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Surfactin alleviated hyperglycaemia in mice with type 2 diabetes induced by a high-fat diet and streptozotocin

Food Science and Human Wellness 2023年第6期12卷 2095-2110页

作者： Xiaoyu Chen Hongyuan Zhao Fanqiang Meng Libang Zhou zhaoxin lu Yingjian lu College of Food Science and Technology Nanjing Agricultural UniversityNanjing 210095China College of Food Science and Engineering Nanjing University of Finance and EconomicsNanjing 210023China

Type 2 diabetes mellitus(T2DM)is associated with liver dysfunction and intestinal *** peptides(BAPs)have been reported to ameliorate T2DM by preventing oxidative damage to the *** amyloliquefaciens fmb50 produces the lipopeptide surfactin with a wide range of biological *** effects of surfactin on T2DM,on the other hand,have not been *** the present study,80 mg/kg body weight surfactin supplementation lowered fasting blood glucose(FBG)levels by 21.05%and insulin resistance(IR)by 18.18%compared with those in the T2DM group,reduced inflammation,and increased antioxidant activity in mice with T2DM induced by a high-fat diet(HFD)and streptozotocin(STZ).According to further research,surfactin administration reduced Firmicutes-to-Bacteroidetes ratios while increasing Bifi dobacterium abundance by 20 times and the level of the tight junction protein Occludin by 18.38%and ZO-1 by 66.60%.Furthermore,surfactin also improved hepatic glucose metabolism by activating the adenosine monophosphate-activated protein kinase(AMPK)signalling pathway,increasing glycogen synthesis and glucose transporter 2(GluT2)protein expression while reducing glucose-6-phosphatase(G6Pase)protein *** addition,the increased Bifi dobacterium abundance indirectly reduced the liver burden of the metabolic products indole,cresol and amine produced by saprophytic *** of these findings revealed that surfactin not only ameliorated HFD/STZ-induced gut dysbiosis and preserved intestinal barrier integrity but also enhanced hepatic glucose metabolism and detoxifi cation function in T2DM *** gut microbiota appeared to be important in controlling glucose metabolism,IR,fat accumulation,inflammation and antioxidation,according to Spearman’s correlation coeffi *** data indicated that surfactin alleviated hyperglycaemia in mice with T2DM induced by HFD/STZ.

关键词： Surfactin Type 2 diabetes mellitus(T2DM) Insulin resistance Gut microbiota Glucose metabolism

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Yogurt-derived Lactobacillus plantarum Q16 alleviated high-fat diet-induced non-alcoholic fatty liver disease in mice

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Food Science and Human Wellness 2022年第5期11卷 1428-1439页

作者： Chao Tang Weiwei Zhou Mengyuan Shan zhaoxin lu Yingjian lu College of Food Science and Technology Nanjing Agricultural UniversityNanjing 210095China College of Food Science and Engineering Nanjing University of Finance and EconomicsNanjing 210023China

Accumulating evidence revealed that some probiotics regulated lipid metabolism and alleviated diet-induced non-alcoholic fatty liver disease(NAFLD).This study mainly explored whether yogurt-derived Lactobacillus plantarum Q16 modulated lipid and energy metabolism,and suppressed microbial dysbiosis in high-fat diet(HFD)-fed *** showed that oral administration of *** Q16 improved serum and hepatic lipid *** analysis showed that *** Q16 could reduce hepatic lipid content by reducing the expression of FAS,ACC,SCD-1,Srebp-lc and ATGL,but increasing expression levels of CPT-1α,PPAR-αand ***,*** Q16 also improved hepatic energy metabolism by regulating FGF21/adiponectin/AMPKα/PGC-1αsignaling *** analysis also discovered that *** Q16 increased species diversity and richness of intestinal microbiota,promoted proliferation of beneficial commensals and suppressed the growth of endotoxin-producing microorganisms in the colon of HFD-fed ***,*** Q16 protected against HFD-induced NAFLD by improving hepatic profile and regulating colonic microbiota composition.

