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Identifying coronary artery bypass grafting patients at high risk for adverse long-term prognosis using serial health-related quality of life assessments

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Chinese Medical Journal 2024年第9期137卷 1069-1077页

作者： Juncheng Wang Hanning liu Chao Yue Limeng Yang Kai Yang Yan Zhao Huan Ren ying Zhang zhe zheng National Clinical Research Center for Cardiovascular Diseases State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Cardiovascular Surgery Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Vascular Surgery Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Cardiac Surgery Wuhan Asia Heart HospitalWuhanHubei 430022China

Background:Patients who undergo coronary artery bypass grafting(CABG)are known to be at a significant risk of experiencing long-term adverse events,emphasizing the importance of regular *** health-related quality of life(HRQoL)serves as a direct method to gauge *** objective is to ascertain the prognostic significance of consecutive HRQoL assessments using the Physical Component Summary(PCS)and Mental Component Summary(MCS)derived from the Short-Form 36(SF-36)health survey in CABG ***:The study population consisted of 433 patients who underwent isolated elective CABG at Fuwai Hospital between 2012 and ***-36 assessments were conducted during both the hospitalization period and *** primary endpoint of the study was all-cause mortality,while the secondary outcome was a composite measure including death,myocardial infarction,stroke,and repeat *** assessed the relationships between the PCS and MCS at baseline,as well as their changes during the first 6 months after the surgery(referred to asΔPCS andΔMCS,respectively),and the observed ***:The patients were followed for an average of 6.28 years,during which 35 individuals(35/433,8.1%)*** adjusting for clinical variables,it was observed that baseline MCS scores(hazard ratio[HR]for a 1-standard deviation[SD]decrease,1.57;95%confidence interval[CI],1.07-2.30)andΔMCS(HR for a 1-SD decrease,1.67;95%CI,1.09-2.56)were associated with all-cause ***,baseline PCS scores andΔPCS did not exhibit a significant relationship with all-cause ***,there was a dose-response relationship observed betweenΔMCS and the likelihood of all-cause mortality(HRs for the 2nd,3rd and 4th quartiles compared to the 1st quartile,0.33,0.45 and 0.11,respectively).Conclusions:Baseline MCS and changes in MCS were independent predictors for long-term mortality of *** mental health status and recovery indicated better prognosis.

关键词： Coronary artery bypass grafting Coronary artery disease Prognosis Quality of life Short-Form 36 Risk factor Serial measurements

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Enhancing thermoelectric performance in P-type Mg_(3)Sb_(2)-based Zintls through optimization of band gap structure and nanostructuring

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Journal of Materials Science & Technology 2024年第3期170卷 25-32页

作者： Yi-bo Zhang Ji-Sheng Liang Chengyan liu Qi Zhou zhe Xu Hong-bo Chen Fu-cong Li ying Peng Lei Miao Guangxi Key Laboratory of Information Material Engineering Research Center of Electronic Information Materials and DevicesMinistry of EducationSchool of Material Science and EngineeringGuilin University of Electronic TechnologyGuilin 541004China Guangxi Key Laboratory for Relativity Astrophysics Center on Nanoenergy ResearchGuangxi Key Laboratory of Processing for Nonferrous Metal and Featured MaterialsSchool of Physical Science&TechnologyGuangxi UniversityNanning 530004China Guangxi Key Laboratory of Precision Navigation Technology and Application Guilin University of Electronic TechnologySchool of Information and CommunicationGuilin 541004China

P-type Mg_(3)Sb_(2)-based Zintls have attracted considerable interest in the thermoelectric(TE)field due to their environmental friendliness and low ***,compared to their n-type counterparts,they show relatively low TE performance,limiting their application in TE *** this work,we simultaneously introduce Bi alloying at Sb sites and Ag doping at Mg sites into the Mg_(3)Sb_(2)to coopera-tively optimize the electrical and thermal properties for the first time,acquiring the highest ZT value of∼0.85 at 723 K and a high average ZT of 0.39 in the temperature range of 323-723 K in sample Mg_(2.94)Ag_(0.06)Sb_(1.9)Bi_(0.1).The first-principle calculations show that the codoping of Ag and Bi can shift the Fermi level into the valence band and narrow the band gap,resulting in the increased carrier concentration from 3.50×10^(17)cm^(-3)in the reference Mg 3 Sb 0.9 Bi 0.1 to∼7.88×10^(19)cm^(-3)in sample Mg 2.94 Ag 0.06 Sb 0.9 Bi *** a result,a remarkable power factor of∼778.9μW m^(-1)K^(-2)at 723 K is achieved in sample Mg 2.94 Ag 0.06 Sb 0.9 Bi ***,a low lattice thermal conductivity of∼0.48 W m^(-1)K^(-1)at 723 K is also obtained with the help of phonon scattering at the distorted lattice,point defects,and nano-precipitates in sample Mg 2.94 Ag 0.06 Sb 0.9 Bi *** synergistic effect of using the multi-element co-doping/-alloying to optimize electrical properties in Mg_(3)Sb_(2)holds promise for further improving the TE performance of Zintl phase materials or even others.

