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Failure mechanisms in flexible electronics

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International Journal of Smart and Nano Materials 2023年第4期14卷 510-565页

作者： zhehui zhao Haoran Fu Ruitao Tang Bocheng Zhang Yunmin Chen Jianqun Jiang MOE Key Laboratory of Soft Soils and Geoenvironmental Engineering Zhejiang UniversityHangzhouChina Department of Civil Engineering Zhejiang UniversityHangzhouChina R&D department Wuxi Innosonics Medical Technology CoLtdWuxiChina R&D Department of devices and processes Jiashan Fudan InstituteJiaxingChina

The rapid evolution of flexible electronic devices promises to revolutionize numerous fields by expanding the applications of smart ***,despite this vast potential,the reliability of these innovative devices currently falls short,especially in light of demanding operation environment and the intrinsic challenges associated with their fabrication *** heterogeneity in these processes and environments gives rise to unique failure modes throughout the devices'*** significantly enhance the reliability of these devices and assure long-term performance,it is paramount to comprehend the underpinning failure mechanisms thoroughly,thereby,enabling,optimal design solutions.A myriad of investigative efforts have been dedicated to unravel these failure mechanisms,utilizing a spectrum of tools from analytical models,numerical methods,to advanced characterization *** review delves into the root causes of device failure,scrutinizing both the fabrication process and the operation ***,We subsequently address the failure mechanisms across four commonly observed modes:strength failure,fatigue failure,interfacial failure,and electrical failure,followed by an overview of targeted characterization methods associated with each *** with an outlook,we spotlight ongoing challenges and promising directions for future research in our pursuit of highly resilient flexible electronic devices.

关键词： Flexible electronic devices failure mechanisms characterization methods

Synthesis of novel 5-O-(6′-O-modified)-desosamine 14-membered ketolides

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Chinese Chemical Letters 2019年第2期30卷 425-427页

作者： zhehui zhao Apeng Wang Xiaoxi Zhang Shuang Yang Zhigang Luo Pingsheng Lei State Key Laboratory of Bioactive Substance and Function of Natural Medicines Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation Institute of Materia Medica Chinese Academy of Medical Sciences ξ Peking Union Medical College

A new and facile procedure was developed to synthesize novel 5-0- (6′-O-modified)-desosamine 14-membered ketolides by adopting different protective strategies and comparing various glycosylation conditions. Two trichloroacetimidate donors, with Lev or Ac substituent groups at the C-6 position, were synthesized to couple with the erythronolide. Several novel 5-0- (6′-O-modified)-desosamine 14-membered ketolides were obtained to verify the utility of the method.

关键词： Ketolides Desosamine Glycosyolation Modification

Semi-synthetic chondroitin sulfate CS-semi5 upregulates miR-122-5p,conferring a therapeutic effect on osteoarthritis via the p38/MMP13 pathway

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3528-3542页

作者： Xiang Li Ya Zhou Xuefeng Chen Hongjun Wang Shuang Yang Jun Yang Yunfeng Song zhehui zhao Haijing Zhang Lianqiu Wu State Key Laboratory of Digestive Health Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Tide Pharmaceutical Co. Ltd.Beijing 100176China Camford Royal School Beijing 100093China

Osteoarthritis(OA)is an aging-associated disease characterized by joint stiffness pain and destroyed articular *** treatments for OA are limited to alleviating various OA *** is a lack of drugs available in clinical practice that can truly repair cartilage ***,we developed the chondroitin sulfate analog CS-semi5,semi-synthesized from chondroitin sulfate *** vivo,CS-semi5 alleviated inflammation,provided analgesic effects,and protected cartilage in the modified Hulth OA rat model and papain-induced OA rat model.A bioinformatics analysis was performed on samples from OA patients and an exosome analysis on papain-induced OA rats,revealing miR-122-5p as the key regulator associated with CS-semi5 in OA *** prediction revealed that miR-122-5p acted on the 30-untranslated region of p38 mitogen-activated protein kinase,which was related to MMP13 *** in vitro experiments revealed that CS-semi5 effectively reduced cartilage degeneration and maintained matrix homeostasis by inhibiting matrix breakdown through the miR-122-5p/p38/MMP13 axis,which was further validated in the articular cartilage of OA *** is the first study to investigate the semi-synthesized chondroitin sulfate CS-semi5,revealing its cartilageprotecting,anti-inflammatory,and analgesic properties that show promising therapeutic effects in OA via the miR-122-5p/p38/MMP13 pathway.

