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Development of a Mengla virus minigenome and comparison of its polymerase complexes with those of other filoviruses

Virologica Sinica 2024年第3期39卷 459-468页

作者： shi-zhe Xie Ke Yao Bei Li Cheng Peng Xing-Lou Yang zheng-Li shi State Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China Yunnan Key Laboratory of Biodiversity Information Kunming Institute of ZoologyChinese Academy of SciencesKunming650201China Hubei Jiangxia Laboratory Wuhan430200China

Ebola virus(EBOV)and Marburg virus(MARV),members of the Filoviridae family,are highly pathogenic and can cause hemorrhagic fevers,significantly impacting human *** are considered reservoirs of these viruses because related filoviruses have been discovered in ***,due to the requirement for maximum containment laboratories when studying infectious viruses,the characterization of bat filoviruses often relies on pseudoviruses and minigenome *** this study,we used RACE technology to sequence the 30-leader and 50-trailer of Mengla virus(MLAV)and constructed a *** to MARV,the transcription activities of the MLAV minigenome are independent of *** further assessed the effects of polymorphisms at the 50 end on MLAV minigenome activity and identified certain mutations that decrease minigenome reporter efficiency,probably due to alterations in the RNA secondary *** reporter activity upon recombination of the 30-leaders and 50-trailers of MLAV,MARV,and EBOV with those of the homologous or heterologous minigenomes was compared and it was found that the polymerase complex and leader and trailer sequences exhibit intrinsic ***,we investigated whether the polymerase complex proteins from EBOV and MARV support MLAV minigenome RNA synthesis and found that the homologous system is more efficient than the heterologous *** efficiently inhibited MLAV as well as EBOV *** summary,this study provides new information on bat filoviruses and the minigenome will be a useful tool for high-throughput antiviral drug screening.

关键词： Bat filovirus Mengla virus(MLAV) Minigenome Replication Antiviral drug screening

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Abnormal Behavior Detection Based on Dense Tracklets 36

Abnormal Behavior Detection Based on Dense Tracklets

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第36届中国控制会议

作者： zhe shi Songhao Zhu Yanyun Cheng Dongsheng Wang School of Automatic Nanjing University of Posts and Telecommunications

ISBN: (纸本)9781538629185

This paper presents an approach for detecting abnormal events in videos by analyzing tracklets extracted in dense optical *** begin with,this method codes a video as a set of spatio-temporal volumes in order to obtain the contextual ***,the dense optical fields is established to extract the dense tracklets,and the descriptor histogram of oriented tracklets is utilized to quantize tracklets in terms of angle and ***,the abnormal behaviors is detected based on probability mechanism using the topology of an ensemble of *** standard approaches that use optical flow,dense trajectories have shown to be efficient for representing *** effectiveness of the proposed method is evaluated on public datasets:UCSD,subway and *** experimental results demonstrates that this method outperformed former approaches based on the dense tracklets and optical flow.

关键词： Abnormal Behavior Detection Spatio-Temporal Volumes Histogram of Oriented Tracklets Dense Tracklets

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Control Model of Multifunctional Hot Metal Ladles

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Journal of Iron and Steel Research International 2016年第12期23卷 1262-1267页

作者： Bang-fu HUANG Nai-yuan TIAN Zhi wei MA zhe shi Xiao-lei ZHOU Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650093YunnanChina Clean Metallurgy Key Laboratory of Complex Iron Resources Kunming 650093YunnanChina School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

For further research on the control model of muhifunctional hot metal ladles between the ironmaking and steelmaking interface, the hot metal ladies of K steel plant were taken as the object to analyze the operation process. The factors of blast furnace supply and basic oxygen furnace demand were proposed. According to the principle of supply and demand balance, the control model of hot metal was researched under the following factor conditions： equal to, greater than, and less than 1, respectively. The distribution model of the blast furnace, sleelmaking works, and online buffering was proposed. When the supply and demand factor is equal to ） , the turnover number of hot metal ladles equals 16 and the turnover cycle of hot metal ladles equals 512 min. When the factor is greater than 1, the total number of hot metal ladles is equal to the normal turnover number plus the turnover number of the cast iron machine. When the factor is less than 1, the total number of hot metal ladles is equal tO the normal turnover number plus the accumulating number. Satisfactory effects were obtained by applying the control model in produc tion. The numbers of turnover ladles and accumulating ladles were reduced.

