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Direct Comparison of Crystal Nucleation Activity of PCL on Patterned Substrates

Chinese Journal of Polymer Science 2019年第7期37卷 693-699页

作者： Jian Hu Rui Xin chun-Yue Hou Shou-Ke Yan Ji-chun Liu Key Laboratory of Rubber-Plastics Ministry of Education/Shandong Provincial Key Laboratory of Rubber-plastics Qingdao University of Science & Technology College of Chemical Engineering and Pharmaceutics Key Laboratory of Polymer Science and Nanotechonology Henan University of Science and Technology

A sample containing different regions with poly(ε-caprolactone)(PCL), oriented polyethylene (PE), and oriented isotactic polypropylene (iPP) films in contact with glass slide has been prepared to be observed in the same view field in an optical microscope and the crystallization of PCL in different regions during cooling from 80 °C down to room temperature at a rate of 1 °C·min^-1 was studied. The results showed that the crystallization of PCL started first at the PE surface and then at the iPP surface, while its bulk crystallization occured much later. This indicates that though both PE and iPP are active in nucleating PCL, the nucleation ability of PE is stronger than that of iPP. This was due to a better lattice matching between PCL and PE than that between PCL and iPP. Moreover, since lattice matching existed between every (hk0) lattice planes of both PCL and PE but only between the (100)PCL and (010)iPP lattice planes, the uniaxial orientation feature of the used PE and iPP films resulted in the existence of much more active nucleation sites of PCL on PE than on iPP. This led to the fact that the nucleation density of PCL at PE surface was so high that the crystallization of PCL at PE surface took place in a way like the film developing process with PCL microcrystallites happened everywhere with crystallization proceeding simultaneously. On the other hand, even though iPP also enhanced the nucleation density of PCL evidently, the crystallization of PCL at iPP surface included still a nucleation and crystal growth processes similar to that of its bulk crystallization.

关键词： Poly(ε-caprolactone) Polypropylene Polyethylene Epitaxy Heterogeneous nucleation

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Impact factors of Blastocystis hominis infection in persons living with human immunodeficiency virus:a large-scale,multi-center observational study from China

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Infectious Diseases of Poverty 2023年第5期12卷 95-96页

作者： Shun-Xian Zhang Ji-chun Wang Zhong-Wei Li Jin-Xin zheng Wen-Ting Zhou Guo-Bing yang Ying-Fang Yu Xiu-Ping Wu Shan Lv Qin Liu Mu-Xin Chen Yan Lu Zhi-Hui Dou Da-Wei Zhang Wen-Wen Lv Lei Wang Zhen-Hui Lu Ming yang Pei-Yong zheng Yue-Lai Chen Li-Guang Tian Xiao-Nong Zhou Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai China Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research) NHC Key Laboratory of Parasite and Vector Biology WHO Collaborating Centre for Tropical Diseases National Center for International Research On Tropical Diseases National Institute of Parasitic Diseases Shanghai China School of Global Health Chinese Center for Tropical Diseases Research-Shanghai Jiao Tong University School of Medicine Shanghai China Department of Science and Technology Chinese Center for Disease Control and Prevention Beijing China Gansu Province People’s Hospital Gansu Provincial Hospital Lanzhou China National Health Commission (NHC) Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China Gansu Provincial Center for Disease Control and Prevention Lanzhou China National Center for AIDS/STD Control and Prevention China Center for Disease Control and Prevention Beijing China The People’s Liberation Army 302 Hospital Beijing China Clinical Research Institute Shanghai Jiao Tong University School of Medicine Shanghai China

Background Blastocystis hominis(Bh)is zoonotic parasitic pathogen with a high prevalent globally,causing opportunistic infections and diarrhea *** immunodeficiency virus(HIV)infection disrupts the immune system by depleting CD4^(+)T lymphocyte(CD4^(+)T)cell counts,thereby increasing Bh infection risk among persons living with HIV(PLWH).However,the precise association between Bh infection risk and HIV-related biological markers and treatment processes remains poorly ***,the purpose of the study was to explore the association between Bh infection risk and CD4^(+)T cell counts,HIV viral load(VL),and duration of interruption in antiviral therapy among *** A large-scale multi-center cross-sectional study was conducted in China from June 2020 to December *** genetic presence of Bh in fecal samples was detected by real-time fluorescence quantitative polymerase chain reaction,the CD4^(+)T cell counts in venous blood was measured using flowcytometry,and the HIV VL in serum was quantified using fluorescence-based *** cubic spline(RCS)was applied to assess the non-linear association between Bh infection risk and CD4^(+)T cell counts,HIV VL,and duration of interruption in highly active antiretroviral therapy(HARRT).Results A total of 1245 PLWH were enrolled in the study,the average age of PLWH was 43 years[interquartile range(IQR):33,52],with 452(36.3%)being female,50.4%(n=628)had no immunosuppression(CD4^(+)T cell counts>500 cells/μl),and 78.1%(n=972)achieved full virological suppression(HIV VL<50 copies/ml).Approximately 10.5%(n=131)of PLWH had *** prevalence of Bh was found to be 4.9%[95%confidence interval(CI):3.8-6.4%]among *** nonlinear associations were observed between the Bh infection risk and CD4^(+)T cell counts(Pfor nonlinearity<0.001,L-shaped),HIV VL(Pfor nonlinearity<0.001,inverted U-shaped),and duration of interruption in HARRT(Pfor nonlinearity<0.001,inverted U-shaped).Conclusions

