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Factors predicting sensory and motor recovery after the repair of upper limb peripheral nerve injuries

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Neural Regeneration Research 2014年第6期9卷 661-672页

作者： Bo He zhaowei zhu Qingtang zhu Xiang Zhou Canbin Zheng Pengliang Li Shuang zhu Xiaolin Liu Jiakai zhu Department of Microsurgery and Orthopedic Trauma the First Affiliated Hospital of Sun Yat-sen University

OBJECTIVE： To investigate the factors associated with sensory and motor recovery after the repair of upper limb peripheral nerve injuries. DATA SOURCES： The online PubMed database was searched for English articles describing outcomes after the repair of median, ulnar, radial, and digital nerve injuries in humans with a publication date between 1 January 1990 and 16 February 2011. STUDY SELECTION： The following types of article were selected：（1） clinical trials describ- ing the repair of median, ulnar, radial, and digital nerve injuries published in English; and （2） studies that reported sufficient patient information, including age, mechanism of injury, nerve injured, injury location, defect length, repair time, repair method, and repair materials. SPSS 13.0 software was used to perform univariate and multivariate logistic regression analyses and to in- vestigate the patient and intervention factors associated with outcomes. MAIN OUTCOME MEASURES： Sensory function was assessed using the Mackinnon-Dellon scale and motor function was assessed using the manual muscle test. Satisfactory motor recovery was defined as grade M4 or M5, and satisfactory sensory recovery was defined as grade S3＋ or S4. RESULTS： Seventy-one articles were included in this study. Univariate and multivariate logistic regression analyses showed that repair time, repair materials, and nerve injured were inde- pendent predictors of outcome after the repair of nerve injuries （P 〈 0.05）, and that the nerve injured was the main factor affecting the rate of good to excellent recovery. CONCLUSION： Predictors of outcome after the repair of peripheral nerve injuries include age, gender, repair time, repair materials, nerve injured, defect length, and duration of follow-up.

关键词： nerve regeneration peripheral nerve injury outcome predictors nerve repair upperlimb univariate analysis prognosis 863 Program neural regeneration

Singularities of Three-Dimensional Cubic Piezoelectric Quasicrystal Composite Wedges and Spaces

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Acta Mechanica Solida Sinica 2023年第1期36卷 143-155页

作者： Xiang Mu Ting Cao Wenshuai Xu zhaowei zhu Taiyan Qin Liangliang Zhang Yang Gao College of Science China Agricultural UniversityBeijing 100083China College of Engineering China Agricultural UniversityBeijing 100083China Key Laboratory of Microgravity Institute of MechanicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

In this paper,the planar problems of three-dimensional(3D)cubic piezoelectric quasicrystal composite wedges and spaces are *** study focuses on the singular behaviors of interface corner and interface crack of composite wedges and *** research the stress singularities,the stress function is assumed to have the exponential *** on the Stroh formalism and Barnett–Lothe matrices,we derive a crucial matrix concerned with material properties and wedge angle and obtain the transcendental equation determining the singular orders by simple multiplication of the crucial *** examples of the singular orders are given for some general cases including single,bi-material,and tri-material wedges and spaces under different boundary *** correctness of numerical results is verified by comparison with the existing results of piezoelectric *** results show that the phonon field,phason field,electric field,material properties,and boundary conditions have great influences on singularities.

关键词： Composite wedges Stroh formalism 3D cubic piezoelectric quasicrystals(QCs) Singular orders

Enhancement of tribological properties in siliconized graphite via hierarchically hybrid SiC/C composite

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Progress in Natural Science:Materials International 2021年第2期31卷 255-263页

作者： Zilin Li zhaowei zhu Xianglong Yu Kai Li Zixi Wang Zezhao Zhang Yuming Wang State Key Laboratory of Tribology Department of Mechanical Engineering Tsinghua University Institute of Chemical Defense Academy of Military Sciences

This study aims to investigate tribological properties in a siliconized graphite(СГ-П-0.5) and hierarchically hybrid Si C/C composites at the load ranging from 10-40 N under dry air/water lubrication conditions. A feasible liquid silicon infiltration(LSI) was used to fabricate the Si C/C composites. Morphology and phase identification of two materials were characterized and analyzed by scanning electron microscope(SEM) and energy dispersive spectrometer(EDS). An image feature extraction was used to post-process the data of wear test, further to gain the wear properties of the samples. The results demonstrated that a lower coefficient of friction(COF) and wear rate can be achieved in the LSI Si C composites than that in the sample of СГ-П-0.5. Both COF decreased under waterlubricated conditions, compared with that under the dry air lubrication. The excellent tribological properties in two materials can be due mainly to the microstructure of the СГ-П-0.5 sample, showing much more graphite and Si dispersed on the matrix. The СГ-П-0.5 sample indicated the typical oxidative wear mechanism, whereas, the sample of LSI Si C demonstrated the combined oxidative and fatigue wear. This finding can provide a promising new siliconized graphite materials for ceramic rolling bearings.

