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Promoter methylation and mRNA expression of DKK-3 and WIF-1 in hepatocellular carcinoma

World Journal of Gastroenterology 2009年第21期15卷 2595-2601页

作者： zhen ding ye-ben qian li-xin zhu qi-ru xiong Department of Surgery First Affiliated Hospital of Anhui Medical University 218 Jixi avenue Hefei 230022 Anhui Province. China

AIM:To investigate the promoter methylation status and mRNA expression of DKK-3 and WIF-1 gene in hepatocellular carcinoma(HCC).METHODS:DKK-3 and WIF-1 acted as Wnt-antagonists and tumor suppressors,but hypermethylation of the gene promoter and low mRNA expression activated Wnt signaling aberrantly and induced the development of *** status of the DKK-3 and WIF-1 gene promoter was investigated using methylation specific polymerase chain reaction(PCR) in tumor and adjacent non-cancerous tissues from 33 HCC patients and 20 normal liver tissues served as *** expression of DKK-3 and WIF-1 mRNA was also determined by real-time quantitative reverse transcriptase *** relationship between methylation,mRNA expression,and clinical data,as well as methylation and mRNA expression of the two genes were ***:The methylation of DKK-3 and WIF-1 genes in HCC increased significantly compared with adjacent non-cancerous tissues and normal control tissues(χ2 =7.79,P < 0.05;χ2 = 4.89,P < 0.05),and no significant difference in methylation between adjacent non-cancerous tissues and normal control tissues was *** HCC tissues,significant differences in the DKK-3 promoter methylation were observed in age and cirrhosis,and significant differences of the WIF-1 promoter methylation were observed in HBsAg and *** average expression of DKK-3 mRNA in HCC and adjacent non-cancerous tissues was increased significantly compared with normal control *** average expression of WIF-1 mRNA showed no significant difference among the three *** mRNA expression of DKK-3 gene in HCC was decreased as the pathological grade ***:The aberrant promoter methylation and decreased expression of DKK-3 and WIF-1 may be an important mechanism in HCC,and may be a far-reaching significance in early diagnosis and therapy of HCC.

关键词： Hepatocellular carcinoma DKK-3 WIF-1 Promoter methylation

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Frontiers in high entropy alloys and high entropy functional materials

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Rare Metals 2024年第10期43卷 4639-4776页

作者： Wen-Tao Zhang Xue-qian Wang Feng-qi Zhang Xiao-Ya Cui Bing-Bing Fan Jia-Ming Guo Zhi-Min Guo rui Huang Wen Huang Xu-Bo li Meng-ru li Yan Ma Zhi-Hua Shen Yong-Gang Sun De-zhuang Wang Fei-Yang Wang li-qiang Wang Nan Wang Tian-li Wang Wei Wang Xiao-Yang Wang Yi-Han Wang Fu-Jie Yu Yu-zhen Yin ling-Kun Zhang Yi Zhang Jian-Yang Zhang qi Zhao Yu-Ping Zhao xin-Dong zhu Yasir Sohail Ya-Nan Chen Tao Feng qi-Long Gao Hai-Yan He Yong-Jiang Huang Zeng-Bao Jiao Hua Ji Yao Jiang qiang li Xiao-Ming li Wei-Bing liao Huai-Jun lin Hui liu qi liu qing-Feng liu Wei-Di liu xiong-Jun liu Yang Lu Yi-Ping Lu Wen Ma Xue-Fei Miao Jie Pan qing Wang Hong-Hui Wu Yuan Wu Tao Yang Wei-Ming Yang qian Yu Jin-Yu Zhang Zhi-Gang Chen liang Mao Yang Ren Bao-Long Shen Xun-li Wang Zhe Jia He zhu zhen-Duo Wu Si Lan School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China Jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and EngineeringSoutheast UniversityNanjing 211189China Department of Physics City University of Hong KongHongKong 999077China School of Materials Science and Engineering Tianjin UniversityTianjin 300072China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China Department of Mechanical Engineering Research Institute for Advanced ManufacturingThe Hong Kong Polytechnic UniversityHong Kong 100872China Center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of Solidification Control and Digital Preparation Technology(liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024China Institute of Advanced Wear&Corrosion Resistance and Functional Materials Jinan UniversityGuangzhou 510632China School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhou 221116China School of Physical Sciences Great Bay UniversityDongguan 523000China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China Beijing Advanced Innovation Center for Materials Genome Engineering Research Institute for Carbon NeutralityUniversity of Science and Technology BeijingBeijing 100083China Department of Mechanical Engineering The University of Hong KongHong Kong 999077China School of Computing Macquarie UniversitySydney 2113Australia Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China State Key Laborato