关键词： Chondroitin sulfate Cartilage Osteoarthritis Extracellular matrix Inflammation miRNA p38 MMP13

The exploration of ketolide antibiotics with new mother structure

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The exploration of ketolide antibiotics with new mother stru...

中国化学会第十三届全国有机合成化学学术研讨会

作者： Xiaoxi Zhang Shuang Yang Guangyan Zhang Qi Liu zhehui zhao Institute of Materia Medica Chinese Academy of Medical Sciences ＆ Peking Union Medical College

Ketolide antibiotics have been in clinical practice has been widely used,owing to its broad antimicrobial spectrum,convenience to take,satety,low side effects in clinical use and so ***,the phenomena such as the abusement of antibiotics and the intensive emergence of antibacterial resistance against antibiotics with high activity,low toxicity has become the main direction of the current study.

关键词： ketolide telithromycin quinoline

Synthesis of chondroitin sulfate E（CS-E） repeating unit

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Synthesis of chondroitin sulfate E（CS-E） repeating unit

中国化学会第十三届全国有机合成化学学术研讨会

作者： Qi Liu Shuang Yang Guangyan Zhang Xiaoxi Zhang zhehui zhao Institute of Materia Medica Chinese Academy of Medical Sciences ＆ Peking Union Medical College

Glycosaminoglycan chains found in proteoglycans consist of a common tetrasaccharide and different types of repeating disaccharide *** on the type of disaccharide unit,which is composed of hexosamine and hexuronic acid,they are classified into heparidheparan sulfate and chondroitin sulfate/dermatan *** construction of the chondroitin sulfate E（CS-E） repeating unit was *** of nonoxidized disaccharide to CS-E repeating unit was easily processed with high yield,demenstrating the feasibility of postglycosylation-oxidation strategy in synthesis of CS-Eoligosaccharides.

关键词： chondroitin sulfate E synthesis

Synthesis a series of chondroitin sulfate E polysaccharide

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Synthesis a series of chondroitin sulfate E polysaccharide

中国化学会第十三届全国有机合成化学学术研讨会

作者： Guangyan Zhang Shuang Yang Xiaoxi Zhang Qi Liu Pingsheng Lei zhehui zhao State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaPeking Union Medical College and Chinese Academy of Medical Sciences

Chondroitin sulfate（CS） glycosaminoglycans play important roles in biological processes,such as neural development,viral invasion,cancer metastasis,and spinal cord injury.1 As with all glycosaminoglycans,the complexity and heterogeneity of CS have hampered efforts to understand its precise biological *** access to CS molecules of defined length and sulfation pattern,in combination with biological studies,should enable a systematic examination of structure-activity *** work is to synthesize a class of different length of chondroitin sulfate E polysaccharide,2 then evaluate their in vitro activities osteoblast differentiation and cartilage tissues.3

关键词： Chondroitin sulfate E polysaccharide osteoblast differentiation

Exploring and Exploiting the Influence of Protection Strategies in Synthesis of Chondroitin Sulfate E Repeating Disaccharide Unit

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Exploring and Exploiting the Influence of Protection Strateg...

