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Chinese Journal of Structural Chemistry 1997年第3期16卷 186-190页

作者： HU chun-Hua CHEN Jian zheng Pei-Ju(Research Center of Analysis and Measurement, Fudan University, Shanghai 200433)ZENG Yi-Bin QIU Zhui-Bai yang Jie(Department of Medicinal Chemistry, Shanghai Medical University, 200032) 复旦大学分析测试研究中心上海上海医科大学药物化学系上海

The title compound, C25H24N2O2, a new rearrangement byproduct,has been found in the O-demethylation of 7a-o-amino pheny1-6, 14-endo-ethenotetrahydro thebaine. Its structure was determined by X-ray crystallography. Its crystal isorthorhombic, space group P212121, Mr= 384. 48 with a= 9. 128(2), b= 11. 953 (3),c=17. 422(4) A, V= 1901 (1) A3, Dc= 1. 34 g/cm3, Z= 4, A(MoKa)=0. 71073A,μ= 0. 8 cm-1, F(000) = 816, R= 0. 048, Rw= 0. 051. The molecule is mainly a closedstructure except three extended legs. It consists of a lot of multi-membered rings suchas five- and six- membered rings.

关键词： crystal structure 6 14-endo-ethenotetrahydro thebaine

DIANP合成及其在发射药中的应用研究进展

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含能材料 2024年第8期32卷 871-884页

作者：岳春晖刘波李曼曼王锋魏伦王琼林西安近代化学研究所陕西西安710065

DIANP发射药作为一种新型发射药,具有能量高,爆温低,燃烧洁净性好,烟焰残渣少等特点。研究介绍了DIANP合成与材料特性,DIANP发射药配方及性能,DIANP发射药制备工艺、表面处理、装药应用和测试方法等方面的研究进展。指出了DIANP发射药... 详细信息

DIANP发射药作为一种新型发射药,具有能量高,爆温低,燃烧洁净性好,烟焰残渣少等特点。研究介绍了DIANP合成与材料特性,DIANP发射药配方及性能,DIANP发射药制备工艺、表面处理、装药应用和测试方法等方面的研究进展。指出了DIANP发射药在燃烧分解机理和相互作用机制等基础理论研究方面存在的不足;提出了应开展适用于DIANP发射药的温度系数控制技术研究、环境适应性研究和DIANP合成的绿色工艺研究;并认为DIANP发射药的改进需将理论研究和实际应用相结合,以此推进高能低烧蚀特征材料在行业内的发展。

关键词：发射药叠氮硝胺应用 DIANP

小生境尺度下喀斯特弃耕地植物多样性、生物量及其影响因素

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草业学报 2024年第2期33卷 28-38页

作者：雷颖罗杰郭旭曼秘二停刘锦春三峡库区生态环境教育部重点实验室重庆市三峡库区植物生态与资源重点实验室西南大学生命科学学院重庆400715

深入探讨小生境尺度下物种多样性及其影响因素,可以为弃耕地演替早期群落恢复提供理论依据。本研究以重庆喀斯特典型弃耕地(弃耕年限为4~6年)为研究对象,根据地下特征选出均质浅土、均质深土、异质梯型和异质漏斗型4种小生境并对其进行... 详细信息

深入探讨小生境尺度下物种多样性及其影响因素,可以为弃耕地演替早期群落恢复提供理论依据。本研究以重庆喀斯特典型弃耕地(弃耕年限为4~6年)为研究对象,根据地下特征选出均质浅土、均质深土、异质梯型和异质漏斗型4种小生境并对其进行植物群落调查,分析不同小生境的土壤理化性质、生物量和物种多样性变化及其之间的关系。结果表明:1) 4种小生境中土壤含水量随着土壤深度的增加呈增加趋势,但总氮含量和碳氮比随着土壤深度的增加呈降低趋势;在2种异质生境中,土壤深度、土壤含水率的变异系数相差不大,均属于高等变异强度。2)不同小生境之间的物种丰富度指数、香农-维纳指数和均匀度指数无显著差异。3)各小生境的地上生物量之间无显著差异,异质性生境的地下生物量和总生物量均高于均质性生境。4)不同小生境中仅异质漏斗型的生物量与多样性存在显著负相关关系(P<0.05)。资源异质性对喀斯特弃耕地演替早期群落生物量产生了积极影响,但物种多样性在该阶段受生境的影响不大。中等厚度土壤促进了植物的生长、有利于生产力的维持。因此在植被恢复的早期阶段,应充分利用各生境类型特点,维持植物的多样性及其生长。