关键词： Lactobacillus plantarum Q16 Non-alcoholic fatty acid liver disease Lipid metabolism Energy metabolism Colonic microbiota

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Lacticaseibacillus rhamnosus Fmb14 ameliorates hyperuricemia-induced hepatocyte pyroptosis via NLRP3 inflammasome cascade inhibition

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Food Science and Human Wellness 2024年第4期13卷 2174-2186页

作者： Hongyuan Zhao Xiaoyu Chen Li Zhang Fanqiang Meng Libang Zhou zhaoxin lu Yingjian lu College of Food Science&Technology Nanjing Agricultural UniversityNanjing 210095China Institute of Vegetable Gansu Academy of Agricultural SciencesLanzhou 730070China College of Food Science&Engineering Nanjing University of Finance and EconomicsNanjing 210023China

Hyperuricemia is a high-risk factor for the development of gout and renal fibrosis,but the adverse effects of hyperuricemia on the liver have been seriously *** research investigated the ameliorating effect of Lacticaseibacillus rhamnosus Fmb14 on hyperuricemia induced liver dysfunction both in vitro and in *** free extracts of high dose *** Fmb14 treatment reduced the death rate of HepG2 cell lines from 24.1%to 14.9%by inhibiting NLRP3 recruitment,which was mainly activated by reactive oxygen species release and mitochondrial membrane potential *** purine dietary induced hyperuricemia(PDIH)mice model,liver oedema and pyroptosis were ameliorated after *** Fmb14 administration through downregulating the expression levels of NLRP3,caspase-1 and gasdermin-D from 1.61 to 0.86,3.15 to 1.01 and 5.63 to 2.02,*** Fmb14 administration restored mitochondrial inner membrane protein(MPV17)and connexin 43 from 2.83 and 0.73 to 0.80 and 0.98 respectively in PDIH mice,indicating that dysbiosis of mitochondrial membrane potential was restored in ***,PDIH pyroptosis stimulates the process of apoptosis,which leads to severe leakage of hepatocytes,and both of pyroptosis and apoptosis were decreased after *** Fmb14 ***,*** Fmb14 is a promising biological resource to maintain homeostasis of the liver in hyperuricemia and the prevention of subsequent complications.

关键词： Lacticaseibacillus rhamnosus Fmb14 Hyperuricemia Pyroptosis NLRP3 pathway

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Ameliorative effect of Lacticaseibacillus rhamnosus Fmb14 from Chinese yogurt on hyperuricemia

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Food Science and Human Wellness 2023年第4期12卷 1379-1390页

作者： Hongyuan Zhao Xiaoyu Chen Fanqiang Meng Libang Zhou Xinyi Pang zhaoxin lu Yingjian lu College of Food Science and Technology Nanjing Agricultural UniversityNanjing 210095China College of Food Science and Engineering Nanjing University of Finance and EconomicsNanjing 210023China

Hyperuricemia is a critical threat to human health,and a high inosine diet can increase the prevalence of *** rhamnosus Fmb14 was isolated from traditional fermented Chinese yogurt,and its inosine degradation rate reached 36.3%at 109 CFU/mL for 24 ***-MS analysis revealed that high concentrations of inosine could activate compensatory metabolic pathways of *** Fmb14 to catalyse inosine as an energy source and produce intracellular folic acid and *** contents of folic acid and riboflavin were 6.0 and 4.3 fold increased after inosine treatment in the cell-free extracts(CFE).*** Fmb14 CFE treatment ameliorates hyperuricemia through xanthine oxidase(XOD)inhibition and ATP-binding cassette subfamily G member 2(ABCG2)promotion,both of which are responsible for uric acid(UA)synthesis and secretion in HepG2 and Caco2 cells,*** in vivo results showed that the serum UA level decreased from 236.28 to 149.28μmol/L after 8 weeks of oral administration of *** Fmb14 in inosine-induced hyperuricemia model *** results revealed that *** Fmb14 has a potential as a biological therapeutic agent in hyperuricemia prevention.