中国化学会第十三届全国有机合成化学学术研讨会

作者： Shuang Yang Guangyan Zhang Qi Liu Xiangjie Di Xiaoxi Zhang zhehui zhao Pingsheng Lei State Key Laboratory of Bioactive Substance and Function of National Medicines Institute of Materia MedicaPeking Union Medical College and Chinese Academy of Medical Sciences

Chondroitin sulfate E（CS-E） is a linear sulfated polysaccharide composed of repeating dimeric units Glc A-β（1→3）-Gal NAc-β（1→4）.Efficient construction of repeating disaccharide unit is crucial for the synthesis of CS-E oligosaccharides and *** on the construction of CS-E disaccharide unit,a set of monosaccharide building blocks was synthesized,and an investigation on the glycosylations was *** glucosyl donor showed much better performance in glycosylation than the corresponding glucuronic acid donor,both on reactivity and ***,a highly efficient synthesis approach was developed towards CS-E disaccharide unit exploiting postglycosylation-oxidation strategy.

关键词： Chondroitin sulfate E reactivity stereoselectivity postglycosylation-oxidation

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塔中地区断裂不同演化阶段对油气聚集的控制

石油与天然气地质 2009年第3期30卷 316-323页

作者：张仲培王毅云金表周波赵泽辉郑孟林中国石油化工股份有限公司石油勘探开发研究院北京100083

塔中地区断层活动时间主要集中在加里东中晚期,海西期活动强度减小,喜马拉雅晚期很弱。主要断裂带在活动时代与期次、对沉积地层改造和建造的控制上以及上、下地层接触关系上存在明显不同。含油气断裂构造带油气聚集差异与断裂的阶段演... 详细信息

塔中地区断层活动时间主要集中在加里东中晚期,海西期活动强度减小,喜马拉雅晚期很弱。主要断裂带在活动时代与期次、对沉积地层改造和建造的控制上以及上、下地层接触关系上存在明显不同。含油气断裂构造带油气聚集差异与断裂的阶段演化有着紧密的内在联系,体现在4个演化阶段的断层对油气聚集的差异控制上,即同沉积断裂控油气、沉积期后断裂控油气、主生烃期断裂控油气和成藏期后断裂控油气。

关键词：断裂构造断层差异演化油气聚集塔中地区塔里木盆地

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填埋场振动台试验及渐进式损伤能量识别

岩土工程学报 2024年第7期46卷 1427-1436页

作者：林浩宇谢海建李俊超赵哲辉陈肖滨蒋建群陈云敏浙江大学软弱土与环境土工教育部重点室验室浙江杭州310058 浙江大学超重力研究中心浙江杭州310058

为了探讨地震作用下含导排衬垫层填埋场的损伤变形特性,开展了含导排衬垫层的填埋场边坡的大型振动台试验,并根据填埋场各处动态响应规律,提出了一种基于希尔伯特-黄(HHT)和边际谱的能量识别方法。该方法能够用于识别填埋场整体损伤和... 详细信息

为了探讨地震作用下含导排衬垫层填埋场的损伤变形特性,开展了含导排衬垫层的填埋场边坡的大型振动台试验,并根据填埋场各处动态响应规律,提出了一种基于希尔伯特-黄(HHT)和边际谱的能量识别方法。该方法能够用于识别填埋场整体损伤和局部损伤,并根据实测位移值对该方法的有效性进行了讨论。试验结果表明,在输入波峰值加速度为0.3g时,坡脚正位移峰值及坡中负位移峰值突变;希尔波特谱峰值(PSHEA)随着高度的增加而增加,填埋场固废层希尔伯特能量大于衬垫及导排系统;输入波峰值加速度为0.3g及0.4g时,导排衬垫界处抗剪强度低面及中老固废交界震陷,边际谱峰值(PMSA)发生突变,能量传递异常。填埋场在地震作用下的损伤主要分为3个阶段:0.1g~0.2g未发生破坏阶段,0.3g~0.4g局部损伤阶段,破坏由导排及衬垫系统开始,0.5g整体破坏阶段填埋场边坡进入塑性变化;输入波幅值达到0.3g时衬垫导排层先产生滑移,峰值时刻固废交界处发生破坏。研究成果可为填埋场在地震作用下的损伤预测及填埋场抗震减灾技术设计提供参考依据。

关键词：填埋场振动台试验能量希尔伯特谱边际谱滑动平均法损伤