关键词：石漠化生境异质性资源有效性生物多样性

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畜禽粪便好氧堆肥雌激素降解调控研究进展

中国环境科学 2024年第7期44卷 3879-3891页

作者：李貌周嘉良丁国春赵枭刘宏斌段娜中国农业大学水利与土木工程学院北京100083 中国农业大学资源与环境学院北京100193 中国农业科学院农业资源与农业区划研究所北京100081

收集并分析了近年来与畜禽粪便及其堆肥相关的成果,总结了雌激素的理化特性及其在畜禽粪便中的赋存情况,阐述了堆肥工艺参数、不同添加剂以及共存污染物对畜禽粪便堆肥过程中雌激素降解的影响及作用机制.在畜禽粪便中威胁较大的雌激素... 详细信息

收集并分析了近年来与畜禽粪便及其堆肥相关的成果,总结了雌激素的理化特性及其在畜禽粪便中的赋存情况,阐述了堆肥工艺参数、不同添加剂以及共存污染物对畜禽粪便堆肥过程中雌激素降解的影响及作用机制.在畜禽粪便中威胁较大的雌激素主要为雌三醇、雌二醇和雌酮.堆肥工艺中保持不低于8d的高温持续时间更有利于雌激素的降解.添加剂中接种微生物菌剂对雌激素的降解效果最佳.重金属、微塑料和抗生素等共存污染物对雌激素的降解更多表现为抑制作用.然而畜禽粪便堆肥中雌激素的降解研究还需不断深入.鉴于此,在已有研究基础上对未来研究和重点关注的方向进行展望.

关键词：畜禽粪便雌激素堆肥影响因素添加剂共存污染物

Ciprofloxacin stress changes key enzymes and intracellular metabolites of Lactobacillus plantarum DNZ-4

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Food Science and Human Wellness 2022年第2期11卷 332-340页

作者： Pin Chen Xiaoqian Chen Wei Yu Bo Zhou Lihua Liu Yuzhuo yang Peng Du Libo Liu chun Li Key Laboratory of Dairy Science Ministry of EducationFood Science CollegeNortheast Agricultural UniversityHarbin 150030China Institute of Animal Science(IAS) Chinese Academy of Agricultural Sciences(CAAS)Beijing 100193China National Dairy Product Quality Supervision and Inspection Center Harbin 150024China

Ciprofloxacin(CIP)is an antibiotic used to treat infections caused by *** this experiment,key enzymes and intracellular metabolites of Lactobacillus plantarum DNZ-4 was researched under CIP *** results showed that the activities of hexokinase,pyruvate kinase,β-galactosidase and Na^(+),K^(+)-ATPase after 1/2 minimum bacteriostatic concentration(MIC)CIP treatment were significantly decreased(P<0.01).Gas chromatography-mass spectrometry was used to analysis the changes of main metabolites in the cells and principal component analysis and partial least square model were *** results indicated that CIP could cause changes in intracellular fatty acids,carbohydrates and amino acids,and the mechanism of amino acid metabolism under CIP stress was significantly *** DNZ-4 made stress response to CIP by regulating the ratio of saturated fatty acids and unsaturated *** experiment revealed the changes of growth and metabolism mechanism of *** DNZ-4 under CIP stress,which help to provide technical means for the development of effective probiotics preparation products.

关键词： Ciprofl oxacin Lactobacillus plantarum DNZ-4 Key enzymes Metabolism

The association of type and number of high-risk criteria with cancer-specific mortality in prostate cancer patients treated with radical prostatectomy

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Current Urology 2024年第2期18卷 128-132页

作者： Francesco Chierigo Rocco Simone Flammia GabrieleSorce Benedikt Hoeh Lukas Hohenhorst Andrea Panunzio Zhe Tian Fred Saad Marcus Graefen Michele Gallucci Alberto Briganti Francesco Montorsi Felix K.H.chun Shahrokh F.Shariat Alessandro Antonelli Giovanni Guano Guglielmo Mantica Marco Borghesi Nazareno Suardi Carlo Terrone Pierre I.Karakiewicz Department of Surgical and Diagnostic Integrated Sciences University of GenovaGenovaItaly IRCCS Ospedale Policlinico San Martino GenovaItaly Cancer Prognostics and Health Outcomes Unit Division of UrologyUniversity ofMontréal Health CenterMontréalQuébecCanada Department of Urology IRCCS Policlinico San MartinoGenovaItaly Department of Maternal-Child and Urological Sciences Sapienza Rome UniversityPoliclinico Umberto I HospitalRomeItaly Department of Urology University Hospital FrankfurtFrankfurt am MainGermany Martini-Klinik Prostate Cancer Center University Hospital Hamburg-EppendorfHamburgGermany Department of Urology University of VeronaAzienda Ospedaliera Universitaria Integrata di VeronaVeronaItaly Division of Experimental Oncology/Unit of Urology URIUrological Research InstituteIRCCS San Raffaele Scientific InstituteMilanItaly Department of Urology Comprehensive Cancer CenterMedical University of ViennaViennaAustria Department of Urology Weill Cornell Medical CollegeNew YorkNYUSA Department of Urology University of Texas SouthwesternDallasTXUSA Department of Urology Second Faculty of MedicineCharles UniversityPragueCzech Republic Institute for Urology and Reproductive Health I.M.Sechenov First Moscow State Medical UniversityMoscowRussia Division of Urology Department of Special SurgeryJordan University HospitalThe University of JordanAmmanJordan