关键词： Lacticaseibacillus rhamnosus Fmb14 Hyperuricemia Inosine degradation Uric acid metabolism

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StripeRust-Pocket:A Mobile-Based Deep Learning Application for Efficient Disease Severity Assessment of Wheat Stripe Rust

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Plant Phenomics 2024年第3期6卷 771-786页

作者： Weizhen Liu Yuxi Chen zhaoxin lu Xiaoyu lu Ze Wu Ziyao Zheng Yongqiang Suo Caixia Lan Xiaohui Yuan School of Computer Science and Artificial Intelligence Wuhan University of TechnologyWuhanHubei 430070China Wuhan University of Technology Chongqing Research Institute Chongqing 401120China Sanya Science and Education Innovation Park of Wuhan University of Technology SanyaHainan 572025China Hubei Hongshan Laboratory College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070HubeiChina Engineering Research Centre of Chinese Ministry of Education for Edible and Medicinal Fungi Jilin Agricultural UniversityChangchunJilin 130118China

Wheat stripe rust poses a marked threat to global wheat *** and effective disease severity assessments are crucial for disease resistance breeding and timely management of field *** this study,we propose a practical solution using mobile-based deep learning and model-assisted ***-Pocket,a user-friendly mobile application developed based on deep learning models,accurately quantifies disease severity in wheat stripe rust leaf images,even under complex ***,StripeRust-Pocket facilitates image acquisition,result storage,organization,and *** underlying model employed by StripeRust-Pocket,called StripeRustNet,is a balanced lightweight 2-stage *** first stage utilizes MobileNetV2-DeepLabV3+for leaf segmentation,followed by ResNet50-DeepLabV3+in the second stage for lesion *** severity is estimated by calculating the ratio of the lesion pixel area to the leaf pixel *** achieves 98.65%mean intersection over union(MIoU)for leaf segmentation and 86.08%MIoU for lesion *** using an additional 100 field images demonstrated a mean correlation of over 0.964 with 3 expert visual *** address the challenges in manual labeling,we introduce a 2-stage labeling pipeline that combines model-assisted labeling,manual correction,and spatial *** apply this pipeline to our self-collected dataset,reducing the annotation time from 20 min to 3 min per *** method provides an efficient and practical solution for wheat stripe rust severity assessments,empowering wheat breeders and pathologists to implement timely disease *** also demonstrates how to address the"last mile"challenge of applying computer vision technology to plant phenomics.

关键词： application learning pocket deep assessment disease efficient mobile-based severity striperust

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Optimization of fermentation factors to enhance rice straw degradation ability using a microbial consortium LZF-12

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International Journal of Agricultural and Biological Engineering 2019年第3期12卷 168-173页

作者： Guoxiang Zheng Chenyang Zhou Ting Yin zhaoxin lu Shuang Ai College of Engineering Northeast Agricultural UniversityHarbin 150030China Key Laboratory of Pig-breeding Facilities Engineering Ministry of Agriculture and Rural AffairsHarbin 150030China Heilongjiang Key Laboratory of Technology and Equipment for the Utilization of Agricultural Renewable Resources Harbin 150030China

Biological pretreatment has broad application prospects in agricultural waste treatment because of its economic benefits,environmental protection and energy saving *** this study,a microbial consortium LZF-12 was applied for a biological pretreatment to degrade rice *** experiments were performed under hydrolysis conditions by using the method of Box-Behnken factorial design(BBD).The results showed that the model multiple correlation coefficient R2 was 0.9816,and the effects of three factors on the degradation of rice straw of LZF-12 as descending order were the initial rice content,chicken manure content,and initial pH *** interaction between straw concentration,chicken manure concentration,and initial pH value had significant effects on the degradation of a microbial *** the optimum conditions of 0.86%rice straw,0.5%chicken manure and the initial pH value of 7.0,the degradation rate of rice straw reached 72.4%.There is only a small difference of 0.55%between the experimental value and predicted value from BBD ***,it is feasible for the established model due to the consistent results between the prediction and experimental *** microbial consortium LZF-12 has high cellulase enzyme activities and degradation ability over a wide range of temperature and pH value,indicating that it has a good development potential and application prospects in waste biodegradation and biomass energy production.