Owing to their exceptional properties,high-entropy alloys(HEAs)and high-entropy materials have emerged as promising research areas and shown diverse ***,the recent advances in the field are comprehensively reviewed,organized into five *** first section introduces the background of HEAs,covering their definition,significance,application prospects,basic properties,design principles,and *** subsequent section focuses on cutting-edge high-entropy structural materials,highlighting developments such as nanostructured alloys,grain boundary engineering,eutectic systems,cryogenic alloys,thin films,micro-nano-lattice structures,additive manufacturing,high entropy metallic glasses,nano-precipitate strengthened alloys,composition modulation,alloy fibers,and refractory *** the following section,the emphasis shifts to functional materials,exploring HEAs as catalysts,magneto-caloric materials,corrosion-resistant alloys,radiation-resistant alloys,hydrogen storage systems,and materials for ***,the review encompasses functional high-entropy materials outside the realm of alloys,including thermoelectric,quantum dots,nanooxide catalysts,energy storage materials,negative thermal expansion ceramics,and high-entropy wave absorption *** paper concludes with an outlook,discussing future directions and potential growth areas in the *** this comprehensive review,researchers,engineers,and scientists may gain valuable insights into the recent progress and opportunities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： High entropy alloys Cutting-edge structural materials Cutting-edgefunctional materials

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DKK-3和WIF-1基因启动子甲基化状态与肝细胞癌的关系研究

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实用临床医药杂志 2009年第2期13卷 12-15,20页

作者：丁振钱叶本熊奇如余宏铸李方跃张超许业传安徽医科大学第一附属医院普外科安徽合肥230022

目的探讨DKK-3和WIF-1基因启动子甲基化状态与肝细胞癌发生的相关性。方法应用甲基化特异性聚合酶链反应检测33例肝细胞癌及相应的癌旁组织和20例正常对照肝组织中DKK-3和WIF-1基因启动子甲基化状态,分析上述组织中两种基因甲基化状态... 详细信息

目的探讨DKK-3和WIF-1基因启动子甲基化状态与肝细胞癌发生的相关性。方法应用甲基化特异性聚合酶链反应检测33例肝细胞癌及相应的癌旁组织和20例正常对照肝组织中DKK-3和WIF-1基因启动子甲基化状态,分析上述组织中两种基因甲基化状态与临床资料的关系。结果DKK-3和WIF-1基因在癌组织中甲基化率明显高于癌旁组织和正常组织(P<0.05,P<0.05),而癌旁组织和正常组织中DKK-3和WIF-1基因甲基化率相比无明显差异;癌组织中DKK-3基因甲基化与临床资料中年龄及肝硬化有关;癌组织中WIF-1基因甲基化与临床资料中乙肝表面抗原、肝硬化有关。结论DKK-3和WIF-1基因启动子甲基化与HCC的发生相关;DKK-3和WIF-1基因致肝细胞癌的发生机制可能与肝硬化致肝细胞癌的发生机制不尽相同,两者是否有相互作用尚不清楚。

关键词： DKK-3 WIF-1 启动子甲基化肝细胞癌

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Consensus statement on layout and delivery of automatic external defibrillator in China

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Journal of Hainan Medical University 2020年第15期26卷 18-23页