关键词： ironmaking steelmaking interface muhifunctional hot metal ladle control model blast furnace basic oxygen furnace

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Physicochemical properties of coconut husk activated carbon modified by Fe(N0_(3))_(3)and Mn(N0_(3))_(2)

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Journal of Iron and Steel Research International 2021年第5期28卷 530-537页

作者： Hong-ming Long Bang-fu Huang zhe shi Lan-peng Liu De-fu Wang Lu Li Key Laboratory of Metallurgical Emission Reduction&Resources Recycling(Anhui University of Technology) Ministry of EducationMa'anshan 243002AnhuiChina Department of Metallurgical Engineering Kunming University of Science and TechnologyKunming 650093YunnanChina Clean Metallurgy Key Laboratory of Complex Iron Resources University of Yunnan ProvinceKunming 650093YunnanChina

Fe-loaded activated carbon(AC)has high surface acidity and more active sites,while manganese-loaded AC has high oxygen *** husk AC modified by Fe-Mn was studied with the aim of revealing the modification ***,HNO_(3)AC was prepared using the nitric acid immersion ***,Fe-Mn/AC was prepared using the Fe(N0_(3))_(3)and Mn(N0_(3))_(2)sequential *** effects of HNO_(3),Fe(N0_(3))_(3),and Mn(N0_(3))_(2)on the pore texture and surface chemical characteristics of carbon materials were examined by scanning electron microscopy,Brunauer-Emmett-Teller(BET)analysis,X-ray diffraction and Fourier-transform infrared *** surface topography,pore structure,active material,and functional groups of AC,HNO_(3)/AC,and Fe-Mn/AC were systematically *** following results were *** surface of HNO_(3)AC has more ditches and air voids;the micropores of HNO_(3)AC are deformed and flattened compared to those of *** surface of Fe-Mn/AC exhibits an accumulation ***_(2)O_(4)and FeMn_(2)O_(4)formed more pore *** and HNO_(3)AC have numerous *** higher loading quantity of Fe-Mn results in bigger specific *** active components of Fe-Mn/AC-1,Fe-Mn/AC-2,Fe-Mn/AC-3,and Fe-Mn/AC-4 are MnFe_(2)O_(4),MnO_(0.43)Fe_(2.57)O_(4),Mn_(3)O_(4),and ot-Fe_(2)O_(3)>*** surface functional groups of AC and HNO_(3)AC are oxygen-containing functional *** effect of Fe-Mn modifying conditions on functional group species is rare;however,Fe/AC has more oxygen-containing functional *** research findings can aid in the desulfurization and denitrification of the Fe-Mn/AC catalyst.

关键词： HNO_(3) Fe(N0_(3))_(3) Mn(N0_(3))_(2) Coconut husk activated carbon Physicochemical property Modification mechanism

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Exchange bias on polycrystalline BiFeO3/CO2Fe(Al0.5Si0.5) heterostructures

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Rare Metals 2017年第1期36卷 32-36页

作者： shi-zhe Wu Yong Wu Shao-Qian Yin Xiao-Guang Xu Jun Miao Yong Jiang School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China

Polycrystalline antiferromagnetic BiFeO(BFO)thin films were grown on Si/Si O/Ti/Pt(111) substrates by pulsed laser deposition and then ferromagnetic films CoFe(AlSi)(CFAS) by magnetron sputtering. After fabrication, the films were vacuum-annealed under a 0.1-T magnetic field at different temperatures from 150 to 500 °*** exchange bias field can be tuned by the annealing temperature for the heterostructures, and the electric domain size can be controlled by the crystal grain size. A large exchange bias of about 5*10T is observed in one of the samples. It can be speculated that the crystal grain sizes are the key element in determining the exchange bias and coercivity of the films annealed at the temperature of higher than Neel temperature(T N) of BFO. Furthermore, it is possible to extend spin theories from single-crystal BFO system to polycrystalline BFO system.

