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Cardiac resident macrophages: Spatiotemporal distribution, development, physiological functions, and their translational potential on cardiac diseases

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1483-1493页

作者： Jing Jin Yurou Wang Yueqin Liu subrata Chakrabarti zhaoliang su International Genome Center Jiangsu UniversityZhenjiang 212013China Institute for Medical Immunology Jiangsu UniversityZhenjiang 212013China Center Laboratory the Fourth People's Hospital of ZhenjiangZhenjiang 212008China Department of Pathology and Laboratory Medicine Western UniversityLondonOntario N6A 5C1Canada

Cardiac resident macrophages (CRMs) are the main population of cardiac immune cells. The role of these cells in regeneration, functional remodeling, and repair after cardiac injury is always the focus of research. However, in recent years, their dynamic changes and contributions in physiological states have a significant attention. CRMs have specific phenotypes and functions in different cardiac chambers or locations of the heart and at different stages. They further show specific differentiation and development processes. The present review will summarize the new progress about the spatiotemporal distribution, potential developmental regulation, and their roles in cardiac development and aging as well as the translational potential of CRMs on cardiac diseases. Of course, the research tools for CRMs, their respective advantages and disadvantages, and key issues on CRMs will further be discussed.

关键词： Cardiac resident macrophages Spatiotemporal distribution Cardiac development Cardiac homeostasis Physiological functions Research tools Clinical translation Transcriptional characteristics

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Dietary reprogram of macrophages for cell competition: a promising strategy for malignant cancer control

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5153-5155页

作者： Jian Chen zhaoliang su Guangchuan Wang Department of Nephrology Affiliated Hospital of Jiangsu UniversityZhenjiang212013China International Genome Center Jiangsu UniversityZhenjiang212013China State Key Laboratory of Molecular Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai20031China

In a recent study published in Nature,Zhang et al.explored the nutrient competition between cancer cells as well as their competition with macrophages during cancer development.1 Their data demonstrated that tumor-associated macrophage(TAM)can be dietarily or genetically reprogrammed to win in the competition with MYC-overexpressing cancer cells,providing new insights into our understanding of tumor development and immunotherapy.

关键词： cancer malignant

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Renewal of embryonic and neonatal-derived cardiac-resident macrophages in response to environmental cues abrogated their potential to promote cardiomyocyte proliferation via Jagged-1-Notch1

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Acta Pharmaceutica Sinica B 2023年第1期13卷 128-141页

作者： Rong Chen Shiqing Zhang Fang Liu Lin Xia Chong Wang Siamak Sandoghchian Shotorbani Huaxi Xu subrata Chakrabarti Tianqing Peng zhaoliang su International Genome Center Jiangsu UniversityZhenjiang 212013China Institute for Medical Immunology Jiangsu UniversityZhenjiang 212013China Department of Laboratory Medicine Affiliated Hospital of Jiangsu UniversityZhenjiang 212001China Department of Immunology Tabriz University of Medical SciencesTabriz ***Iran Lawson Health Research Institute London Health Sciences CentreLondonOntario N6A 5w9Canada Department of Pathology and Laboratory Medicine Western UniversityLondonOntario N6A 5CICanada

Cardiac-resident macrophages(CRMs)play important roles in homeostasis,cardiac function,and remodeling.Although CRMs play critical roles in cardiac regeneration of neonatal mice,their roles are yet to be fully elucidated.Therefore,this study aimed to investigate the dynamic changes of CRMs during cardiac ontogeny and analyze the phenotypic and functional properties of CRMs in the promotion of cardiac regeneration.During mouse cardiac ontogeny,four CRM subsets exist successively:CX3CR1+CCR2-Ly6C-MHCII-(MP1),CX3CR1lowCCR2lowLy6C-MHCII-(MP2),CX3CR1-CCR2+Ly6C+MHCII-(MP3),and CX3CR1+CCR2-Ly6C-MHCII+(MP4).MP1 cluster has different derivations(yolk sac,fetal liver,and bone marrow)and multiple functions population.Embryonic and neonatal-derived-MP1 directly promoted cardiomyocyte proliferation through Jagged-1-Notch1 axis and significantly ameliorated cardiac injury following myocardial infarction.MP2/3 subsets could survive throughout adulthood.MP4,the main population in adult mouse hearts,contributed to inflammation.During ontogeny,MP1 can convert into MP4 triggered by changes in the cellular redox state.These findings delineate the evolutionary dynamics of CRMs under physiological conditions and found direct evidence that embryonic and neonatal-derived CRMs regulate cardiomyocyte proliferation.Our findings also shed light on cardiac repair following injury.