作者： Yu Cao Song Chen Yan-Fen Chai Xiao-Hui Chen Yu-Guo Chen Shao-Wen Cheng Wen-Wei Cheng Bang-Han ding Yang Deng Jie Fu Bang-Jiang Fang Mai-Ying Fan li Gui Ping Gong Wei Guo Shu-Bin Guo liang Huang Ji-Yuan Han Zhong Ji Xian-Fei Ji xin-Cai Ji Hong-Xu Jin xin-Jun Jiang Wang-Xiang Jiang Jia-liang liu Xiao-Ran liu Zhi liu Chuan-zhu Lv Feng Lu Tan-Shi li xin li Yong li Shang-Lun li Shuang-Ming li Xiao-Gang li Bao-Jun li Pei-Wu li Chun-Sheng li Zhi-Jun li Chang-Luo li Xiang-Min li Yin-Ping li Zong-Jun Lu Zu-Xun Lu Zhong-qiu Lu Zhi-qian Luo Xiao-xing liao Jian-Bo Lei Tao Ma Yu Ma Yue-Feng Ma qing-Bian Ma lin-Hao Ma Jun-qi Ma Shi-Nan Nie Jie-Miao Ou-Yang Peng Peng qiao Pei Shu-Ming Pan Guo-Zhong qing li-Jie qin Wu-Ying qiao Fei Shao Wei Song xing-Yue Song zhen-Ju Song Rong-Ju Sun De-Ya Shang Du-Juan Sha Gui-Lan Tao Guo-Gang Tian Ying-Ping Tian Jian-Guang Tian Chao-Yang Tong Zi-Ren Tang Meng-xiong Tang Guo-Ping Wu Zhi Wan Tao Wang xin Wang Peng Wang Zhong Wang Tong Wang Ri-xing Wang Yi-xin Wang Xiao-Dan Wang ling Wu Wei Wei Hua Xiang Feng Xu Jun Xu Jie Xu Miao-Rong Xie Shuo-Gui Xu Tie Xu Feng Yu Wen Yi li-Shan Yang Shi-Jiao Yan Jin-Jian Yao Shou-Chun Yan Xue-Zhong Yu Xian-Zhi ye Xian-liang Yan Fu-Bing Zhou Rong-Bin Zhou Ming Zhou qiang Zhou Jin Zhou Ping Zhou Chang-Ju zhu Hua-Dong zhu Ji-Hong zhu Hong Zhang Mao Zhang Hua Zhang Na Zhang Guo-qiang Zhang Guo-Xiu Zhang Jin-Song Zhang Wen-Wu Zhang Wen-Zhong Zhang Jian-Feng Zhang Yi-Min zhu Jun Zeng Yuan zheng Zhi-Jie zheng Shen Zhao Yan Zhao Min Zhao Bin Zhao Xiao-Dong Zhao Xiao-Jing Zhao Hong-Ke Zeng Sheng-qiang Zou The Chinese Society of Emergency Medicine Research Unit of Island Emergency Medicine Chinese Academy of Medical SciencesHainan Medical University Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical UniversityHaikouHainanChina Emergency and Trauma College Hainan Medical UniversityHaikouHainanChina Department of Emergency Hainan Clinical Research Center for Acute and Critical DiseasesThe Second Affiliated Hospital of Hainan Medical UniversityHaikouHainanChina Key Laboratory of Hainan Trauma and Disaster Rescue Key Laboratory of Trauma of Hainan Medical University

*** Sudden cardiac death(SCD)refers to sudden death due to a variety of cardiac *** is manifested as a sudden loss of consciousness,cardiac arrest,and respiratory arrest and generally shows early symptoms that are atypical and not easily detected[1].According to a recent study,nearly 544000 patients suffer from SCD every year in China[2].

关键词： cardiac death respiratory

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Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng ding Yayun ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete li-Cheng Feng qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yan yerevan Physics Institute YerevanArmenia Universitélibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro RioBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi’an Jiaotong University Xi’anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung University Hsinchu National United University Miao-Li Department of Physics National T

The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main *** of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator *** this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approximately 60,000 signal and 30,000 background events are *** large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith ***,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment.

关键词： neutrino oscillation solar neutrino JUNO

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Future Physics Programme of BESⅢ

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Chinese Physics C 2020年第4期44卷 I0001-I0004,1-102页

