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Cytoskeleton-a crucial key in host cell for coronavirus infection

Journal of Molecular Cell Biology 2020年第12期12卷 968-979页

作者： Zeyu Wen Yue Zhang zhekai lin Kun Shi Yarning jiu The Center for Microbes Development and HealthKey Laboratory of Molecular Virology and ImmunologyInstitut Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China Department of Gynecology and Obstetrics Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China

The emerging coronavirus(CoV)pandemic is threatening the public health all over the *** is an intricate network involved in controlling cell shape,cargo transport,signal transduction,and cell *** biology studies have illuminated essential roles for cytoskeleton in mediating the outcome of host-virus *** this review,we discuss the dynamic interactions between actin filaments,microtubules,intermediate filaments,and *** one round of viral life cycle,CoVs surf along filopodia on the host membrane to the entry sites,utilize specific intermediate filament protein as co-receptor to enter target cells,hijack microtubules for transportation to replication and assembly sites,and promote actin filaments polymerization to provide forces for *** CoV infection,disruption of host cytoskeleton homeostasis and modification state is tightly connected to pathological processes,such as defective cytokinesis,demyelinating,cilia loss,and neuron *** are increasing mechanistic studies on cytoskeleton upon CoV infection,such as viral protein-cytoskeleton interaction,changes in the expression and post-translation modification,related signaling pathways,and incorporation with other host ***,these insights provide new concepts for fundamental virology and the control of CoV infection.

关键词： coronavirus host cytoskeleton actin filaments microtubules intermediate filaments pathology

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Vagal-mAChR4 signaling promotes Friend virus complex(FV)-induced acute erythroleukemia

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Virologica Sinica 2023年第3期38卷 429-439页

作者： Shuting Song zhekai lin Caiqi Zhao Jing Wen Jie Chen Shitao Xie Huaxin Qi Jianhua Wang Xiao Su Unit of Respiratory Infection and Immunity Institute Pasteur of ShanghaiChinese Academy of SciencesShanghai200031China CAS Key Laboratory of Molecular Virology and Immunology Institute Pasteur of ShanghaiChinese Academy of SciencesShanghai200031China University of Chinese Academy of Sciences Beijing101408China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou510530China Shanghai Key Laboratory of Lung Inflammation and Injury Shanghai200031China

Erythroleukemia belongs to acute myeloid leukemia(AML)type 6(M6),and treatment remains difficult due to the poor prognosis of the *** virus(FV)is a complex of two viruses:Friend murine leukemia virus(F-MuLV)strain along with a defective spleen focus-forming virus(SFFV),which can induce acute eryth-roleukemia in *** have previously reported that activation of vagalα7 nicotinic acetylcholine receptor(nAChR)signaling promotes HIV-1 *** vagal muscarinic signaling mediates FV-induced erythroleukemia and the underlying mechanisms remain *** this study,sham and vagotomized mice were intraperitoneally injected with *** infection caused anemia in sham mice,and vagotomy reversed this *** infection increased erythroblasts ProE,EryA,and EryB cells in the spleen,and these changes were blocked by *** bone marrow,FV infection reduced EryC cells in sham mice,an effect that was coun-teracted by *** infection increased choline acetyltransferase(ChAT)expression in splenic CD4^(+)and CD8þT cells,and this change was reversed by ***,the increase of EryA and EryB cells in spleen of FV-infected wild-type mice was reversed after deletion of ChAT in CD4^(+)T *** bone marrow,FV infection reduced EryB and EryC cells in sham mice,whereas lack of ChAT in CD4^(+)T cells did not affect this *** of muscarinic acetylcholine receptor 4(mAChR4)by clozapine N-oxide(CNO)significantly increased EryB in the spleen but decreased the EryC cell population in the bone marrow of FV-infected ***,vagal-mAChR4 signaling in the spleen and bone marrow synergistically promotes the pathogenesis of acute *** uncover an unrecognized mechanism of neuromodulation in erythroleukemia.

关键词： Vagus nerve Friend virus(FV) Acute erythroleukemia Erythroblast Choline acetyltransferase(ChAT)

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基于卷积神经网络和PFSS磁图的L1点处近地太阳风速度预测（英文）

基于卷积神经网络和PFSS磁图的L1点处近地太阳风速度预测（英文）

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作者： Rong lin zhekai LUO Jiansen HE Lun XIE Peking University

An accurate model for ambient solar wind speed is important for space weather predictions,catastrophic event warning and other issues concerning solar wind – magnetosphere *** this work,we construct a model based on ... 详细信息

关键词：太阳风速度卷积神经网络

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气浮-水解酸化-AO-BAF工艺在家具集聚区污水处理厂中的应用

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给水排水 2022年第S1期48卷 844-847,850页

作者：洪平涂勋林雪平赵倩邹哲凯吴永明吴代赦邓觅江西省华赣格丰生态环保有限公司南昌330096 南昌大学资源与环境学院鄱阳湖环境与资源利用教育部重点实验室南昌330031 江西省科学院微生物研究所南昌330096

针对江西某工业园区的家具集聚区废水,采用气浮-水解酸化-AO-曝气生物滤池组合工艺处理,介绍了工艺流程、工艺参数及其运行效果。经过稳定运行结果显示该工艺能达到较好的处理结果,COD、BOD_(5)、SS、NH_(3)-N、TN和TP的去除率分别达到9... 详细信息

针对江西某工业园区的家具集聚区废水,采用气浮-水解酸化-AO-曝气生物滤池组合工艺处理,介绍了工艺流程、工艺参数及其运行效果。经过稳定运行结果显示该工艺能达到较好的处理结果,COD、BOD_(5)、SS、NH_(3)-N、TN和TP的去除率分别达到91.1%、97.9%、97.5%、92.4%、85.4%和95.0%,对应出水水质分别达43.6、7.4、8.6、3.4、10.2和0.4 mg/L,优于《城镇污水处理厂污染物排放标准》(GB 19818-2002)中的一级A类标准。电费和药剂费分别约0.81元/m^(3)和0.61元/m^(3),合计废水处理成本为1.42元/m^(3)。

关键词：家具集聚区废水气浮水解酸化 AO工艺曝气生物滤池

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