关键词： Blastocystis hominis Human immunodeficiency virus Viral load Non-linear association Restricted cubic spline Propensity score China

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基于模式识别的高水平运动员RS-fMRI数据分类研究

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科学技术与工程 2024年第8期24卷 3145-3154页

作者：张可盈张栋丁宇曹春梅东南大学体育系南京210018 清华大学体育部北京100084 首都体育学院体育人工智能研究院北京100191 北京语言大学心理学院北京100083

为弥补传统的广义线性模型(generalized linear model,GLM)方法的不足,并探索模式识别在运动脑科学当中的应用价值。使用支持向量机(support vector machine,SVM)模式识别算法,以低频振幅(fractional amplitude of low-frequency fluctuations,fALFF)、局部一致性(regional homogeneity,ReHo)和度中心度(degree centrality,DC)作为学习特征,对射击运动组和滑冰运动组(分类1)、射击运动组和对照组(分类2)以及速滑运动组和对照组(分类3)之间进行二分类,并计算每一个脑区在分类算法当中的权重。使用留一交叉验证法计算分类正确率,使用总的准确率、接受者操作特性曲线(receiver operating characteristic curve,ROC)、以及预测准确率来衡量机器分类算法的优劣性。结果表明:分类1中SVM算法的正确率较高且分类效果更稳定,总的准确率(total accuracy,tACC)可以维持在96.67%以上,曲线下面积(area under curve,AUC)均为1,说明SVM算法对区分不同项目运动员脑静息态功能特征时更有优势;在分类2和分类3中,SVM算法效果取决于使用的指标。其中,使用fALFF或者综合使用三个静息态指标的分类效果较稳定(tACC均在80%以上,AUC均在0.88以上);小脑在分类1算法中占较多的权重,提示不同运动项目运动员的脑功能活动之间差异最明显的部位主要在小脑上。而分类2和3中,除了小脑,还有一些与运动执行和控制及其他功能活动相关的脑区参与了算法的构成。通过SVM分类算法的应用获得较为理想的结果,展示了模式识别方法在运动科学领域的应用价值。研究成果有助于体育科学研究者从新的角度更加全面地理解运动与脑的关系。

关键词：模式识别高水平运动员功能磁共振成像(fMRI) 脑静息态

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临床科室视角下探析全面预算管理的优化策略研究

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现代医院管理 2024年第5期22卷 20-23页

作者：何青陈春屹四川大学华西第二医院成都市610041 出生缺陷与相关妇儿疾病教育部重点实验室成都市610041

随着医保支付制度改革的推进和药品耗材加成的取消,医院未来的发展方向开始从传统的增收逐步向成本管控转变,而成本管控的重要手段之一就是全面预算管理。其中,临床科室全面预算的执行情况对医院整体预算管理尤为重要。本文以此为背景,... 详细信息

随着医保支付制度改革的推进和药品耗材加成的取消,医院未来的发展方向开始从传统的增收逐步向成本管控转变,而成本管控的重要手段之一就是全面预算管理。其中,临床科室全面预算的执行情况对医院整体预算管理尤为重要。本文以此为背景,通过对四川省某大型三级甲等公立医院临床科室(以下简称X科室)日常的预算执行现状和存在的问题进行了深入探讨,总结出在临床科室层面开展全面预算管理的重要性以及适应的、可行的全面预算管理方法优化策略。这些策略有望提高临床科室全面预算管理的效率和效益,提升精细化管理质量,也为其他医院临床科室全面预算管理的优化提供参考。

关键词：全面预算管理临床科室公立医院优化策略

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A Few Frontier Issues in Ocean Engineering Mechanics

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China Ocean Engineering 2021年第1期35卷 1-11页

作者： LI Jia-chun NIE Bing-chuan Key Laboratory for Mechanics in Fluid Solid Coupling System Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China School of Civil Engineering Beijing Jiaotong UniversityBeijing 100044China Beijing’s Key Laboratory of Structural Wind Engineering and Urban Wind Environment Beijing 100044China

In this review,we primarily address the present state of the arts and latest progresses in a few frontier issues mostly relevant to free surface/interface in ocean *** include TC(tropical cyclone)induced extreme surface wave,sloshing of LNG(liquefied natural gas),cavitation/bubble dynamics and VIM(vortex-induced motion)and VIV(vortex-induced vibration).In addition to general description,we mainly focus on the recent advances and challenging aspects of above-mentioned *** by the achievements in the previous 70 years,mankind starts a new round of ocean exploration ***,we can find obvious trends:the realm of ocean engineering is expanding from sea surface to deep sea,from low and middle latitude to polar region and from fossil to renewable energy in near future.