关键词： Siliconized graphite Coefficient of friction Surface microstructure Feature extraction

Glycyrrhizic Acid Attenuates Balloon-Induced Vascular Injury Through Inactivation of RAGE Signaling Pathways

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Cardiovascular Innovations and Applications 2020年第2期4卷 239-249页

作者： zhaowei zhu Yanan Guo Xuping Li Shuai Teng Xiaofan Peng Pu Zou Shenghua Zhou Department of Cardiovascular Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunanChina

Percutaneous coronary intervention is a well-established technique used to treat coronary artery disease,but the risk of coronary artery in-stent restenosis following percutaneous coronary intervention is still *** studies revealed that high mobility group protein B1(HMGB1)plays a critical role in neointima *** this study,we aimed to investigate the role of glycyrrhizic acid(GA),an HMGB1 inhibitor,in the process of neointima formation and the potential *** investigated the role of GA in neointima formation through an iliac artery balloon injury model in ***,migration,and phenotype transformation of human vascular smooth muscle cells(VSMCs)were ***,infl ammation and receptor for advanced glycosylation end products(RAGE)signaling pathways were *** results indicate that GA attenuated neointima formation and downregulated HMGB1 expression in injured artery in ***1 promoted proliferation,migration,and phenotype transformation through the activation of RAGE signaling pathways in VSMCs,and blockade of HMGB1 by GA(1,10,and 100μM)could attenuate those processes and reduce proliferation of human *** conclusion,the HMGB1 inhibitor GA might be useful to treat proliferative vascular diseases by downregulating RAGE signaling *** results indicate a new and promising therapeutic agent for restenosis.

关键词： Glycyrrhizic acid high mobility group protein B1 infl ammation vascular smooth muscle cell receptor for advanced glycosylation end products

A Giant Right Atrial Myxoma with Blood Supply from the Left and Right Coronary Arteries:Once in a Blue Moon

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Cardiovascular Innovations and Applications 2020年第1期4卷 201-204页

作者： Yichao Xiao Zhenfei Fang Xinqun Hu Qiming Liu zhaowei zhu Na Liu Xiaofan Peng Shenghua Zhou Department of Cardiology The Second Xiangya Hospital of Central South UniversityChangsha410011 HunanPeople’s Republic of China

Cardiac myxomas,the commonest primary benign cardiac tumors,are extremely rare,with an incidence ranging from 0.0017 to 0.19%and only about one-fi fth of them originating from the right chambers of the heart.A 60-year-old woman was admitted because of recurrent attacks of chest tightness and shortness of *** echocardiography detected a giant mass in the right atrium;myxoma was indicated by[18 F]fl uorodeoxyglucose PET/*** selective coronary angiography was performed to assess the extent and severity of coronary stenosis,and showed a strongly neovascularized right atrial mass supplied by two feeding vessels with multiple branches from the left and right coronary *** myxoma was successfully excised with open heart surgery and the patient was free of myxoma recurrence during the 3-year follow-up.

关键词： cardiac myxomas coronary angiography neovascularization

Clinical Signifi cance of Angiographically Detectable Neovascularity in Patients with Cardiac Myxoma

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Cardiovascular Innovations and Applications 2021年第4期6卷 99-108页

作者： Xiaofan Peng Yichao Xiao Yanan Guo zhaowei zhu Liyan Liao Xiaobo Liao Xinqun Hu Zhenfei Fang Xuping Li Shenghua Zhou Department of Cardiovascular Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunanChina Department of Pathology The Second Xiangya HospitalCentral South UniversityChangshaHunanChina Department of Cardiovascular and Thoracic Surgery The Second Xiangya HospitalCentral South UniversityChangshaHunanChina

