现了学术发展力量和政府管理力量的最终博弈。评价干预必须保持一个合理的尺度,评价的行政管理化走向应引起深思。

关键词：评价干预学术自由