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Crocus sativus *** anti-inflammatory effects and regulates the NLRP3–NF-κB pathway

Acupuncture and Herbal Medicine 2024年第3期4卷 375-385页

作者： Liang Yang Huanhua Xu Qian Hong Nuo Xu Yan Zhang Rui Tao Shuai Li Zizheng Zhang Jiahao Geng Zihan Wang Huizi Hu Yan Dong zhaoyi chu Bin Zheng Jinmiao Zhu Ming Geng Yue Gao School of Chemistry and Pharmaceutical Engineering Hefei Normal UniversityHefeiChina National Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine Jiangxi University of Chinese MedicineNanchangChina Huaihai Hospital Affiliated to Xuzhou Medical University/PLA 71st Group Military Hospital XuzhouChina Beijing Institution of Radiation Medicine BeijingChina

Objective:This study aimed to evaluate the anti-inflammatory effects of petal and stamen extracts of saffron crocus(Crocus sativus)and explore the underlying ***:Local and systemic inflammation models were used to investigate the anti-inflammatory effects of ***.A xyleneinduced inflammation model or lipopolysaccharide(LPS)-induced inflammation model was used in this *** petal and stamen extracts were each administered to the mice in the xylene and LPS models by gavage for 14 d at 0.1 and 0.4 g/kg doses,***-linked immunosorbent assay(ELISA)was used to measure the concentrations of tumor necrosis factor(TNF)-αand interleukin(IL)-1βin mouse *** and eosin(H&E)staining was used to observe the pathological changes in the ear in the xylene-induced inflammation model and in the spleen in the LPS-induced inflammation ***-like receptor thermal protein domain associated protein 3(NLRP3)protein levels within the nuclear factor-kappa B(NF-κB)pathway were assessed using western ***264.7 cells were treated with LPS(5μg/mL)and LPS+***(0.05,0.1,and 0.2 mg/mL)for 24 h,and a Cell Counting Kit-8 was used to measure cell *** in NLRP3 and NF-κB levels were evaluated by western ***:Petal and stamen extracts of *** attenuated the anti-inflammatory effects in local or systemic inflammatory models and repaired pathological changes in the ear in the xylene-induced inflammation model and spleen in the LPS-induced inflammation *** extracts also decreased the concentrations of TNF-αand IL-1βin the mouse serum in the LPS-induced inflammation *** downregulated NLRP3 protein level through the NF-κB pathway and downregulated LC-3 and BECLIN1 in vivo and in *** Cyanide3-ChloroPhenylhydrazone(CCCP)weakened the effects of *** on the NLRP3–NF-κB ***:*** has anti-inflammatory effects and regulates the NLRP3-NF-κB pathway.

关键词： Autophagy Crocus sativus L. Inflammatory NOD-like receptor thermal protein domain associated protein 3 Nuclear factor kappa B

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Continuous high-efficient water-electricity cogeneration over a hybrid solar-driven water evaporation system and the working mechanism

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Science China Materials 2024年第7期67卷 2371-2372页

作者： Dewei chu School of Materials Science and Engineering University of New South WalesSydneyNSW 2052Australia

With the escalation of industrialization and population growth,energy and clean water shortages pose an unprecedented threat to sustainable ***,it is imperative to develop green and effective strategies to address these *** this context,solar-driven interfacial water evaporation(SIWE)has emerged as a highly promising low-carbon solution to the water-energy nexus[1].By locating the evaporator at airwater interfaces,heat localization can be achieved,leading to high-efficient water evaporation and freshwater *** significantly,taking advantage of the special conditions during SIWE has opened numerous opportunities for generation of extra electrical power[2,3].Throughout the processes of SIWE,various elements such as photons,waves,capillary flow,evaporation,vapor motions,condensation,and droplet sliding can all be harnessed to produce electricity through photovoltaic,thermoelectric,thermogalvanic,pyroelectric,piezoelectric,triboelectricity and hydrovoltaic effects[3].Extensive research efforts have provided valuable insights for the development of water-electricity cogeneration(WEG)hybrid systems.

关键词： mechanism evaporation piezoelectric

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Paving the way toward soil safety and health:current status,challenges,and potential solutions

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 63-73页

作者： Chiheng chu Lizhong Zhu College of Environmental and Resource Sciences Zhejiang UniversityHangzhou 310058China

Soil is a non-renewable resource,providing a majority of the world’s food and fiber while serving as a vital carbon ***,the health of soil faces global threats from human activities,particularly widespread contamination by industrial *** physical,chemical,and biological remediation approaches encounter challenges in preserving soil structure and function throughout the remediation process,as well as addressing the complexities of soil contamination on a regional *** solutions encompass monitoring and simulating soil processes,with a focus on utilizing big data to bridge micro-scale and macro-scale ***,reducing pollutant emissions to soil is paramount due to the significant challenges associated with removing contaminants once they have entered the soil,coupled with the high economic costs of ***,it is imperative to implement advanced remediation technologies,such as monitored natural attenuation,and embrace holistic soil management approaches that involve regulatory frameworks,soil health indicators,and soil safety monitoring *** the enduring health and resilience of soils necessitates a blend of interdisciplinary research,technological innovation,and collaborative initiatives.

