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Current status of surgical treatment of colorectal liver metastases

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World Journal of Clinical Cases 2018年第14期6卷 716-734页

作者： Feng xu Bin tang tian-Qiang jin Chao-Liu Dai Department of hepatobiliary and Splenic Surgery Shengjing Hospital China Medical University Shenyang 110004 Liaoning Province China

Liver metastasis （LM） is one of the major causes of death in patients with colorectal cancer （CRC）. Approxi-mately 60% of CRC patients develop LM during the course of their illness. About 85% of these patients have unresectable disease at the time of presenta-tion. Surgical resection is currently the only curative treatment for patients with colorectal LM （CRLM）. In recent years, with the help of modern multimodality therapy including systemic chemotherapy, radiation therapy, and surgery, the outcomes of CRLM treatment have signifcantly improved. This article summarizes the current status of surgical treatment of CRLM including evaluation of resectability, treatment for resectable LM, conversion therapy and liver transplantation for unresectable cases, liver resection for recurrent CRLM and elderly patients, and surgery for concomitanthepatic and extra-hepatic metastatic disease （EHMD）. We believe that with the help of modern multimodality therapy, an aggressive oncosurgical approach should be implemented as it has the possibility of achieving a cure, even when EHMD is present in patients with CRLM.

关键词： Colorectal cancer Neoadjuvant therapy Liver metastasis Liver Surgery Liver transplantation hepatectomy Laparoscopy

Yangtze River Delta Aerosol liquid water in PM_(2.5)and its roles in secondary aerosol formation at a regional site of Yangtze River Delta

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Journal of Environmental Sciences 2024年第4期138卷 684-696页

作者： Ruifang Shi Fei Zhang Yemin Shen Jiasi Shen Bingye xu Binyu Kuang Zhengning xu Lingling jin Qian tang xudong tian Zhibin Wang College of Environmental and Resource Sciences Zhejiang Provincial Key Laboratory of Organic Pollution Process and ControlZhejiang UniversityHangzhou 310058China ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311215China Zhejiang Ecological and Environmental Monitoring Center Hangzhou 310012China

Aerosol liquid water content(ALWC)plays an important role in secondary aerosol *** this study,a whole year field campaign was conducted at Shanxi in north Zhejiang Province during *** estimated by ISORROPIA-Ⅱ was then investigated to explore its characteristics and relationship with secondary *** exhibited a highest value in spring(66.38μg/m^(3)),followed by winter(45.08μg/m^(3)),summer(41.64μg/m^(3)),and autumn(35.01μg/m^(3)),*** was supposed that the secondary inorganic aerosols(SIA)were facilitated under higher ALWC conditions(RH>80%),while the secondary organic species tended to form under lower ALWC *** RH(>80%)promoted the NO_(3)^(-)formation via gas-particle partitioning,while SO_(4)^(2-)was generated at a relative lower RH(>50%).The ALWC was more sensitive to NO_(3)^(-)(R=0.94)than SO_(4)^(2-)(R=0.90).Thus,the self-amplifying processes between the ALWC and SIA enhanced the particle mass *** sensitivity of ALWC and OX(NO_(2)+O_(3))to secondary organic carbon(SOC)varied in different seasons at Shanxi,more sensitive to aqueous-phase reactions(daytime R=0.84;nighttime R=0.54)than photochemical oxidation(daytime R=0.23;nighttime R=0.41)in wintertime with a high level of OX(daytime:130-140μg/m^(3);nighttime:100-140μg/m^(3)).The self-amplifying process of ALWC and SIA and the aqueous-phase formation of SOC will enhance aerosol formation,contributing to air pollution and reduction of visibility.

关键词： Aerosol liquid water content Nitrate Sulfate Secondary organic compounds Aqueous-phase reaction

Cross Project Defect Prediction via Balanced Distribution Adaptation Based Transfer Learning

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Journal of Computer Science & Technology 2019年第5期34卷 1039-1062页

作者： Zhou xu Shuai Pang Tao Zhang Xia-Pu Luo jin Liu Yu-tian tang Xiao Yu Lei xue College of Computer Science and Technology Harbin Engineering UniversityHarbin 150001China School of Computer Science Wuhan UniversityWuhan 430072China Department of Computing The Hong Kong Polytechnic UniversityHong Kong 999077China Department of ComputingThe Hong Kong Polytechnic UniversityHong Kong 999077China Key Laboratory of Network Assessment Technology Institute of Information EngineeringChinese Academy of Sciences Beijing 100190China Guangxi Key Laboratory of Trusted Software Guilin University of Electronic TechnologyGuilin 541004China Department of Computer Science City University of Hong KongHong Kong 999077China