关键词： tropical cyclone wind wave sloshing cavitation bubble vortex-induced vibration

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Honoring a legend: Celebrating the life and legacy of Professor Heng Li

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Plant Diversity 2023年第3期45卷 239-240页

作者： Hui-Jun Guo Jin-Ling Huang Yun-Heng Ji Rong Li chun-Lin Long Qin-Er yang Yong-Ping yang Ting-Shuang Yi National Plateau Wetlands Research Center Southwest Forestry UniversityKunming 650224YunnanChina Department of Biology East Carolina UniversityGreenville 27858NCUSA CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina Key Laboratory of Ecology and Environment in Minority Areas(Minzu University of China) National Ethnic Affairs CommissionBeijing 100081China College of Life and Environmental Sciences Minzu University of ChinaBeijing 100081China CAS Key Laboratory of Plant Resources Conservation and Sustainable Utilization South China Botanical GardenChinese Academy of SciencesGuangzhou 510650GuangdongChina CAS Key Laboratory of Tropical Plant Resources and Sustainable Use Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesXishuangbanna 666303YunnanChina Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina

Professor Heng Li(李恒,March 9,1929-January 12,2023)was a legendary plant taxonomist and phytogeographer at the Kunming Institute of Botany,Chinese Academy of Sciences(Fig.1).She made important contributions to our understanding of China's flora,including the biodiversity and biogeography of Dulong Valley and the Gaoligong Mountains,as well as the vegetation of plateau lakes and wetlands in Southwest *** Heng Li received her Bachelor's degree in Russian from Beijing Foreign Studies University in 1956 and immediately joined the Institute of Geography(now Institute of Geographic Sciences and Natural Resources Research),Chinese Academy of Sciences,as a Russian *** 1961,Prof.

关键词： translator plateau Hen

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使用数学模型对髁突颈骨折愈合过程中骨与软骨组织变化的研究

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华中科技大学学报（医学版） 2024年第1期53卷 86-89页

作者：谢春邬琼辉祁峰沈振宇华中科技大学同济医学院附属协和医院口腔医学中心武汉430022 华中科技大学同济医学院口腔医学院武汉430030 华中科技大学同济医学院附属协和医院口腔颌面发育与再生湖北省重点实验室武汉430022 华中科技大学同济医学院附属协和医院检验科武汉430022

目的使用数学模型模拟大鼠髁突颈骨折愈合过程中成骨与成软骨的动态变化过程,探索髁突颈骨折的愈合模式。方法构建模拟大鼠髁突颈骨折愈合的数学模型,并统计该数学模型28 d内不同时间点生成的各参数(mb, mc, cb和cc)的数值,进而拟合... 详细信息

目的使用数学模型模拟大鼠髁突颈骨折愈合过程中成骨与成软骨的动态变化过程,探索髁突颈骨折的愈合模式。方法构建模拟大鼠髁突颈骨折愈合的数学模型,并统计该数学模型28 d内不同时间点生成的各参数(mb, mc, cb和cc)的数值,进而拟合骨、软骨、成骨细胞及成软骨细胞的密度云图和生长曲线并推算成骨方式。结果数学模型模拟的骨面积比与大鼠骨折实验所测接近(P>0.05)。数学模型模拟的密度云图显示,在骨折后第3天至第7天成骨集中在骨膜周围,在第7天至第21天成骨集中在软骨所在区域并逐渐替代软骨。骨生长曲线与软骨生长曲线在骨折后第5至第8天与第21至第28天正相关,与第8至第14天呈负相关。成骨细胞生长曲线和成软骨细胞生长曲线均呈现先升后降的趋势,成软骨细胞在第6天达到最大密度,成骨细胞则在第13天达到最大密度。结论数学模型能有效模拟大鼠髁突颈骨折愈合过程,可动态展示该过程中成骨与成软骨的动态变化,为研究髁突颈骨折的愈合方法提供了新思路。

关键词：数学模型髁突颈骨折骨折愈合骨组织软骨组织

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酵母提取物诱导花楸悬浮细胞的三萜类化学成分研究

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中国中药杂志 2024年第1期49卷 130-140页

作者：张琴李强王健蒋汶利海萍贾春梅任柳怡吴旭东康传志杨健高原郭兰萍宜宾学院材料与化学工程学部四川宜宾644000 中国中医科学院中药资源中心道地药材品质保障与资源持续利用全国重点实验室北京100700