关键词： Soil safety and health Source emission reduction Process monitoring and simulation Green remediation technology Soil health management

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TDP-43 is a key molecule accelerating development of Alzheimer’s disease following traumatic brain injury

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Neural Regeneration Research 2024年第5期19卷 955-956页

作者： chu Chen Department of Cellular and Integrative Physiology Long School of MedicineUniversity of Texas Health Science Center at San AntonioSan AntonioTXUSA

Currently,more than 55 million people have dementia worldwide and Alzheimer’s disease(AD)is one of the most common causes of dementia in ***,no effective therapies are currently available for the prevention and treatment of *** is largely due to our limited understanding of the mechanisms underlying the neuropathogenesis of *** has widely been recognized that AD is heterogeneous and that multi-factors are contributing to the pathogenesis of *** evidence suggests that traumatic brain injury(TBI)is an important risk factor for the development of AD and dementia later in life(Guo et al.,2000;Johnson et al.,2010).However,the precise mechanism by which TBI contributes to developing AD has yet to be elucidated.

关键词： Alzheimer traumatic

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Motor cortical circuit adaptations in parkinsonism

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Neural Regeneration Research 2024年第10期19卷 2107-2108页

作者： Hong-Yuan chu Department of Neurodegenerative Science Van Andel Research InstituteGrand RapidsMIUSA Aligning Science Across Parkinson’s(ASAP)Collaborative Research Network

Parkinson's disease is a chronic and progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta,which leads to the featured motor impairment of parki... 详细信息

关键词： parkin impairment rigidity

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Resource Allocation to Minimize the Makespan with Multi-Resource Operations

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Journal of Systems Science & Complexity 2024年第5期37卷 2054-2070页

作者： WENG Wuyan chu Chengbin WU Peng School of Economics and Management Fuzhou UniversityFuzhou 350108China Univ Gustave Eiffel ESIEE Paris&COSYS-GRETTIAF-77454 Marne-la-ValléeFrance

This paper investigates a new resource-allocation problem involving multi-resource operations,where completing an operation requires simultaneous use of multiple(renewable)resources,probably of different *** goal of the study is to provide a solution method that minimizes the *** authors formulate the problem into a novel mixed-integer linear program(MILP)*** efficiently solve practical-sized instances,an exact Benders decomposition algorithm is *** algorithm divides the original problem into a master problem of allocating resources and a subproblem of calculating the makespan,and both are linked via Benders *** convergence is sped up by improving the mathematical model and embedding the variable neighborhood search *** with CPLEX,a commonly used MILP solver,the computational results demonstrate that the proposed algorithm provides tighter upper and lower bounds in most *** particular,compared with CPLEX,the proposed method can on average improve the upper and lower bounds by 4.76%and 4.39%,respectively,in solving practical-sized instances.

关键词： Benders decomposition multi-resources operations resource allocation

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Process metallurgy and data-driven prediction and feedback of blast furnace heat indicators

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1228-1240页

作者： Quan Shi Jue Tang Mansheng chu School of Metallurgy Northeastern UniversityShenyang 110819China Institute for Frontier Technologies of Low-carbon Steelmaking Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-carbon Steelmaking(Ministry of Education) Shenyang 110819China

The prediction and control of furnace heat indicators are of great importance for improving the heat levels and conditions of the complex and difficult-to-operate hour-class delay blast furnace(BF)*** this work,a prediction and feedback model of furnace heat indicators based on the fusion of data-driven and BF ironmaking processes was *** data on raw and fuel materials,process op-eration,smelting state,and slag and iron discharge during the whole BF process comprised 171 variables with 9223 groups of data and were comprehensively analyzed.A novel method for the delay analysis of furnace heat indicators was *** extracted delay variables were found to play an important role in *** method that combined the genetic algorithm and stacking efficiently im-proved performance compared with the traditional machine learning algorithm in improving the hit ratio of the furnace heat prediction *** hit ratio for predicting the temperature of hot metal in the error range of±10℃ was 92.4%,and that for the chemical heat of hot metal in the error range of±0.1wt%was 93.3%.On the basis of the furnace heat prediction model and expert experience,a feedback model of furnace heat operation was established to obtain quantitative operation suggestions for stabilizing BF heat *** sugges-tions were highly accepted by BF ***,the comprehensive and dynamic model proposed in this work was successfully ap-plied in a practical BF *** improved the BF temperature level remarkably,increasing the furnace temperature stability rate from 54.9%to 84.9%.This improvement achieved considerable economic benefits.