Defect prediction assists the rational allocation of testing resources by detecting the potentially defective software modules before releasing products. When a project has no historical labeled defect data, cross project defect prediction (CPDP) is an alternative technique for this scenario. CPDP utilizes labeled defect data of an external project to construct a classification model to predict the module labels of the current project. Transfer learning based CPDP methods are the current mainstream. In general, such methods aim to minimize the distribution differences between the data of the two projects. However, previous methods mainly focus on the marginal distribution difference but ignore the conditional distribution difference, which will lead to unsatisfactory performance. In this work, we use a novel balanced distribution adaptation (BDA) based transfer learning method to narrow this gap. BDA simultaneously considers the two kinds of distribution differences and adaptively assigns different weights to them. To evaluate the effectiveness of BDA for CPDP performance, we conduct experiments on 18 projects from four datasets using six indicators (i.e., F-measure, g-means, Balance, AUC, EARecall, and EAF-measure). Compared with 12 baseline methods, BDA achieves average improvements of 23.8%, 12.5%, 11.5%, 4.7%, 34.2%, and 33.7% in terms of the six indicators respectively over four datasets.

关键词： cross-project defect prediction transfer learning balancing distribution effort-aware indicator

Erect panicle super rice varieties enhance yield by harvest index advantages in high nitrogen and density conditions

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Journal of Integrative Agriculture 2017年第7期16卷 1467-1473页

作者： tang Liang GAO Hong Hirooka Yoshihiro Homma Koki Nakazaki Tetsuya LIU tian-sheng Shiraiwa Tatsuhiko xu Zheng-jin Rice Research Institute Shenyang Agricultural University/Key Laboratory of Northeast Rice Biology and BreedingMinistry of Agriculture/Key Laboratory of Northern japonica Super Rice BreedingMinistry of EducationShenyang 110866P.R.China Liaoning Academy of Agricultural Sciences Shenyang 110161P.R.China Laboratory of Plant Breeding Graduate School of AgricultureKyoto UniversityKyoto 606-8502Japan

The erect panicle （Ep） type is an important characteristic for japonica super rice in Northeast China and plays a significant role in enhancing yield. The Ep type is considered to be a genetic ideotype resource to the japonica super rice group by virtue of its agronomic advantages such as grain number per panicle and biomass. This study addresses the effects of nitrogen and planting density conditions on yielding performance regarding panicle type （PT） using the recombinant inbred line （RIL） population derived from the cross between an Ep variety Liaogeng 5 and non-Ep variety Wanlun 422. The genetics underlying the Ep type proved to be robust not only for panicle-type optimization but also plant height, panicle length, flag leaf length and seed density. We also found that regardless of nitrogen and density, correlation between harvest index （HI） and plant height was not significant in Ep type whatever the nitrogen and density. The application of Ep type provides a potential strategy for yield improvement by increasing biomass through HI maintainable in rice.

关键词： super rice erect panicle harvest index nitrogen planting density

Tertiary orientation structures enhance the piezoelectricity of MXene/PVDF nanocomposite

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Nano Research 2024年第6期17卷 5629-5635页

作者： Yong Ao Tao Yang Guo tian Shenglong Wang tianpei xu Lin Deng Jieling Zhang Lihua tang Weili Deng Long jin Weiqing Yang Key Laboratory of Advanced Technologies of Materials(Ministry of Education) School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China Department of Mechanical Engineering The University of AucklandAuckland 1010New Zealand Research Institute of Frontier Science Southwest Jiaotong UniversityChengdu 610031China

With the increasing demand for flexible piezoelectric sensor components,research on polyvinylidene fluoride(PVDF)based piezoelectric polymers is mounting ***,the low dipole polarization and disordered polarization direction presented in PVDF hinder further improvement of piezoelectric ***,we constructed an oriented tertiary structure,consisting of molecular chains,crystalline region,and MXene sheets,in MXene/PVDF nanocomposite via a temperature-pressure dual-field regulation *** highly oriented PVDF molecular chains form approximately 90%of theβ*** addition,the crystalline region structure with long-range orientation achieves out of plane polarization *** parallel orientation arrangement of MXene effectively enhances the piezoelectric performances of the nanocomposite,and the current output of the device increases by nearly 23 *** high output device is used to monitor exercise action,exploring the potential applications in wearable electronics.

