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Recent progress on fluorescent probes for viruses

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Chinese Chemical Letters 2024年第1期35卷 72-83页

作者： Siyang Shen Weilin Xu Jianxiang Lu Shuhui Wang Yurou huang Xiaoyan Zeng Weimin Xiao Jun Yin Key Laboratory of Pesticide and Chemical Biology Ministry of EducationHubei International Scientific and Technological Cooperation Base of Pesticide and Green SynthesisInternational Joint Research Center for Intelligent Biosensing Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China Shenzhen Academy of Metrology and Quality Inspection Shenzhen 518109China

Viruses are ubiquitous in human life. Some viruses can be used as vectors of genetic engineering and specific pesticides. Other viruses trigger a variety of diseases in humans, animals and plants, resulting in high infection rates and mortality. Therefore, convenient, accurate and rapid detection of viruses is of great significance for the diagnosis and treatment of subsequent diseases. In contrast to traditional methods of detection, which rely on time-consuming and complex techniques such as polymerase chain reaction (PCR), fluorescent probes and imaging methods generate real-time results, with high specificity, and have been widely used in viral detection. In this review, the application of viral fluorescent probes in analyzing the molecular structure, detection and biological imaging is discussed. In particular, we categorized the probes based on their specificity for human and plant viruses, reviewing the latest findings and analyzing their limitations. The potential of fluorescent molecular probes in the treatment of viral disease and environmental analysis, and their possible combinations with protein and immune technology are discussed.

关键词： Fluorescent probe Detection Bioimaging Virus Health

State-of-the-art of biomass-derived carbon dots: Preparation, properties, and applications

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Chinese Chemical Letters 2024年第1期35卷 64-71页

作者： Mengyuan Fang Boyang Wang Xiaoli Qu Senrui Li Jinsheng huang Jiangnan Li Siyu Lu Nan Zhou The First Affiliated Hospital of zhengzhou University Zhengzhou 450001China Green Catalysis Center and College of ChemistryZhengzhou UniversityZhengzhou 450001China Erythrocyte Biology Laboratory School of Life SciencesZhengzhou UniversityZhengzhou 450001China

Carbon dots (CDs) have attracted considerable attention as a new type of fluorescent carbon nanomaterial because of their excellent optical properties, biocompatibility, and high electrical conductivity. Research on CDs has been conducted for nearly two decades and has focused on numerous precursors, various synthesis conditions and properties and applications of CDs. Biomass is critical in the green development of CDs because of its low cost, environmental friendliness, and sustainable properties. This review focuses on the advantages and applications of biomass-derived CDs. In addition, the challenges of photobleaching, toxicity, and stability of biomass-based CDs are discussed in detail. Lastly, the prospects and challenges of biomass-derived CDs are highlighted.

关键词： Carbon dots Biomass Properties Modification Applications

面向输变电场景的无线传感网通信性能测试研究

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电气技术 2024年第3期25卷 53-57页

作者：黄震敬沅坤闫克任春梅许昌开普检测研究院股份有限公司河南许昌461000 北京理工大学珠海学院广东珠海519088

无线传感网在输变电设备状态监测领域的应用,能够有效提升电网运行效率,实现更高的经济价值和社会效益。通过分析无线传感网在输变电场景下的通信特征,提出通信性能测试方法,构建闭环测试平台,对无线传感网的接入容量、组网性能等关键... 详细信息

无线传感网在输变电设备状态监测领域的应用,能够有效提升电网运行效率,实现更高的经济价值和社会效益。通过分析无线传感网在输变电场景下的通信特征,提出通信性能测试方法,构建闭环测试平台,对无线传感网的接入容量、组网性能等关键指标开展测试验证。结果表明,所提测试方法能有效评估无线传感网的终端接入、数据传输能力,可为无线传感网在电力系统的推广提供技术支撑。

关键词：输变电无线传感网通信性能闭环验证

水化学条件对钒钛磁铁矿尾矿胶体稳定性的影响

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环境化学 2024年第7期43卷 2409-2420页

作者：赵启迪黄明正周丹黄艺马中建成都理工大学生态环境学院成都610059 攀钢集团矿业有限公司攀枝花617000

尾矿胶体的稳定性对其携带污染物的迁移能力具有重要影响,但目前其稳定性尚未得到关注.为探究不同水化学条件对钒钛磁铁矿尾矿胶体稳定性的影响,采用扫描电子显微镜和X射线能量色散谱仪、傅里叶变换红外光谱和X射线光电子能谱分析尾矿... 详细信息

