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Liver abscess and tracheal fistula induced by transcatheter arterial chemoembolization for hepatocellular carcinoma:A case report

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World Journal of Clinical Cases 2024年第16期12卷 2911-2916页

作者： Fu-Long Zhang Jing Xu Yu-Hong Jiang Yuan-Dong Zhu Qian-Neng wu Yan Shi Fang-Yuan Zhu Jing-Wen Chen Liang-Xiao wu Department of Gastroenterology Hangzhou Xixi HospitalHangzhou 310023Zhejiang ProvinceChina Department of Hepatopathy Hangzhou Xixi HospitalHangzhou 310023Zhejiang ProvinceChina

BACKGROUND Transarterial chemoembolization(TACE)is a standard treatment for intermediate-stage hepatocellular carcinoma(HCC).The complications of TACE include biliary tract infection,liver dysfunction,tumor lysis syndrome,biloma,partial intestinal obstruction,cerebral lipiodol embolism,*** are few reports about tracheal fistula induced by *** SUMMARY A 42-year-old man came to our hospital with cough and expectoration for 1 month after TACE for *** test results showed abnormalities of albumin,hemoglobin,prothrombin time,C-reactive protein,D-dimer,and *** of both phlegm and liver pus revealed growth of Citrobacter *** tomography showed infection in the inferior lobe of the right lung and a low-density lesion with gas in the right *** ultrasound showed that there was a big hypoechoic liquid lesion without blood flow *** for liver abscess by needle puncture under ultrasonic guidance was *** 1 month of drainage and anti-infection therapy,the abscess in the liver and the infection in the lung were reduced obviously,and the symptom of expectoration was *** Clinicians should be alert to the possibility of complications of liver abscess and tracheal fistula after TACE for *** for liver abscess by needle puncture under ultrasonic guidance could relieve the liver abscess and tracheal fistula.

关键词： Tracheal fistula Liver abscess Transcatheter arterial chemoembolization Hepatocellular carcinoma Drainage Case report

Fecal microbiota transplantation from blueberry and blackberry anthocyanins-supplemented mice ameliorated metabolic syndrome by regulating gut microbiota in a high-fat diet model

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Food Science and Human Wellness 2024年

作者： Lanlan Du Xiaoqin Ding Yan Chen Han Chen Han Lü Yanan Gai Tunyu Jian Wenlong wu Jian Chen Weilin Li Co-Innovation Center for Sustainable Forestry in Southern China， College of Forestry， Nanjing Forestry University Jiangsu Key Laboratory for the Research and Utilization of Plant Resources， Institute of Botany， Jiangsu Province and Chinese Academy of Sciences

Blueberry anthocyanins (VA) and blackberry anthocyanins (RA) showed benefits on metabolic syndrome (MS) induced by high-fat diet in mice. In this study， we investigated whether the therapeutic effects of VA and RA were achieved by the gut microbiota regulation and whether these effects could be replicated through fecal microbiota transplantation (FMT) using the high-fat diet caused MS model in pseudo-germ-free (PGF) mice. The results demonstrated that the beneficial effects of VA and RA on MS， including reducing body weight gain and fat accumulation， improving glucose and lipid metabolism， and mitigating intestinal barrier damage， were attributed to the gut microbiota and could be replicated by FMT. 16S rRNA sequencing analysis suggested that FMT from donor mice supplemented with VA and RA could regulate the gut microbiota composition. Particularly， FMT from RA supplemented mice displayed the potential to restore the diversity of gut microbiota and the ratio of Firmicutes to Bacteroidetes. Meanwhile， FMT from VA supplemented mice appeared to exert its effects by selectively influencing specific gut microbiota， such as the genus Akkermansia. Furthermore， our analysis identified 10 common differential ASVs among groups compared to HFD-HFD group. Notably， ASV＿36450 was negatively associated with metabolic parameters， suggesting that Lactobacillus might be the potential bacteria in regulating MS. Overall， our study demonstrated that FMT from VA and RA supplemented mice could ameliorate MS induced by high-fat diet in mice through regulating specific gut microbiota.