关键词： Thermoelectric materials Band engineering Nanostructuring P-type Mg_(3)Sb_(2) Ag and Bi Co-doping

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Homological dimensions of gentle algebras via geometric models

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Science China Mathematics 2024年第4期67卷 733-766页

作者： Yu-zhe liu Hanpeng Gao Zhaoyong Huang Department of Mathematics Nanjing UniversityNanjing 210093China School of Mathematical Sciences Anhui UniversityHefei 230601China

Let A=kQ/I be a finite-dimensional basic algebra over an algebraically closed field k,which is a gentle algebra with the marked ribbon surface(SA,MA,ΓA).It is known that SAcan be divided into some elementary polygons{Δi|1≤i≤d}byΓA,which has exactly one side in the boundary of ***■(Δi)be the number of sides ofΔibelonging toΓAif the unmarked boundary component of SAis not a side ofΔi;otherwise,■(Δi)=∞,and let f-Δbe the set of all the non-co-elementary polygons and FA(resp.f-FA)be the set of all the forbidden threads(*** finite length).Then we have(1)the global dimension of A is max1≤i≤d■(Δi)-1=maxΠ∈FAl(Π),where l(Π)is the length ofΠ;(2)the left and right self-injective dimensions of A are 0,if Q is either a point or an oriented cycle with full ***Δi∈f-Δ{1,■(Δi)-1}=max n∈f-F_(A)l(П),otherwise,As a consequence,we get that the finiteness of the global dimension of gentle algebras is invariant under AvellaGeiss(AG)-*** addition,we get that the number of indecomposable non-projective Gorenstein projective modules over gentle algebras is also invariant under AG-equivalence.

关键词： global dimension self-injective dimension gentle algebras marked ribbon surfaces geometric models AG-equivalence

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Clinical applications of metagenomics next-generation sequencing in infectious diseases

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Journal of zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第6期25卷 471-484页

作者： ying liu Yongjun MA Department of Clinical Laboratory Affiliated Jinhua HospitalZhejiang University School of MedicineJinhua 321000China

Infectious diseases are a great threat to human *** and accurate detection of pathogens is important in the diagnosis and treatment of infectious *** next-generation sequencing(mNGS)is an unbiased and comprehensive approach for detecting all RNA and DNA in a *** the development of sequencing and bioinformatics technologies,mNGS is moving from research to clinical application,which opens a new avenue for pathogen *** studies have revealed good potential for the clinical application of mNGS in infectious diseases,especially in difficult-to-detect,rare,and novel ***,there are several hurdles in the clinical application of mNGS,such as:(1)lack of universal workflow validation and quality assurance;(2)insensitivity to high-host background and low-biomass samples;and(3)lack of standardized instructions for mass data analysis and report ***,a complete understanding of this new technology will help promote the clinical application of mNGS to infectious *** review briefly introduces the history of next-generation sequencing,mainstream sequencing platforms,and mNGS workflow,and discusses the clinical applications of mNGS to infectious diseases and its advantages and disadvantages.

关键词： Metagenomics next-generation sequencing(mNGS) Infectious disease Cerebrospinal fluid(CSF) Oxford Nanopore Technologies(ONT) Microbiome

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Neighborhood predictors of short sleep duration and bedtime irregularity among children in the United States: results from the 2019-2020 National Surveyof Children's Health

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World Journal of Pediatrics 2024年第1期20卷 73-81页

作者： ying Dai Jianghong liu School of Nursing University of Pennsylvania418 Curie Blvd.Room 426Claire M.Fagin HallPhiladelphiaPA19104-6096USA