关键词： Exchange bias BiFeO3 Polycrystalline Domain walls

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Design,synthesis and in vitro evaluation of a series thiazolidinediones analogs as PPAR modulators

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Chinese Chemical Letters 2007年第1期18卷 45-47页

作者： Jun Feng Ying Lu zhe Feng Cai shi Peng Zhang Zong Ru Guo Institute of Materia Medica Chinese Academy of Medical Science and Peking Union Medical College Beijing 100050 China

A series of thiazolidinediones analogs, as PPAR modulators, were designed, synthesized and evaluated in vitro.

关键词： Peroxisome proliferator-activated receptors PPAR modulators Thiazolidinediones

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Bioprinting of inorganic-biomaterial/neural-stem-cell constructs for multiple tissue regeneration and functional recovery

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National Science Review 2024年第4期11卷 228-244页

作者： Hongjian Zhang Chen Qin zhe shi Jianmin Xue Jianxin Hao Jinzhou Huang Lin Du Hongxu Lu Chengtie Wu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Tissue regeneration is a complicated process that relies on the coordinated effort of the nervous, vascular and immune systems. While the nervous system plays a crucial role in tissue regeneration, current tissue engineering approaches mainly focus on restoring the function of injury-related cells, neglecting the guidance provided by nerves. This has led to unsatisfactory therapeutic outcomes. Herein, we propose a new generation of engineered neural constructs from the perspective of neural induction, which offers a versatile platform for promoting multiple tissue regeneration. Specifically, neural constructs consist of inorganic biomaterials and neural stem cells(NSCs), where the inorganic biomaterials endows NSCs with enhanced biological activities including proliferation and neural differentiation. Through animal experiments, we show the effectiveness of neural constructs in repairing central nervous system injuries with function recovery. More importantly, neural constructs also stimulate osteogenesis, angiogenesis and neuromuscular junction formation, thus promoting the regeneration of bone and skeletal muscle, exhibiting its versatile therapeutic performance. These findings suggest that the inorganic-biomaterial/NSC-based neural platform represents a promising avenue for inducing the regeneration and function recovery of varying tissues and organs.

关键词： 3D bioprinting neural stem cells inorganic biomaterials neural constructs multiple tissue regeneration

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Non-fullerene Acceptors with a Thieno[3,4-c]pyrrole-4,6-dione(TPD) Core for Efficient Organic Solar Cells

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Chinese Journal of Polymer Science 2019年第10期37卷 1005-1014,I0005页

作者： shi-zhe Geng Wei-Tao Yang Jian Gao Shui-Xing Li Min-Min shi Tsz-Ki Lau Xin-Hui Lu Chang-Zhi Li Hong-zheng Chen Key Laboratory of Macromolecular Synthesis and Functionalization(Ministry of Education) State Key Laboratory of Silicon MaterialsDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Department of Physics The Chinese University of Hong KongNew TerritoriesHong KongChina