关键词： microbial consortium biological pretreatment biodegradation rice straw optimization

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Screening and performance of L-14, a novel, highly efficient and low temperature-resistant cellulose-degrading strain

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International Journal of Agricultural and Biological Engineering 2020年第1期13卷 247-254页

作者： Guoxiang Zheng zhaoxin lu Jian Li Shuang Ai Yong Sun College of Engineering Northeast Agricultural UniversityHarbin 150030China Key Laboratory of Pig-breeding Facilities Engineering Ministry of Agriculture and Rural AffairsHarbin 150030China Heilongjiang Key Laboratory of Technology and Equipment for the Utilization of Agricultural Renewable Resources Harbin 150030China

In view of the low bioconversion efficiency of agricultural biomass waste in low-temperature environments in winter,a low-temperature-resistant cellulose-degrading strain,L-14,was successfully screened by restrictive cultures from humus-rich soil in the Daqing Zhalong wetland *** to morphological observations and 18S rDNA sequence analysis,the cellulose-degrading strain L-14 was identified as a Neurospora sp,belonging to *** parameters,such as temperature,initial pH,carbon,nitrogen and lecithin,were optimized using a single-factor experiment and a response surface methodology(RSM).When the temperature was 16°C,the optimal conditions for enzyme production were an initial pH 8.20,10.45 g/L of bran,5.28 g/L of yeast powder,and 4.25 g/L of *** carboxymethyl cellulase(CMCase)activity of strain L-14 was 63.598 IU/*** L-14 had a high level of cellulose degradation activity,excellent resistance to low temperatures and environmental adaptability,indicating its good application prospects in substrates pretreatment of biogas engineering.

关键词： low-temperature-resistant Neurospora sp. 18S rDNA sequence carboxymethyl cellulase response surface methodology

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Substitution of the communication‑mediating domain and the interaction between modules in bacillomycin D produced by Bacillus amyloliquefaciens

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Systems Microbiology and Biomanufacturing 2023年第4期3卷 792-804页

作者： Ziyan Lv Wenjie Ma zhaoxin lu Ping Zhang Fengxia lu Haizhen Zhao Xiaomei Bie College of Food Science and Technology Nanjing Agricultural UniversityNanjing 210095People’s Republic of China

Bacillomycin D is a nonribosomal peptide produced by Bacillus amyloliquefaciens *** this study,the biosynthesis of bacillomycin D was mediated by replacing the intermodule donor,acceptor,and communication-mediating(COM)domain pairs and introducing the COM domain between the surfactin *** the homologous donor and the COM domain pair replacement strains eliminated the selective barrier of the original COM domain pair to a certain extent,resulting in a more flexible hybrid biosynthesis system that provides simultaneous biosynthesis of different lipopeptide *** synthesis of bacillomycin D in the homologous acceptor replacement strains was barely *** COM domains between the surfactin subunits cannot establish efficient communication between the bacillomycin D *** conclusion,the COM domains compatibility between the bacillomycin D modules are extremely strong,and the conserved amino acid residues in the acceptor domain are an important part of module–module interactions and efficient communication during bacillomycin D synthesis.

关键词： Bacillomycin D COM domain Surfactin Intermodule interaction Synthetase reprogramming

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Effects of dietary Bacillus amyloliquefaciens supplementation on growth performance,intestinal morphology, inflammatory response, and microbiota of intra-uterine growth retarded weanling piglets

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Journal of Animal Science and Biotechnology 2018年第2期9卷 480-495页

作者： Yue Li Hao Zhang Weipeng Su Zhixiong Ying Yueping Chen Lili Zhang zhaoxin lu Tian Wang College of Animal Science and Technology Nanjing Agricultural University College of Food Science and Technology Nanjing Agricultural University