Background Environmental factors may contribute to short sleep duration and irregular bedtime in *** factors and children's sleep duration and bedtime regularity remain a less investigated *** aim of this study was to investigate the national and state-level proportions of children with short sleep duration and irregular bedtime and their neighborhood *** A total of 67,598 children whose parents completed the National Survey of Children's Health in 2019-2020 were included in the ***-weighted Poisson regression was used to explore the neighborhood predictors of children's short sleep duration and irregular *** The prevalence of short sleep duration and irregular bedtime among children in the United States(US)was 34.6%[95%confidence interval(CI)=33.8%-35.4%]and 16.4%(95%CI=15.6%-17.2%)in 2019-2020,*** neighborhoods,supportive neighborhoods,and neighborhoods with amenities were found to be protective factors against children's short sleep duration,with risk ratios ranging between 0.92 and 0.94,P<*** with detracting elements were associated with an increased risk of short sleep duration[risk ratio(RR)=1.06,95%CI=1.00-1.12]and irregular bedtime(RR=1.15,95%CI=1.03-1.28).Child race/ethnicity moderated the relationship between neighborhood with amenities and short *** Insufficient sleep duration and irregular bedtime were highly prevalent among US children.A favorable neighborhood environment can decrease children's risk of short sleep duration and irregular *** the neighborhood environment has implications for children's sleep health,especially for children from minority racial/ethnic groups.

关键词： Child National Survey of Children's Health Neighborhood.Sleep Social determinants of health

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Development *** in limited urban sprawl:An integrated framework for resolving the urban boundary dilemma in China

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Journal of Geographical Sciences 2024年第7期34卷 1371-1393页

作者： SONG Xiangxiang ZHANG Zuo WANG zhe liu Yanzhong School of Public Administration Central China Normal UniversityWuhan430079China College of Resource and Environmental Engineering Wuhan University of Science and TechnologyWuhan430081China

The strategic delineation of the urban development boundary(UDB)is an effective initiative for efficient land resource allocation and for facilitating planned urban *** align with sustainable development objectives,UDB definitions have evolved to reconcile urban development with ecological *** study presents a UDB delineation framework from an integrated perspective that incorporates both demand-oriented and comprehensive ***,the urban construction land demand area was estimated based on population projections,meanwhile,the ecological red line(ERL)was delineated and integrated into the evaluation of the construction land ***,with the demand area as the simulation target and unsuitable areas as comprehensive constraints,the UDB was delineated by simulating future land use *** proposed framework was applied to Wuhan,a rapidly urbanizing city in central China,where the delineation of the UDB serves the dual purpose of managing the rapid expansion of built-up land and achieving a harmonious balance between urban development imperatives and ecological protection ***,based on the results and analysis,policy implications for the rational spatial planning of Wuhan were proposed,encompassing the spatial patterns and scientific decision-making in ecological conservation and urban *** results demonstrate that the efficacy of adopting a comprehensive perspective in delineating UDB effectively reconciles the competing needs of urban development and *** framework and the policy insights derived in this study could inform spatial planning efforts not only in Wuhan but also in other cities facing the dilemma of urban development and ecological protection.

关键词： urban development boundary(UDB) ecological red line(ERL) urban land suitability land use simulation integrated framework spatial decision-making

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The important role of Turbidity Maximum Zone in sedimentary dynamic of estuarine mangrove swamp

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Frontiers of Earth Science 2024年第1期18卷 219-226页

作者： Tao liu ying liu Baoqing HU Key laboratory of Environment Change and Resources Use in Beibu Gulf(Ministry of Education) Nanning Normal UniversityNanning 530001China School of Civil Engineering and Architecture Guangxi UniversityNanning 530004China

Sedimentation is a key process affecting wetland sustainability and carbon burial *** context of sea level rise,climate change and human activities,further understanding about the sedimentary dynamic in wetland is critical in predicting the landscape evolution or the change in carbon burial *** this study,based on the field hydrological observation in a mangrove system in the Nanliu River estuary,we found the net flux of suspended sediment to mangrove is 39−72 kg/m in tidal cycles with Turbidity Maximum Zone(TMZ)forming in surface layer and only is 9−18 kg/m in tidal cycles without *** higher net flux of suspended sediment to mangrove in tidal cycles with TMZ forming in surface layer is attributed to high SSC in rising tide and intense flocculation in *** significant discrepancy in sedimentation rate in the mangrove patches also can be explained by the probability of TMZ forming in the surface layer of *** future,rapid sea level rising may lead to the change of TMZ pattern in estuary,which will result in non-negligible variation in sedimentation rate in *** to the present data of sedimentation rate in wetlands,the fragility of wetlands in river estuary may be miscalculated.

