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Mycobacterium tuberculosis bacteremia in a human immunodeficiency virus-negative patient with liver cirrhosis:A case report

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World Journal of Clinical Cases 2022年第10期10卷 3284-3290页

作者： zhe-zhe lin Dan Chen Sai Liu Jian-Hua Yu Shou-Rong Liu Ming-Li Zhu Department of Open Laboratory Medicine Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical UniversityHangzhou 310000Zhejiang ProvinceChina Department of Infectious Diseases Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical UniversityHangzhou 310000Zhejiang ProvinceChina Department of Hepatology Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical UniversityHangzhou 310000Zhejiang ProvinceChina

BACKGROUND With the increasing prevalence of human immunodeficiency virus(HIV),the incidence of Mycobacterium tuberculosis(***)bacteremia has also *** a common affliction of acquired immunodeficiency syndrome patients,*** infection is associated in these patients with severe sepsis and high *** contrast,*** bacteremia is rarely seen in HIVnegative patients,and *** has never been reported from the blood of patients with liver *** SUMMARY We evaluated a 55-year-old Chinese male patient who had been admitted to the hospital with abdominal distension of unknown cause of one-week duration,accompanied by diarrhea,shortness of breath,and occasional *** on these indicators of abnormal inflammation and fever,we suspected the presence of an *** evidence of microbial infection was not found in routine clinical tests and the patient did not show typical clinical symptoms of infection with ***,next-generation sequencing of blood samples nevertheless demonstrated the presence of ***,which was subsequently isolated from blood samples grown in conventional Bac T/ALERT FA blood culture *** Our findings demonstrate that HIV-negative liver cirrhosis patients can also be infected with ***.

关键词： Mycobacterium tuberculosis Bacteremia Human immunodeficiency virus Liver cirrhosis High-throughput nucleotide sequencing Case report

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A credibility-aware swarm-federated deep learning framework in internet of vehicles

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Digital Communications and Networks 2024年第1期10卷 150-157页

作者： zhe Wang Xinhang Li Tianhao Wu Chen Xu lin Zhang School of Artificial Intelligence Beijing University of Posts and TelecommunicationsBeijing100876China

Although Federated Deep Learning(FDL)enables distributed machine learning in the Internet of Vehicles(IoV),it requires multiple clients to upload model parameters,thus still existing unavoidable communication overhead and data privacy *** recently proposed Swarm Learning(SL)provides a decentralized machine learning approach for unit edge computing and blockchain-based coordination.A Swarm-Federated Deep Learning framework in the IoV system(IoV-SFDL)that integrates SL into the FDL framework is proposed in this *** IoV-SFDL organizes vehicles to generate local SL models with adjacent vehicles based on the blockchain empowered SL,then aggregates the global FDL model among different SL groups with a credibility weights prediction *** experimental results show that compared with the baseline frameworks,the proposed IoV-SFDL framework reduces the overhead of client-to-server communication by 16.72%,while the model performance improves by about 5.02%for the same training iterations.

关键词： Swarm learning Federated deep learning Internet of vehicles Privacy Efficiency

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Trojan horses in tumor:engineered pyroelectric and photodynamic nanocomposites for NIR-induced cell apoptosis and tumor growth inhibition

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Science China Chemistry 2024年第9期67卷 3050-3062页

作者： Yanxi Yang Xinru Kong Xueli Ren Yandai lin zhe Liu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjin 300072China Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjin 300072China

It is desirable but always challenging to develop a cutting-edge tumor treatment strategy with high therapeutic efficacy,lesiontargeted precision and mild *** to traditional treatment modalities,photodynamic therapy has been widely studied since the generation of reactive oxygen species(ROS)at cancerous lesions unprecedentedly offers a convenient approach for localized tumor ***,the consumption of oxygen for ROS production in a hypoxic tumor microenvironment has dramatically limited its feasibility and ***,the engineered nanocomposites of BTO@PDA-ICGHA with photodynamic and pyroelectric performances have been fabricated and applied to the photodynamic-pyroelectric dynamic *** continuing ROS production derived from intracellular oxygen(O_(2))and water(H_(2)O)by laser irradiation contributed to the superb tumor cell apoptosis and significant tumor growth ***,this study has validated a new concept by depositing the engineered nanocomposites at the tumor just like Trojan horses,facilitating ROS release as killers and exerting the NIR-induced cell apoptosis and tumor growth inhibition with high therapeutic efficiency and expectable translational perspectives.