Background:Myxomas are the most common primary cardiac *** detectable neovascularity(ADN)of myxoma is increasingly being reported as a result of the use of coronary angiography(CAG)to detect coronary artery ***,the clinical signifi cance of these fi ndings is not fully ***:We enrolled 59 patients with cardiac myxoma who also underwent CAG between January 2013 and October *** were followed up for a mean of 28.9 months(range 1-69 months).The clinical features,echocardiography measurements,pathological examination fi ndings,CAG results,and outcomes during follow-up were compared between patients with ADN and patients without ***:ADN was found in 25 patients(42.4%).The arteries feeding the ADN included the right coronary artery(n=15),the left circumfl ex coronary artery(n=7),and both arteries(n=3).The patients with ADN had a higher proportion of eosinophils(3.2%vs.2.2%,P=0.03)and higher low-density lipoprotein cholesterol level(2.7 mmol/L vs.2.2 mmol/L,P=0.02).Myxoma pedicles were more likely to be located in the interatrial septum in patients with ADN(96%vs.73.5%,P=0.02).No signifi cant correlation was observed between the groups in clinical manifestations,atrial arrhythmia,myxoma size,cardiac chamber size,left ventricular ejection fraction,and the prevalence of complication with coronary artery disease[16%in the ADN group(n=4)vs.20.6%in the non-ADN group(n=7),P=0.66].However,patients with ADN tended to have a lower incidence of major adverse cardiac and cerebrovascular events on long-term follow-up(0%vs.14.7%,P=0.07).Conclusion:CAG-detected ADN in patients with cardiac myxoma is associated with a borderline lower rate of major adverse cardiac and cerebrovascular events.

关键词： Cardiac myxomas coronary angiography angiographically detectable neovascularity major adverse cardiac and cerebrovascular events

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Cardiovascular Innovations and Applications 2021年第3期6卷 25-32页

作者： zhaowei zhu Jianjun Tang Xiangping Chai Zhenfei Fang Qiming Liu Xinqun Hu Danyan Xu Jia He Liang Tang Shi Tai Yuzhi Wu Shenghua Zhou Department of Cardiovascular Medicine the Second Xiangya HospitalCentral South UniversityChangshaHunanChina Department of Emergency the Second Xiangya HospitalCentral South UniversityChangshaHunanChina Department of Radiology the Second Xiangya HospitalCentral South UniversityChangshaHunanChina

Aims:During the COVID-19 epidemic,chest computed tomography(CT)has been highly recommended for screen-ing of patients with suspected COVID-19 because of an unclear contact history,overlapping clinical features,and an overwhelmed health ***,there has not been a full comparison of CT for diagnosis of heart failure or COVID-19 ***:Patients with heart failure(n=23)or COVID-19 pneumonia(n=23)and one patient with both diseases were retrospectively *** information and chest CT images were obtained and ***:There was no difference in ground-glass opacity,consolidation,crazy paving pattern,the lobes affected,and septal thickening between heart failure and COVID-19 ***,a less rounded morphology(4%vs.70%,P=0.00092),more peribronchovascular thickening(70%vs.35%,P=0.018)and fi ssural thickening(43%vs.4%,P=0.002),and less peripheral distribution(30%vs.87%,P=0.00085)were found in the heart failure group than in the COVID-19 ***,there were also more patients with upper pulmonary vein enlargement(61%vs.4%,P=0.00087),subpleural effusion(50%vs.0%,P=0.00058),and cardiac enlargement(61%vs.4%,P=0.00075)in the heart failure group than in the COVID-19 ***,more fi brous lesions were found in the COVID-19 group,although there was no statistical difference(22%vs.4%,P=0.080).Conclusions:Although there is some overlap of CT features between heart failure and COVID-19,CT is still a useful tool for differentiating COVID-19 pneumonia.

关键词： Computed tomography COVID-19 pneumonia heart failure

右美托咪定对肾上腺嗜铬细胞瘤切除术循环波动、麻醉深度、肌松及安全性作用

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中华内分泌外科杂志（中英文） 2024年第4期18卷 538-543页

作者：朱永霞孔莉朱照伟商丘市第一人民医院麻醉科商丘476000 郑州大学第一附属医院泌尿外科郑州450003

目的探究不同剂量的右美托咪定(dexmedetomidine,DEX)对肾上腺嗜铬细胞瘤切除术中循环波动、麻醉深度、肌松及安全性的影响。方法选取2020年9月至2022年9月商丘市第一人民医院和郑州大学第一附属医院收治的78例行肾上腺嗜铬细胞瘤切除... 详细信息