Objectives:This study aimed to test the association between of type and number of D'Amico high-risk criteria(DHRCs)with cancer-specific mortality(CSM)in high-risk prostate cancer patients treated with radical *** and methods:In the Surveillance,Epidemiology,and End Results database(2004–2016),we identified 31,281 radical prostatectomy patients with at least 1 DHRC,namely,prostate-specific antigen(PSA)>20 ng/mL(hrPSA),biopsy Gleason Grade Group(hrGGG)score of 4 and 5,or clinical tumor stage≥T3(hrcT).Multivariable Cox regression models and competing risks regression models(adjusting for other cause mortality)tested the association between DHRCs and 5-year ***:Of 31,281 patients,14,394(67%)exclusively harbored hrGGG,3189(15%)harbored hrPSA,and 1781(8.2%)harbored *** 2132 patients(6.8%)harbored a combination of the 2 DHRCs,and 138(0.6%)had all 3 ***-year CSMrates ranged from 0.9%to 3.0%when any individual DHRC was present(hrcT,hrPSA,and hrGGG,in that order),1.6%to 5.9%when 2 DHRCs were present(hrPSA-hrcT,hrcT-hrGGG,and hrPSA-hrGGG,in that order),and 8.1%when all 3 DHRCs were *** regression models and competing risks regression confirmed the independent predictor status of DHRCs for 5-year CSM that was observed in univariable analyses,with hazard ratios from 1.00 to 2.83 for 1 DHRC,2.35 to 5.88 for combinations of 2 DHRCs,and 7.13 for all 3 ***:Within individual DHRCs,hrcT and hrPSA exhibited weaker effects than hrGGG ***,a dose-response effect was identified according to the number of ***,the type and number of DHRCs allow further risk stratification within the high-risk subgroup.

关键词： High risk prostate cancer Radical prostatectomy Cancer-specific mortality Staging SEER

Lentivirus vectors construction of SiRNA targeting interference GPC3 gene and its biological effects on liver cancer cell lines Huh-7

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Asian Pacific Journal of Tropical Medicine 2014年第10期7卷 780-786页

作者： Chang-Jiang Lei chun Yao Qing-Yun Pan Hao-Cheng Long Lei Li Shu-Ping zheng Cheng Zeng Jian-Bin Huang Department of General Surgery the Second Affiliated Hospital of Jianghan University(Wuhan City Fifth Hospital) Wuhan Institute of Hematology the Second Affiliated Hospital of Jianghan University(Wuhan City Fifth Hospital) Integrated Department Branch of Jianqiao.Hanyang Affiliated Hospital of Wuhan University of Science and Technology Department of Pediatrics the Second Affiliated Hospital of Jianghan University(Wuhan City Fifth Hospital)

Objective:To build GPC3 gene short hairpin interference RNA(shRNA)slow virus *** expression of Huh-7 GPC3 gene in human liver cell line proliferation apoptosis and the effect of GPC3 gene influencing on liver cancer cell growth,and provide theoretical basis for genc therapy of liver ***:Hepatocellular carcinoma cell line Huh-7 wsa transfected by a RNA interference ***3 gene expression in a variety of liver cancer cell lines was detected by fluorescence quantitative *** GPC3 gene seqnences of small interfering RNA(siRNA)PGC-shRNA-GPC3 were *** expression cell linse of siRNA were screened and established with the heplp of liposomes(lipofectamine^(TM2000))as carrier transfcetion of human liver cell *** order to validate siRNA interference ***3 siRNA mRNA expression was detected after transfection by using RT-PCR and Western *** absorbance value of the cells of blank group,untransfection group and transfection group,the cell cycle and cell apoptosis were calculated,and effects of GPC3 gene nn Huh-7 cell proliferation and apoptosis were ***:In the liver cancer cell lines Huh-7 GPC3 gene showed high ***-shRNA-GPC3 recombinant plasmid was constructde successfully via sequencing *** recombinant plasmid transfected into liver cancer cell linse Huh-7can obviously inhibit GPC3 mRNA expression ***:The targeted GPC3 siRNA can effectively inhibit the expression of GPC3.