作者： M.Ablikim M.N.Achasov P.Adlarson S.Ahmed M.Albrecht M.Alekseev A.Amoroso F.F.An Q.An Y.Bai O.Bakina R.Baldini Ferroli Y.Ban K.Begzsuren J.V.bennett N.Berger M.Bertani D.Bettoni F.Bianchi J Biernat J.Bloms I.Boyko R.A.Briere L.Calibbi H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.Chai J.F.Chang W.L.Chang J.Charles G.Chelkov Chen G.Chen H.S.Chen J.C.Chen M.L.Chen S.J.Chen Y.B.Chen H.Y.Cheng W.Cheng G.Cibinetto F.Cossio X.F.Cui H.L.Dai J.P.Dai X.C.Dai A.Dbeyssi D.Dedovich Z.Y.Deng A.Denig Denysenko M.Destefanis S.Descotes-Genon F.De Mori Y.ding C.Dong J.Dong L.Y.Dong M.Y.Dong Z.L.Dou S.X.Du S.I.Eidelman J.Z.Fan J.Fang S.S.Fang Y.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng M.Fritsch C.D.Fu Y.Fu Q.Gao X.L.Gao Y.Gao Y.Gao Y.G.Gao Z.Gao B.Garillon I.Garzia E.M.Gersabeck A.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl M.Greco L.M.Gu M.H.Gu Y.T.Gu A.Q.Guo F.K.Guo L.B.Guo R.P.Guo Y.P.Guo A.Guskov S.Han X.Q.Hao F.A.Harris K.L.He F.H.Heinsius T.Held Y.K.Heng Y.R.Hou Z.L.Hou H.M.Hu J.F.Hu T.Hu Y.Hu G.S.Huang J.S.Huang X.T.Huang X.Z.Huang Z.L.Huang N.Huesken T.Hussain W.Ikegami Andersson W.Imoehl M.Irshad Q.Ji Q.P.Ji X.B.Ji X.L.Ji H.L.Jiang X.S.Jiang X.Y.Jiang J.B.Jiao Z.Jiao D.P.Jin S.Jin Y.Jin T.Johansson N.Kalantar-Nayestanaki X.S.Kang R.Kappert M.Kavatsyuk B.C.Ke I.K.Keshk T.Khan A.Khoukaz P.Kiese R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc M.Kurth M.G.Kurth W.Kuhn J.S.Lange P.Larin L.Lavezzi H.Leithoff T.Lenz C.li Cheng li D.M.li F.li F.Y.li G.li H.B.li H.J.li J.C.li J.W.li Ke li L.K.li Lei li P.L.li P.R.li Q.Y.li W.D.li W.G.li X.H.li X.L.li X.N.li X.Q.li Z.B.li H.liang H.liang Y.F.liang Y.T.liang G.R.liao L.Z.liao J.libby C.X.lin D.X.lin Y.J.lin B.liu B.J.liu C.X.liu D.liu D.Y.liu F.H.liu Fang liu Feng liu H.B.liu H.M.liu Huanhuan liu Huihui liu J.B.liu J.Y.liu K.Y.liu Ke liu Q.liu S.B.liu T.liu X.liu X.Y.liu Y.B.liu Z.A.liu Zhiqing liu Y.F.Long X.C.Lou H.J.Lu J.D.Lu J.G.Lu Y.Lu Y.P.Lu C.L.Luo M.X.Luo P.W.Luo T.Luo X.L.Luo S.Lusso X.R.Lyu F.C.Ma H.L.Ma L.L.Ma M.M.Ma Q.M.Ma X.N.Ma X.X. Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Beijing Institute of Petrochemical Technology Beijing 102617China Bochum ruhr-University D-44780 BochumGermany Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China China Center of Advanced Science and Technology Beijing 100190China COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200443China G.I.Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Helmholtz Institute Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University of Science and Technology Luoyang 471003China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati I-00044FrascatiItaly INFN Sezione di Ferrara I-44122FerraraItaly Institute of Physics and Technology Peace Ave.54BUlaanbaatar 13330Mongolia Johannes Gutenberg University of Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany Joint Institute for Nuclear Research 141980 DubnaMoscow regionRussia Justus-liebig-Universitaet Giessen II.Physikalisches InstitutHeinrich-Buff-Ring 16D-35392 GiessenGermany KVI-CART University of GroningenNL-9747 AA GroningenThe Netherlands Lanzhou University Lanzhou 730000China liaoning University Shenyang 110036China Nanjing Normal University Nanjing 210023China Nanjing University Nanjing 210093China Nankai University Tianjin 300071China Peking University Beijing 100871China Shandong University Jinan 250100China Shanghai

There has recently been a dramatic renewal of interest in hadron spectroscopy and charm physics. This renaissance has been driven in part by the discovery of a plethora of charmonium-like XYZ states at BESⅢ and B factories, and the observation of an intriguing proton-antiproton threshold enhancement and the possibly related X(1835) meson state at BESⅢ, as well as the threshold measurements of charm mesons and charm baryons. We present a detailed survey of the important topics in tau-charm physics and hadron physics that can be further explored at BESⅢ during the remaining operation period of BEPCⅡ. This survey will help in the optimization of the data-taking plan over the coming years, and provides physics motivation for the possible upgrade of BEPCⅡ to higher luminosity.

