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Occurrence,sources,and relationships of soil microplastics with adsorbed heavy metals in the Ebinur Lake Basin,Northwest China

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Journal of Arid Land 2022年第8期14卷 910-924页

作者： zhang zhaoyong GUO Jieyi WANG Pengwei School of Environment and Surveying Engineering Suzhou UniversitySuzhou 234000China College of Resource and Environmental Sciences Xinjiang UniversityUrumqi 830046China Key Laboratory of Oasis Ecology Ministry of EducationXinjiang UniversityUrumqi 830046China

There is a lack of research on soil microplastics in arid oases considering the rapid economic development of northwestern ***,we studied the occurrence and sources of microplastics in soil,as well as the relationships between microplastics and adsorbed heavy metals in the Ebinur Lake Basin,a typical arid oasis in *** showed that(1)the average microplastic content in all soil samples was 36.15(±3.27)mg/*** contents of microplastics at different sampling sites ranged from 3.89(±1.64)to 89.25(±2.98)mg/***,the proportions of various microplastic shapes decreased in the following order:film(54.25%)>fiber(18.56%)>particle(15.07%)>fragment(8.66%)>foam(3.46%);(2)among all microplastic particles,white particles accounted for the largest proportion(52.93%),followed by green(24.15%),black(12.17%),transparent(7.16%),and yellow particles(3.59%).The proportions of microplastic particle size ranges across all soil samples decreased in the following order:1000-2000μm(40.88%)>500-1000μm(26.75%)>2000-5000μm(12.30%)>100-500μm(12.92%)>0-100μm(7.15%).FTIR(Fourier transform infrared)analyses showed that polyethylene terephthalate(PET),polypropylene(PP),polycarbonate(PC),polyethylene(PE),and polystyrene(PS)occurred in the studied soil;(3)random forest predictions showed that industrial and agricultural production activities and the discharge of domestic plastic waste were related to soil microplastic pollution,in which agricultural plastic film was the most important factor in soil pollution in the study area;and(4)seven heavy metals extracted from microplastics in the soil samples showed significant positive correlations with soil pH,EC,total salt,N,P,and K contents(P<0.01),indicating that these soil factors could significantly affect the contents of heavy metals carried by soil *** research demonstrated that the contents of soil microplastics are lower than other areas of the world,and they mainly come from industrial and agricultural activitie

关键词： occurrence characteristics source analysis soil microplastics heavy metals Ebinur Lake Basin

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Dialogue, Thinking and Experiencing the Dao

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Social Sciences in China 2016年第1期37卷 203-204页

作者： zhang zhaoyong

As a collection of papers,Dialogue,Thinking and Experiencing the Dao(对话、思维、体道)aims at reconstructing a larger interpreting space to investigate the academic missions of some Chinese scholars since ancient time... 详细信息

关键词：对话中国学者价值观

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新疆尾闾盐湖滨岸盐碱土中碳酸盐的固碳效应及影响因素

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农业工程学报 2019年第2期35卷 122-127页

作者：张芳熊黑钢张兆永新疆大学资源与环境科学学院乌鲁木齐830046 教育部新疆绿洲生态重点实验室乌鲁木齐830046 北京联合大学应用文理学院北京100083

土壤碳酸盐对现代大气CO_2的截存与土壤中的硅酸盐矿物组成、盐基元素供给、有机碳含量等因子密切相关。该文结合土壤理化性质和碳同位素分馏特性,以新疆艾比湖为例,探讨了干旱区尾闾盐湖滨岸盐碱土中碳酸盐的固碳效应和影响因素,研究... 详细信息

土壤碳酸盐对现代大气CO_2的截存与土壤中的硅酸盐矿物组成、盐基元素供给、有机碳含量等因子密切相关。该文结合土壤理化性质和碳同位素分馏特性,以新疆艾比湖为例,探讨了干旱区尾闾盐湖滨岸盐碱土中碳酸盐的固碳效应和影响因素,研究结果表明:1)土壤碳酸盐是干旱区最重要的碳库,艾比湖滨岸土壤碳酸盐的平均碳密度是有机碳的4.05倍;2)艾比湖滨岸盐碱土中的δ13CSCC介于-7.9‰～0.3‰之间,δ13CSCC与HCO3-存在良好的线性负相关关系,决定系数高达0.669 9,大气碳以重碳酸盐形式存在是次生碳酸盐淀积的关键环节之一;3)土壤δ13CSCC值与硅酸盐矿物阳起石、绿泥石、伊利石存在着良好的线性负相关关系,δ13CSCC值随着富Ca、Mg、Fe矿物的含量增加明显向负向漂移;4)土壤中有机碳含量越高,生物风化过程越强烈时,δ13CSCC负向漂移越大,土壤碳酸盐截存较多大气中的轻碳;当土壤含盐量超过一定程度时,有机过程受到抑制,土壤碳酸盐则截存较多大气中的重碳。因此,干旱区存在着有机-无机耦合固碳效应,提高干旱区植被覆盖,可以增加有机碳库储量,同时,经有机过程分馏转移到土壤中的CO_2可进一步促进土壤硅酸盐矿物风化,使这部分CO_2不再返回大气,而是以碳酸盐形式被长久固存。