关键词： GPC3 gene Slow virus carrier Liver cancer cell lines RNA interference

Round-robin differential quadrature phase-shift quantum key distribution

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Chinese Physics B 2017年第2期26卷 63-67页

作者： chun Zhou Ying-Ying Zhang Wan-Su Bao Hong-Wei Li yang Wang Mu-Sheng Jiang zhengzhou Information Science and Technology Institute Zhengzhou 450001 China Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China Hefei 230026 China

Recently,a round-robin differential phase-shift（RRDPS） protocol was proposed[Nature 509,475（2014）],in which the amount of leakage is bounded without monitoring the signal *** states of the phase-encoded Bennett-Brassard 1984 protocol（PE-BB84） to the RRDPS,this paper presents another quantum key distribution protocol called round-robin differential quadrature phase-shift（RRDQPS） quantum key *** a train of many pulses as a single packet,the sender modulates the phase of each pulse by one of {0,π/2,π,3π/2},then the receiver measures each packet with a Mach-Zehnder interferometer having a phase basis of 0 or π/*** RRDQPS protocol can be implemented with essential similar hardware to the PE-BB84,so it has great compatibility with the current quantum *** we analyze the security of the RRDQPS protocol against the intercept-resend attack and the beam-splitting *** show that the proposed protocol inherits the advantages arising from the simplicity of the RRDPS protocol and is more robust against these attacks than the original protocol.

关键词： round-robin differential phase-shift protocol quantum key distribution intercept-resend attack beam-splitting attack

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建筑配电箱设备安装与施工技术研究

工程建设与设计 2024年第2期 89-91页

作者：李春雪杨永明王昕慧马振国中建二局安装工程有限公司北京100000

针对配电箱设备安装与施工问题,通过各部件检查与基础安装、箱体安装与穿线、配电箱试验调整、准备送电运行与成品保护等一系列环节,有效解决了配电箱安装不当、线路杂乱、受损和污染等问题,实现了配电箱的科学高效运行。结果表明,通过... 详细信息

针对配电箱设备安装与施工问题,通过各部件检查与基础安装、箱体安装与穿线、配电箱试验调整、准备送电运行与成品保护等一系列环节,有效解决了配电箱安装不当、线路杂乱、受损和污染等问题,实现了配电箱的科学高效运行。结果表明,通过优化配电箱设备的安装与施工流程,明确各项工艺要点,不仅可以确保配电箱正确安装,促进其工作效能发挥,还能够节约施工用时,提高整体建筑工程质量,研究结果可用于电气工程优化改造中。

关键词：建筑工程配电箱安装施工工艺技术要点

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MCPH1基因变异致原发性小头畸形患儿的表型及遗传学分析

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罕少疾病杂志 2024年第3期31卷 1-3页

作者：吴婉悦刘毓陈凯文静马春元杨莹贵阳市妇幼保健院罕见病中心内分泌遗传代谢科贵州贵阳550001 贵州省职工医院消化内科贵州贵阳550025

目的对1例原发性小头畸形患儿进行临床分析和基因检测,以明确致病原因。方法对1例原发性小头畸形患儿的临床资料进行回顾性分析。采用下一代测序(NGS)技术对患儿进行全外显子基因检测,对变异位点采用Sanger测序法进行验证。对变异位点... 详细信息

目的对1例原发性小头畸形患儿进行临床分析和基因检测,以明确致病原因。方法对1例原发性小头畸形患儿的临床资料进行回顾性分析。采用下一代测序(NGS)技术对患儿进行全外显子基因检测,对变异位点采用Sanger测序法进行验证。对变异位点进行生物信息学分析。结果患儿主要的临床表现为小头畸形、下颌稍小、高腭弓、眼眦稍上斜、运动及认知发育落后。基因结果显示,患儿MCPH1基因存在第6外显子c.445G>A(Val149Lle)及第13外显子c.2312C>G(Pro771Arg)复合杂合变异。患儿父亲携带MCPH1基因c.445G>A杂合变异,母亲携带MCPH1基因c.2312C>G杂合变异,姐姐未检测到该变异。HGMD Pro、PubMed和ClinVar数据库无关于MCPH1基因c.445G>A和c.2312C>G变异的报道。ExAC数据库和千人基因组数据库中未收录MCPH1基因c.445G>A变异和c.2312C>G变异。Polyphen2、SIFT、Mutation Taster在线软件预测MCPH1基因c.445G>A变异为良性(BH4),MCPH1基因c.2312C>G变异为有害。根据美国医学遗传学与基因组学学会(ACMG)指南评估2个变异均为可能致病的变异。结论患儿临床表型高度符合小头畸形的诊断,但基因检测致病证据不充分。因此除MCPH1基因(8p23.1)区域突变外,可能还存在影响功能内含子区域的突变。

关键词： MCPH1基因原发性小头畸形基因变异

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