关键词： flexible sensor piezoelectric MXene/polyvinylidene fluoride(PVDF)nanocomposite orientation structures

Groundwater resources survey of tongchuan city using the audio magnetotelluric method

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Applied Geophysics 2020年第5期17卷 660-671,900页

作者： xu Zhi-min tang jing-tian Li Guang Xin Hui-Cui xu Zhang-jian Tan Xin-ping LI jin heibei Instrument&Meter Engineering Technology Research Center Chengde Petroleum CollegeChengde 067000China School of Geosciences and Info-Physics Central South UniversityChangsha 410083China Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring Ministry of Education(Central South University)Changsha 410083China Northwest Research Institution of Engineering Investigations and Design Xi’an 710003China School of Geophysics and Measurement-control Technology Nanchang 330013China College of Information Science and Engineering Hunan Normal UniversityChangsha 410081China

The development of Tongchuan City,Shaanxi Province,located in the northwestern region of China,is restricted by water *** direct current resistivity and induced polarization sounding methods are typically applied in finding urban *** methods,however,are not effective due to their complicated topography and geological *** application practice shows that the audio magnetotelluric(AMT)method has a large depth of exploration,high work effi ciency,and high lateral *** investigate the distribution of groundwater resources,we deployed three audio-frequency magnetotelluric profiles in the city *** impedance tensor information of AMT data is obtained using *** data dimension analysis reveals that the two-dimensional structural features of the observation area are *** main structure of the observation area is about 45°northeast,as indicated by structural trend analysis.A shallow two-dimensional electrical profile of 1 km in Tongchuan City is obtained by two-dimensional nonlinear conjugate gradient ***,combined with regional geological information,the geological structure characteristics reflected by the electrical profile were obtained along with the detailed characteristics of water-rich structures in the *** infl uence of the structure on the groundwater distribution was analyzed,and the water-rich areas were identifi *** work contributes to the prospective development of Tongchuan City.

关键词： urban geology audio magnetotelluric sounding method electrical structure groundwater resources

Racemic Bisindole Alkaloids: Structure, Bioactivity, and Computational Study

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Chinese Journal of Chemistry 2021年第9期39卷 2588-2598页

作者： tian-Yun jin Ping-Lin Li Ci-Li Wang xu-Li tang Mei-Mei Cheng Yuan Zong Lian-Zhong Luo Hui-Long Ou Ke-Chun Liu Guo-Qiang Li Key Laboratory of Marine Drugs Chinese Ministry of EducationSchool of Medicine and Pharmacy DepartmentOcean University of ChinaQingdaoShandong 266003China Laboratory of Marine Drugs and Biological Products National Laboratory for Marine Science and TechnologyQingdaoShandong 266235China College of Chemistry and Chemical Engineering State-Province Joint Engineering Laboratory of Marine Bioproducts and TechnologyOcean University of ChinaQingdaoShandong 266003China Engineering Research Center of Marine Biopharmaceutical Resource Xiamen Medical CollegeXiamenFujian 361023China College of Ocean and Earth Sciences Xiamen UniversityXiamenFujian 361006China Biology Institute Qilu University of Technology(Shandong Academy of Sciences)JinanShandong 250099China

The new racemic and dimeric in dole alkaloids with the characteristic cyclope nta[b]indole backb one,(+)-and(-)-sp on domi ne(la/lb),were isolated from a cultured sponge Tedania anhelans.A semi-synthesis was employed to obtain la/lb and the other four stereoisomers *** structures were determined by spectroscopic analysis,single-crystal X-ray,and quantum chemical *** stereoisomers differ in bioactivity according to their absolute con ***,(+)-sp on domi ne(la)displayed cytotoxicity against the K562 cell line and exhibited stronger Wnt and HIF1 dual signaling inhibitory activity at 5 pmol/L than the positive control,which offers an exciting starting point for further *** stereoisomers significantly promoted angiogenesis and showed moderate anti-inflammation in zebrafish.A quantum chemical calculation and deuteration experiment were applied to unveil the reacti on mechanism which guides the synthesis of the target compounds.