To achieve the red-shifted absorptions and appropriate energy levels of A-D-A type non-fullerene acceptors(NFAs), in this work, we design and synthesize two new NFAs, named TPDCIC and TPDCNC, whose electron-donating(D) unit is constructed by a thieno[3,4-c]pyrrole-4,6-dione(TPD) core attached to two cyclopentadithiophene(CPDT) moieties at both sides, and the electronaccepting(A) end-groups are 2-(3-oxo-2,3-dihydroinden-1-ylidene)malononitrile(IC) and 2-(3-oxo-2,3-dihydro-1 H-cyclopenta[b]naphthalen-1-ylidene)malononitrile(NC), respectively. Benefiting from TPD core, which easily forms quinoid structure and O···H or O···S intramolecular noncovalent interactions, TPDCIC and TPDCNC show more delocalization of π-electrons and perfect planar molecular geometries, giving the absorption ranges extended to 822 and 852 nm, respectively. Furthermore, the highest occupied molecular orbital(HOMO) levels of TPDCIC and TPDCNC remain relatively low-lying due to the electronegativity of the carbonyl groups on TPD core. Considering that the absorptions and energy levels of the two NFAs match well with those of a widely used polymer donor, PBDB-T, we fabricate two kinds of organic solar cells(OSCs) based on the PBDB-T:TPDCIC and PBDB-T:TPDCNC blended films, respectively. Through a series of optimizations, the TPDCIC-based devices yield an impressing power conversion efficiency(PCE)of 10.12% with a large short-circuit current density(JSC) of 18.16 mA·cm-2, and the TPDCNC-based ones exhibit a comparable PCE of9.80% with a JSC of 17.40 mA·cm-2. Our work is the first report of the TPD-core-based A-D-A type NFAs, providing a good reference for the molecular design of high-performance NFAs.

关键词： Non-fullerene acceptors (NFAs) Organic solar cells (OSCs) Thieno[3,4-c]pyrrole-4,6-dione (TPD) Narrow bandgap Energy levels

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位场延拓的积分-迭代法

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地球物理学报 2006年第4期49卷 1176-1182页

作者：徐世浙浙江大学地球科学系杭州310027

本文介绍一种新的位场延拓方法———积分-迭代法.将起伏面上的实测位场值,垂直投影至起伏面下部的一个水平面上,作为该水平面上的位场初始值.根据该水平面上的初始值,用积分方法计算起伏面上的位场值.用起伏面上的实测值与计算值的差值... 详细信息

本文介绍一种新的位场延拓方法———积分-迭代法.将起伏面上的实测位场值,垂直投影至起伏面下部的一个水平面上,作为该水平面上的位场初始值.根据该水平面上的初始值,用积分方法计算起伏面上的位场值.用起伏面上的实测值与计算值的差值,对水平面上的位场值进行校正.如此反复迭代,直至起伏面上的实测值与计算值的差值小到可以忽略.有了水平面上的位场值后,就可以用积分的方法或其他方法计算水平面以上的任意曲面或水平面的位场值.该方法原理简单,不用解线性代数方程组,有较高的计算速度.它特别适用于位场向下延拓,有良好的延拓效果.本文还介绍了积分迭代法的应用实例.

关键词：航磁异常位场延拓积分-迭代法快速傅里叶变换法等效源法

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迭代法与FFT法位场向下延拓效果的比较

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地球物理学报 2007年第1期50卷 285-289页

作者：徐世浙浙江大学地球科学系杭州310027

将水平观测面上的实测位场值,垂直投影至下部的延拓水平面上,作为该水平面上的位场初始值.根据该水平面上的初始值,用快速傅里叶变换(FFT)的方法向上延拓计算观测面上的位场值.用观测面上的实测值与计算值的差值,对延拓面上的位场值进... 详细信息

将水平观测面上的实测位场值,垂直投影至下部的延拓水平面上,作为该水平面上的位场初始值.根据该水平面上的初始值,用快速傅里叶变换(FFT)的方法向上延拓计算观测面上的位场值.用观测面上的实测值与计算值的差值,对延拓面上的位场值进行校正.如此反复迭代,直至观测面上的实测值与计算值的差值小到可以忽略.这种空间域的迭代法原理简单,不用解线性代数方程组,有较高的计算速度和良好的延拓效果.本文用迭代法对模型数据和实际数据进行向下延拓,对比了迭代法与常规的FFT法在位场向下延拓中的效果,迭代法显著优于FFT法.

关键词：位场向下延拓空间域迭代法频率域快速傅里叶变换法

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