目的探究不同剂量的右美托咪定(dexmedetomidine,DEX)对肾上腺嗜铬细胞瘤切除术中循环波动、麻醉深度、肌松及安全性的影响。方法选取2020年9月至2022年9月商丘市第一人民医院和郑州大学第一附属医院收治的78例行肾上腺嗜铬细胞瘤切除术患者,随机数字表法分为0.2μg组和0.4μg组,各39例。0.2μg组在全麻诱导前30 min给予0.2μg·kg^(-1)·h^(-1)DEX,0.4μg组在全麻诱导前30 min给予0.4μg·kg^(-1)·h^(-1)DEX,直至肿瘤血管完全钳闭。比较两组各时间循环波动[心率(heart rate,HR)、平均动脉压(mean arterial pressure,MAP)、血氧饱和度(blood oxygen saturation,SpO2)]、麻醉深度[Narcotrend指数(NI)]、肌松效果、麻醉恢复情况[Ricker镇静-躁动评分(SAS评分)]、血管活性药物使用情况及安全性。结果0.4μg组麻醉诱导后、术毕HR分别为(92.73±9.58)次/min、(84.39±8.65)次/min,均低于0.2μg组的(103.57±6.91)次/min、(91.53±7.27)次/min;MAP分别为(85.30±4.29)mmHg、(80.45±6.38)mmHg,均低于0.2μg组的(96.35±5.88)mmHg、(84.92±5.19)mmHg;肿瘤切除后HR、MAP分别为(80.22±7.30)次/min、(77.46±7.10)mmHg,均高于0.2μg组的(75.14±5.82)次/min、(73.92±6.03)mmHg(P0.05)。结论肾上腺嗜铬细胞瘤切除术中应用0.2μg·kg^(-1)·h^(-1)和0.4μg·kg^(-1)·h^(-1)DEX均有较高的安全性,而后者麻醉效果较好,能减少血管活性药物剂量和复苏期躁动,改善肌松状态,有助于维持循环稳定。

关键词：肾上腺嗜铬细胞瘤右美托咪定循环波动镇静-躁动评分肌松麻醉深度复苏时间

miR-130a-3p对膀胱癌细胞侵袭、迁移和凋亡的影响及对SPOCK1的调控作用

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郑州大学学报（医学版） 2020年第4期55卷 541-546页

作者：宋歌董彪朱照伟安阳市人民医院泌尿外科河南安阳455000 郑州大学第一附属医院泌尿外科郑州450052

目的:探讨微小RNA-130a-3p(miR-130a-3p)对膀胱癌细胞侵袭、迁移和凋亡的影响及其分子机制。方法:采用qRT-PCR和Western blot法检测膀胱癌组织、癌旁正常组织以及人正常膀胱上皮细胞SV-HUC-1、膀胱癌细胞5637中miR-130a-3p和细胞外基质... 详细信息

目的:探讨微小RNA-130a-3p(miR-130a-3p)对膀胱癌细胞侵袭、迁移和凋亡的影响及其分子机制。方法:采用qRT-PCR和Western blot法检测膀胱癌组织、癌旁正常组织以及人正常膀胱上皮细胞SV-HUC-1、膀胱癌细胞5637中miR-130a-3p和细胞外基质蛋白多糖(SPOCK1)mRNA及蛋白的表达。取5637细胞,分别转染miR-130a-3p mimics或si-SPOCK1,同时设阴性对照和空白对照,用MTT法检测细胞存活,Transwell小室法测定细胞侵袭和迁移,AnnexinV-FITC/PI双染法检测细胞凋亡,Western blot法检测MMP-2和Caspase-3蛋白的表达;用生物学信息预测和双荧光素酶报告实验分析miR-130a-3p和SPOCK1的靶向关系。结果:与癌旁组织和SV-HUC-1细胞相比,膀胱癌组织和细胞中miR-130a-3p的表达下调,SPOCK1 mRNA和蛋白的表达上调(P<0.05)。转染miR-130a-3p或沉默SPOCK1均可抑制膀胱癌细胞存活、侵袭和迁移,诱导其凋亡,并抑制MMP-2蛋白表达,促进Caspase-3蛋白表达(P<0.05)。经验证SPOCK1是miR-130a-3p的靶基因。结论:miR-130a-3p可能通过靶向调控SPOCK1的表达来抑制膀胱癌细胞侵袭、迁移,诱导其凋亡。

关键词：膀胱癌凋亡 miR-130a-3p SPOCK1