Cytoskeleton-a crucial key in host cell for coronavirus infection
作者机构：The Center for MicrobesDevelopment and HealthKey Laboratory of Molecular Virology and ImmunologyInstitut Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China University of Chinese Academy of SciencesBeijing 100049China Department of Gynecology and ObstetricsGuangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China
出 版 物：《Journal of Molecular Cell Biology》 (分子细胞生物学报（英文版）)
年 卷 期：2020年第12卷第12期
页 面：968-979页
核心收录：
学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071009[理学-细胞生物学] 09[农学] 100103[医学-病原生物学] 0901[农学-作物学] 090102[农学-作物遗传育种] 10[医学]
基 金：This study was supported by Shanghai Municipal Science and Technology Major Project(20431900402 and 2019SHZDZX02) the National Natural Science Foundation of China(31970660) Natural Science Foundation of Shanghai(19ZR1463000) Chemical Reagent Instrumental Development Foundation of Shanghai(1914200700) ‘100 Talents Program’from the Chinese Academy of Sciences Shanghai Talent Development Funding
主 题：coronavirus host cytoskeleton actin filaments microtubules intermediate filaments pathology
摘 要：The emerging coronavirus(CoV)pandemic is threatening the public health all over the *** is an intricate network involved in controlling cell shape,cargo transport,signal transduction,and cell *** biology studies have illuminated essential roles for cytoskeleton in mediating the outcome of host-virus *** this review,we discuss the dynamic interactions between actin filaments,microtubules,intermediate filaments,and *** one round of viral life cycle,CoVs surf along filopodia on the host membrane to the entry sites,utilize specific intermediate filament protein as co-receptor to enter target cells,hijack microtubules for transportation to replication and assembly sites,and promote actin filaments polymerization to provide forces for *** CoV infection,disruption of host cytoskeleton homeostasis and modification state is tightly connected to pathological processes,such as defective cytokinesis,demyelinating,cilia loss,and neuron *** are increasing mechanistic studies on cytoskeleton upon CoV infection,such as viral protein-cytoskeleton interaction,changes in the expression and post-translation modification,related signaling pathways,and incorporation with other host ***,these insights provide new concepts for fundamental virology and the control of CoV infection.
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