利用酵母提取物(yeast extract, YE)作为模拟生物胁迫的诱导子,诱导花楸悬浮细胞(Sorbus pohuashanensis suspension cell, SPSC)产生生物胁迫作用,对胁迫下产生的三萜类次生代谢产物进行分离鉴定。采用正相硅胶、葡聚糖凝胶、中压制备... 详细信息

利用酵母提取物(yeast extract, YE)作为模拟生物胁迫的诱导子,诱导花楸悬浮细胞(Sorbus pohuashanensis suspension cell, SPSC)产生生物胁迫作用,对胁迫下产生的三萜类次生代谢产物进行分离鉴定。采用正相硅胶、葡聚糖凝胶、中压制备液相等色谱技术对SPSC甲醇提取物进行分离纯化,并运用波谱分析技术鉴定出26个三萜类化合物,包括15个乌苏烷三萜(1~15),2个18,19-裂环乌苏烷三萜(16~17),4个羽扇豆烷三萜(18~21),2个环阿屯烷三萜(22~23),以及3个鲨烯型三萜(24~26)。所有三萜均为首次从YE诱导SPSC中分离得到,其中化合物22-O-acetyltripterygic acid A(1)为新化合物。对分离得到的化合物进行抗真菌、抗肿瘤和抗炎活性评估,结果表明化合物1对脂多糖(LPS)诱导的小鼠巨噬细胞RAW264.7释放一氧化氮(NO)具有一定的抑制作用。

关键词：花楸悬浮细胞生物胁迫化学成分三萜抗炎活性

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A risk score model for predicting cardiac rupture after acute myocardial infarction

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Chinese Medical Journal 2019年第9期132卷 1037-1044页

作者： Yuan Fu Kui-Bao Li Xin-chun yang Department of Cardiology Chaoyang HospitalCapital Medical UniversityBeijing 100020China

Background:Cardiac rupture (CR) is a major lethal complication of acute myocardial infarction (AMI).However,no valid risk score model was found to predict CR after AMI in previous *** study aimed to establish a simple model to assess risk of CR after AMI,which could be easily used in a clinical ***:This was a retrospective case-control study that included 53 consecutive patients with CR after AMI during a period from January 1,2010 to December 31,*** controls included 524 patients who were selected randomly from 7932 AMI patients without CR at a 1:10 *** factors for CR were identified using univariate analysis and multivariate logistic *** score model was developed based on multiple regression *** of risk model was evaluated using receiveroperating characteristic (ROC) curves and internal validity was explored using bootstrap ***:Among all 7985 AMI patients,53 (0.67%) had CR (free wall rupture,n=39;ventricular septal rupture,n=14).Hospital mortalities were 92.5% and 4.01% in patients with and without CR (P<0.001).Independent variables associated with CR included:older age,female gender,higher heart rate at admission,body mass index (BMI)<25 kg/m^2,lower left ventricular ejection fraction (LVEF) and no primary percutaneous coronary intervention (pPCI) *** ROC analysis,our CR risk assess model demonstrated a very good discriminate power (area under the curve [AUC]= 0.895,95% confidence interval:0.845–0.944,optimism-corrected AUC= 0.821,P<0.001).Conclusion:This study developed a novel risk score model to help predict CR after AMI,which had high accuracy and was very simple to use.

关键词： Acute myocardial infarction Mechanical complications Cardiac rupture Risk score model Primary percutaneous coronary intervention

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基于超高密度电阻率法的工程场地溶洞探测试验研究

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广州建筑 2024年第3期52卷 27-30页

作者：杨兆坚陈煜烽谢小荣刘春林杨学顺胡贺松李涛广州建设工程质量安全检测中心有限公司广州510440 广州建筑股份有限公司广州510030 广州市建筑科学研究院集团有限公司广州510440

溶洞的精准探测并采取相应的处理措施是保证工程建设安全的重要前提和保障。高密度电阻率法以地下岩石的导电性差异为主要物性基础探查岩石分布、垂向分层情况,对岩石的含水性尤为敏感。本文尝试采用超高密度电阻率法不同装置模式获得... 详细信息

溶洞的精准探测并采取相应的处理措施是保证工程建设安全的重要前提和保障。高密度电阻率法以地下岩石的导电性差异为主要物性基础探查岩石分布、垂向分层情况,对岩石的含水性尤为敏感。本文尝试采用超高密度电阻率法不同装置模式获得研究区的数据,经过预处理和反演得到研究区域的电性结构,揭示研究区地下溶洞的分布特征。经与地质资料对比,结果表明:超高密度电阻率法对于建筑场地的地层划分和了解岩层溶洞发育程度及分布范围具有良好的应用效果。

关键词：溶洞高密度电阻率法电阻率反演探测试验

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