关键词：土壤生态碳干旱区尾闾盐湖成土碳酸盐碳稳定同位素分馏固碳效应

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Trivalent SARS-CoV-2 virus-like particle vaccines exhibit broad-spectrum neutralization and protection against XBB.1 and BA.2.86 variants

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Virologica Sinica 2024年第5期39卷 836-839页

作者： Lu zhang Siyu Tian Jun Dai Yuanyuan Li Yu Zhou Yan Li Jiao Xu Shuyun Liu Zhiwei Lin zhaoyong zhang Jiantao Chen Peilan Wei Jingxian Zhao Jing Jin Yanqun Wang Jincun Zhao State Key Laboratory of Respiratory Disease Public Health Safety Center Laboratory of General Administration of CustomsGuangzhou Customs Technology CenterGuangzhouGuangdong510182China Patronus Biotech Co.Ltd. Guangzhou510182China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong510182China Guangzhou National Laboratory GuangzhouGuangdong510182China Clinical Laboratory Medicine Department The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong510182China Shanghai Institute for Advanced Immunochemical Studies School of Life Science and TechnologyShanghaiTech UniversityShanghai201210China Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhen518000China

Dear Editor,The newly emerged severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron subvariants(XBB.1,EG.5 and JN.1)and sublineages have been circulating globally with superior growth advantages over other Omicron variants(Tamura et al.,2023).However,second-generation vaccines,including the BA.2 or BA.5 bivalent vaccine boosters,did not produce robust neutralization against the newly emerged XBB.1 or EG.5(Zou et al.,2023).Compared with variants BA.2 and BA.5,XBB.1 carries more mutations in the receptor binding domain(RBD)and exhibits significant immune evasion(Wang et al.,2023b).XBB.1 and its descendent lineages have rapidly become the dominant SARS-CoV-2 strain and are causing the next global wave of ***,it is essential to develop an updated vaccine against the newly emerged SARS-CoV-2 variants.

关键词： vaccine vaccines acute

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Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis,prognosis and drug target discovery

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1535-1545页

作者： Yuming Li Guixue Hou Haibo Zhou Yanqun Wang Hein Min Tun Airu Zhu Jingxian Zhao Fei Xiao Shanwen Lin Dongdong Liu Dunrong Zhou Lang Mai Lu zhang zhaoyong zhang Lijun Kuang Jiao Guan Qiushi Chen Liyan Wen Yanjun zhang Jianfen Zhuo Fang Li Zhen Zhuang Zhao Chen Ling Luo Donglan Liu Chunke Chen Mian Gan Nanshan Zhong Jincun Zhao Yan Ren Yonghao Xu State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina BGI-Shenzhen ShenzhenChina The Sixth Affiliated Hospital of Guangzhou Medical University Qingyuan People's HospitalQingyuanGuangdongChina HKU-Pasteur Research Pole School of Public HealthLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina Department of Infectious Diseases Guangdong Provincial Key Laboratory of Biomedical ImagingGuangdong Provincial Engineering Research Center of Molecular ImagingThe Fifth Affiliated HospitalSun Yat-sen UniversityZhuhaiGuangdongChina Yangjiang People's Hospital YangjiangGuangdongChina Yangjiang Center for Disease Control and Prevention YangjiangGuangdongChina Guangzhou Eighth People's Hospital of Guangzhou Medical University GuangzhouGuangdongChina Guangzhou Customs District Technology Center GuangzhouChina

Disease progression prediction and therapeutic drug target discovery for Coronavirus disease 2019(COVID-19)are particularly important,as there is still no effective strategy for severe COVID-19 patient ***,we performed multi-platform omics analysis of serial plasma and urine samples collected from patients during the course of *** analyses of these omics data revealed several potential therapeutic targets,such as ANXA1 and *** changes in plasma indicated dysregulation of macrophage and suppression of T cell functions in severe patients compared to those in non-severe ***,we chose 25 important molecular signatures as potential biomarkers for the prediction of disease *** prediction power was validated using corresponding urine samples and plasma samples from new COVID-19 patient cohort,with AUC reached to 0.904 and 0.988,*** conclusion,our omics data proposed not only potential therapeutic targets,but also biomarkers for understanding the pathogenesis of severe COVID-19.