关键词： meson hadron optimization

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2018 Chinese Guidelines for Prevention and Treatment of Hypertension——A report of the Revision Committee of Chinese Guidelines for Prevention and Treatment of Hypertension

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Journal of Geriatric Cardiology 2019年第3期16卷 182-241页

作者： Joint Committee for Guideline Revision Chinese Hypertension League Chinese Society of Cardiology Hypertension Committee of the Chinese Medical Doctor Association Hypertension Branch of the China Association for the Promotion of International Exchanges of Health Care Hypertension Branch of the Chinese Geriatrics Society li–Sheng liU Chinese Hypertension LeagueChinese Society of CardiologyHypertension Committee of the Chinese Medical Doctor AssociationHypertension Branch of the China Association for the Promotion of International Exchanges of Health CareHypertension Branch of the Chinese Geriatrics SocietyRevision Committee MembersChair: li-Sheng liU[*]Deputy Chairs: Zhao-Su WU Ji-Guang WANG Wen WANGMembers (Listed in alphabetic order by last name in Chinese Pinyin)Yu-Jing BAO Jun CAI Lu-Yuan CHEN Wei-Wei CHEN Shao-Li CHU Ying-Qing FENG Ping-Jin GAO Ting-Rui GUAN Zi-Hong GUO Qi HUA Jun HUANG Yong HUO Wei-Ping JIA Xiong-Jing JIANG Yi-Nong JIANG Li LI Li-Huan LI Nan-Fang LI Wei LI Xiao-Ying LI Xue-Wang LI Yan LI Yong LI Jin-Xiu LIN Li-Sheng LIU Xin-Zheng LU Ji-Xiang MA Jie MI Jian-Jun MU Chang-Yu PAN Gang SUN Ning-Ling SUN Ying-Xian SUN Jun TAO Hao WANG Ji-Guang WANG Wen WANG Wen-Zhi WANG Yong-Jun WANG Yu WANG Zeng-Wu WANG Hai-Ying WU Zhao-Su WU Liang-Di XIE Zhang-Rong XU Xiao-Wei YAN Yan-Min YANG Chong-Hua YAO Zheng-Pei ZENG Jian ZHANG Wei-Zhong ZHANG Xin-Hua ZHANG Xin-Jun ZHANG Yu-Qing ZHANG Ding-Liang ZHU Jun ZHU Zhi-Ming ZHUScientific Committee MembersXiang-Mei CHEN Hong CHEN Jun-Shi CHEN Xiao-Ping CHEN Yun-Dai CHEN Zhao-Qiang CUI Xue-Ping DU Li FAN Run-Lin GAO Jun-Bo GE Luo-Bu GE-SANG Dong-Feng GU Jing-Xuan GUO Yi-Fang GUO Qing-Hua HAN Ya-Ling HAN Zhao-Guang HONG Da-Yi HU Jian-Ping LI Guang-Wei LI Guang-Ping LI Xin-Li LI Yu-Ming LI Xiao-Feng LIANG Yi-Shi LI Yu-Hua LIAO Shu-Guang LIN Mei-Lin LIU Jing LIU Wei LIU Fang-Hong LU Shu-Ping MA Qian-Hui SHANG Yi-Pu CHEN Hai-Qin Tang Xin-Hua TANG Gang TIAN Ke-An WANG Xing-Yu WANG Dao-Wen WANG Shou-Ling WU Cheng-Bin XU Shou-Chun XU Xin-Juan XU Xin-Hua YIN Bo YU Guo-Ying YU Jing YU Wei YU Meng-Sun YU Hong YUAN Ru-Yu YUAN Chun-Yu ZENG Zhe-Chun ZENG Lin ZHANG Hui-Min ZHANG Dong ZHAO Luo-Sha ZHAO Lian-You ZHAO Xiao-Fang ZHOU Man-Lu ZHU*Correspondence to:moc.621@lhcsll (LIU LS)

Table of Contents Preamble 1 Prevalence of hypertension in Chinese population 1.1 Prevalence,incidence and epidemic trend of hypertension in Chinese population 1.2 Awareness,treatment and control of Hypertension in China 1.3 Important risk factors for hypertension in Chinese population 2 Hypertension and cardiovascular risk 2.1 Relationship between blood pressure and cardiovascular risk 2.2 Cardiovascular risk characteristics of hypertension population in China 3 Diagnostic evaluation 3.1 Medical history 3.2 Physical examination 3.3 Laboratory examinations 3.4 Genetic analysis 3.5 BP measurement 3.6 Evaluation of target organ damage.

关键词： 2018 Chinese Guidelines Contents Preamble Prevention and Treatment

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