Factors predicting sensory and motor recovery after the repair of upper limb peripheral nerve injuries

作     者：Bo He Zhaowei Zhu Qingtang Zhu Xiang Zhou Canbin Zheng Pengliang Li Shuang Zhu Xiaolin Liu Jiakai Zhu 

作者机构：Department of Microsurgery and Orthopedic Traumathe First Affiliated Hospital of Sun Yat-sen University 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2014年第9卷第6期

页      面：661-672页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National High-Technology Research and Development Program of China(863 Program),No.2012A A020507 985 Program of Sun Yat-sen University,No.90035-3283312 Specialized Research Fund for the Doctoral Program of Higher Education,No.20120171120075 Doctoral Start-up Project of the Natural Science Foundation of Guangdong Province,No.S201204006336 

主　　题：nerve regeneration peripheral nerve injury outcome predictors nerve repair upperlimb univariate analysis prognosis 863 Program neural regeneration 

摘      要：OBJECTIVE： To investigate the factors associated with sensory and motor recovery after the repair of upper limb peripheral nerve injuries. DATA SOURCES： The online PubMed database was searched for English articles describing outcomes after the repair of median, ulnar, radial, and digital nerve injuries in humans with a publication date between 1 January 1990 and 16 February 2011. STUDY SELECTION： The following types of article were selected： （1） clinical trials describ- ing the repair of median, ulnar, radial, and digital nerve injuries published in English; and （2） studies that reported sufficient patient information, including age, mechanism of injury, nerve injured, injury location, defect length, repair time, repair method, and repair materials. SPSS 13.0 software was used to perform univariate and multivariate logistic regression analyses and to in- vestigate the patient and intervention factors associated with outcomes. MAIN OUTCOME MEASURES： Sensory function was assessed using the Mackinnon-Dellon scale and motor function was assessed using the manual muscle test. Satisfactory motor recovery was defined as grade M4 or M5, and satisfactory sensory recovery was defined as grade S3＋ or S4. RESULTS： Seventy-one articles were included in this study. Univariate and multivariate logistic regression analyses showed that repair time, repair materials, and nerve injured were inde- pendent predictors of outcome after the repair of nerve injuries （P 〈 0.05）, and that the nerve injured was the main factor affecting the rate of good to excellent recovery. CONCLUSION： Predictors of outcome after the repair of peripheral nerve injuries include age, gender, repair time, repair materials, nerve injured, defect length, and duration of follow-up.