关键词： pathogenesis urine drug

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硅热流量传感器的研究与发展

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电子器件 2001年第1期24卷 41-47页

作者：张昭勇秦明黄庆安东南大学微电子中心南京210096

本文详细地介绍了硅热流量传感器的工作原理并对它进行了细致的分类 ,同时概括了其发展和应用情况。

关键词：硅热流量传感器工作原理流量测量

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Characterization of humoral immune responses against SARS-CoV-2 accessory proteins in infected patients and mouse model

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Virologica Sinica 2024年第3期39卷 414-421页

作者： Yuming Li Yanhong Tang Xiaoqian Wang Airu Zhu Dongdong Liu Yiyun He Hu Guo Jie Zheng Xinzhuo Liu Fengyu Chi Yanqun Wang Zhen Zhuang zhaoyong zhang Donglan Liu Zhao Chen Fang Li Wei Ran Kuai Yu Dong Wang Liyan Wen Jianfen Zhuo Yanjun zhang Yin Xi Jingxian Zhao Jincun Zhao Jing Sun School of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesJi'nan250117China Key Laboratory of Emerging Infectious Diseases in Universities of Shandong Shandong First Medical University&Shandong Academy of Medical SciencesJi'nan250117China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong510182China Hunan Provincial People's Hospital The First Affiliated Hospital of Hunan Normal UniversityHunan Normal UniversityChangsha410005China Guangzhou National Laboratory GuangzhouGuangdong510005China Shanghai Institute for Advanced Immunochemical Studies School of Life Science and TechnologyShanghai Tech UniversityShanghai201210China Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People's HospitalThe Second Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhen518005China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative agent of COVID-19,encodes several accessory proteins that have been shown to play crucial roles in regulating the innate immune ***,their expressions in infected cells and immunogenicity in infected humans and mice are still not fully *** study utilized various techniques such as luciferase immunoprecipitation system(LIPS),immunofluorescence assay(IFA),and western blot(WB)to detect accessory protein-specific antibodies in sera of COVID-19 *** antibodies to proteins 3a,3b,7b,8 and 9c can be detected by LIPS,but only protein 3a antibody was detected by IFA or *** against proteins 3a and 7b were only detected in ICU patients,which may serve as a marker for predicting disease ***,we investigated the expression of accessory proteins in SARS-CoV-2-infected cells and identified the expressions of proteins 3a,6,7a,8,and *** also analyzed their ability to induce antibodies in immunized mice and found that only proteins 3a,6,7a,8,9b and 9c were able to induce measurable antibody productions,but these antibodies lacked neutralizing activities and did not protect mice from SARS-CoV-2 *** findings validate the expression of SARS-CoV-2 accessory proteins and elucidate their humoral immune response,providing a basis for protein detection assays and their role in pathogenesis.

关键词： SARS-CoV-2 Accessory protein Humoral immune responses COVID-19 Mouse model

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斜盘式轴向柱塞泵柱塞颈部最小直径设计

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机械工程学报 2024年第4期60卷 430-437页

作者：李莹张嘉方张钊墉王鑫丞张晋孔祥东燕山大学机械工程学院秦皇岛066004 河北省重型机械流体动力传输与控制实验室秦皇岛066004

为了解决斜盘式轴向柱塞泵在高速高压下产生柱塞颈部断裂的问题,对柱塞泵柱塞颈部的设计及校核开展研究,提出柱塞颈部最小直径的设计方法。基于排油区柱塞滑靴组件的受力分析,建立高压下柱塞颈部受力模型。基于应力-强度干涉分布理论,... 详细信息