关键词： blast furnace furnace heat genetic algorithm stacking prediction and feedback

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Aberrant protamination in sperm correlates to anomalous nuclear and cytoplasmic architectures in infertile males with sperm dysmorphology

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Asian Journal of Andrology 2024年第2期26卷 183-188页

作者： Huan Jiang chu-Jie Huang Department of Reproductive Endocrinology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)Shenzhen 518172China Institute of Reproductive Immunology College of Life Science and TechnologyJinan UniversityGuangzhou 510632China

Aberrant sperm protamination is linked to sperm dysmorphology and nuclear chromatin ***,its effects on sperm cytoplasmic maturation remain largely *** relationships of protamines,sperm morphology,DNA damage,and cytoplasmic remodeling were illustrated in this study to provide fresh perspectives on the mechanisms of male infertility.A total of 205 infertile males were allocated into 5 groups according to the percentage of spermatozoa exhibiting abnormal morphology within their *** concentration,motility,abnormal sperm morphology,cytoplasmic droplets(CDs),and excess residual cytoplasm(ERC)were analyzed according to the World Health Organization manual(2010).Sperm nuclear vacuoles(NVs)were determined by propidium iodide(PI)*** protamine expressions(P1 and P2)were detected by western *** damage was measured by acridine orange test(AOT)to calculate the proportion of sperm with single-strand DNA breaks(SSBs).Our data showed that sperm concentration and motility in infertile males significantly decreased with the severity of abnormal sperm morphology(both P<0.01).P1 level,P1/P2 ratio,and SSB rate increased with the severity of sperm dysmorphology,whilst the P2 level decreased(all P

关键词： abnormal sperm morphology excess residual cytoplasm male infertility protamines sperm DNA damage sperm nuclear vacuoles

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A Fully-Integrated Memristor Chip for Edge Learning

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Nano-Micro Letters 2024年第9期16卷 123-127页

作者： Yanhong Zhang Liang chu Wenjun Li School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018People’s Republic of China

It is still challenging to fully integrate computing in memory chip as edge learning *** recent work published on Science,a fully-integrated chip based on neuromorphic memristors was developed for edge learning as artificial neural networks with functionality of synapses,dendrites,and somas.A crossbar-array memristor chip facilitated edge learning including hardware realization,learning algorithm,and cycle-parallel sign-and threshold-based learning(STELLAR)*** motion control and demonstration platforms were executed to improve the edge learning ability for adapting to new scenarios.

关键词： Computing in memory Edge learning Fully-integrated chip

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Insights into adsorbent tortuosity across aqueous adsorption systems

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Particuology 2024年第5期88卷 71-88页

作者： Ackmez Mudhoo Marta Otero Khim Hoong chu Department of Chemical and Environmental Engineering Faculty of EngineeringUniversity of MauritiusRéduit 80837Mauritius Department of Applied Chemistry and Physics Universidad de LeónCampus de Vegazana 24071 LeónSpain Department of Chemical Engineering Faculty of EngineeringUniversity of MalayaKuala Lumpur 50603Malaysia

Pore network,pore connectivity,and the resulting effective adsorbate pore diffusivity within an adsorbent are critical physical considerations in mass transport modeling of aqueous *** to these three adsorbent features are the adsorbent tortuosity and tortuosity factor *** concepts encompass the collective hindrance to intra-adsorbent adsorbate transport arising because of a disorderly adsorbent porous *** is crucial for materials scientists,chemists,chemical engineers,and water treatment specialists to understand the complex and variable connections among adsorbate chemistry,adsorbent chemistry,adsorbent porosity,pore shape,size,and tortuosity,pore wall effect,adsorbate-adsorbent interactions,and adsorbate-adsorbate interactions in competitively contaminated aqueous *** tortuosity has been sporadically studied in aqueous adsorption *** the small population of these studies,insightful observations and inferences have been ***,as it appears,no review has been published to compile,compare,and contrast these ***,this review concisely brings up those observations and interpretations around adsorbent tortuosity for aqueous adsorption *** notion of an adsorbent's tortuosity being single-valued is argued to be ***,perspectives are aired on possible research and development directions for elucidating the dynamic attributes of adsorbent tortuosity and applying them in real-scale adsorption-oriented water *** data acquired by filling in these research gaps can enable the design of adsorbents more adapted for real-scale water purification.

关键词： Adsorbent Tortuosity Porosity Pore diffusion models Aqueous systems

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