关键词： Cardiac resident macrophages Cardiac regeneration Cardiac injury Cardiomyocyte proliferation Myocardial infarction

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High Mobility Group Box 1 and Traumatic Brain Injury

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Journal of Behavioral and Brain Science 2017年第2期7卷 50-61页

作者： Seidu A. Richard Wu Min zhaoliang su Huaxi Xu Department of Neurosurgery Affiliated Hospital of Jiangsu University (Jiangbin Hospital) Zhenjiang China Department of Immunology Jiangsu University Zhenjiang China

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. We identify High Mobility Group Box 1 (HMGB1) as a novel causative factor in the development of cerebral oedema, mediating coagulation, preventing secondary brain damage as well as serving as a novel therapeutic target to limit secondary neurological injury after TBI. As a prototypical danger associated molecular patterns (DAMP), HMGB1 is released from necrotic neurons via a NR2B-mediated mechanism during TBI. The secretion of HMGB1 requires severe injury and tissue hypoperfusion, and is associated with posttraumatic coagulation abnormalities, activation of complement and severe systemic inflammatory response. HMGB1 is clinically associated with elevated intracranial pressure (ICP) in patients and functionally promoted cerebral edema after TBI. The detrimental effects of HMGB1 is mediated at least in part between activation of microglial toll-like receptor 4 (TLR4) and the subsequent expression of the astrocytic water channel aquaporin-4 (AQP4). Anti-HMGB1mAb remarkably inhibited fluid percussion-induced brain edema by inhibiting HMGB1 translocation, protection of blood-brain barrier (BBB) integrity, suppression of inflammatory molecule expression and improvement of motor function. Our review demonstrates the pathological role of HMGB1 as well as the possible therapeutic valve of HMGB1 in patients with TBI.

关键词： HMGB1 TBI Biomarker Brain Edema Coagulation Anti-HMGB1 Therapy

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氧掺杂氮化碳的制备及对农田环境残留农药的降解性能

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农药 2024年第5期63卷 330-336页

作者：马志远戴华伟王瑞闯高峰李虎朱友福苏兆亮邱军刘雪山东淄博烟草有限公司山东淄博256100 中国农业科学院烟草研究所山东青岛266101

[目的]构建适用于多菌灵等4种烟-稻轮作农田常用农药的可见光催化降解技术,并阐释降解机制,为缓解农田环境农药残留造成的采收期作物农残超标问题提供理论和技术支撑。[方法]通过高温聚合法制备氧掺杂氮化碳纳米材料,通过扫描电子显微... 详细信息

[目的]构建适用于多菌灵等4种烟-稻轮作农田常用农药的可见光催化降解技术,并阐释降解机制,为缓解农田环境农药残留造成的采收期作物农残超标问题提供理论和技术支撑。[方法]通过高温聚合法制备氧掺杂氮化碳纳米材料,通过扫描电子显微镜等表征技术分析材料微观结构。通过光催化降解试验,评价并筛选出降解性能最优的材料,同时研究复杂因素对降解过程的影响。[结果]氧元素掺杂可有效提高氮化碳纳米材料对目标农药的光催化降解性能,最优材料OCN_(0.1)对多菌灵可见光下1 h内降解率即可达到94.6%,通过活性物种捕获试验,证实在目标农药的降解过程中,活性物种的贡献度排序为h+>^(1)O_(2)>·O_(2)^(-)。OCN_(0.1)不仅能有效降解水环境残留农药,在作物生长阶段,喷施OCN_(0.1)材料48 h后,农残降解率最大也可提高39.95%。[结论]制备获得的OCN_(0.1)纳米材料,可有效降低农田环境及作物中的农药残留水平,具有良好的应用前景。

关键词：氮化碳农药残留光催化降解机制作物

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