尾矿胶体的稳定性对其携带污染物的迁移能力具有重要影响,但目前其稳定性尚未得到关注.为探究不同水化学条件对钒钛磁铁矿尾矿胶体稳定性的影响,采用扫描电子显微镜和X射线能量色散谱仪、傅里叶变换红外光谱和X射线光电子能谱分析尾矿样品和尾矿胶体的性质,并通过团聚动力学试验和DLVO理论计算考察了不同pH(6—9)、离子强度(1—150 mmol·L^(-1) NaCl)和天然有机质(0.1—100 mg·L^(-1)腐殖酸钠和0.01—10 mmol·L^(-1)乙酸)条件下尾矿胶体的稳定性.结果表明:(1)pH的升高增加了尾矿胶体表面的负电荷量,使得胶体颗粒间静电排斥力增大,增加了尾矿胶体在水溶液中的稳定性.(2)在设置的离子强度梯度下,离子强度越大,尾矿胶体越不稳定.这是由于尾矿胶体的双电层结构被压缩,导致胶体颗粒之间的静电斥力减弱从而失稳团聚.(3)尾矿胶体的水动力学直径(Dh)随着腐殖酸钠浓度的提高而显著减小.因腐殖酸钠的吸附导致的负电荷增加和空间位阻效应,使得尾矿胶体更加稳定.而尾矿胶体Dh随乙酸浓度提高显著增大.这是由于乙酸的zeta电位随乙酸浓度增加趋近于中性.高浓度乙酸与尾矿胶体吸附后,降低了尾矿胶体间的静电斥力,导致失稳团聚.

关键词：尾矿胶体稳定性团聚 DLVO理论

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Stay in touch with the endoplasmic reticulum

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Science China(Life Sciences) 2024年第2期67卷 230-257页

作者： Sha Sun Gan Zhao Mingkang Jia Qing Jiang Shulin Li Haibin Wang Wenjing Li Yunyun Wang Xin Bian Yan G.Zhao Xun huang Ge Yang Huaqing Cai Jose C.Pastor-Pareja Liang Ge Chuanmao Zhang Junjie Hu National Laboratory of Biomacromolecules Institute of BiophysicsUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China The Ministry of Education Key Laboratory of Cell Proliferation and Differentiation College of Life SciencesPeking UniversityBeijing 100871China State Key Laboratory of Membrane Biology Tsinghua-Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China Laboratory of Computational Biology&Machine Intelligence School of Artificial IntelligenceUniversity of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Medicinal Chemical Biology College of Life SciencesNankai UniversityTianjin 300071China Brain Research Center Department of BiologySchool of Life SciencesSouthern University of Science and TechnologyShenzhen 518055China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China Institute of Neurosciences Consejo Superior de Investigaciones Científicas-Universidad Miguel HernándezSan Juan de Alicante 03550Spain

The endoplasmic reticulum(ER),which is composed of a continuous network of tubules and sheets,forms the most widely distributed membrane system in eukaryotic *** a result,it engages a variety of organelles by establishing membrane contact sites(MCSs).These contacts regulate organelle positioning and remodeling,including fusion and fission,facilitate precise lipid exchange,and couple vital signaling ***,we systematically review recent advances and converging themes on ER-involved organellar *** molecular basis,cellular influence,and potential physiological functions for ER/nuclear envelope contacts with mitochondria,Golgi,endosomes,lysosomes,lipid droplets,autophagosomes,and plasma membrane are summarized.