关键词： mangrove wetland sedimentation Turbidity Maximum Zone Nanliu River

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Tissue optical clearing enhances efficacy of vascular targeted photodynamic therapy of mouse dorsal skin

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Journal of Innovative Optical Health Sciences 2024年第2期17卷 67-78页

作者： ying liu Qiushi Wang Yidi liu ying Wang Haixia Qiu Dan Zhu ying Gu Defu Chen School of Optics and Photonics Beijing Institute of TechnologyBeijing 100081P.R.China School of Medical Technology Beijing Institute of TechnologyBeijing 100081P.R.China Department of Laser Medicine First Medical Center of PLA General HospitalBeijing 100853P.R.China Britton Chance Center for Biomedical Photonics-MoE Key Laboratory for Biomedical Photonics A duanced Biomedical Imaging FacilityWuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074HubeiP.R.China Precision Laser Medical Diagnosis and Treatment Innovation Unit Chinese A cademy of Medical SciencesBeijing 100000P.R.China

Vascular-targeted photodynamic therapy(V-PDT)is an effective treatment for port wine stains(PWS).However,repeated treatment is usually needed to achieve optimal treatment outcomes,possibly due to the limited treatment light penetration depth in the PWS *** optical clearing technique can increase light penetration in depth by reducing light *** study aimed to investigate the V-PDT in combination with an optical clearing agent(OCA)for the therapeutic enhancement of V-PDT in the rodent skinfold window chamber *** responses were closely monitored with laser speckle contrast imaging(LSCI),optical coherence tomography angiography,and stereo microscope before,during,and after the *** further quantitatively demonstrated the effects of V-PDT in combination with OCA on the blood flow and blood vessel size of skin *** combination of OCA and V-PDT resulted in significant vascular damage,including vasoconstriction and the reduction of blood *** results indicate the promising potential of OCA for enhancing V-PDT for treating vascular-related diseases,including PWS.

关键词： Vascular-targeted photodynamic therapy(V-PDT) optical clearing agent(OCA) treatment efficacy enhancement skin-fold window chamber port wine stains

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A Novel Extremum Seeking Control to Enhance Convergence and Robustness in the Presence of Nonlinear Dynamic Sensors

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Journal of Systems Science & Complexity 2024年第1期37卷 3-21页

作者： liu Hengchang TAN ying OETOMO Denny School of Electrical Mechanical and Infrastructure EngineeringThe University of MelbourneParkville VIC 3010Australia

This paper focuses on optimizing an unknown cost function through extremum seeking(ES)control in the presence of a slow nonlinear dynamic sensor responsible for measuring the *** contrast to traditional perturbation-based ES control,which often suffers from sluggish convergence,the proposed method eliminates the time-scale separation between sensor dynamics and ES control by using the relative degree of the nonlinear sensor *** improve the convergence rate,the authors incorporate high-frequency dither signals and a *** enhance the robustness with the existence of rapid disturbances,an off-the-shelf linear high-gain differentiator is *** first result demonstrates that,for any desired convergence rate,with properly tuned parameters for the proposed ES algorithm,the input of the cost function can converge to an arbitrarily small neighborhood of the optimal solution,starting from any initial condition within any given compact ***,the second result shows the robustness of the proposed ES control in the presence of sufficiently fast,zero-mean periodic *** results substantiate these theoretical findings.

关键词： Averaging extremum seeking optimization singular perturbation time-scale separation

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Trojan horses in tumor:engineered pyroelectric and photodynamic nanocomposites for NIR-induced cell apoptosis and tumor growth inhibition

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Science China Chemistry 2024年第9期67卷 3050-3062页

作者： Yanxi Yang Xinru Kong Xueli Ren Yandai Lin zhe liu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjin 300072China Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjin 300072China

It is desirable but always challenging to develop a cutting-edge tumor treatment strategy with high therapeutic efficacy,lesiontargeted precision and mild *** to traditional treatment modalities,photodynamic therapy has been widely studied since the generation of reactive oxygen species(ROS)at cancerous lesions unprecedentedly offers a convenient approach for localized tumor ***,the consumption of oxygen for ROS production in a hypoxic tumor microenvironment has dramatically limited its feasibility and ***,the engineered nanocomposites of BTO@PDA-ICGHA with photodynamic and pyroelectric performances have been fabricated and applied to the photodynamic-pyroelectric dynamic *** continuing ROS production derived from intracellular oxygen(O_(2))and water(H_(2)O)by laser irradiation contributed to the superb tumor cell apoptosis and significant tumor growth ***,this study has validated a new concept by depositing the engineered nanocomposites at the tumor just like Trojan horses,facilitating ROS release as killers and exerting the NIR-induced cell apoptosis and tumor growth inhibition with high therapeutic efficiency and expectable translational perspectives.

关键词： nanocomposites pyroelectric effect photodynamic therapy cell apoptosis tumor growth inhibition

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