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Deriving skeletal muscle cells from adipose-derived stem cells:Current differentiation strategies

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Chinese Medical Journal 2024年第12期137卷 1498-1500页

作者： Wei Liang Meng Han Huiting wu Wanwen Dang Xiaoyu Meng Yonghuan Zhen Yang An Department of Plastic Surgery Peking University Third HospitalBeijing 100191China

To the Editor:Adipose-derived stem cells(ASCs)are promising multipotent stem cells for regeneration of skeletal muscle(SM)tissues.[1]However,the low myogenic differentiation ability limits the application.[2]Therefore,it is necessary to summarize the current differentiation strategy to improve the differentiation *** methods(biochemical induction)and non-traditional strategies(co-culture,biomechanical approaches,and biomaterial utilization)are commonly used for the differentiation of ASCs into myogenic *** both strategies can effectively induce differentiation of myogenic cells,cellular unhealthy or immature myogenic differentiation status is still the greatest challenge for ***,the combination of non-traditional methods and traditional methods has the potential to significantly enhance myogenesis of ASCs with remarkable efficacy,however,evidence is currrently *** review discusses the traditional and non-traditional strategies,as well as several combination motheds of above strategies,for inducing ASCs differentiation into myogenic cells[Figure 1].

关键词： skeletal Figure strategies

Cratonic Strike-Slip Faults in the Southwest Ordos Basin(Central China)， and Their Influence on Hydrocarbon Accumulation

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Journal of Earth Science 2024年

作者： Zhao Wang Lei Huang Chiyang Liu Faqi He Huichong Jia Fubin Wang Peng Yang Fei Yang Xiaowei Li Sixuan wu State Key Laboratory of Continental Dynamics， Northwest University Institute of Oil and Gas Basin， Northwest University Xi'an Sinopec North China Oil and Gas Branch Geology and Geophysics Program， Missouri University of Science and Technology Exploration and Development Research Institute， PetroChina Southwest Oil & Gasfield Company

Cratonic strike-slip fault， despite its potentially significant influence on hydrocarbon accumulation， has attracted limited attention. This study investigates the geometry and kinematics of the cratonic strike-slip faults newly identified within the southwest Ordos Basin， Central China， based on 3D seismic reflection data. We recognized three dominant sets of faults with strike-slip nature trending respectively in NW， ENE， and N–S directions in the study area. These faults exhibit a stratified style characterized by distinct trends across various strata， with ENE-trending faults in the Mesozoic strata (Area A)， N-S-trending faults in the Paleozoic strata， and vertically discontinuous structures in the Mesozoic and Paleozoic strata (NW-trending Yudu fault zone and ENE-trending Yulinzi and Zaosheng fault zones). The contrasting kinematics of strike-slip faults observed in deep and shallow layers further confirm such fault stratification， suggesting isolated fault evolution within respective layers. The quantified fault parameters obtained from seismic reflection data， including length， width and displacement， suggest that these cratonic strike-slip faults in the Ordos Basin are immature. Comparisons with strike-slip faults in other cratonic basins and active tectonic settings suggest that the strike-slip faults within the Ordos Basin are representative of cratonic strike-slip faults， characterized by low maturity and a stratified faulting style， and they have special propagation mechanism (preferentially occurring in the shallow strata of the interior of the basin). Moreover， these fault characteristics have dual impacts on petroleum accumulation in the southwest Ordos Basin. The low faulty maturity makes the fault zone a special hydrocarbon reservoir (fault-fracture volume) in tight sandstone， while the stratified faulting style vertically separates the Mesozoic and Paleozoic petroleum systems in the southwest Ordos Basin. Our findings therefore contribute significa

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基于tSNE多特征融合的JTC轨旁设备故障检测

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铁道科学与工程学报 2024年第3期21卷 1244-1255页

作者：武晓春郜文祥兰州交通大学自动化与电气工程学院甘肃兰州730070

无绝缘轨道电路(Jointless Track Circuit,JTC)的轨旁设备在室外长期运营过程中,其可靠性会逐渐降低,进而给列车行车安全带来严重威胁。以轨道电路读取器(Track Circuit Reader,TCR)感应电压为基础,针对JTC故障诊断研究中轨旁设备故障... 详细信息

无绝缘轨道电路(Jointless Track Circuit,JTC)的轨旁设备在室外长期运营过程中,其可靠性会逐渐降低,进而给列车行车安全带来严重威胁。以轨道电路读取器(Track Circuit Reader,TCR)感应电压为基础,针对JTC故障诊断研究中轨旁设备故障类型复杂和故障特征提取不充分等问题,提出一种基于t分布随机邻域嵌入(t-distribution Stochastic Neighbor Embedding,tSNE)多特征融合的JTC轨旁设备故障检测模型。首先,根据不同轨旁设备故障对TCR感应电压信号的影响,分析各轨旁设备的故障特性。其次,提取TCR感应电压信号的方差、有效值、峰值因子等幅值域特征,以及排列熵、散布熵特征构成原始故障特征集。为了去除其中的冗余信息,得到具有较高判别性的融合流形特征,利用tSNE算法进行特征融合。最后输入深度残差网络(Deep Residual Network,DRN)得到故障检测混淆矩阵,实现轨旁设备故障定位。实验结果表明:tSNE算法融合后的特征在异类和同类故障样本之间分别有较大的类间间距和较小的类内间距,相比主成分分析(Principal Component Analysis, PCA)、随机相似性嵌入(Stochastic Proximity Embedding, SPE)、随机邻域嵌入(Stochastic Neighbor Embedding,SNE)算法具有更优的融合特征提取效果。此外,结合DRN可以有效识别多种轨旁设备故障,达到98.28%的故障检测准确率。通过现场信号进行实例验证,结果表明该故障检测模型能满足铁路现场对室外设备进行故障定位的实际需求。