关键词： nanocomposites pyroelectric effect photodynamic therapy cell apoptosis tumor growth inhibition

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Effect of End Shape on Flow and Heat Transfer Characteristics of Two Parallel Plates

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Journal of Thermal Science 2024年第3期33卷 815-832页

作者： ZHANG Guang HONG Tianxiao WANG Dongrui XIN Jialin TAO Junyu lin zhe Key Laboratory of Fluid Transmission Technology of zhejiang Province Zhejiang Sci-Tech UniversityHangzhou310018China

Flow around a pair of flat plates is a basic hydrodynamics *** this paper,the flow and heat transfer characteristics of two parallel plates with different edge shapes are numerically *** different inclined angles,the influence of chamfered and rounded structures with different sizes at the end-edge on unsteady flow and heat transfer characteristics of two parallel plates are *** is found that the instability and unsteadiness of flow decrease with the increase of end-edge size,and the non-uniformity of wake velocity of both rounded and chamfered plates decreases *** non-uniformity of wake temperature increases firstly and then decreases at a small inclined angle,and the amplitude becomes the largest when S_(rou)(S_(cha))=3,while it basically keeps monotonically increasing at a large inclined ***,the global heat transfer performance of the flat plate is obviously affected by the end-edge modification,especially the chamfered *** the increase of chamfered size,the global Nusselt number basically shows the decreasing *** study provides a theoretical basis for the application of plate-shape structure in engineering fields.

关键词： two parallel plates end shape flow characteristic heat transfer numerical simulation

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A game-theoretic approach for federated learning:A trade-off among privacy,accuracy and energy

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Digital Communications and Networks 2024年第2期10卷 389-403页

作者： Lihua Yin Sixin lin zhe Sun Ran Li Yuanyuan He Zhiqiang Hao Cyberspace Institute of Advanced Technology Guangzhou UniversityGuangzhou510006China School of Cyber Science and Engineering Huazhong University of Science and TechnologyWuhan430074China China Industrial Control Systems Cyber Emergency Response Team Beijing100040China

Benefiting from the development of Federated Learning(FL)and distributed communication systems,large-scale intelligent applications become *** devices not only provide adequate training data,but also cause privacy leakage and energy *** to optimize the energy consumption in distributed communication systems,while ensuring the privacy of users and model accuracy,has become an urgent *** this paper,we define the FL as a 3-layer architecture including users,agents and *** order to find a balance among model training accuracy,privacy-preserving effect,and energy consumption,we design the training process of FL as game *** use an extensive game tree to analyze the key elements that influence the players’decisions in the single game,and then find the incentive mechanism that meet the social norms through the repeated *** experimental results show that the Nash equilibrium we obtained satisfies the laws of reality,and the proposed incentive mechanism can also promote users to submit high-quality data in *** the multiple rounds of play,the incentive mechanism can help all players find the optimal strategies for energy,privacy,and accuracy of FL in distributed communication systems.

关键词： Federated learning Privacy preservation Energy optimization Game theory Distributed communication systems

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Numerical modeling and experimental investigation of a two-phase sink vortex and its fluid-solid vibration characteristics

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Journal of zhejiang University-Science A(Applied Physics & Engineering) 2024年第1期25卷 47-62页

作者： Zichao YIN Yesha NI lin LI Tong WANG Jiafeng WU zhe LI Dapeng TAN College of Mechanical Engineering Zhejiang University of TechnologyHangzhou310014China State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou310058China

A sink vortex is a common physical phenomenon in continuous casting,chemical extraction,water conservancy,and other industrial processes,and often causes damage and loss in ***,the real-time monitoring of the sink vortex state is important for improving industrial production ***,its suction-extraction phenomenon and shock vibration characteristics in the course of its formation are complex mechanical dynamic factors for flow field state *** address this issue,we set up a multi-physics model using the level set method(LSM)for a free sink vortex to study the two-phase interaction ***,a fluid–solid coupling dynamic model was deduced to investigate the shock vibration characteristics and reveal the transition mechanism of the critical flow *** numerical results show that the coupling energy shock induces a pressure oscillation phenomenon,which appears to be a transient enhancement of vibration at the vortex penetration *** central part of the transient enhancement signal is a high-frequency *** on the dynamic coupling model,an experimental observation platform was established to verify the accuracy of the numerical *** water-model experiment results were accordant with the numerical *** above results provide a reference for fluid state recognition and active vortex control for industrial monitoring systems,such as those in aerospace pipe transport,hydropower generation,and microfluidic devices.

关键词： Free sink vortex Fluid-solid coupling Level set method(LSM) Multi-physics model Vibration characteristics

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LAMDA-SSL:a comprehensive semi-supervised learning toolkit

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Science China(Information Sciences) 2024年第1期67卷 306-307页

作者： lin-Han JIA Lan-zhe GUO Zhi ZHOU Yu-Feng LI National Key Laboratory for Novel Software Technology Nanjing University

Machine learning, particularly deep learning, has achieved remarkable success across a wide range of tasks. However,most of these tasks demand a substantial amount of labeled training data, which can be challenging to obtain in many real-world applications due to difficulties, costs, or time constraints associated with labeling. In this context,semi-supervised learning (SSL) has emerged as a promising paradigm to alleviate the dependency on large labeled datasets by harnessing the power of unlabeled data [1–3].