关键词： Tedania anhelans Alkaloids Cyclopenta[b]indole Biological activity Reaction mechanisms

Magnetotelluric signal-noise separation method based on SVM–CEEMDWT

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Applied Geophysics 2019年第2期16卷 160-170,252-253页

作者： Li jin Cai jin tang jing-tian Li Guang Zhang Xian xu Zhi-Min Hunan Provincial Key Laboratory of Intelligent Computing and Language Information Processing College of Information Science and EngineeringHunan Normal UniversityChangsha 410081China School of Geosciences and Info-Physics Key Laboratory of Metallogenic Prediction of Non-Ferrous Metals and Geological Environment MonitorMinistry of EducationCentral South UniversityChangsha 410083China State Key Laboratory Breeding Base of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China

To better retain useful weak low-frequency magnetotelluric(MT)signals with strong interference during MT data processing,we propose a SVM-CEEMDWT based MT data signal-noise separation method,which extracts the weak MT signal affected by strong ***,the approximate entropy,fuzzy entropy,sample entropy,and Lempel-Ziv(LZ)complexity are extracted from the magnetotelluric ***,four robust parameters are used as the inputs to the support vector machine(SVM)to train the sample library and build a model based on the different complexity of *** on this model,we can only consider time series with strong interference when using the complementary ensemble empirical mode decomposition(CEEMD)and wavelet threshold(WT)for noise *** results suggest that the SVM based on the robust parameters can distinguish the time periods with strong interference well before noise *** with the CEEMD WT,the proposed SVM-CEEMDWT method retains more low-frequency low-variability information,and the apparent resistivity curve is smoother and more ***,the results better reflect the deep electrical structure in the field.

关键词： SVM-CEEMDWT magnetotelluric signal-noise separation MT data processing

Identification of novel mammalian viruses in tree shrews(Tupaia belangeri chinensis)

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Zoological Research 2024年第2期45卷 429-438页

作者： Hong Zhou Ren-Rong tian Xiu-Rong Wang jin-xuan Yang Yun-Xiao Wang Ming-Liang Zhao xu-Dong Zhang Yu-Hua Ma Long-Bao Lv Edward CHolmes Yong-tang Zheng Wei-Feng Shi School of Clinical and Basic Medical Sciences Shandong First Medical University&Shandong Academy of Medical SciencesJi’nanShandong 250117China Key Laboratory of Emerging Infectious Diseases in Universities of Shandong Shandong First Medical University and Shandong Academy of Medical SciencesTaianShandong 271000China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesCenter for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China School of Public health Shandong First Medical University&Shandong Academy of Medical SciencesJi’nanShandong 250117China National Resource Center for Non-Human Primates Kunming Primate Research CenterKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China Sydney Institute for Infectious Diseases School of Medical SciencesThe University of SydneySydneyNew South Wales 2006Australia Department of Infectious Diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Institute of Virology Shanghai Jiao Tong University School of MedicineShanghai 200025China

The Chinese tree shrew(Tupaia belangeri chinensis),a member of the mammalian order Scandentia,exhibits considerable similarities with primates,including humans,in aspects of its nervous,immune,and metabolic *** similarities have established the tree shrew as a promising experimental model for biomedical research on cancer,infectious diseases,metabolic disorders,and mental health ***,we used metatranscriptomic sequencing to analyze plasma,as well as oral and anal swab samples,from 105 healthy asymptomatic tree shrews to identify the presence of potential zoonotic *** total,eight mammalian viruses with complete genomes were identified,belonging to six viral families,including Flaviviridae,hepeviridae,Parvovirinae,Picornaviridae,Sedoreoviridae,and ***,the presence of rotavirus was recorded in tree shrews for the first *** viruses-hepacivirus 1,parvovirus,and picornavirus-exhibited low genetic similarity(he whole-genome scale,indicating ***,three other viruses-hepacivirus 2,hepatovirus A and hepevirus-exhibited high similarity(>94%)to known viral *** analyses also revealed that the rotavirus and mammalian orthoreovirus identified in this study may be novel *** findings provide insights into the diverse viral spectrum present in captive Chinese tree shrews,highlighting the necessity for further research into their potential for crossspecies transmission.

关键词： Tree shrew(Tupaia belangeri chinensis) Meta-transcriptomic sequencing Mammalian viruses Genomic analysis