关键词：轨旁设备幅值域排列熵散布熵多特征融合故障检测

High-performance GaSb planar PN junction detector

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Journal of Semiconductors 2024年第9期45卷 48-52页

作者： Yuanzhi Cui Hongyue Hao Shihao Zhang Shuo Wang Jing Zhang Yifan Shan Ruoyu Xie Xiaoyu Wang Chuang Wang Mengchen Liu Dongwei Jiang Yingqiang Xu Guowei Wang Donghai wu Zhichuan Niu Derang Cao College of Physics National Demonstration Center for Experimental Applied Physics EducationQingdao UniversityQingdao 266071China Key Laboratory of Optoelectronic Materials and Devices Chinese Academy of SciencesBeijing 100083China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049China

This paper examines GaSb short-wavelength infrared detectors employing planar PN junctions. The fabrication was based on the Zn diffusion process and the diffusion temperature was optimized. Characterization revealed a 50% cut-off wavelength of 1.73 μm, a maximum detectivity of 8.73 × 10^(10) cm·Hz^(1/2)/W, and a minimum dark current density of 1.02 × 10^(-5) A/cm^(2).Additionally, a maximum quantum efficiency of 60.3% was achieved. Subsequent optimization of fabrication enabled the realization of a 320 × 256 focal plane array that exhibited satisfactory imaging results. Remarkably, the GaSb planar detectors demonstrated potential in low-cost short wavelength infrared imaging, without requiring material epitaxy or deposition.

关键词： antimonide short-wave infrared planar junction zinc diffusion

Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong wu Yushan Chen Zhen Wei Yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： Jian Yang Jiang wu Xueshun Xie Pengfei Xia Jinxin Lu Jiale Liu Lei Bai Xiang Li Zhengquan Yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

Study on the Mechanism of Glutamine Promoting the Synthesis of Colonic Mucin and Maintaining the Stability of Intestinal Microbiota in Septic Mice

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Food Science and Human Wellness 2024年

作者： Yanyan Pan Gang Yang Dan wu Yan Wei Shijun Fan Lin Xia Qian Chen Qianying Huang Yongling Lu Xi Peng Clinical Medical Research Center， Southwest Hospital， Third Military Medical University (Army Medical University) Burn Department， Ningbo No.2 Hospital nstitute of Burn Research， State Key Laboratory of Trauma and Chemical Poisoning， Southwest Hospital， Third Military Medical University (Army Medical University)

Colonic mucus and gut microbiota closely linked through mutual regulatory effect. While their alterations during sepsis and whether glutamine can maintain the colonic mucus barrier and gut microbiota stability are unclear. Cecal ligation and puncture-induced sepsis in mice was utilized to observe changes in colonic mucus， gut microbiota， and their interaction with glutamine intervention. Our findings indicated that glutamine mitigated sepsis-induced intestinal damage and restores colonic mucus barrier function by augmenting mucin synthesis. Further analysis revealed that goblet cells were under oxidative stress after sepsis， resulting in anterior gradient-2 (AGR2)， the key mucin-modifying enzyme， being dissynthesized， and inhibiting mucin2 (MUC2) maturation. glutamine could ameliorates this situation by promoting the key enzyme glucose-6-phosphate dehydrogenase (G6PD) glycosylation in the pentose phosphate pathway， increasing the reduced nicotinamide adenine dinucleotide phosphate (NADPH) synthesis， reducing endoplasmic reticulum stress， and accelerating AGR2 synthesis and MUC2 maturation. Additionally， glutamine aided in maintaining gut microbiota stability during sepsis， up-regulating mucin-associated bacteria such as Akkermansia and Alistipes. These bacteria， intimately linked to mucin synthesis and degradation， may impact intestinal mucus stability. In conclusion， glutamine can maintain goblet cell redox balance， promotes AGR2 synthesis and MUC2 maturation， shields the mucus barrier， and potentially maintains gut microbiota stability by regulating the interaction between bacteria and mucus， thus alleviating sepsis-induced intestinal damage.

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