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Hemoglobin loss method calculates blood loss during pancreaticoduodenectomy and predicts bleeding-related risk factors

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 419-428页

作者： Chao Yu Yi-Min lin Guo-zhe Xian Department of Hepatobiliary Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina

BACKGROUND The common clinical method to evaluate blood loss during pancreaticoduoden-ectomy(PD)is visual inspection,but most scholars believe that this method is extremely subjective and ***,there is no accurate,objective me-thod to evaluate the amount of blood loss in PD *** retrospectively analyzed the clinical data of 341 patients who underwent PD in Shandong Provincial Hospital from March 2017 to February *** to different surgical methods,they were divided into an open PD(OPD)group and a laparoscopic PD(LPD)*** differences and correlations between the in-traoperative estimation of blood loss(IEBL)obtained by visual inspection and the intraoperative calculation of blood loss(ICBL)obtained using the Hb loss method were ***,IEBL and perioperative calculation of blood loss(PCBL)were compared between the two groups,and single-factor regression analysis was *** There was no statistically significant difference in the preoperative general patient information between the two groups(P>0.05).PD had an ICBL of 743.2(393.0,1173.1)mL and an IEBL of 100.0(50.0,300.0)mL(P200μmol/L(95%CI:7.09-644.26;P=0.045)were independent risk factors for *** ICBLs of the LPD group and OPD group were 767.7(435.4,1249.0)mL and 663.8(347.7,1138.2)mL,respectively(P>0.05).The IEBL of the LPD group 200.0(50.0,200.0)mL was slightly greater than that of the OPD group 100.0(50.0,300.0)mL(P>0.05).PCBL was greater in the LPD group than the OPD group[1061.6(612.3,1632.3)mL vs 806.1(375.9,1347.6)mL](P<0.05).CONCLUSION The ICBL in patients who underwent PD was greater than

关键词： Pancreaticoduodenectomy Hemoglobin loss Calculated blood loss Estimated blood loss

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Middle hepatic vein variation provides a safe path for anterior transection of hepatocellular carcinoma in caudate lobe

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 438-440页

作者： Bing-Yi lin Qi-Jun Zhang zhe Yang Shu-Sen zheng Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Thyroid Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Division of Hepatobiliary Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310000China

To the Editor:Hepatocellular carcinoma(HCC)is one of the main causes of cancer related death worldwide,and new cases are expected to continue to increase in future[1].Surgical resection is still the best way to remove the tumor and improve patient’s ***,resection of caudate lobe often presents a technical challenge,even to accomplished hepatic *** lobe is located anterior to the inferior vena cava(IVC)and posterior to the bifurcation of the portal vein(PV),generally consists of three regions:the paracaval portion,the left Spiegel lobe and the process portion[2].The anatomy of the paracaval portion includes the liver parenchyma ventral to the hepatic IVC and the area between the Spiegel lobe and the right lobe adjacent to the middle hepatic vein(MHV)ventrally,which was classified by Couinaud as segment IX[3].Here,we presented a case of HCC with successful downstaging therapy,as well as variation of MHV,which provides a safe path for anterior transection of segment IX.

关键词： hepatic anatomy Middle

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Experimental Investigation on Heat Transfer and Combustion of a Stirling Engine Combustor Fueled by Reformed Gas and Diesel Fuel

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Journal of Thermal Science 2024年第5期33卷 1907-1919页

作者： LAN Jian ZHAO Yanchun lin Guangtao LI Yelin REN zhe LYU Tian SHEN Mengmeng GU Genxiang HAN Dong Key Laboratory for Power Machinery and Engineering Ministry of EducationShanghai Jiao Tong UniversityShanghai200240China Shanghai Marine Diesel Engine Research Institute Shanghai 201108China

Thermochemical recuperation heat recovery is an advanced waste heat utilization technology that can effectively recover exhaust waste heat from oxy-fuel Stirling *** novel combustor of a Stirling engine with thermochemical recuperation heat recovery system is expected to utilize both reformed gas and diesel fuels as sources of *** this research,the effects of various factors,including the H_(2)O addition,fuel distribution ratio(FDR),excess oxygen coefficient,and cyclone structure on the temperature distribution in the combustor,combustion emissions,and external combustion system efficiency of the Stirling engine were experimentally *** the increase of steam-to-carbon ratio(S/C),the temperature difference between the upper and lower heating tubes reduces and the circumferential temperature fluctuation decreases,and the combustion of diesel and reformed gas remains close to complete *** S/C=2,the external combustion efficiency is 80.6%,indicating a 1.6%decrease compared to conventional *** the increase of FDR,the temperature uniformity of the heater tube is improved,and the CO and HC emissions ***,the impact of the FDR on the maximum temperature difference and temperature fluctuation across the heater is *** the FDR rises from 21%to 38%,the external combustion efficiency increases from 87.4%to92.3%.The excess oxygen coefficient plays a secondary role in influencing temperature uniformity and temperature difference,and the reformed gas and diesel fuel can be burned efficiently at a low excess oxygen coefficient of *** an increase in the cyclone angle,the heater tube temperature increases,while the maximum temperature difference at the lower part decreases,and the temperature fluctuation ***,the CO and HC emissions increase,and the external combustion efficiency experiences a decrease.A cyclone angle of 30°is found to be an appropriate value for achieving optimal

关键词： Stirling engine fuel reforming synthetic gas oxy-combustion external combustion efficiency

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