关键词： endoplasmic reticulum nuclear envelope mitochondria Golgi apparatus endosome lysosome lipid droplets autophagosome plasma membrane membrane contact site

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药品连续制造中工艺疲劳的监管考量

中国新药杂志 2024年第4期33卷 407-411页

作者：曹妆宁黄哲沈阳药科大学工商管理学院沈阳110016 沈阳药科大学药品监管科学研究院沈阳110016

药品连续制造已进入施行统一监管的全新发展时代,其将成为未来药品生产模式的大趋势和战略要求。尽管现有监管框架足以支撑药品连续制造技术的发展,但仍不能解决应用方面的具体问题。本文以长期运行下的连续生产工艺为主题,探究工艺疲... 详细信息

药品连续制造已进入施行统一监管的全新发展时代,其将成为未来药品生产模式的大趋势和战略要求。尽管现有监管框架足以支撑药品连续制造技术的发展,但仍不能解决应用方面的具体问题。本文以长期运行下的连续生产工艺为主题,探究工艺疲劳对化学药、生物药及中药连续制造的影响,并提出相应监管考量。期望以此进一步聚焦连续制造技术在我国制药领域的实施困境,为我国药品连续制造的开发、实施、监管提供助力。促进ICH Q13指导原则尽早在我国落地转化,推动国内药品连续制造技术及先进生产技术的发展。

关键词：药品连续制造工艺疲劳监管考量

A unified user behavior model for trajectory-based tasks with different types of path constraints

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Science China(Information Sciences) 2023年第10期66卷 316-318页

作者： Hao ZHANG Jin huang Huawei TU feng TIAN Guozhong DAI Hongan WANG Beijing Key Laboratory of Human-Computer Interaction Institute of Software Chinese Academy of Sciences School of Computer Science and Technology University of Chinese Academy of Sciences School of Artificial Intelligence University of Chinese Academy of Sciences Department of Computer Science and Information Technology La Trobe University

An important research branch of human-computer interaction(HCI) is to develop predictive models for human performance in fundamental interactions [1]. On today’s graphical user interface(GUI), users often implicitly perform various trajectory-based interactions, such as navigating through menus [2], entering the boundary of a button,

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ASb(SO_(4))_(2)(A=Rb,Cs):Two short-wave UV antimony sulfates exhibiting large birefringence

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Chinese Chemical Letters 2024年第1期35卷 514-517页

作者： Yang Lan Jinxuan Ren Pu Zhang Xuehua Dong Ling huang Liling Cao Daojiang Gao Guohong Zou College of Chemistry and Materials Science Sichuan Normal UniversityChengdu 610066China College of Chemistry Sichuan UniversityChengdu 610065China

Herein,two antimony sulfates,named RbSb(SO_(4))_(2)(1)and CsSb(SO_(4))_(2)(2),have been successfully synthesized with the introduction of Sb^(3+)cation with stereochemically active lone pairs(SCALP)into sulfates by the conventional hydrothermal *** two compounds endow short ultraviolet(UV)absorption edges(281 nm and 278 nm,respectively)and large birefringence(0.171@546 nm and 0.174@546 nm,respectively),which means that they are promising short-wave UV optical ***,though both of the two compounds exhibit similar 1D chained structures,and possess the same functional moieties including SbO4 seesaws and SO4 tetrahedral groups,they exhibit significantly opposite macroscopic symmetries,i.e.,compound 1 crystallizes in a centrosymmetric(CS)manner(P2_(1)/n)and compound 2 in a noncentrosymmetric(NCS)manner(P2_(1)2_(1)2_(1)),due to the size of cations[r(Rb+)=1.56 A˚,r(Cs+)=1.67 A˚]affects the orientation of SCALP of the adjacent Sb^(3+).

关键词： Antimony sulfates Birefringent crystals Large birefringence Short UV absorption edge Stereochemically active lone pair

国内药政改革背景下中小型合同研究生产组织的发展战略探索

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中国新药杂志 2024年第11期33卷 1089-1092页

作者：吴晓燕黄哲沈阳药科大学沈阳110179

通过研究当前国内药品管理相关制度,对国内合同研究生产组织(contract development manufacture organization,CDMO)的发展现状和问题进行分析,为中小型CDMO的发展战略提出建议。研究结果表明适合中小型CDMO的发展战略包括:选择特色化... 详细信息

通过研究当前国内药品管理相关制度,对国内合同研究生产组织(contract development manufacture organization,CDMO)的发展现状和问题进行分析,为中小型CDMO的发展战略提出建议。研究结果表明适合中小型CDMO的发展战略包括:选择特色化发展道路,打造高技术壁垒的平台;持续完善质量管理体系;引进和培养专业技术人才和管理人才;加强外部联盟与合作。

关键词：药品上市持有人制度合同研究生产组织发展战略药品研发药政改革