为了解决斜盘式轴向柱塞泵在高速高压下产生柱塞颈部断裂的问题,对柱塞泵柱塞颈部的设计及校核开展研究,提出柱塞颈部最小直径的设计方法。基于排油区柱塞滑靴组件的受力分析,建立高压下柱塞颈部受力模型。基于应力-强度干涉分布理论,结合柱塞颈部应力分布和柱塞疲劳强度,提出柱塞颈部疲劳可靠度表达式,得到轴向柱塞泵柱塞颈部最小直径。利用有限元法对最小颈部直径柱塞进行静力学仿真分析,结合应力云图实现柱塞强度的安全性校核。在额定工况下,对根据柱塞颈部最小直径的设计方法设计出的轴向柱塞泵开展了容积效率和机械效率试验,利用本研究的设计准则针对同类产品的轴向柱塞泵柱塞颈部进行设计验证,验证所提出的柱塞颈部最小直径设计方法的合理性。

关键词：柱塞颈部轴向柱塞泵应力场仿真静态可靠性应力-强度干涉

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膜蛋白配体hMSH2在肺癌中的可溶性表达及影响因素

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中国免疫学杂志 2022年第23期38卷 2897-2901页

作者：代玉梅张昭勇广州医科大学附属妇女儿童医疗中心临床检验部广州市儿研所广州510623 广州医科大学附属第一医院呼吸疾病重点实验室广州510623

目的:探讨Vγ9Vδ2 T细胞识别的肿瘤相关内源性膜蛋白配体人MutS同源蛋白2(hMSH2)在肺癌血清中的可溶性表达及影响因素。方法:ELISA定量检测肺癌、肺结节及健康人群血清hMSH2的可溶(s)形式,分析其表达与肺癌类型、转移、吸烟史/家族史... 详细信息

目的:探讨Vγ9Vδ2 T细胞识别的肿瘤相关内源性膜蛋白配体人MutS同源蛋白2(hMSH2)在肺癌血清中的可溶性表达及影响因素。方法:ELISA定量检测肺癌、肺结节及健康人群血清hMSH2的可溶(s)形式,分析其表达与肺癌类型、转移、吸烟史/家族史及常用血清标志物的相关性。结果:三组血清均首次发现hMSH2的可溶形式,肺癌组shMSH2表达低于肺结节组和健康对照组,但差异无统计学意义(P>0.05),且与肺癌类型、转移、吸烟/家族史及常用血清标志物无明显相关性(P>0.05)。结论:shMSH2可能并非适宜的肺癌血清诊断标志物。

关键词：人MutS同源蛋白2 可溶性表达肺癌影响因素

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Genetic and pathogenicity diversity of dengue virus type 2 strains circulating in Guangdong,China

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Biosafety and Health 2021年第6期3卷 333-342页

作者： Lu zhang Lingzhai Zhao zhaoyong zhang Wenxin Hong Jian Wang Shuang Qiu Huiqin Yang Mian Gan Jing Sun Jingxian Zhao Yanqun Wang Jincun Zhao Fuchun zhang Institute of Infectious Disease Guangzhou Eighth People's Hospital of Guangzhou Medical UniversityGuangzhou 510120China Technology Center Guangzhou CustomsGuangzhou 510120China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China

Dengue fever is a mosquito-borne viral disease spread in tropical and subtropical regions caused by the dengue virus(DENV).DENV causes a febrile illness,severe forms including hemorrhagic fevers and shock with fatalities in ***-2 is frequently associated with severe dengue infections and ***-2 strains from Guangdong,China,have not been characterized to compare the phylogenetics and pathogenicity of different DENV-2 subgenotype strains in both vitro and vivo.A total of 22 patients tested to be DENV-2 positive and were enrolled in this study,22 complete genomes were obtained by virus isolation and high-throughput *** and single amino polymorphism(SAP)analysis indicated that two major subgenotypes(A and C)of DENV-2 Cosmopolitan were prevalent in Guangdong in *** apparent change of major subgenotypes of DENV-2 circulating in Guangdong indicated the diversity of DENV-2 strains,including endemic genotype and imported *** alerted the risk of cross-border transmission of DENV.A significant difference in replication rate was observed in C6/36 between different DENV-2 strains,although growth kinetics comparison of different DENV-2 Cosmopolitan subgenotypes showed similar ***-2 subgenotypes(A and C)replicated efficiently in IFNAR−/−C57BL/6 mice,and subgenotype A of Cosmopolitan infected mice showed increased weight loss and delayed viral clearance compared with the subgenotype C ***-2 prevalent in Guangdong in 2018 showed apparent genetic and pathogenicity diversity in both vitro and vivo,indicating the necessity of molecular surveillance and exploration of the relationship between its pathogenicity and clinical characteristics.

关键词： DENV-2 Genetic Pathogenicity Diversity

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