Background: The focus of recent research has been directed toward the probiotic potential of Bacillus amyloliquefaciens(BA) on the gut health of animals. However, little is known about BA's effects on piglets with intra-uterine growth retardation(IUGR). Therefore, this study investigated the effects of BA supplementation on the growth performance,intestinal morphology, inflammatory response, and microbiota of IUGR ***: Eighteen litters of newborn piglets were selected at birth, with one normal birth weight(NBW) and two IUGR piglets in each litter(i.e., 18 NBW and 36 IUGR piglets in total). At weaning, the NBW piglet and one of the IUGR piglets were assigned to groups fed a control diet(i.e., the NBW-CON and IUGR-CON groups). The other IUGR piglet was assigned to a group fed the control diet supplemented with 2.0 g BA per kg of diet(i.e., IUGR-BA group). The piglets were thus distributed across three groups for a four-week ***: IUGR reduced the growth performance of the IUGR-CON piglets compared with the NBW-CON piglets. It was also associated with decreased vil us sizes, increased apoptosis rates, reduced goblet cel numbers, and an imbalance between pro-and anti-inflammatory cytokines in the smal intestine. Supplementation with BA improved the average daily weight gain and the feed efficiency of the IUGR-BA group compared with the IUGR-CON group(P < 0.05). The IUGR-BA group exhibited increases in the ratio of jejunal vil us height to crypt depth, in ileal vil us height, and in ileal goblet cel density. They also exhibited decreases in the numbers of jejunal and ileal apoptotic cel s and ileal proliferative cel s(P < 0.05). Supplementation with BA increased interleukin 10 content, but it decreased tumor necrosis factor alpha level in the smal intestines of the IUGR-BA piglets(P < 0.05). Furthermore, compared with the IUGR-CON piglets, the IUGR-BA piglets had less Escherichia coli in their jejunal digesta, but more Lactobacil us and Bifidobacter

关键词： Apoptosis Bacillus amyloliquefaciens Immune status Intra-uterine growth retardation Microbiota Piglet Small intestine

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Translocation of subunit PPSE in plipastatin synthase and synthesis of novel lipopeptides

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Synthetic and Systems Biotechnology 2022年第4期7卷 1173-1180页

作者： Ling Gao Wenjie Ma zhaoxin lu Jinzhi Han Zhi Ma Hongxia Liu Xiaomei Bie Nanjing Agricultural University College of Food Science and TechnologyNanjing210095China Jiangnan University The Key Laboratory of Industrial BiotechnologyWuxi214122China

Nonribosomal peptide synthase(NRPS)is a unique molecular assembly mechanism with high *** recombination is conducive to the development of novel ***,there are few reports on NRPS subunit recombination of plipastatin at *** this paper,plipastatin synthase was modified by the forward movement of subunit PPSE and the replacement of the communication-mediating(COM)*** results showed that ppsABE,a new assembly line,could synthesize novel lipopeptides such as cycle pentapeptide(C16-18β-OHFA-E-O-cyclo(Y-T-I),and its antimicrobial activity against Rhizopus stolonifer and Staphylococcus aureus was better than that of ***,the reactivity of ppsABCE disappeared,but the substitution of COM^(D)_(ppsC)/COM^(A)_(ppsD) or COM^(D)_(ppsD)/COM^(A)_(ppsE) for COM^(D)_(ppsC)/COM^(A)_(ppsE) could restore its activity and conduct the biosynthesis of linear hexapeptide(C16-17β-OHFA-E-O-Y-T-E-A/V)and heptapeptide(C17-18β-OHFA-E-O-Y-T-E-A-I).Collectively,these findings indicated that the COM donor domain at the C-terminus of PPSB could communicate with the COM acceptor domain at the N-terminus of PPSE and that the compatible COM domain is an important tool for communication between nonpartner ***,the integrity and selective compatibility of the COM acceptor domain of subunit PPSE are essential to promote the interaction between PPSE and other *** work further complemented the rules of NRPS subunit recombination and provided a theoretical basis for the development of novel high-efficiency lipopeptides.

关键词： Plipastatin Subunit translocation COM domain Compatibility Antimicrobial activity Novel lipopeptides

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